Relapsing polychondritis (RP) is characterised by recurrent flares, and comparative evidence for relapse prevention using biologics remains limited. We evaluated the association between biologic exposure and relapse incidence.

Calcinosis cutis (CC) is disabling for systemic sclerosis (SSc) patients, and quantitative outcomes and treatments are needed. We performed computer-assisted mapping of CC lesions on computed tomography (CT) exams and quantified CC during sodium thiosulfate (STS) treatment.

Obesity is a prevalent comorbidity in psoriatic arthritis (PsA). We aimed to evaluate the association between body mass index (BMI) and minimal disease activity (MDA) state in PsA and examine this across different drug classes.

To investigate why, when and in which patterns decisions about changes in systemic medications were made in a cohort of juvenile idiopathic arthritis (JIA) patients.

Advances in high-throughput sequencing and genotype-first approaches have revealed a growing number of monogenic autoimmune and autoinflammatory conditions that present in late adolescence or adulthood and sometimes mimic more common rheumatologic diseases. These disorders arise from both germline and somatic mutations and span a broad spectrum of immune dysregulation, including autoinflammation, autoimmunity, immunodeficiency, allergic disease, and hematological disorders. Importantly, many affected individuals do not exhibit classical Mendelian inheritance or early-onset disease, instead presenting with incomplete penetrance, variable expressivity, or atypical phenotypes that fulfill established classification criteria for diseases such as systemic lupus erythematosus and vasculitides. In this review, we highlight recently described monogenic immune disorders with relevance to adult rheumatology practice, including germline inborn errors of immunity and somatic mutation-driven conditions. We discuss emerging mechanisms that link innate and adaptive immune dysregulation, clinical features that should prompt genetic evaluation, and practical considerations for genetic testing in adult patients. Finally, we examine current challenges and future opportunities in integrating molecular diagnostics into rheumatology care, emphasizing the potential for genetic diagnoses to refine disease classification and inform targeted, mechanism-based therapeutic approaches.

The biomarker potential of CD4+T cell subsets (naive, regulatory (Treg), inflammation-related cells (IRC)) in patients with rheumatoid arthritis (RA) has been described.

Discordance between patient and physician perspectives on disease activity in idiopathic inflammatory myopathies (IIM) can compromise treatment outcomes. This study aimed to characterize patterns of discordance and distinct longitudinal trajectories in the MyoCite IIM cohort.

Prior studies examining the malignancy risk in polymyalgia rheumatica (PMR) have reported conflicting results, with some indicating an increased risk within 6-12 months after diagnosis. This study assessed malignancy risk over the lifetime and at different follow-up horizons in a population-based inception cohort of PMR patients.

Glucocorticoid (GC)- and methotrexate (MTX)-sparing strategies are clinically important in rheumatoid arthritis (RA), yet comparative real-world evidence for sarilumab (SAR) vs Janus kinase inhibitors (JAKi) is limited. Whether treatment effects differ by age at onset-late-onset RA (LORA) vs young-onset RA (YORA)-also remains unclear. This study aimed to compare the effectiveness and safety of sarilumab and JAK inhibitors in patients with late- and younger-onset rheumatoid arthritis.

to evaluate humoral immune response to recombinant zoster vaccine(RZV) in immunosuppressed patients with systemic sclerosis(SSc) compared with healthy controls, to identify factors influencing vaccine response, and to assess RZV safety and impact on patient-reported outcome measures(PROMs) and disease activity(DA).

To investigate the genetic basis of early-onset systemic lupus erythematosus (EOSLE) in a large Indian pediatric SLE (pSLE) cohort.

Juvenile Inflammatory Arthritis (JIA) affects ∼1-2/2,000 children in the UK. Adults with inflammatory arthritis have ∼10% increased malignancy risk. JIA malignancy rates in Nordic data are 3-5/10 000 person years, with conflicting evidence on comparative risk. This study calculated malignancy rates in England of patients with JIA, vs matched controls and general population estimates.

Gout is among the most prevalent arthritides worldwide and is associated with high morbidity, cardiovascular risk, and substantial healthcare burden. Despite effective urate-lowering therapies (ULT), many patients remain undertreated, particularly those with severe or complex disease. Nurse-led gout management has improved outcomes in primary care, but data in multimorbid tertiary center populations are lacking. We aimed to evaluate the effectiveness of a supervised nurse-led gout clinic in achieving and maintaining serum urate (SU) targets in a tertiary hospital cohort.