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2. Neutralising autoantibodies against IL-10 and HLA-DRB1*01:03 in paediatric patients with inflammatory bowel disease.
作者: Nima Gharahdaghi.;Pai-Jui Yeh.;Katherine Vadakethala.;Madeleine Coy.;Ladan Kabiri.;Bushra Naz.;Chamara Jayamanne.;Linn Hansson.;Viktor Zouboulis.;Astor Rodrigues.;Lucy Howarth.;Fatimah Alqahtani.;Arya Ghate.;Fernando Vázquez López.;Zachary Green.;Robert M Beattie.;Marco Gasparetto.;Natalia Nedelkopoulou.;Ashrita Iyengar.;Amrit Gopan.;Nicholas M Croft.;Carla Grimaldi.;Jochen Kammermeier.;Kelsey Jones.;Danielle M H Barendregt.;Mian Chen.;Martin Barnardo.;Qian Zhang.;Laura Fachal.;Carl A Anderson.;Anna Adams.;Hazel Johnson.;Hannah Gordon.;Noa Tal.;Elizabeth Renji.;David C Wilson.;Paul Henderson.;Rafeeq Muhammed.;Kwang Yang Lee.;Akshay Kapoor.;Rachel Levi.;Matthias Zilbauer.;Anne M Griffiths.;Dan Turner.;Sophie Hambleton.;Rainer Doffinger.;Janneke N Samsom.; .;Miles Parkes.;Simon P Travis.;Dror S Shouval.;Lissy de Ridder.;Aleixo Muise.;Scott B Snapper.;James J Ashton.;Sarah Ennis.;Holm H Uhlig.
来源: Gut. 2026年
Interleukin-10 (IL-10) is an essential regulator of intestinal immune homeostasis. Neutralising autoantibodies against IL-10 (anti-IL-10) have been identified in children and also adult patients with IBD. Positivity for anti-IL-10 autoantibodies was associated with carriage of HLA-DRB1*01:03 allele.
4. Faecal proteases and immune signatures drive subtype-specific enteric neuronal activation in IBS.
作者: Lejla Ridžal.;Thomas Frieling.;Richárd Róka.;Orsolya Inczefi.;Péter Bacsur.;Dóra Bajcsi.;Michel M Neunlist.;Claire Cardaillac.;Vassilia Theodorou.;Hongsup Yoon.;Jiancheng Wang.;Christina Ludwig.;Susanne I Wudy.;Tibor Pankotai.;Zoltán G Páhi.;Nooshin Mansouri.;Harald Luksch.;Klaus Michel.;Michael Schemann.;Anita Annaházi.
来源: Gut. 2026年
Luminal proteases have been implicated in epithelial barrier dysfunction and visceral hypersensitivity in irritable bowel syndrome (IBS), yet their impact on the enteric nervous system (ENS), the principal regulator of gastrointestinal function, remains unknown.
7. Circulating extracellular vesicles carrying PD-1, PD-L1 and CTLA-4 inform resistance to anti-PD-L1-based therapy in HCC.
作者: João Gorgulho.;Ramsha Masood.;Gustav Buescher.;Franziska Giehren.;Henrike Salié.;Davina David.;Francesca Pagani.;Lorenz Kocheise.;Constantin Schmidt.;Moritz Waldmann.;Mohsin Shafiq.;Katharina Möller.;Carsten Bokemeyer.;Thomas Renné.;Samuel Huber.;Ansgar W Lohse.;Henning Wege.;Cecile L Maire.;Franz Ricklefs.;Katrin Lamszus.;Kai Breitwieser.;Meike J Saul.;Carolin Zimpel.;Jens Marquardt.;Bernhard Scheiner.;Lorenz Balcar.;Matthias Pinter.;Enrico de Toni.;Ignazio Piseddu.;Najib Ben Khaled.;Kornelius Schulze.;Johann von Felden.
来源: Gut. 2026年
First-line immune checkpoint inhibitor (ICI) therapy has contributed to improved outcomes in hepatocellular carcinoma (HCC). However, only around 30% of patients respond, highlighting the need for biomarker-driven patient selection. Considering the lack of tissue acquirement in HCC in clinical routine, liquid biopsy holds great promise.
8. Impact of surveillance colonoscopy on colorectal cancer incidence and mortality in Lynch syndrome: a national observational cohort study of patients in the English NHS 2010-2022.
作者: Catherine Huntley.;Lucy Loong.;Corinne Mallinson.;Tameera Rahman.;Beth Torr.;Sophie Allen.;Isaac Allen.;Hend Hassan.;Yvonne Walburga Joko Fru.;Daniela Tataru.;Lizz Paley.;Sally Vernon.;Richard S Houlston.;David Muller.;Fiona Lalloo.;Adam C Shaw.;John Burn.;Eva J A Morris.;Marc Tischkowitz.;Antonis C Antoniou.;Paul D P Pharoah.;Kevin Monahan.;Steven Hardy.;Clare Turnbull.
来源: Gut. 2026年
Lynch syndrome (LS) is a cancer susceptibility syndrome caused by germline pathogenic variants in DNA mismatch repair (MMR) genes. Due to increased risk of colorectal cancer (CRC), enhanced colonoscopic surveillance is recommended for heterozygote MMR carriers.
12. Enhanced acetate uptake and metabolism in endothelial cells promote tumour angiogenesis and immunosuppression by increasing histone acetylation.
作者: Jie-Ying Chen.;Yu-Chen Ji.;Chen-Hui Wu.;Jun-Guang Chen.;Hui-Xian Zeng.;Chen Xie.;Jian-Hong Fang.;Shi-Mei Zhuang.
来源: Gut. 2026年
Acetate is the metabolic precursor of acetyl-coenzyme A (CoA), fuelling histone acetylation.
14. Rate and clinical predictors of skeletal muscle loss in patients with cirrhosis.
作者: Tsung-Chieh Yang.;Nghiem Bao Ha.;Bo Fan.;Fawzy Barry.;Srilakshmi Seetharaman.;Benjamin Cho.;Kathryn Czepiel.;Arjun Sharma.;Leena Usman.;Jennifer C Lai.
来源: Gut. 2026年
Skeletal muscle mass predicts outcomes in cirrhosis and represents a therapeutic target. However, the natural rate of muscle change in this population remains poorly defined.
15. Decompression of portal hypertension by transjugular intrahepatic portosystemic shunt reverses markers of gut barrier dysfunction and cirrhosis-associated immune dysfunction.
作者: Felix Piecha.;Amirah Al Jawazneh.;Gustav Buescher.;Aenne Harberts.;Michael Spohn.;Johannes Chang.;Franziska Schneider.;Beatrice-Victoria Jahn.;Johannes Köntopf.;Anja Koop.;Daniel Benten.;Christoph Riedel.;Peter Buggisch.;Peter Hübener.;Malik Alawi.;Samuel Huber.;Ansgar W Lohse.;Peter Bannas.;Lidia Bosurgi.;Johannes Kluwe.; .
来源: Gut. 2026年
Decompensated cirrhosis is associated with cirrhosis-associated immune dysfunction (CAID), predisposing patients to bacterial infections and poor outcomes. The mechanisms driving CAID remain incompletely understood.
16. Proteomic resolution of the MASLD cardiometabolic spectrum identifies sex-driven endotypes and predicts systemic mortality.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a heterogeneous condition where overlapping cardiometabolic risk factors challenge accurate prognostic prediction.
17. Galectin-14, a primate-specific oncofetal protein, impairs anti-tumour immunity in hepatocellular carcinoma by driving elevated heparan sulphate modification.
作者: Gang Yang.;Liming Gou.;Xuebin Liu.;Chi Xu.;Qian Yang.;Yue Zhu.;Dandan Zheng.;Ming Lu.;Chunfu Zhu.;Yonglin Yang.;Yiqing Yang.;Sujuan Ma.;Tong Ding.;Luan Sun.;Bin Xue.;Fang Liu.;Wei Gao.
来源: Gut. 2026年
The liver naturally exhibits robust glycosylation processes, yet how aberrant glycosylation affects hepatocellular carcinoma (HCC) and its underlying mechanisms remains poorly understood.
18. Macropinocytosis of neutrophil extracellular trap by gastric cancer cells promotes immune escape and peritoneal metastasis.
作者: Qian Chen.;Lu Zhang.;Biying Chen.;Mengjie Li.;Muzixian Zhang.;Yirou Liu.;Meng Sun.;Yuchao Jiang.;Mengting Hong.;Yinuo Ding.;Yingshuo Yang.;Jiaojiao Ni.;Jieer Ying.;Tianhua Zhou.;Wei Zhuo.
来源: Gut. 2026年
Patients with gastric cancer (GC) and peritoneal metastasis (PM) have poor prognoses due to drug resistance and metastatic relapse. The mechanism underlying PM recurrence remains unclear.
20. In-person therapist-delivered hypnotherapy versus smartphone-based self-guided hypnotherapy in IBS: a multicentre three-armed randomised controlled trial.
作者: Johanna T W Snijkers.;Michelle H M A Bosman.;Bjorn Winkens.;Bertram J T Haarhuis.;Ben J M Witteman.;Nikolien Pijnenborg.;Annieke S de Ruiter.;Laurens A van der Waaij.;Andrea M H Bours.;Cynthia Elderson.;Yanda R van Rood.;Niek de Wit.;Carla E Flik.;Ad A M Masclee.;Daniel Keszthelyi.
来源: Gut. 2026年
Hypnotherapy is an evidence-based therapy recommended for IBS, but access to therapist-led hypnotherapy is limited by costs and availability.
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