2. Is Higher Dose of Inhaled Treprostinil Truly Superior to Lower Dose of Inhaled Treprostinil in Patients With Pulmonary Hypertension Associated With Interstitial Lung Diseases?7. Pleural Effusion Caused by an Unusual Mass in the Right Hemithorax.
作者: Magnus Bluhm.;Bassam Atmeh.;Stephan Boehm.;Jan Hendrik Rüschoff.;Peter Bode.;Corina Dommann-Scherrer.
来源: Chest. 2024年165卷5期e151-e155页
An 80-year-old woman presented with complaints of weakness and dizziness. She had a medical history of subacute cerebral ischemia, vertigo, hypertension, and thalassemia minor. The patient was born and raised in Turkey and has lived in Switzerland for 50 years. Her sister died of a mesothelioma caused by asbestos exposure at the age of 60 years but had lived in Turkey until her death. The patient had neither a history of TB nor B symptoms. She has never smoked.
10. A 1-Day-Old Girl With Infantile Hemangioma and Sternal Cleft.
作者: Meer S Hossain.;Alexia T Stamatiou.;Kellianne C Kleeman.;Brian C Kellogg.;Peter D Wearden.;Angelo A Leto Barone.;Jennifer S Nelson.
来源: Chest. 2024年165卷5期e137-e142页
A newborn girl presented to the hospital on the first day of life because of respiratory failure. She was born at home at 37 weeks' gestation with minimal prenatal care and was found to be small for gestational age. The patient was found to have partial sternal agenesis and sternal cleft, cutis aplasia, left facial hemangioma, micrognathia, wide-spaced nipples, and low-set ears. The mother's and baby's urine toxicology screening were positive for amphetamines. Chest radiographs on admission showed bilateral hazy opacities. CT scan of the chest showed an absent sternum with midline chest wall concavity. The patient was monitored preoperatively in the cardiac ICU for risks of arrythmia, respiratory failure, altered cardiac output, and acute cardiopulmonary decompensation.
11. Case of a 33-Year-Old Woman With Hemoptysis and Migrant Nodular Cavitary Lesions.
作者: Francesco Varone.;Alessia Martini.;Giuseppe Cicchetti.;Bruno Iovene.;Giacomo Sgalla.;Luca Richeldi.;Alessandra Cancellieri.
来源: Chest. 2024年165卷5期e133-e136页
We describe the case of a young 33-year-old woman that was referred to our clinic for evidence of migrant cavitary nodules at CT scan, dyspnea, and blood sputum. Her physical examination showed translucent and thin skin, evident venous vascular pattern, vermilion of the lip thin, micrognathia, thin nose, and occasional Raynaud phenomenon. We prescribed another CT scan that showed multiple pulmonary nodules in both lungs, some of which had evidence of cavitation. Because bronchoscopy was not diagnostic, we decided to perform surgical lung biopsy. At histologic examination, we found the presence of irregularly shaped, but mainly not dendritic, foci of ossification that often contained bone marrow and were embedded or surrounded by tendinous-like fibrous tissue. After incorporating data from the histologic examination, we decided to perform genetic counseling and genetic testing with the use of whole-exome sequencing. The genetic test revealed a heterozygous de novo missense mutation of COL3A1 gene, which encodes for type III collagen synthesis, and could cause vascular Ehlers-Danlos syndrome.
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