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1. Atezolizumab plus FOLFOX for Stage III Mismatch Repair-Deficient Colon Cancer.
作者: Frank A Sinicrope.;Fang-Shu Ou.;Dirk Arnold.;Walter R Peters.;Robert J Behrens.;Christopher H Lieu.;Khalid Matin.;Deirdre J Cohen.;Samara L Potter.;Andrew B Nixon.;Lisa A Kottschade.;Emily Kathol.;Wendy L Frankel.;Ardaman Shergill.;Dennis Hsu.;Anke Reinacher-Schick.;Paul Mehan.;Philip J Gold.;Maged F Khalil.;Tyler Zemla.;Clare Gatten.;Eileen M O'Reilly.;Jeffrey A Meyerhardt.
来源: N Engl J Med. 2026年394卷12期1155-1166页
Standard adjuvant chemotherapy for stage III colon cancer consists of a fluoropyrimidine-plus-oxaliplatin regimen. Whether the addition of atezolizumab (an anti-programmed death ligand 1 agent) to a modified FOLFOX6 regimen (fluorouracil, oxaliplatin, and leucovorin; called mFOLFOX6) would improve outcomes in patients with stage III colon cancer with mismatch repair-deficient (dMMR) status is unclear.
3. Cabotegravir plus Rilpivirine for Persons with HIV and Adherence Challenges.
作者: Aadia I Rana.;Lu Zheng.;Jose Castillo-Mancilla.;Yajing Bao.;Sara Sieczkarski.;Kristina M Brooks.;Jordan E Lake.;Carl Fichtenbaum.;Sonya L Heath.;Pablo F Belaunzaran-Zamudio.;Karin Klingman.;Lawrence Fox.;Tia Morton.;Michael Stirratt.;Jonathan Z Li.;Edward P Acosta.;Charles Venuto.;Omar Galáarraga.;Steven Shoptaw.;David Wohl.;Madison Green.;Ceora Beijer.;Kathie Ferbas.;Cheryl Jennings.;Katherine Shin.;Romina Collahua.;Michael Dorosh.;Paul Wannamaker.;Ronald D'Amico.;Kimberly Smith.;William Spreen.;Kati Vandermeulen.;Rodica Van Solingen-Ristea.;Chanelle Wimbish.;Karen T Tashima.;Raphael J Landovitz.; .
来源: N Engl J Med. 2026年394卷9期858-871页
Randomized trials of long-acting injectable antiretroviral therapy (ART) in persons with human immunodeficiency virus (HIV) who face challenges with adherence to oral medication are lacking.
4. Revival of Ethionamide by Alpibectir.
作者: Michel Pieren.;Glenn E Dale.;Marc Gitzinger.;Simon Tiberi.;Sophie L Penman.;Modesto J Remuiñán.;Ilse R Dubbelboer.;Ulrika S H Simonsson.;Caryn M Upton.;Thabo Mabuka.;Andreas H Diacon.
来源: N Engl J Med. 2026年394卷8期818-819页 5. Hematopoietic Stem-Cell Gene Therapy for Cystinosis.
作者: Bruce A Barshop.;Edward D Ball.;Nadine Benador.;Doris Trauner.;Susan Phillips.;Ranjan Dohil.;Natalie A Afshari.;Sohini Roy.;Beatriz Campo Fernandes.;Donald Kohn.;Katayoon Shayan.;John K Everett.;Frederic D Bushman.;Julian Midgley.;Hong Liang.;Anne Sawyers.;Jon A Gangoiti.;Maulik Panchal.;Imama Ahmed.;Stephanie Cherqui.
来源: N Engl J Med. 2026年394卷8期753-762页
Cystinosis is a multisystemic lysosomal storage disorder caused by pathogenic variants in CTNS, the gene encoding cystinosin, a lysosomal transmembrane cystine transporter. In patients with cystinosis, cystine accumulates within lysosomes in all organs. The cystine-depleting agent cysteamine delays but does not prevent disease progression.
6. Adenoviral Inciting Antigen and Somatic Hypermutation in VITT.
作者: Jing Jing Wang.;Linda Schönborn.;Theodore E Warkentin.;Luisa Müller.;Thomas Thiele.;Lena Ulm.;Uwe Völker.;Sabine Ameling.;Sören Franzenburg.;Lars Kaderali.;Ana Tzvetkova.;Alex Colella.;Tim Chataway.;Chee Wee Tan.;Bridie Armour.;Alexander Troelnikov.;Lucy Rutten.;James McCluskey.;Roland Zahn.;Tom P Gordon.;Andreas Greinacher.
来源: N Engl J Med. 2026年394卷7期669-683页
Vaccine-induced immune thrombocytopenia and thrombosis (VITT) is a rare prothrombotic complication that occurs after adenoviral vector-based vaccination against coronavirus disease 2019; in rare cases, it can also occur after natural adenovirus infection. VITT is mediated by platelet-activating antibodies against the highly cationic protein platelet factor 4 (PF4). The underlying inciting antigen trigger and immunopathogenesis remain unknown.
8. Mental Health Outcomes in Children after Parental Firearm Injury.
作者: George Karandinos.;Mia Giuriato.;José R Zubizarreta.;Katherine A Koh.;Peter T Masiakos.;Zirui Song.;Chana A Sacks.
来源: N Engl J Med. 2026年394卷5期475-485页
Every year, approximately 20,000 youths lose a parent to firearm injury in the United States. Many more youths have parents who sustain nonfatal firearm injuries. The effect of parents' firearm injuries on their children's health and health care is poorly understood.
12. Trial of High-Dose Oral Rifampin in Adults with Tuberculous Meningitis.
作者: David B Meya.;Fiona V Cresswell.;Biyue Dai.;Nicole Engen.;Kogieleum Naidoo.;Ahmad Rizal Ganiem.;Darma Imran.;Mable Kabahubya.;Richard J Lessells.;Vycke Yunivita.;Riwanti Estiasari.;Lillian Tugume.;Bongeka Hlabisa.;Media Yuni Kurniawati.;Noveline Sagita.;Enock Kagimu.;Kartika Maharani.;Jane Gakuru.;Maula N Gaharu.;Timothy Mugabi.;Sarah Kimuda.;Suzan Namombwe.;Lindsey Te Brake.;Rob Aarnoutse.;Elin M Svensson.;Ananta S Bangdiwala.;Sylvia Namanda.;Nathan C Bahr.;Abdu K Musubire.;Mahomed Yunus Suleman Moosa.;Raph L Hamers.;Suzaan Marais.;David R Boulware.;Reinout van Crevel.;Rovina Ruslami.; .
来源: N Engl J Med. 2025年393卷24期2434-2446页
Tuberculous meningitis is often lethal, and many survivors have disabilities despite antimicrobial treatment and adjunctive glucocorticoid therapy. Standard-dose rifampin has limited central nervous system penetration. Whether high-dose rifampin could improve survival outcomes is unknown.
13. Molecular Evidence of Multiorgan Damage in Patients with Immune-Related Adverse Events.
作者: Yuxuan Wang.;Howard L Li.;Chetan Bettegowda.;Kenneth W Kinzler.;Nickolas Papadopoulos.;Mark Yarchoan.;Bert Vogelstein.
来源: N Engl J Med. 2025年393卷23期2377-2379页 14. Ketamine or Etomidate for Tracheal Intubation of Critically Ill Adults.
作者: Jonathan D Casey.;Kevin P Seitz.;Brian E Driver.;Kevin W Gibbs.;Adit A Ginde.;Stacy A Trent.;Derek W Russell.;Amelia L Muhs.;Matthew E Prekker.;John P Gaillard.;Daniel Resnick-Ault.;L Jane Stewart.;Micah R Whitson.;Stephanie C DeMasi.;Aaron E Robinson.;Jessica A Palakshappa.;Neil R Aggarwal.;Jason C Brainard.;David J Douin.;Tanya K Marvi.;Benjamin K Scott.;Sarah M Alber.;Carolynn Lyle.;Sheetal Gandotra.;Graham W Van Schaik.;Aaron J Lacy.;Kristen C Sherlin.;Heidi L Erickson.;J Maycee Cain.;Brianne Redman.;Logan L Beach.;Barbara Gould.;Jasmine McIntosh.;Ariel A Lewis.;Bradley D Lloyd.;Tiffany L Israel.;Brant Imhoff.;Li Wang.;Alexandra B Spicer.;Matthew M Churpek.;Todd W Rice.;Wesley H Self.;Jin H Han.;Matthew W Semler.; .
来源: N Engl J Med. 2025年
For critically ill adults undergoing tracheal intubation, observational studies suggest that the use of etomidate to induce anesthesia may increase the risk of death. Whether the use of ketamine rather than etomidate decreases the risk of death is uncertain.
15. Stability of Avian Influenza A(H5N1) Virus in Milk from Infected Cows and Virus-Spiked Milk.
作者: Lizheng Guan.;David Pattinson.;Amie J Eisfeld.;Tong Wang.;Peter J Halfmann.;Gabriele Neumann.;Tera R Barnhardt.;Alexis C Thompson.;Amy K Swinford.;Kiril M Dimitrov.;Keith Poulsen.;Yoshihiro Kawaoka.
来源: N Engl J Med. 2025年393卷22期2271-2273页 16. Adrenal Aldosterone Synthase Expression Imaging in Primary Aldosteronism.
作者: Erik Årstad.;Kerstin Sander.;Tom R Kurzawinski.;Cameron Anderson.;Yazead Buhidma.;Ramla O Awais.;Fatih Sirindil.;Robert Shortman.;Louise Dickinson.;Aidan G O'Keeffe.;John Dickson.;Teng-Teng Chung.;Morris J Brown.;Bryan Williams.
来源: N Engl J Med. 2025年393卷21期2168-2170页 17. Daily Mosnodenvir as Dengue Prophylaxis in a Controlled Human Infection Model.
作者: Anna P Durbin.;Liesbeth Van Wesenbeeck.;Kristen K Pierce.;Guillermo Herrera-Taracena.;Laura Ebone.;Annemie Buelens.;Patricia Lutton.;Beulah P Sabundayo.;Veerle Van Eygen.;Kim De Clerck.;Isabel Fetter.;Natalia V Voge.;Xi Fang.;Nele Goeyvaerts.;Yannick Vandendijck.;Jeffrey Mayfield.;Oliver Lenz.;Sandra De Meyer.;Thomas N Kakuda.;Huili He.;Emérito Amaro-Carambot.;Ruxandra Draghia Akli.;Marya Carmolli.;Tine De Marez.;Stephen S Whitehead.;Marnix Van Loock.;Freya Rasschaert.
来源: N Engl J Med. 2025年393卷21期2107-2118页
Approximately half the worldwide population is at risk for dengue. No antiviral prophylaxis or treatment options are available.
18. A Multicomponent Intervention to Improve Maternal Infection Outcomes.
作者: David Lissauer.;Luis Gadama.;Catriona Waitt.;Sonia Whyte.;Girvan Burnside.;Aiswarya Anilkumar.;Regina Makuluni.;Peace Okwaro.;Liu Yang.;Peter Waitt.;Owen Musopole.;Rosemary Bilesi.;Bertha Maseko.;Joel Lwasa.;Richard Mugahi.;Charles Olaro.;Mohammed Lamorde.;Mirriam Makuta.;Chimwemwe Kachiwaya.;Tionge Mkandawire.;Adrian Malunga.;Nyadani Chitsulo.;Prisca Abitimo.;Tabitha Ayabo.;Andrew Weeks.;James Martin.;Karla Hemming.;Ioannis Gallos.;Edward J M Monk.;Jennifer Riches.;Chikondi Chapuma.;Judith Nanyondo S.;Fabiana Lorencatto.;Mark Monahan.;Benedetta Allegranzi.;Catherine Dunlop.;Lou Atkins.;Anna Rosala-Hallas.;Tracy Roberts.;Carrol Gamble.;Address Malata.;Nicola Desmond.;Edward Kommwa.;Abi Merriel.;William Parry-Smith.;Rebecca Smith.;Ivy Ndumu.;Eleanor Williams.;Bob Faque.;Gertrude Banda.;Alinane L Nyondo-Mipando.;Adelline Twimukye.;Tim Chater.;Aristotelis Diplas.;Vanessa Brizuela.;Joao Paulo Souza.;Jamie Rylance.;James Cheshire.;Lydia Hawker.;Arri Coomarasamy.;Mercedes Bonet.
来源: N Engl J Med. 2025年
Maternal infection and sepsis are major causes of maternal death and severe illness worldwide, particularly in low- and middle-income countries. Inconsistent implementation of evidence-based recommendations for infection prevention and management and delays in detection and treatment of maternal sepsis contribute to the number of preventable deaths.
20. A Mammarenavirus Close to Lassa Virus in a Patient with Meningoencephalitis.
作者: Sylvain Baize.;Delphine Pannetier.;Christophe Rodriguez.;Laurence Josset.;Franck de Laval.;Bernadette Gergonne.;Jean-Baptiste Mardon.;Caroline Picard.;Alexandra Journeaux.;Damien Thomas.;Elodie Moissonnier.;Céline Ragot.;Thibault Martinez.;Estelle Lara.;Anne-Laure Favier.;Olivier Ferraris.;Magali Billhot.;Mathieu Cabon.; .
来源: N Engl J Med. 2025年393卷19期1960-1962页 |