"Ann Intern Med"[journal] 检索结果

1. In older adults at risk for dementia, a structured vs. self-guided lifestyle intervention improved cognitive function over 2 y.

作者: Terry Quinn.; .
来源: Ann Intern Med. 2025年178卷11期JC123页

GIM/FP/GP: [Formula: see text] Geriatrics: [Formula: see text] Public Health: [Formula: see text].

2. In adults with obesity but without type 2 diabetes, tirzepatide increased weight loss at 72 wk compared with semaglutide.

作者: Lenard I Lesser.; .
来源: Ann Intern Med. 2025年178卷11期JC122页

GIM/FP/GP: [Formula: see text] Endocrinology: [Formula: see text].

3. In early T2D inadequately controlled with diet and exercise, once-daily orforglipron reduced HbA1c vs. placebo at 40 wk.

作者: Maham Shahid.;Gunjan Y Gandhi.; .
来源: Ann Intern Med. 2025年178卷10期JC114页

GIM/FP/GP: [Formula: see text] Endocrinology: [Formula: see text].

4. In insulin-naive T2D, fixed-dose weekly efsitora was noninferior to daily glargine for reducing HbA1c at 52 wk.

作者: Michael Tanner.; .
来源: Ann Intern Med. 2025年178卷10期JC113页

GIM/FP/GP: [Formula: see text] Endocrinology: [Formula: see text].

5. In primary CDI, fecal microbiota transplantation was noninferior to vancomycin for clinical cure at 14 d without recurrence at 60 d.

作者: Henry S Sacks.; .
来源: Ann Intern Med. 2025年178卷10期JC117页

GIM/FP/GP: [Formula: see text] Gastroenterology: [Formula: see text] Infectious Disease: [Formula: see text].

6. In T2D and hypertension, the lower-sodium DASH4D diet reduced SBP more than a higher-sodium comparison diet at 5 wk.

作者: Darren Lau.;Raj Padwal.; .
来源: Ann Intern Med. 2025年178卷10期JC115页

GIM/FP/GP: [Formula: see text] Endocrinology: [Formula: see text].

7. In adults with overweight or obesity, weekly subcutaneous cagrilintide-semaglutide increased weight loss at 68 wk.

作者: Arnav Agarwal.;Raj Padwal.; .
来源: Ann Intern Med. 2025年178卷10期JC112页

GIM/FP/GP: [Formula: see text].

8. Effect of Personalized Risk Messages on Uptake of Colorectal Cancer Screening : A Randomized Controlled Trial.

作者: Peter H Schwartz.;Susan M Perkins.;Susan M Rawl.;Karen K Schmidt.;Sandra Althouse.;Thomas F Imperiale.
来源: Ann Intern Med. 2025年178卷10期1390-1399页

Providing personalized risk information to patients and their providers could improve colorectal cancer (CRC) screening.

9. In resistant hypertension, amiloride was noninferior to spironolactone for reducing home SBP at 12 wk.

作者: Giulio Francesco Romiti.;Niccolò Bonini.; .
来源: Ann Intern Med. 2025年178卷9期JC98页

GIM/FP/GP: [Formula: see text] Cardiology: [Formula: see text].

10. Cytisinicline for 6 or 12 wk increased smoking cessation rates after treatment and up to 24 wk.

作者: David King.; .
来源: Ann Intern Med. 2025年178卷9期JC105页

GIM/FP/GP: [Formula: see text] Public Health: [Formula: see text].

11. Comparison of an Energy-Reduced Mediterranean Diet and Physical Activity Versus an Ad Libitum Mediterranean Diet in the Prevention of Type 2 Diabetes : A Secondary Analysis of a Randomized Controlled Trial.

作者: Miguel Ruiz-Canela.;Dolores Corella.;Miguel Ángel Martínez-González.;Nancy Babio.;J Alfredo Martínez.;Luis Forga.;Ángel M Alonso-Gómez.;Julia Wärnberg.;Jesús Vioque.;Dora Romaguera.;José López-Miranda.;Ramón Estruch.;José Manuel Santos-Lozano.;Luis Serra-Majem.;Aurora Bueno-Cavanillas.;Josep A Tur.;Vicente Martín-Sánchez.;Antoni Riera-Mestre.;Miguel Delgado-Rodríguez.;Pilar Matía-Martín.;Josep Vidal.;Clotilde Vázquez.;Lidia Daimiel.;Pilar Buil-Cosiales.;Sangeetha Shyam.;Jose V Sorlí.;Olga Castañer.;Antonio García-Rios.;Laura Torres-Collado.;Enrique Gómez-Gracia.;M Ángeles Zulet.;Jadwiga Konieczna.;Rosa Casas.;Naomi Cano-Ibáñez.;Lucas Tojal-Sierra.;Rosa M Bernal-López.;Estefanía Toledo.;Jesús García-Gavilán.;Rebeca Fernández-Carrión.;Albert Goday.;Antonio P Arenas-Larriva.;Sandra González-Palacios.;Helmut Schröder.;Emilio Ros.;Montserrat Fitó.;Frank B Hu.;Francisco J Tinahones.;Jordi Salas-Salvadó.
来源: Ann Intern Med. 2025年178卷10期1378-1389页

Limited research has been done to evaluate the combined effect of energy reduction, Mediterranean diet (MedDiet), and physical activity on type 2 diabetes incidence.

12. Treatment With Canagliflozin Versus Placebo in Children and Adolescents With Type 2 Diabetes : A Randomized Clinical Trial.

作者: Ulhas Nadgir.;Saberi Rana Ali.;Jagadish Gogate.;Wayne Shaw.;José Antunes.;Sergio Fonseca.
来源: Ann Intern Med. 2025年178卷9期1217-1226页

Treatment options for children and adolescents with type 2 diabetes mellitus (T2DM) are limited. Canagliflozin is a sodium-glucose cotransporter-2 inhibitor approved for the treatment of T2DM in adults.

13. Efficacy of a Very-Low-Calorie Weight Loss Diet Plus Exercise Compared With Exercise Alone on Hip Osteoarthritis Pain : A Randomized Controlled Trial.

作者: Michelle Hall.;Rana S Hinman.;Gabrielle Knox.;Libby Spiers.;Fiona McManus.;Anurika P De Silva.;Priya Sumithran.;Anthony Harris.;Nicholas J Murphy.;Flavia Cicuttini.;David J Hunter.;Stephen P Messier.;Kim L Bennell.
来源: Ann Intern Med. 2025年178卷9期1227-1237页

Exercise is recommended to manage hip osteoarthritis, but weight loss recommendations are conflicting.

14. In insulin-treated T2D, automated insulin delivery reduced HbA1c without increasing hypoglycemic events vs. usual care at 13 wk.

作者: Darren Lau.;Peter Senior.; .
来源: Ann Intern Med. 2025年178卷8期JC95页

GIM/FP/GP: [Formula: see text] Endocrinology: [Formula: see text].

15. High Tibial Osteotomy for Medial Compartment Knee Osteoarthritis : A Randomized Trial With Parallel Preference Arm.

作者: Trevor B Birmingham.;Codie A Primeau.;Rebecca F Moyer.;Dianne M Bryant.;Jinhui Ma.;Kristyn M Leitch.;Wolfgang Wirth.;Ryan Degen.;Alan M Getgood.;Robert B Litchfield.;Kevin R Willits.;Felix Eckstein.;J Robert Giffin.
来源: Ann Intern Med. 2025年178卷9期1238-1248页

Medial opening wedge high tibial osteotomy (HTO) is a limb realignment surgery that aims to preserve joint structure and improve clinical outcomes by redistributing ambulatory loads on the knee among patients with knee osteoarthritis and varus alignment.

16. Rituximab Versus Conventional Therapy for Remission Induction in Eosinophilic Granulomatosis With Polyangiitis : A Randomized Controlled Trial.

作者: Benjamin Terrier.;Grégory Pugnet.;Claire de Moreuil.;Bernard Bonnotte.;Ygal Benhamou.;Dominique Chauveau.;Marie-Charlotte Besse.;Pierre Duffau.;Nicolas Limal.;Antoine Néel.;Geoffrey Urbanski.;Noémie Jourde-Chiche.;Nicolas Martin-Silva.;Julien Campagne.;Arsène Mekinian.;Nicolas Schleinitz.;Felix Ackermann.;Anne-Laure Fauchais.;Antoine Froissart.;Thomas Le Gallou.;Yurdagul Uzunhan.;Jean-François Viallard.;Alice Bérezné.;Laurent Chiche.;Camille Taillé.;Guillaume Direz.;Cécile-Audrey Durel.;Pascal Godmer.;Salim Trad.;Marc Lambert.;Mathilde de Menthon.;Thomas Quéméneur.;Jacques Cadranel.;Pierre Charles.;Antoine Dossier.;Léa Jilet.;Loïc Guillevin.;Hendy Abdoul.;Xavier Puéchal.; .
来源: Ann Intern Med. 2025年178卷9期1249-1257页

Eosinophilic granulomatosis with polyangiitis (EGPA) is an eosinophilic antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. Rituximab has emerged as the standard of care in other types of ANCA-associated vasculitis, but controlled studies on its use in EGPA are yet lacking.

17. Vaporized Nicotine Products for Smoking Cessation Among People Experiencing Social Disadvantage : A Randomized Clinical Trial.

作者: Ryan J Courtney.;Bridget C Howard.;Daniel Barker.;Dennis Petrie.;Ron Borland.;Anthony Shakeshaft.;Coral Gartner.;Colin Mendelsohn.;Veronica C Boland.;Alexandra Henderson.;Robyn L Richmond.;Piotr Tutka.;Felix Naughton.;Wayne Hall.;Nicholas Zwar.;Michael Farrell.;Richard P Mattick.;Hayden McRobbie.
来源: Ann Intern Med. 2025年178卷8期1085-1094页

Vaporized nicotine products (VNPs) are more effective than nicotine replacement therapy (NRT) for smoking cessation in general populations, but their effectiveness among low socioeconomic groups is largely unknown.

18. Improvements in Cardiometabolic Risk Factors by Weight Reduction: A Post Hoc Analysis of Adults With Obesity Randomly Assigned to Tirzepatide.

作者: Bruno Linetzky.;Naveed Sattar.;Subodh Verma.;Harlan M Krumholz.;Cathy Chang Xie.;Hunter T Hoffmann.;Sarah Zimner-Rapuch.;Amelia Torcello-Gómez.;Adam Stefanski.
来源: Ann Intern Med. 2025年178卷8期1095-1105页

Tirzepatide reduced weight and improved cardiometabolic risk factors for participants in the SURMOUNT-1 trial. The changes in cardiometabolic risk factors by degree of tirzepatide-induced weight reduction across a wide spectrum of weight loss have not been reported.

19. Fecal Microbiota Transplantation Versus Vancomycin for Primary Clostridioides difficile Infection : A Randomized Controlled Trial.

作者: Frederik Emil Juul.;Michael Bretthauer.;Peter H Johnsen.;Faye Samy.;Kristian Tonby.;Jan Erik Berdal.;Dag Arne L Hoff.;Eirik H Ofstad.;Awet Abraham.;Birgitte Seip.;Håvard Wiig.;Øyvind Bakken Rognstad.;Ida F Glad.;Jørgen Valeur.;Axel E Nissen-Lie.;Eivind Ness-Jensen.;Kristine M A Lund.;Linn K Skjevling.;Kurt Hanevik.;Hilde Skudal.;Ellen J Melsom.;Raziye Boyar.;Trond J Cooper.;Trond E Ranheim.;Esben M Riise.;Hans-Olov Adami.;Mette Kalager.;Magnus Løberg.;Kjetil K Garborg.
来源: Ann Intern Med. 2025年178卷7期940-947页

Fecal microbiota transplantation (FMT) is recommended for recurrent Clostridioides difficile infection (CDI), but its role in primary CDI is unclear.

20. Effects of a Hypotension-Avoidance Versus a Hypertension-Avoidance Strategy on Neurocognitive Outcomes After Noncardiac Surgery.

作者: Maura Marcucci.;Matthew T V Chan.;Thomas W Painter.;Sergey Efremov.;Hector J Aguado.;Sergey V Astrakov.;Ydo V Kleinlugtenbelt.;Ameen Patel.;Juan P Cata.;Mohammed Amir.;Mikhail Kirov.;Kate Leslie.;Emmanuelle Duceppe.;Flavia K Borges.;Miriam de Nadal.;Vikas Tandon.;Giovanni Landoni.;Valery V Likhvantsev.;Vladimir Lomivorotov.;Daniel I Sessler.;María José Martínez-Zapata.;Denis Xavier.;Edith Fleischmann.;Chew Yin Wang.;Christian S Meyhoff.;Maria Wittmann.;David Torres.;David Highton.;Michael Jacka.;Vishwanath B.;Kelly Zarnke.;Ravinder Singh Sidhu.;Giorgio Oriani.;Sabry Ayad.;Steven Minear.;Tristan E Weaver.;Kurt Ruetzler.;Claudia Brusasco.;Joel L Parlow.;Elizabeth Maxwell.;Scott Miller.;Marko Mrkobrada.;Keyur Suresh Chandra Bhatt.;Prashant Rahate.;Ana Kowark.;Giuseppe De Blasio.;Sandra N Ofori.;David Conen.;Sadeesh Srinathan.;Wojciech Szczeklik.;Raja Jayaram.;Richard K Ellerkmann.;Mona Momeni.;Ingrid Copland.;Jessica Vincent.;Kumar Balasubramanian.;Zhuoru Li.;Michael Ke Wang.;Deyang Li.;Michael H McGillion.;Andrea Kurz.;Mukul Sharma.;Timothy G Short.;P J Devereaux.; .
来源: Ann Intern Med. 2025年178卷7期909-920页

Perioperative hemodynamic abnormalities have been associated with neurocognitive outcomes after noncardiac surgery.

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1. In older adults at risk for dementia, a structured vs. self-guided lifestyle intervention improved cognitive function over 2 y.

2. In adults with obesity but without type 2 diabetes, tirzepatide increased weight loss at 72 wk compared with semaglutide.

3. In early T2D inadequately controlled with diet and exercise, once-daily orforglipron reduced HbA1c vs. placebo at 40 wk.

4. In insulin-naive T2D, fixed-dose weekly efsitora was noninferior to daily glargine for reducing HbA1c at 52 wk.

5. In primary CDI, fecal microbiota transplantation was noninferior to vancomycin for clinical cure at 14 d without recurrence at 60 d.

6. In T2D and hypertension, the lower-sodium DASH4D diet reduced SBP more than a higher-sodium comparison diet at 5 wk.

7. In adults with overweight or obesity, weekly subcutaneous cagrilintide-semaglutide increased weight loss at 68 wk.

8. Effect of Personalized Risk Messages on Uptake of Colorectal Cancer Screening : A Randomized Controlled Trial.

9. In resistant hypertension, amiloride was noninferior to spironolactone for reducing home SBP at 12 wk.

10. Cytisinicline for 6 or 12 wk increased smoking cessation rates after treatment and up to 24 wk.

11. Comparison of an Energy-Reduced Mediterranean Diet and Physical Activity Versus an Ad Libitum Mediterranean Diet in the Prevention of Type 2 Diabetes : A Secondary Analysis of a Randomized Controlled Trial.

12. Treatment With Canagliflozin Versus Placebo in Children and Adolescents With Type 2 Diabetes : A Randomized Clinical Trial.

13. Efficacy of a Very-Low-Calorie Weight Loss Diet Plus Exercise Compared With Exercise Alone on Hip Osteoarthritis Pain : A Randomized Controlled Trial.

14. In insulin-treated T2D, automated insulin delivery reduced HbA1c without increasing hypoglycemic events vs. usual care at 13 wk.

15. High Tibial Osteotomy for Medial Compartment Knee Osteoarthritis : A Randomized Trial With Parallel Preference Arm.

16. Rituximab Versus Conventional Therapy for Remission Induction in Eosinophilic Granulomatosis With Polyangiitis : A Randomized Controlled Trial.

17. Vaporized Nicotine Products for Smoking Cessation Among People Experiencing Social Disadvantage : A Randomized Clinical Trial.

18. Improvements in Cardiometabolic Risk Factors by Weight Reduction: A Post Hoc Analysis of Adults With Obesity Randomly Assigned to Tirzepatide.

19. Fecal Microbiota Transplantation Versus Vancomycin for Primary Clostridioides difficile Infection : A Randomized Controlled Trial.

20. Effects of a Hypotension-Avoidance Versus a Hypertension-Avoidance Strategy on Neurocognitive Outcomes After Noncardiac Surgery.