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1. In patients with subclinical AF, apixaban vs. aspirin reduced stroke or systemic embolism at 3.5 y in those with previous stroke or TIA.
GIM/FP/GP: [Formula: see text] Cardiology: [Formula: see text] Neurology: [Formula: see text] Hematology: [Formula: see text].
2. In early postmenopausal women, zoledronate vs. placebo at baseline and 5 y reduced morphometric vertebral fractures at 10 y.
GIM/FP/GP: [Formula: see text] Endocrinology: [Formula: see text] Geriatrics: [Formula: see text] Public Health: [Formula: see text].
3. Comparison of Dose Escalation Versus Switching to Tirzepatide Among People With Type 2 Diabetes Inadequately Controlled on Lower Doses of Dulaglutide : A Randomized Clinical Trial.
作者: Liana K Billings.;Linsey Winne.;Palash Sharma.;Elisa Gomez-Valderas.;K Karthik Chivukula.;Anita Y M Kwan.
来源: Ann Intern Med. 2025年178卷5期609-619页
Tirzepatide, a once-weekly glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonist approved for the treatment of adults with type 2 diabetes or obesity, showed clinically meaningful reductions in hemoglobin A1c (HbA1c) and body weight in the SURPASS phase 3 clinical trial program.
4. The Effect of 4:3 Intermittent Fasting on Weight Loss at 12 Months : A Randomized Clinical Trial.
作者: Victoria A Catenacci.;Danielle M Ostendorf.;Zhaoxing Pan.;Laura K Kaizer.;Seth A Creasy.;Adnin Zaman.;Ann E Caldwell.;Jared Dahle.;Bryan Swanson.;Matthew J Breit.;Kristen Bing.;Liza T Wayland.;Shelby L Panter.;Jared J Scorsone.;Daniel H Bessesen.;Paul MacLean.;Edward L Melanson.
来源: Ann Intern Med. 2025年178卷5期634-644页
Long-term (≥12 months) randomized trials evaluating the efficacy of intermittent fasting (IMF) as a dietary weight loss strategy are limited. Furthermore, no studies have compared IMF versus daily caloric restriction (DCR) when both interventions are provided in the context of a guidelines-based behavioral weight loss program.
5. Patient Navigation to Improve Colonoscopy Completion After an Abnormal Stool Test Result : A Randomized Controlled Trial.
作者: Gloria D Coronado.;Amanda F Petrik.;Jamie H Thompson.;Michael C Leo.;Matthew Slaughter.;Priyanka Gautom.;Syed A Hussain.;Leslie Mosso.;Jeffrey Gibbs.;Neha Yadav.;Rajasekhara R Mummadi.;Eric S Johnson.;Ricardo Jimenez.
来源: Ann Intern Med. 2025年178卷5期645-654页
Patient navigation is a recommended practice of the Guide to Community Preventive Services; little is known about whether it improves colonoscopy completion for adults who have received an abnormal stool test result.
6. In arterial hypertension, renal denervation vs. a sham procedure reduces ambulatory and office BP at ≤6 mo.
GIM/FP/GP: [Formula: see text] Cardiology: [Formula: see text] Nephrology: [Formula: see text].
7. In adults with obesity and knee OA, adding weekly semaglutide to diet and activity counseling reduced weight and knee pain at 68 wk.
GIM/FP/GP: [Formula: see text] Endocrinology: [Formula: see text] Rheumatology: [Formula: see text].
8. Effects of Noise and Public Setting on Blood Pressure Readings : A Randomized Crossover Trial.
作者: Junichi Ishigami.;Hairong Liu.;Di Zhao.;Ahmed Sabit.;Chathurangi H Pathiravasan.;Jeanne Charleston.;Edgar R Miller.;Kunihiro Matsushita.;Lawrence J Appel.;Tammy M Brady.
来源: Ann Intern Med. 2025年178卷2期149-156页
Guidelines emphasize quiet settings for blood pressure (BP) measurement.
10. In asymptomatic severe AS, early surgery vs. conservative therapy reduced a composite of death, MI, stroke, or HF hospitalization at 63 mo.
GIM/FP/GP: [Formula: see text] Cardiology: [Formula: see text].
11. In insulin-naive T2D, weekly efsitora was noninferior to daily degludec for reducing HbA1c at 52 wk.
GIM/FP/GP: [Formula: see text] Endocrinology: [Formula: see text].
12. The Effect of the "Safety in Dementia" Online Tool to Assist Decision Making for Caregivers of Persons With Dementia and Access to Firearms : A Randomized Trial.
作者: Marian E Betz.;Jennifer Portz.;Christopher Knoepke.;Megan L Ranney.;Stacy M Fischer.;Ryan A Peterson.;Rachel L Johnson.;Faris Omeragic.;Mirella Castaneda.;Emily Greenway.;Daniel Matlock.
来源: Ann Intern Med. 2024年177卷12期1630-1640页
Caregivers face challenges (including competing desires to prevent injury, respect autonomy, and avoid conflict) when addressing firearm access by community-dwelling persons with Alzheimer disease and related dementias (ADRD).
13. Diabetes Risk Factors in People With HIV Receiving Pitavastatin Versus Placebo for Cardiovascular Disease Prevention : A Randomized Trial.
作者: Kathleen V Fitch.;Markella V Zanni.;Jennifer Manne-Goehler.;Marissa R Diggs.;Arijeet K Gattu.;Judith S Currier.;Gerald S Bloomfield.;Chiu-Bin Hsiao.;Samir K Gupta.;Judith A Aberg.;Carlos D Malvestutto.;Carl J Fichtenbaum.;Michael T Lu.;Pamela S Douglas.;Heather J Ribaudo.;Steven K Grinspoon.
来源: Ann Intern Med. 2024年177卷11期1449-1461页
REPRIEVE (Randomized Trial to Prevent Vascular Events in HIV) led to new guidelines for statin use among people with HIV (PWH) with low to moderate risk for atherosclerotic cardiovascular disease (ASCVD). Little is known about the natural history of diabetes mellitus (DM) or mechanisms contributing to statin effects on DM among this population.
14. Effect of Four Hemoglobin Transfusion Threshold Strategies in Patients With Acute Myocardial Infarction and Anemia : A Target Trial Emulation Using MINT Trial Data.
作者: Gerard T Portela.;Jeffrey L Carson.;Sonja A Swanson.;John H Alexander.;Paul C Hébert.;Shaun G Goodman.;Philippe Gabriel Steg.;Marnie Bertolet.;Jordan B Strom.;Dean A Fergusson.;Tabassome Simon.;Harvey D White.;Howard A Cooper.;J Dawn Abbott.;Sunil V Rao.;Bernard R Chaitman.;Christopher B Fordyce.;Renato D Lopes.;Benoit Daneault.;Maria M Brooks.; .
来源: Ann Intern Med. 2024年177卷11期1489-1498页
The optimal hemoglobin threshold to guide red blood cell (RBC) transfusion for patients with acute myocardial infarction (MI) and anemia is uncertain.
15. Effectiveness of Integrating Suicide Care in Primary Care : Secondary Analysis of a Stepped-Wedge, Cluster Randomized Implementation Trial.
作者: Julie Angerhofer Richards.;Maricela Cruz.;Christine Stewart.;Amy K Lee.;Taylor C Ryan.;Brian K Ahmedani.;Gregory E Simon.
来源: Ann Intern Med. 2024年177卷11期1471-1481页
Primary care encounters are common among patients at risk for suicide.
16. Time-Restricted Eating in Adults With Metabolic Syndrome : A Randomized Controlled Trial.
作者: Emily N C Manoogian.;Michael J Wilkinson.;Monica O'Neal.;Kyla Laing.;Justina Nguyen.;David Van.;Ashley Rosander.;Aryana Pazargadi.;Nikko R Gutierrez.;Jason G Fleischer.;Shahrokh Golshan.;Satchidananda Panda.;Pam R Taub.
来源: Ann Intern Med. 2024年177卷11期1462-1470页
Time-restricted eating (TRE), limiting daily dietary intake to a consistent 8 to 10 hours without mandating calorie reduction, may provide cardiometabolic benefits.
17. Long-Term Effects of Individualized Acupuncture for Chronic Neck Pain : A Randomized Controlled Trial.
作者: Ling Zhao.;Mingsheng Sun.;Zihan Yin.;Jin Cui.;Ruihui Wang.;Laixi Ji.;Guoyan Geng.;Jiao Chen.;Dingjun Cai.;Qi Liu.;Hui Zheng.;Fanrong Liang.
来源: Ann Intern Med. 2024年177卷10期1330-1338页
Long-term effects of individualized acupuncture in persons with chronic neck pain (CNP) remain unknown.
18. Endoscopic Ultrasound-Guided Rendezvous Technique Versus Precut Sphincterotomy as Salvage Technique in Patients With Benign Biliary Disease and Difficult Biliary Cannulation : A Randomized Controlled Trial.
作者: Arup Choudhury.;Jayanta Samanta.;Gaurav Muktesh.;Jahnvi Dhar.;Antriksh Kumar.;Jimil Shah.;Marco Spadaccini.;Pankaj Gupta.;Alessandro Fugazza.;Vikas Gupta.;Thakur Deen Yadav.;Rakesh Kochhar.;Cesare Hassan.;Alessandro Repici.;Antonio Facciorusso.
来源: Ann Intern Med. 2024年177卷10期1361-1369页
The standard salvage technique used for difficult bile duct cannulation is precut sphincterotomy, whereas endoscopic ultrasound-guided rendezvous technique (EUS-RV) is a relatively newer method. Prospective comparative data between these 2 techniques as salvage for biliary access in patients with benign biliary disease and difficult bile duct cannulation is lacking.
19. Efficacy of a Therapeutic Pelvic Yoga Program Versus a Physical Conditioning Program on Urinary Incontinence in Women : A Randomized Trial.
作者: Alison J Huang.;Margaret Chesney.;Michael Schembri.;Harini Raghunathan.;Eric Vittinghoff.;Wendy Berry Mendes.;Sarah Pawlowsky.;Leslee L Subak.
来源: Ann Intern Med. 2024年177卷10期1339-1349页
Pelvic floor yoga has been recommended as a complementary treatment strategy for urinary incontinence (UI) in women, but evidence of its efficacy is lacking.
20. Pain Reduction With Oral Methotrexate in Knee Osteoarthritis : A Randomized, Placebo-Controlled Clinical Trial.
作者: Sarah R Kingsbury.;Puvan Tharmanathan.;Ada Keding.;Fiona E Watt.;David L Scott.;Edward Roddy.;Fraser Birrell.;Nigel K Arden.;Mike Bowes.;Catherine Arundel.;Michelle Watson.;Sarah J Ronaldson.;Catherine Hewitt.;Michael Doherty.;Robert J Moots.;Terence W O'Neill.;Michael Green.;Gulam Patel.;Toby Garrood.;Christopher J Edwards.;Phil J Walmsley.;Tom Sheeran.;David J Torgerson.;Philip G Conaghan.
来源: Ann Intern Med. 2024年177卷9期1145-1156页
Treatments for osteoarthritis (OA) are limited. Previous small studies suggest that the antirheumatic drug methotrexate may be a potential treatment for OA pain.
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