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1781. Outcomes 1 year after thrombus aspiration for myocardial infarction.
作者: Bo Lagerqvist.;Ole Fröbert.;Göran K Olivecrona.;Thórarinn Gudnason.;Michael Maeng.;Patrik Alström.;Jonas Andersson.;Fredrik Calais.;Jörg Carlsson.;Olov Collste.;Matthias Götberg.;Peter Hårdhammar.;Dan Ioanes.;Anders Kallryd.;Rickard Linder.;Anders Lundin.;Jacob Odenstedt.;Elmir Omerovic.;Verner Puskar.;Tim Tödt.;Eva Zelleroth.;Ollie Östlund.;Stefan K James.
来源: N Engl J Med. 2014年371卷12期1111-20页
Routine intracoronary thrombus aspiration before primary percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI) has not been proved to reduce short-term mortality. We evaluated clinical outcomes at 1 year after thrombus aspiration.
1782. Fractional flow reserve-guided PCI for stable coronary artery disease.
作者: Bernard De Bruyne.;William F Fearon.;Nico H J Pijls.;Emanuele Barbato.;Pim Tonino.;Zsolt Piroth.;Nikola Jagic.;Sven Mobius-Winckler.;Gilles Rioufol.;Nils Witt.;Petr Kala.;Philip MacCarthy.;Thomas Engström.;Keith Oldroyd.;Kreton Mavromatis.;Ganesh Manoharan.;Peter Verlee.;Ole Frobert.;Nick Curzen.;Jane B Johnson.;Andreas Limacher.;Eveline Nüesch.;Peter Jüni.; .
来源: N Engl J Med. 2014年371卷13期1208-17页
We hypothesized that in patients with stable coronary artery disease and stenosis, percutaneous coronary intervention (PCI) performed on the basis of the fractional flow reserve (FFR) would be superior to medical therapy.
1783. Ivabradine in stable coronary artery disease without clinical heart failure.
作者: Kim Fox.;Ian Ford.;Philippe Gabriel Steg.;Jean-Claude Tardif.;Michal Tendera.;Roberto Ferrari.; .
来源: N Engl J Med. 2014年371卷12期1091-9页
An elevated heart rate is an established marker of cardiovascular risk. Previous analyses have suggested that ivabradine, a heart-rate-reducing agent, may improve outcomes in patients with stable coronary artery disease, left ventricular dysfunction, and a heart rate of 70 beats per minute or more.
1784. Angiotensin-neprilysin inhibition versus enalapril in heart failure.
作者: John J V McMurray.;Milton Packer.;Akshay S Desai.;Jianjian Gong.;Martin P Lefkowitz.;Adel R Rizkala.;Jean L Rouleau.;Victor C Shi.;Scott D Solomon.;Karl Swedberg.;Michael R Zile.; .
来源: N Engl J Med. 2014年371卷11期993-1004页
We compared the angiotensin receptor-neprilysin inhibitor LCZ696 with enalapril in patients who had heart failure with a reduced ejection fraction. In previous studies, enalapril improved survival in such patients.
1785. Prehospital ticagrelor in ST-segment elevation myocardial infarction.
作者: Gilles Montalescot.;Arnoud W van 't Hof.;Frédéric Lapostolle.;Johanne Silvain.;Jens Flensted Lassen.;Leonardo Bolognese.;Warren J Cantor.;Angel Cequier.;Mohamed Chettibi.;Shaun G Goodman.;Christopher J Hammett.;Kurt Huber.;Magnus Janzon.;Béla Merkely.;Robert F Storey.;Uwe Zeymer.;Olivier Stibbe.;Patrick Ecollan.;Wim M J M Heutz.;Eva Swahn.;Jean-Philippe Collet.;Frank F Willems.;Caroline Baradat.;Muriel Licour.;Anne Tsatsaris.;Eric Vicaut.;Christian W Hamm.; .
来源: N Engl J Med. 2014年371卷11期1016-27页
The direct-acting platelet P2Y12 receptor antagonist ticagrelor can reduce the incidence of major adverse cardiovascular events when administered at hospital admission to patients with ST-segment elevation myocardial infarction (STEMI). Whether prehospital administration of ticagrelor can improve coronary reperfusion and the clinical outcome is unknown.
1786. Multidrug-resistant tuberculosis and culture conversion with bedaquiline.
作者: Andreas H Diacon.;Alexander Pym.;Martin P Grobusch.;Jorge M de los Rios.;Eduardo Gotuzzo.;Irina Vasilyeva.;Vaira Leimane.;Koen Andries.;Nyasha Bakare.;Tine De Marez.;Myriam Haxaire-Theeuwes.;Nacer Lounis.;Paul Meyvisch.;Els De Paepe.;Rolf P G van Heeswijk.;Brian Dannemann.; .
来源: N Engl J Med. 2014年371卷8期723-32页
Bedaquiline (Sirturo, TMC207), a diarylquinoline that inhibits mycobacterial ATP synthase, has been associated with accelerated sputum-culture conversion in patients with multidrug-resistant tuberculosis, when added to a preferred background regimen for 8 weeks.
1787. Oral GS-5806 activity in a respiratory syncytial virus challenge study.
作者: John P DeVincenzo.;Richard J Whitley.;Richard L Mackman.;Cecilia Scaglioni-Weinlich.;Lisa Harrison.;Eric Farrell.;Stephen McBride.;Robert Lambkin-Williams.;Robert Jordan.;Yan Xin.;Srini Ramanathan.;Thomas O'Riordan.;Sandra A Lewis.;Xiaoming Li.;Seth L Toback.;Shao-Lee Lin.;Jason W Chien.
来源: N Engl J Med. 2014年371卷8期711-22页
Respiratory syncytial virus (RSV) is a common cause of infant hospitalizations and is increasingly recognized as a cause of considerable morbidity and mortality. No accepted antiviral treatment exists.
1788. Controlled trial of transfusions for silent cerebral infarcts in sickle cell anemia.
作者: Michael R DeBaun.;Mae Gordon.;Robert C McKinstry.;Michael J Noetzel.;Desiree A White.;Sharada A Sarnaik.;Emily R Meier.;Thomas H Howard.;Suvankar Majumdar.;Baba P D Inusa.;Paul T Telfer.;Melanie Kirby-Allen.;Timothy L McCavit.;Annie Kamdem.;Gladstone Airewele.;Gerald M Woods.;Brian Berman.;Julie A Panepinto.;Beng R Fuh.;Janet L Kwiatkowski.;Allison A King.;Jason M Fixler.;Melissa M Rhodes.;Alexis A Thompson.;Mark E Heiny.;Rupa C Redding-Lallinger.;Fenella J Kirkham.;Natalia Dixon.;Corina E Gonzalez.;Karen A Kalinyak.;Charles T Quinn.;John J Strouse.;J Philip Miller.;Harold Lehmann.;Michael A Kraut.;William S Ball.;Deborah Hirtz.;James F Casella.
来源: N Engl J Med. 2014年371卷8期699-710页
Silent cerebral infarcts are the most common neurologic injury in children with sickle cell anemia and are associated with the recurrence of an infarct (stroke or silent cerebral infarct). We tested the hypothesis that the incidence of the recurrence of an infarct would be lower among children who underwent regular blood-transfusion therapy than among those who received standard care.
1789. Efficacy of high-dose versus standard-dose influenza vaccine in older adults.
作者: Carlos A DiazGranados.;Andrew J Dunning.;Murray Kimmel.;Daniel Kirby.;John Treanor.;Avi Collins.;Richard Pollak.;Janet Christoff.;John Earl.;Victoria Landolfi.;Earl Martin.;Sanjay Gurunathan.;Richard Nathan.;David P Greenberg.;Nadia G Tornieporth.;Michael D Decker.;H Keipp Talbot.
来源: N Engl J Med. 2014年371卷7期635-45页
As compared with a standard-dose vaccine, a high-dose, trivalent, inactivated influenza vaccine (IIV3-HD) improves antibody responses to influenza among adults 65 years of age or older. This study evaluated whether IIV3-HD also improves protection against laboratory-confirmed influenza illness.
1791. Spread of artemisinin resistance in Plasmodium falciparum malaria.
作者: Elizabeth A Ashley.;Mehul Dhorda.;Rick M Fairhurst.;Chanaki Amaratunga.;Parath Lim.;Seila Suon.;Sokunthea Sreng.;Jennifer M Anderson.;Sivanna Mao.;Baramey Sam.;Chantha Sopha.;Char Meng Chuor.;Chea Nguon.;Siv Sovannaroth.;Sasithon Pukrittayakamee.;Podjanee Jittamala.;Kesinee Chotivanich.;Kitipumi Chutasmit.;Chaiyaporn Suchatsoonthorn.;Ratchadaporn Runcharoen.;Tran Tinh Hien.;Nguyen Thanh Thuy-Nhien.;Ngo Viet Thanh.;Nguyen Hoan Phu.;Ye Htut.;Kay-Thwe Han.;Kyin Hla Aye.;Olugbenga A Mokuolu.;Rasaq R Olaosebikan.;Olaleke O Folaranmi.;Mayfong Mayxay.;Maniphone Khanthavong.;Bouasy Hongvanthong.;Paul N Newton.;Marie A Onyamboko.;Caterina I Fanello.;Antoinette K Tshefu.;Neelima Mishra.;Neena Valecha.;Aung Pyae Phyo.;Francois Nosten.;Poravuth Yi.;Rupam Tripura.;Steffen Borrmann.;Mahfudh Bashraheil.;Judy Peshu.;M Abul Faiz.;Aniruddha Ghose.;M Amir Hossain.;Rasheda Samad.;M Ridwanur Rahman.;M Mahtabuddin Hasan.;Akhterul Islam.;Olivo Miotto.;Roberto Amato.;Bronwyn MacInnis.;Jim Stalker.;Dominic P Kwiatkowski.;Zbynek Bozdech.;Atthanee Jeeyapant.;Phaik Yeong Cheah.;Tharisara Sakulthaew.;Jeremy Chalk.;Benjamas Intharabut.;Kamolrat Silamut.;Sue J Lee.;Benchawan Vihokhern.;Chanon Kunasol.;Mallika Imwong.;Joel Tarning.;Walter J Taylor.;Shunmay Yeung.;Charles J Woodrow.;Jennifer A Flegg.;Debashish Das.;Jeffery Smith.;Meera Venkatesan.;Christopher V Plowe.;Kasia Stepniewska.;Philippe J Guerin.;Arjen M Dondorp.;Nicholas P Day.;Nicholas J White.; .
来源: N Engl J Med. 2014年371卷5期411-23页
Artemisinin resistance in Plasmodium falciparum has emerged in Southeast Asia and now poses a threat to the control and elimination of malaria. Mapping the geographic extent of resistance is essential for planning containment and elimination strategies.
1792. Spiroindolone KAE609 for falciparum and vivax malaria.
作者: Nicholas J White.;Sasithon Pukrittayakamee.;Aung Pyae Phyo.;Ronnatrai Rueangweerayut.;François Nosten.;Podjanee Jittamala.;Atthanee Jeeyapant.;Jay Prakash Jain.;Gilbert Lefèvre.;Ruobing Li.;Baldur Magnusson.;Thierry T Diagana.;F Joel Leong.
来源: N Engl J Med. 2014年371卷5期403-10页
KAE609 (cipargamin; formerly NITD609, Novartis Institute for Tropical Diseases) is a new synthetic antimalarial spiroindolone analogue with potent, dose-dependent antimalarial activity against asexual and sexual stages of Plasmodium falciparum.
1794. Assessment of second-line antiretroviral regimens for HIV therapy in Africa.
作者: Nicholas I Paton.;Cissy Kityo.;Anne Hoppe.;Andrew Reid.;Andrew Kambugu.;Abbas Lugemwa.;Joep J van Oosterhout.;Mary Kiconco.;Abraham Siika.;Raymond Mwebaze.;Mary Abwola.;George Abongomera.;Aggrey Mweemba.;Hillary Alima.;Dickens Atwongyeire.;Rose Nyirenda.;Justine Boles.;Jennifer Thompson.;Dinah Tumukunde.;Ennie Chidziva.;Ivan Mambule.;Jose R Arribas.;Philippa J Easterbrook.;James Hakim.;A Sarah Walker.;Peter Mugyenyi.; .
来源: N Engl J Med. 2014年371卷3期234-47页
The efficacy and toxic effects of nucleoside reverse-transcriptase inhibitors (NRTIs) are uncertain when these agents are used with a protease inhibitor in second-line therapy for human immunodeficiency virus (HIV) infection in resource-limited settings. Removing the NRTIs or replacing them with raltegravir may provide a benefit.
1795. Lanreotide in metastatic enteropancreatic neuroendocrine tumors.
作者: Martyn E Caplin.;Marianne Pavel.;Jarosław B Ćwikła.;Alexandria T Phan.;Markus Raderer.;Eva Sedláčková.;Guillaume Cadiot.;Edward M Wolin.;Jaume Capdevila.;Lucy Wall.;Guido Rindi.;Alison Langley.;Séverine Martinez.;Joëlle Blumberg.;Philippe Ruszniewski.; .
来源: N Engl J Med. 2014年371卷3期224-33页
Somatostatin analogues are commonly used to treat symptoms associated with hormone hypersecretion in neuroendocrine tumors; however, data on their antitumor effects are limited.
1796. Effects of extended-release niacin with laropiprant in high-risk patients.
作者: .;Martin J Landray.;Richard Haynes.;Jemma C Hopewell.;Sarah Parish.;Theingi Aung.;Joseph Tomson.;Karl Wallendszus.;Martin Craig.;Lixin Jiang.;Rory Collins.;Jane Armitage.
来源: N Engl J Med. 2014年371卷3期203-12页
Patients with evidence of vascular disease are at increased risk for subsequent vascular events despite effective use of statins to lower the low-density lipoprotein (LDL) cholesterol level. Niacin lowers the LDL cholesterol level and raises the high-density lipoprotein (HDL) cholesterol level, but its clinical efficacy and safety are uncertain.
1797. Secukinumab in plaque psoriasis--results of two phase 3 trials.
作者: Richard G Langley.;Boni E Elewski.;Mark Lebwohl.;Kristian Reich.;Christopher E M Griffiths.;Kim Papp.;Lluís Puig.;Hidemi Nakagawa.;Lynda Spelman.;Bárður Sigurgeirsson.;Enrique Rivas.;Tsen-Fang Tsai.;Norman Wasel.;Stephen Tyring.;Thomas Salko.;Isabelle Hampele.;Marianne Notter.;Alexander Karpov.;Silvia Helou.;Charis Papavassilis.; .; .
来源: N Engl J Med. 2014年371卷4期326-38页
Interleukin-17A is considered to be central to the pathogenesis of psoriasis. We evaluated secukinumab, a fully human anti-interleukin-17A monoclonal antibody, in patients with moderate-to-severe plaque psoriasis.
1798. Effects of hypothermia for perinatal asphyxia on childhood outcomes.
作者: Denis Azzopardi.;Brenda Strohm.;Neil Marlow.;Peter Brocklehurst.;Aniko Deierl.;Oya Eddama.;Julia Goodwin.;Henry L Halliday.;Edmund Juszczak.;Olga Kapellou.;Malcolm Levene.;Louise Linsell.;Omar Omar.;Marianne Thoresen.;Nora Tusor.;Andrew Whitelaw.;A David Edwards.; .
来源: N Engl J Med. 2014年371卷2期140-9页
In the Total Body Hypothermia for Neonatal Encephalopathy Trial (TOBY), newborns with asphyxial encephalopathy who received hypothermic therapy had improved neurologic outcomes at 18 months of age, but it is uncertain whether such therapy results in longer-term neurocognitive benefits.
1799. Dupilumab treatment in adults with moderate-to-severe atopic dermatitis.
作者: Lisa A Beck.;Diamant Thaçi.;Jennifer D Hamilton.;Neil M Graham.;Thomas Bieber.;Ross Rocklin.;Jeffrey E Ming.;Haobo Ren.;Richard Kao.;Eric Simpson.;Marius Ardeleanu.;Steven P Weinstein.;Gianluca Pirozzi.;Emma Guttman-Yassky.;Mayte Suárez-Fariñas.;Melissa D Hager.;Neil Stahl.;George D Yancopoulos.;Allen R Radin.
来源: N Engl J Med. 2014年371卷2期130-9页
Dupilumab, a fully human monoclonal antibody that blocks interleukin-4 and interleukin-13, has shown efficacy in patients with asthma and elevated eosinophil levels. The blockade by dupilumab of these key drivers of type 2 helper T-cell (Th2)-mediated inflammation could help in the treatment of related diseases, including atopic dermatitis.
1800. Letrozole versus clomiphene for infertility in the polycystic ovary syndrome.
作者: Richard S Legro.;Robert G Brzyski.;Michael P Diamond.;Christos Coutifaris.;William D Schlaff.;Peter Casson.;Gregory M Christman.;Hao Huang.;Qingshang Yan.;Ruben Alvero.;Daniel J Haisenleder.;Kurt T Barnhart.;G Wright Bates.;Rebecca Usadi.;Scott Lucidi.;Valerie Baker.;J C Trussell.;Stephen A Krawetz.;Peter Snyder.;Dana Ohl.;Nanette Santoro.;Esther Eisenberg.;Heping Zhang.; .
来源: N Engl J Med. 2014年371卷2期119-29页
Clomiphene is the current first-line infertility treatment in women with the polycystic ovary syndrome, but aromatase inhibitors, including letrozole, might result in better pregnancy outcomes.
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