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162. Myo-inositol Supplementation to Prevent Pregnancy Complications in Polycystic Ovary Syndrome: A Randomized Clinical Trial.
作者: Anne W T van der Wel.;Chryselle M C Frank.;Rebekka Bout-Rebel.;Ruben G Duijnhoven.;Bo E van Bree.;Olivier Valkenburg.;Salwan Al-Nasiry.;Robbert H F van Oppenraaij.;Tatjana E Vogelvang.;Michelle E M H Westerhuis.;Hedwig P van de Nieuwenhof.;Susanne C J P Gielen.;Myrthe L Bandell.;Mireille N Bekker.;Maurice G A J Wouters.;Velja Mijatovic.;Arie Franx.;Cornelis B Lambalk.;Frank J M Broekmans.;Sabina de Weerd.;Jet M H Gerards.;Jelle H Baalman.;Jeroen van Disseldorp.;Josje Langenveld.;Marlise N Gunning.;Geert W J Frederix.;Rebecca C Painter.;Bart C J M Fauser.;Joop S E Laven.;Bas B van Rijn.
来源: JAMA. 2025年334卷13期1151-1159页
Pregnant individuals with polycystic ovary syndrome (PCOS) present with a higher risk of pregnancy complications, including gestational diabetes, preeclampsia, and preterm birth. Myo-inositol supplementation may reduce these risks.
163. Accountable Care Organization Assignment and Outcomes and Spending for TEAM Surgical Conditions.
作者: Nicholas L Berlin.;Yanlei Ma.;Jie Zheng.;John Orav.;Jose F Figueroa.;Andrew M Ryan.;Karen E Joynt Maddox.;Thomas C Tsai.
来源: JAMA. 2025年334卷17期1553-1555页 170. Single Treatment With MM120 (Lysergide) in Generalized Anxiety Disorder: A Randomized Clinical Trial.
作者: Reid Robison.;Robert Barrow.;Craig Conant.;Eric Foster.;Jamie M Freedman.;Paula L Jacobsen.;Jamileh Jemison.;Sarah M Karas.;Daniel R Karlin.;Todd M Solomon.;Miri Halperin Wernli.;Maurizio Fava.
来源: JAMA. 2025年334卷15期1358-1372页
Effective and well-tolerated pharmacotherapies for generalized anxiety disorder (GAD), which is one of the most common psychiatric disorders, are needed.
173. Reporting of Clinical Trial Uncertainties With New Cancer Drugs in Journal Publications and Clinical Guidelines.
作者: Avi Cherla.;Anita K Wagner.;Olivier J Wouters.;Steven Woloshin.;Courtney Davis.;Elias Mossialos.;Huseyin Naci.
来源: JAMA. 2025年334卷16期1480-1482页 174. Hypothyroidism: A Review.
Hypothyroidism is a disease of thyroid hormone deficiency. The prevalence ranges from 0.3% to 12% worldwide, depending on iodine intake, and it is more common in women and older adults. Untreated hypothyroidism can cause serious health complications such as heart failure and myxedema coma.
178. Transparent Reporting of Observational Studies Emulating a Target Trial-The TARGET Statement.
作者: Aidan G Cashin.;Harrison J Hansford.;Miguel A Hernán.;Sonja A Swanson.;Hopin Lee.;Matthew D Jones.;Issa J Dahabreh.;Barbra A Dickerman.;Matthias Egger.;Xabier Garcia-Albeniz.;Robert M Golub.;Nazrul Islam.;Sara Lodi.;Margarita Moreno-Betancur.;Sallie-Anne Pearson.;Sebastian Schneeweiss.;Melissa K Sharp.;Jonathan A C Sterne.;Elizabeth A Stuart.;James H McAuley.
来源: JAMA. 2025年334卷12期1084-1093页
When randomized trials are unavailable or not feasible, observational studies can be used to answer causal questions about the comparative effects of interventions by attempting to emulate a hypothetical pragmatic randomized trial (target trial). Published guidance to aid reporting of these studies is not available.
179. Fractional Flow Reserve-Guided Complete vs Culprit-Only Revascularization in Non-ST-Elevation Myocardial Infarction and Multivessel Disease: The SLIM Randomized Clinical Trial.
作者: Tobias F S Pustjens.;Leo Veenstra.;Cyril Camaro.;Alexander W Ruiters.;Árpad Lux.;Zoltán Ruzsa.;Zsolt Piroth.;Mustafa Ilhan.;Jindrich Vainer.;Ben Gho.;Patty J C Winkler.;Mera Stein.;Ralph A L J Theunissen.;Petr Kala.;Jawed Polad.;Balázs Berta.;Andrea Gabrio.;Niels van Royen.;Arnoud W J van 't Hof.;Saman Rasoul.
来源: JAMA. 2025年334卷18期1628-1637页
The benefits of fractional flow reserve (FFR)-guided complete coronary revascularization in patients with non-ST-segment elevation myocardial infarction (NSTEMI) and multivessel disease remain unclear.
180. Long-Term Anticoagulation Discontinuation After Catheter Ablation for Atrial Fibrillation: The ALONE-AF Randomized Clinical Trial.
作者: Daehoon Kim.;Jaemin Shim.;Eue-Keun Choi.;Il-Young Oh.;Jun Kim.;Young Soo Lee.;Junbeom Park.;Jum-Suk Ko.;Kyoung-Min Park.;Jung-Hoon Sung.;Hyung Wook Park.;Hyung-Seob Park.;Jong-Youn Kim.;Ki-Woon Kang.;Dongmin Kim.;Jin-Kyu Park.;Dae-Hyeok Kim.;Jin-Bae Kim.;Hee Tae Yu.;Tae-Hoon Kim.;Jae-Sun Uhm.;Hui-Nam Pak.;Boyoung Joung.; .
来源: JAMA. 2025年334卷14期1246-1254页
Data from randomized clinical trials on a long-term anticoagulation strategy for patients after catheter-based ablation for atrial fibrillation (AF) are lacking.
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