当前位置: 首页 >> 检索结果
161. Antihypertensive treatment and secondary prevention of cardiovascular disease events among persons without hypertension: a meta-analysis.
作者: Angela M Thompson.;Tian Hu.;Carrie L Eshelbrenner.;Kristi Reynolds.;Jiang He.;Lydia A Bazzano.
来源: JAMA. 2011年305卷9期913-22页
Cardiovascular disease (CVD) risk increases beginning at systolic blood pressure levels of 115 mm Hg. Use of antihypertensive medications among patients with a history of CVD or diabetes and without hypertension has been debated.
162. Association of myocardial enzyme elevation and survival following coronary artery bypass graft surgery.
作者: Michael J Domanski.;Kenneth Mahaffey.;Vic Hasselblad.;Sorin J Brener.;Peter K Smith.;Graham Hillis.;Milo Engoren.;John H Alexander.;Jerrold H Levy.;Bernard R Chaitman.;Samuel Broderick.;Michael J Mack.;Karen S Pieper.;Michael E Farkouh.
来源: JAMA. 2011年305卷6期585-91页
Several small studies have suggested that cardiac enzyme elevation in the 24 hours following coronary artery bypass graft (CABG) surgery is associated with worse prognosis, but a definitive study is not available. Also, the long-term prognostic impact of small increases of perioperative enzyme has not been reported.
163. Treatment-related mortality with bevacizumab in cancer patients: a meta-analysis.
Fatal adverse events (FAEs) have been reported in cancer patients treated with the widely used angiogenesis inhibitor bevacizumab in combination with chemotherapy. Currently, the role of bevacizumab in treatment-related mortality is not clear.
164. Management of chronic prostatitis/chronic pelvic pain syndrome: a systematic review and network meta-analysis.
作者: Thunyarat Anothaisintawee.;John Attia.;J Curtis Nickel.;Sangsuree Thammakraisorn.;Pawin Numthavaj.;Mark McEvoy.;Ammarin Thakkinstian.
来源: JAMA. 2011年305卷1期78-86页
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is common, but trial evidence is conflicting and therapeutic options are controversial.
165. Diagnosis, microbial epidemiology, and antibiotic treatment of acute otitis media in children: a systematic review.
作者: Tumaini R Coker.;Linda S Chan.;Sydne J Newberry.;Mary Ann Limbos.;Marika J Suttorp.;Paul G Shekelle.;Glenn S Takata.
来源: JAMA. 2010年304卷19期2161-9页
Acute otitis media (AOM) is the most common condition for which antibiotics are prescribed for US children; however, wide variation exists in diagnosis and treatment.
166. Reduced-function CYP2C19 genotype and risk of adverse clinical outcomes among patients treated with clopidogrel predominantly for PCI: a meta-analysis.
作者: Jessica L Mega.;Tabassome Simon.;Jean-Philippe Collet.;Jeffrey L Anderson.;Elliott M Antman.;Kevin Bliden.;Christopher P Cannon.;Nicolas Danchin.;Betti Giusti.;Paul Gurbel.;Benjamin D Horne.;Jean-Sebastian Hulot.;Adnan Kastrati.;Gilles Montalescot.;Franz-Josef Neumann.;Lei Shen.;Dirk Sibbing.;P Gabriel Steg.;Dietmar Trenk.;Stephen D Wiviott.;Marc S Sabatine.
来源: JAMA. 2010年304卷16期1821-30页
Clopidogrel, one of the most commonly prescribed medications, is a prodrug requiring CYP450 biotransformation. Data suggest its pharmacologic effect varies based on CYP2C19 genotype, but there is uncertainty regarding the clinical risk imparted by specific genotypes.
167. Perinatal regionalization for very low-birth-weight and very preterm infants: a meta-analysis.
作者: Sarah Marie Lasswell.;Wanda Denise Barfield.;Roger William Rochat.;Lillian Blackmon.
来源: JAMA. 2010年304卷9期992-1000页
For more than 30 years, guidelines for perinatal regionalization have recommended that very low-birth-weight (VLBW) infants be born at highly specialized hospitals, most commonly designated as level III hospitals. Despite these recommendations, some regions continue to have large percentages of VLBW infants born in lower-level hospitals.
168. Delirium in elderly patients and the risk of postdischarge mortality, institutionalization, and dementia: a meta-analysis.
作者: Joost Witlox.;Lisa S M Eurelings.;Jos F M de Jonghe.;Kees J Kalisvaart.;Piet Eikelenboom.;Willem A van Gool.
来源: JAMA. 2010年304卷4期443-51页
Delirium is a common and serious complication in elderly patients. Evidence suggests that delirium is associated with long-term poor outcome but delirium often occurs in individuals with more severe underlying disease.
169. Prenatal and postpartum depression in fathers and its association with maternal depression: a meta-analysis.
It is well established that maternal prenatal and postpartum depression is prevalent and has negative personal, family, and child developmental outcomes. Paternal depression during this period may have similar characteristics, but data are based on an emerging and currently inconsistent literature.
170. Genome-wide analysis of genetic loci associated with Alzheimer disease.
作者: Sudha Seshadri.;Annette L Fitzpatrick.;M Arfan Ikram.;Anita L DeStefano.;Vilmundur Gudnason.;Merce Boada.;Joshua C Bis.;Albert V Smith.;Minerva M Carassquillo.;Jean Charles Lambert.;Denise Harold.;Elisabeth M C Schrijvers.;Reposo Ramirez-Lorca.;Stephanie Debette.;W T Longstreth.;A Cecile J W Janssens.;V Shane Pankratz.;Jean François Dartigues.;Paul Hollingworth.;Thor Aspelund.;Isabel Hernandez.;Alexa Beiser.;Lewis H Kuller.;Peter J Koudstaal.;Dennis W Dickson.;Christophe Tzourio.;Richard Abraham.;Carmen Antunez.;Yangchun Du.;Jerome I Rotter.;Yurii S Aulchenko.;Tamara B Harris.;Ronald C Petersen.;Claudine Berr.;Michael J Owen.;Jesus Lopez-Arrieta.;Badri N Varadarajan.;James T Becker.;Fernando Rivadeneira.;Michael A Nalls.;Neill R Graff-Radford.;Dominique Campion.;Sanford Auerbach.;Kenneth Rice.;Albert Hofman.;Palmi V Jonsson.;Helena Schmidt.;Mark Lathrop.;Thomas H Mosley.;Rhoda Au.;Bruce M Psaty.;Andre G Uitterlinden.;Lindsay A Farrer.;Thomas Lumley.;Agustin Ruiz.;Julie Williams.;Philippe Amouyel.;Steve G Younkin.;Philip A Wolf.;Lenore J Launer.;Oscar L Lopez.;Cornelia M van Duijn.;Monique M B Breteler.; .; .; .
来源: JAMA. 2010年303卷18期1832-40页
Genome-wide association studies (GWAS) have recently identified CLU, PICALM, and CR1 as novel genes for late-onset Alzheimer disease (AD).
171. Benefit of adjuvant chemotherapy for resectable gastric cancer: a meta-analysis.
作者: .;Xavier Paoletti.;Koji Oba.;Tomasz Burzykowski.;Stefan Michiels.;Yasuo Ohashi.;Jean-Pierre Pignon.;Philippe Rougier.;Junichi Sakamoto.;Daniel Sargent.;Mitsuru Sasako.;Eric Van Cutsem.;Marc Buyse.
来源: JAMA. 2010年303卷17期1729-37页
Despite potentially curative resection of stomach cancer, 50% to 90% of patients die of disease relapse. Numerous randomized clinical trials (RCTs) have compared surgery alone with adjuvant chemotherapy, but definitive evidence is lacking.
172. Effect of noninsulin antidiabetic drugs added to metformin therapy on glycemic control, weight gain, and hypoglycemia in type 2 diabetes.
作者: Olivia J Phung.;Jennifer M Scholle.;Mehak Talwar.;Craig I Coleman.
来源: JAMA. 2010年303卷14期1410-8页
Metformin is the recommended initial drug therapy for patients with type 2 diabetes mellitus (DM). However, the optimal second-line drug when metformin monotherapy fails is unclear.
173. Stopping randomized trials early for benefit and estimation of treatment effects: systematic review and meta-regression analysis.
作者: Dirk Bassler.;Matthias Briel.;Victor M Montori.;Melanie Lane.;Paul Glasziou.;Qi Zhou.;Diane Heels-Ansdell.;Stephen D Walter.;Gordon H Guyatt.; .;David N Flynn.;Mohamed B Elamin.;Mohammad Hassan Murad.;Nisrin O Abu Elnour.;Julianna F Lampropulos.;Amit Sood.;Rebecca J Mullan.;Patricia J Erwin.;Clare R Bankhead.;Rafael Perera.;Carolina Ruiz Culebro.;John J You.;Sohail M Mulla.;Jagdeep Kaur.;Kara A Nerenberg.;Holger Schünemann.;Deborah J Cook.;Kristina Lutz.;Christine M Ribic.;Noah Vale.;German Malaga.;Elie A Akl.;Ignacio Ferreira-Gonzalez.;Pablo Alonso-Coello.;Gerard Urrutia.;Regina Kunz.;Heiner C Bucher.;Alain J Nordmann.;Heike Raatz.;Suzana Alves da Silva.;Fabio Tuche.;Brigitte Strahm.;Benjamin Djulbegovic.;Neill K J Adhikari.;Edward J Mills.;Femida Gwadry-Sridhar.;Haresh Kirpalani.;Heloisa P Soares.;Paul J Karanicolas.;Karen E A Burns.;Per Olav Vandvik.;Fernando Coto-Yglesias.;Pedro Paulo M Chrispim.;Tim Ramsay.
来源: JAMA. 2010年303卷12期1180-7页
Theory and simulation suggest that randomized controlled trials (RCTs) stopped early for benefit (truncated RCTs) systematically overestimate treatment effects for the outcome that precipitated early stopping.
174. Vitamin B6 and risk of colorectal cancer: a meta-analysis of prospective studies.
Mounting evidence indicates that vitamin B(6), a coenzyme involved in nearly 100 enzymatic reactions, may reduce the risk of colorectal cancer.
175. Higher vs lower positive end-expiratory pressure in patients with acute lung injury and acute respiratory distress syndrome: systematic review and meta-analysis.
作者: Matthias Briel.;Maureen Meade.;Alain Mercat.;Roy G Brower.;Daniel Talmor.;Stephen D Walter.;Arthur S Slutsky.;Eleanor Pullenayegum.;Qi Zhou.;Deborah Cook.;Laurent Brochard.;Jean-Christophe M Richard.;Francois Lamontagne.;Neera Bhatnagar.;Thomas E Stewart.;Gordon Guyatt.
来源: JAMA. 2010年303卷9期865-73页
Trials comparing higher vs lower levels of positive end-expiratory pressure (PEEP) in adults with acute lung injury or acute respiratory distress syndrome (ARDS) have been underpowered to detect small but potentially important effects on mortality or to explore subgroup differences.
176. Association between 9p21 genomic markers and heart disease: a meta-analysis.
Associations between chromosome 9p21 single-nucleotide polymorphisms (SNPs) and heart disease have been reported and replicated. If testing improves risk assessments using traditional factors, it may provide opportunities to improve public health.
177. Risk of deep vein thrombosis following a single negative whole-leg compression ultrasound: a systematic review and meta-analysis.
作者: Stacy A Johnson.;Scott M Stevens.;Scott C Woller.;Erica Lake.;Marco Donadini.;Ji Cheng.;José Labarère.;James D Douketis.
来源: JAMA. 2010年303卷5期438-45页
In patients with suspected lower extremity deep vein thrombosis (DVT), compression ultrasound (CUS) is typically the initial test to confirm or exclude DVT. Patients with an initial negative CUS result often require repeat CUS after 5 to 7 days. Whole-leg CUS may exclude proximal and distal DVT in a single evaluation.
178. Antidepressant drug effects and depression severity: a patient-level meta-analysis.
作者: Jay C Fournier.;Robert J DeRubeis.;Steven D Hollon.;Sona Dimidjian.;Jay D Amsterdam.;Richard C Shelton.;Jan Fawcett.
来源: JAMA. 2010年303卷1期47-53页
Antidepressant medications represent the best established treatment for major depressive disorder, but there is little evidence that they have a specific pharmacological effect relative to pill placebo for patients with less severe depression.
179. Motor development in very preterm and very low-birth-weight children from birth to adolescence: a meta-analysis.
作者: Jorrit F de Kieviet.;Jan P Piek.;Cornelieke S Aarnoudse-Moens.;Jaap Oosterlaan.
来源: JAMA. 2009年302卷20期2235-42页
Infants who are very preterm (born < or = 32 weeks of gestation) and very low birth weight (VLBW) (weighing < or = 1500 g) are at risk for poor developmental outcomes. There is increasing evidence that very preterm birth and VLBW have a considerable effect on motor development, although findings are inconsistent.
180. Combined corticosteroid and antiviral treatment for Bell palsy: a systematic review and meta-analysis.
作者: John R de Almeida.;Murtadha Al Khabori.;Gordon H Guyatt.;Ian J Witterick.;Vincent Y W Lin.;Julian M Nedzelski.;Joseph M Chen.
来源: JAMA. 2009年302卷9期985-93页
New evidence has emerged regarding the use of corticosteroids and antiviral agents in Bell palsy.
|