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1701. Effect of nonoxynol-9 gel on urogenital gonorrhea and chlamydial infection: a randomized controlled trial.
作者: Ronald E Roddy.;Léopold Zekeng.;Kelley A Ryan.;Ubald Tamoufé.;Kathryn G Tweedy.
来源: JAMA. 2002年287卷9期1117-22页
Nonoxynol-9 has been suggested as a vaginal microbicide to protect against common sexually transmitted infections.
1702. Raloxifene and cardiovascular events in osteoporotic postmenopausal women: four-year results from the MORE (Multiple Outcomes of Raloxifene Evaluation) randomized trial.
作者: Elizabeth Barrett-Connor.;Deborah Grady.;Andreas Sashegyi.;Pamela W Anderson.;David A Cox.;Krzysztof Hoszowski.;Pentti Rautaharju.;Kristine D Harper.; .
来源: JAMA. 2002年287卷7期847-57页
Raloxifene, a selective estrogen receptor modulator, improves cardiovascular risk factors, but its effect on cardiovascular events is unknown.
1703. Effects of hydration on fluid balance and lower-extremity blood viscosity during long airplane flights.
作者: Koichiro Hamada.;Tatsuya Doi.;Masao Sakura.;Keitaro Matsumoto.;Kae Yanagisawa.;Toshimi Suzuki.;Noriaki Kikuchi.;Joji Okuda.;Hiroshi Miyazaki.;Hirofumi Okoshi.;Mikio Zeniya.;Ichiro Asukata.
来源: JAMA. 2002年287卷7期844-5页 1704. Cardiovascular effects of sildenafil during exercise in men with known or probable coronary artery disease: a randomized crossover trial.
作者: Adelaide M Arruda-Olson.;Douglas W Mahoney.;Ajay Nehra.;Marilyn Leckel.;Patricia A Pellikka.
来源: JAMA. 2002年287卷6期719-25页
The relationship between sildenafil citrate use and reported adverse cardiovascular events in men with coronary artery disease (CAD) is unclear.
1705. Long-term efficacy of platelet glycoprotein IIb/IIIa integrin blockade with eptifibatide in coronary stent intervention.
作者: J Conor O'Shea.;Christopher E Buller.;Warren J Cantor.;A Bleakley Chandler.;Eric A Cohen.;David J Cohen.;Ian C Gilchrist.;Neal S Kleiman.;Marino Labinaz.;Mina Madan.;Gail E Hafley.;Robert M Califf.;Michael M Kitt.;John Strony.;James E Tcheng.; .
来源: JAMA. 2002年287卷5期618-21页
In the Enhanced Suppression of the Platelet IIb/IIIa Receptor with Integrilin Therapy (ESPRIT) trial, treatment with eptifibatide, a platelet glycoprotein IIb/IIIa integrin blocker, was found to reduce the ischemic complications of nonurgent coronary stent implantation at 48 hours and 30 days.
1706. Effects of diet and simvastatin on serum lipids, insulin, and antioxidants in hypercholesterolemic men: a randomized controlled trial.
作者: Antti Jula.;Jukka Marniemi.;Risto Huupponen.;Arja Virtanen.;Merja Rastas.;Tapani Rönnemaa.
来源: JAMA. 2002年287卷5期598-605页
Limited information exists on the interaction between diet and 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) and the interaction's effect on serum lipid and lipoprotein levels, insulin sensitivity, and circulating antioxidant vitamin and provitamin levels.
1707. Quality-of-life and depressive symptoms in postmenopausal women after receiving hormone therapy: results from the Heart and Estrogen/Progestin Replacement Study (HERS) trial.
作者: Mark A Hlatky.;Derek Boothroyd.;Eric Vittinghoff.;Penny Sharp.;Mary A Whooley.; .
来源: JAMA. 2002年287卷5期591-7页
Postmenopausal hormone therapy is commonly used by women for disease prevention, but its effects on quality of life have not been well documented.
1708. Chelation therapy for ischemic heart disease: a randomized controlled trial.
作者: Merril L Knudtson.;D George Wyse.;P Diane Galbraith.;Rollin Brant.;Kathy Hildebrand.;Diana Paterson.;Deborah Richardson.;Connie Burkart.;Ellen Burgess.; .
来源: JAMA. 2002年287卷4期481-6页
Chelation therapy using EDTA is an unproven but widely used alternative therapy for ischemic heart disease.
1709. Short-term quality-of-life outcomes following laparoscopic-assisted colectomy vs open colectomy for colon cancer: a randomized trial.
作者: Jane C Weeks.;Heidi Nelson.;Shari Gelber.;Daniel Sargent.;Georgene Schroeder.; .
来源: JAMA. 2002年287卷3期321-8页
Laparoscopic-assisted colectomy (LAC) has emerged as the preferred minimally invasive surgical strategy for diseases of the colon. The safety and efficacy of LAC for colon cancer are unknown, and the nature and magnitude of any quality-of-life (QOL) benefit resulting from LAC for colon cancer is also unknown.
1710. Serum estradiol level and risk of breast cancer during treatment with raloxifene.
作者: Steven R Cummings.;Tu Duong.;Emily Kenyon.;Jane A Cauley.;Malcolm Whitehead.;Kathryn A Krueger.; .
来源: JAMA. 2002年287卷2期216-20页
As endogenous estradiol increases, risk of breast cancer increases. Raloxifene competes with endogenous estrogen for binding to estrogen receptors in breast tissue. A woman's estradiol level may alter the effects of raloxifene on breast cancer and other outcomes.
1711. Efficacy of rofecoxib, celecoxib, and acetaminophen in osteoarthritis of the knee: a randomized trial.
作者: Gregory P Geba.;Arthur L Weaver.;Adam B Polis.;Mary E Dixon.;Thomas J Schnitzer.; .
来源: JAMA. 2002年287卷1期64-71页
Osteoarthritis (OA) is often treated with nonsteroidal anti-inflammatory drugs (NSAIDs), acetaminophen, or specific inhibitors of cyclooxygenase 2 (COX-2).
1712. Acupuncture for the treatment of cocaine addiction: a randomized controlled trial.
作者: Arthur Margolin.;Herbert D Kleber.;S Kelly Avants.;Janet Konefal.;Frank Gawin.;Elena Stark.;James Sorensen.;Eleanor Midkiff.;Elizabeth Wells.;T Ron Jackson.;Milton Bullock.;Patricia D Culliton.;Sharon Boles.;Roger Vaughan.
来源: JAMA. 2002年287卷1期55-63页
Auricular acupuncture is widely used to treat cocaine addiction in the United States and Europe. However, evidence from controlled studies regarding this treatment's effectiveness has been inconsistent.
1713. Comparison of cefuroxime with or without intranasal fluticasone for the treatment of rhinosinusitis. The CAFFS Trial: a randomized controlled trial.
作者: R J Dolor.;D L Witsell.;A S Hellkamp.;J W Williams.;R M Califf.;D L Simel.; .
来源: JAMA. 2001年286卷24期3097-105页
It is not known whether intranasal corticosteroids are beneficial to treat acute rhinosinusitis in patients with a history of chronic or recurrent sinus symptoms.
1714. Effect of omalizumab on symptoms of seasonal allergic rhinitis: a randomized controlled trial.
作者: T B Casale.;J Condemi.;C LaForce.;A Nayak.;M Rowe.;M Watrous.;M McAlary.;A Fowler-Taylor.;A Racine.;N Gupta.;R Fick.;G Della Cioppa.; .
来源: JAMA. 2001年286卷23期2956-67页
Seasonal allergic rhinitis is a common IgE-mediated disorder that produces troublesome symptoms. A recombinant humanized monoclonal anti-IgE antibody (omalizumab) forms complexes with free IgE, blocking its interaction with mast cells and basophils and lowering free IgE levels in the circulation.
1715. Similar effectiveness of paroxetine, fluoxetine, and sertraline in primary care: a randomized trial.
作者: K Kroenke.;S L West.;R Swindle.;A Gilsenan.;G J Eckert.;R Dolor.;P Stang.;X H Zhou.;R Hays.;M Weinberger.
来源: JAMA. 2001年286卷23期2947-55页
Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed class of antidepressant, yet it is not known whether one SSRI is more effective than another.
1716. Aptiganel hydrochloride in acute ischemic stroke: a randomized controlled trial.
Tissue plasminogen activator is the only thrombolytic agent approved in the United States for treatment of acute ischemic stroke, and has limitations. Aptiganel hydrochloride is a novel and selective ligand for the ion-channel site of the N-methyl-D-aspartate receptor-channel complex and a promising neuroprotective agent in animal models of focal brain ischemia.
1717. Morbidity and mortality in breastfed and formula-fed infants of HIV-1-infected women: A randomized clinical trial.
作者: D Mbori-Ngacha.;R Nduati.;G John.;M Reilly.;B Richardson.;A Mwatha.;J Ndinya-Achola.;J Bwayo.;J Kreiss.
来源: JAMA. 2001年286卷19期2413-20页
Breastfeeding among women infected with human immunodeficiency virus type 1 (HIV-1) is associated with substantial risk of HIV-1 transmission, but little is known about the morbidity risks associated with formula feeding in infants of HIV-1-infected women in resource-poor settings.
1718. Ability of minor elevations of troponins I and T to predict benefit from an early invasive strategy in patients with unstable angina and non-ST elevation myocardial infarction: results from a randomized trial.
作者: D A Morrow.;C P Cannon.;N Rifai.;M J Frey.;R Vicari.;N Lakkis.;D H Robertson.;D A Hille.;P T DeLucca.;P M DiBattiste.;L A Demopoulos.;W S Weintraub.;E Braunwald.; .
来源: JAMA. 2001年286卷19期2405-12页
Cardiac troponins I (cTnI) and T (cTnT) are useful for assessing prognosis in patients with unstable angina and non-ST-segment elevation myocardial infarction (UA/NSTEMI). However, the use of cardiac troponins for predicting benefit of an invasive vs conservative strategy in this patient population is not clear.
1719. Relationship between interleukin 6 and mortality in patients with unstable coronary artery disease: effects of an early invasive or noninvasive strategy.
Inflammatory activity is associated with high rates of long-term mortality in unstable coronary artery disease (CAD). Interleukin 6 (IL-6) induces C-reactive protein and fibrinogen, systemic markers of inflammation.
1720. Purified poloxamer 188 for treatment of acute vaso-occlusive crisis of sickle cell disease: A randomized controlled trial.
作者: E P Orringer.;J F Casella.;K I Ataga.;M Koshy.;P Adams-Graves.;L Luchtman-Jones.;T Wun.;M Watanabe.;F Shafer.;A Kutlar.;M Abboud.;M Steinberg.;B Adler.;P Swerdlow.;C Terregino.;S Saccente.;B Files.;S Ballas.;R Brown.;S Wojtowicz-Praga.;J M Grindel.
来源: JAMA. 2001年286卷17期2099-106页
Sickle cell disease (SCD) can cause severe painful episodes that are often thought to be caused by vaso-occlusion. The current therapy for these uncomplicated painful episodes includes hydration, oxygen, and analgesics. Purified poloxamer 188 may increase tissue oxygenation and thereby reduce inflammation, pain, and the overall duration of such painful episodes in patients with SCD.
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