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143. Immunogenicity and Safety of Influenza and COVID-19 Multicomponent Vaccine in Adults ≥50 Years: A Randomized Clinical Trial.
作者: Amanda K Rudman Spergel.;Iris Wu.;Weiping Deng.;Jose Cardona.;Kimball Johnson.;Ivette Espinosa-Fernandez.;Melissa Sinkiewicz.;Veronica Urdaneta.;Lizbeth Carmona.;Kristin Schaefers.;Bethany Girard.;Yamuna D Paila.;Darshan Mehta.;Benoit Callendret.;Lusine Kostanyan.;Jintanat Ananworanich.;Jacqueline Miller.;Rituparna Das.;Christine A Shaw.
来源: JAMA. 2025年333卷22期1977-1987页
Uptake of recommended seasonal influenza and COVID-19 vaccines remains suboptimal.
144. Association of Stratified Benchmarks With Financial Penalties in the ESRD Treatment Choices Model.
作者: Sri Lekha Tummalapalli.;Yuvaram N V Reddy.;Yueming Zhao.;Nuo Chen.;Seojeong Hong.;Yuntian Shi.;Zhimeng Yan.;Amol S Navathe.
来源: JAMA. 2025年334卷1期85-87页 145. Midurethral Sling vs OnabotulinumtoxinA in Females With Urinary Incontinence: The MUSA Randomized Clinical Trial.
作者: Heidi S Harvie.;Shawn A Menefee.;Holly E Richter.;Vivian W Sung.;Christopher J Chermansky.;David D Rahn.;Cindy L Amundsen.;Lily A Arya.;Evan Rhodes.;Donna Mazloomdoost.;Sonia Thomas.; .
来源: JAMA. 2025年333卷21期1887-1896页
Mixed urinary incontinence, which includes both stress and urgency urinary incontinence, adversely affects quality of life and can be difficult to manage. Studies comparing procedural-based treatments for mixed urinary incontinence are lacking.
148. Extended Caffeine for Apnea in Moderately Preterm Infants: The MoCHA Randomized Clinical Trial.
作者: Waldemar A Carlo.;Eric C Eichenwald.;Benjamin A Carper.;Edward F Bell.;Martin Keszler.;Ravi M Patel.;Pablo J Sánchez.;Ronald N Goldberg.;Carl T D'Angio.;Krisa P Van Meurs.;Anna Maria Hibbs.;Namasivayam Ambalavanan.;Shirley S Cosby.;Nancy S Newman.;Betty R Vohr.;Michele C Walsh.;Abhik Das.;Robin K Ohls.;Janell Fuller.;Matthew A Rysavy.;Sarvin Ghavam.;Luc P Brion.;Karen M Puopolo.;Ryan Moore.;Michelle L Baack.;Tarah T Colaizy.;Mariana Baserga.;Ahmed F Osman.;Stephanie L Merhar.;Brenda B Poindexter.;Sara B DeMauro.;Vasanth Kumar.;C Michael Cotten.; .
来源: JAMA. 2025年333卷24期2154-2163页
Hospitalization of moderately preterm infants may be prolonged while waiting for apnea of prematurity to resolve after discontinuing caffeine.
149. Long-Term Spending of Accountable Care Organizations in the Medicare Shared Savings Program.
作者: Amelia M Bond.;Yasin Civelek.;William L Schpero.;Lawrence P Casalino.;Manyao Zhang.;Reekarl Pierre.;Dhruv Khullar.
来源: JAMA. 2025年333卷21期1897-1905页
Evidence from initial cohorts of accountable care organizations (ACOs) participating in the Medicare Shared Savings Program (MSSP) found modest reductions in health care spending. Little is known about whether these effects have changed over time.
152. Metformin for Knee Osteoarthritis in Patients With Overweight or Obesity: A Randomized Clinical Trial.
作者: Feng Pan.;Yuanyuan Wang.;Yuan Z Lim.;Donna M Urquhart.;Mahnuma Mahfuz Estee.;Anita E Wluka.;Rory Wolfe.;Flavia M Cicuttini.
来源: JAMA. 2025年333卷20期1804-1812页
Preclinical and preliminary human evidence suggests that metformin, a first-line treatment for type 2 diabetes, reduces inflammation, preserves cartilage, and improves knee pain in knee osteoarthritis.
153. Modeling Reemergence of Vaccine-Eliminated Infectious Diseases Under Declining Vaccination in the US.
作者: Mathew V Kiang.;Kate M Bubar.;Yvonne Maldonado.;Peter J Hotez.;Nathan C Lo.
来源: JAMA. 2025年333卷24期2176-2187页
Widespread childhood vaccination has eliminated many infectious diseases in the US. However, vaccination rates are declining, and there are ongoing policy debates to reduce the childhood vaccine schedule, which may risk reemergence of previously eliminated infectious diseases.
154. Trends in Mental Health Diagnoses Among Publicly Insured Children.
作者: Janet R Cummings.;Xin Hu.;Jordan Marchak.;Cristian Ramos.;Ilana Graetz.;Xu Ji.
来源: JAMA. 2025年333卷22期1988-1997页
Children living in poverty are at increased risk of mental health and neurodevelopmental disorders. Little is known about the trends in diagnoses of these disorders among children enrolled in public insurance programs, such as Medicaid, which insure more than 1 in 3 US children.
156. Herpes Zoster Vaccination and Dementia Occurrence.
作者: Michael Pomirchy.;Christian Bommer.;Fabienne Pradella.;Felix Michalik.;Ruth Peters.;Pascal Geldsetzer.
来源: JAMA. 2025年333卷23期2083-2092页
Recent evidence from a quasi-experiment in Wales showed that herpes zoster (HZ) vaccination appears to prevent or delay dementia. Exploiting a similar quasi-experiment in Australia, this study investigated the effect of HZ vaccination on dementia occurrence in a different population and health system setting.
158. Varenicline for Youth Nicotine Vaping Cessation: A Randomized Clinical Trial.
作者: A Eden Evins.;Corinne Cather.;Harrison T Reeder.;Bryn Evohr.;Kevin Potter.;Gladys N Pachas.;Kevin M Gray.;Sharon Levy.;Nancy A Rigotti.;Vanessa Iroegbulem.;Jason Dufour.;Kelly Casottana.;Meghan A Costello.;Jodi M Gilman.;Randi M Schuster.
来源: JAMA. 2025年333卷21期1876-1886页
Electronic cigarette use (vaping) among adolescents and young adults is common. Few treatments have been tested in this population.
159. Non-Risk-Based Lung Cancer Screening With Low-Dose Computed Tomography.
作者: Caichen Li.;Bo Cheng.;Jianfu Li.;Shan Xiong.;Wenhai Fu.;Yu Jiang.;Chujing Zhou.;Ran Zhong.;Feng Li.;Qing Zhang.;Hengrui Liang.;Wei Wang.;Chi-Fu Jeffrey Yang.;Alexandra L Potter.;Xiaoqin Du.;Qiuxia Qiu.;Chunyu Yang.;Baoqing Sun.;Ying Chen.;Junzhe Liu.;Bin Xu.;Nanshan Zhong.;Wenhua Liang.;Jianxing He.; .
来源: JAMA. 2025年333卷23期2108-2110页 160. Has This Child Experienced Physical Abuse?: The Rational Clinical Examination Systematic Review.
作者: Sonal N Shah.;Hiu-Fai Fong.;Suzanne B Haney.;Nancy S Harper.;Mary Clyde Pierce.;Mark I Neuman.
来源: JAMA. 2025年334卷2期160-170页
Nearly 100 000 children experience physical abuse each year in the US. Among approximately 2000 annual deaths related to child maltreatment, more than 40% resulted from physical abuse, and half of those children were younger than 1 year. Many of these young children had unidentified abusive injuries before the fatal event.
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