142. Efficacy and Safety of Obinutuzumab in Active Systemic Lupus Erythematosus.
作者: Richard A Furie.;Maria Dall'Era.;Edward M Vital.;Jay P Garg.;Fedra Irazoque Palazuelos.;Adolfina E Zuta Santillán.;Jorge Ravelo-Hernández.;Mittermayer B Santiago.;Beatriz Zazueta Montiel.;Stella Botha.;Piotr Leszczyński.;Viviane Angelina de Souza.;Sandra A Sicsik.;Luis Bellatin.;Asokan Naidoo.;Zahir Amoura.;Maria Antonietta D'Agostino.;Sunil Kumar.;Biruh Workeneh.;Julie Rae.;Huiyan A Mao.;Felix Erblang.;Oliver Meier.;Justine C Maller.;Anca D Askanase.; .
来源: N Engl J Med. 2026年
Obinutuzumab, a glycoengineered type II anti-CD20 monoclonal antibody, induces potent B-cell depletion and is approved for the treatment of active lupus nephritis. Its efficacy and safety in patients with active systemic lupus erythematosus (SLE) are yet to be determined.
143. Zorevunersen in Children and Adolescents with Dravet Syndrome.
作者: Linda Laux.;Joseph Sullivan.;M Scott Perry.;Andreas Brunklaus.;Archana Desurkar.;John M Schreiber.;Colin M Roberts.;Kelly G Knupp.;James W Wheless.;Elaine C Wirrell.;Pam Ventola.;Fei Wang.; Meena.;Jessie Lynch.;Kimberly A Parkerson.;Barry Ticho.;J Helen Cross.; .
来源: N Engl J Med. 2026年394卷10期969-982页
Dravet syndrome is a severe developmental and epileptic encephalopathy caused primarily by SCN1A haploinsufficiency. Risks of sudden unexpected death in epilepsy and cognitive deficits are higher among patients with this syndrome than in the general population with epilepsy. The effects of zorevunersen, an antisense oligonucleotide designed to up-regulate NaV1.1 sodium channels, in patients with Dravet syndrome are not known.
157. Blinatumomab in Combined Immune Thrombocytopenia and Antiphospholipid Syndrome.
作者: Adrian Gottschlich.;Veit Bücklein.;Karim El-Marouk.;Rainer Kaiser.;Michael Schmid.;Thomas A Janert.;Michael Winkelmann.;Frank Ziemann.;Gerulf Hänel.;Stefan Handtke.;Thomas Thiele.;Christian Wichmann.;Sebastian Kobold.;Gerhard Zugmaier.;Christian Rausch.;Hendrik Schulze-Koops.;Lars H Lindner.;Karsten Spiekermann.;Michael von Bergwelt-Baildon.;Marion Subklewe.
来源: N Engl J Med. 2026年394卷10期1030-1033页 |