141. Electronic notifications for providers of patients with severe AS vs. usual care increased aortic valve replacement rates at 1 y.
GIM/FP/GP: [Formula: see text] Cardiology: [Formula: see text].
142. In AIS due to LVO presenting within 4.5 h of onset, adding tenecteplase to EVT increased functional independence at 90 d.
Emergency Med: [Formula: see text] GIM/FP/GP: [Formula: see text] Neurology: [Formula: see text].
143. In symptomatic peripheral artery disease with T2D, semaglutide increased maximum walking distance at 1 y.
GIM/FP/GP: [Formula: see text] Cardiology: [Formula: see text] Endocrinology: [Formula: see text].
144. The Role of Medical Experts in Transgender Legal Advocacy: A Historical Perspective on Kantaras v. Kantaras.
This article examines the ethical challenges that medical experts have navigated when mobilizing biological and psychological evidence to advocate for transgender patients in legal proceedings across a quarter of a century. In 2002, clinicians from a private clinic in Galveston, Texas, testified on behalf of Michael Kantaras, a transgender male patient, during his divorce and custody trial. Presenting gender identity as an innate product of neuroendocrine development, medical experts in Kantaras v. Kantaras challenged portrayals of gender dysphoria as a psychological illness resulting from sociocultural factors. Although this biological argument was key to destigmatizing transgender identity and convincing the judge to rule in Michael's favor, transgender advocates have argued that such claims strengthen medical authority over transgender identities. The article draws parallels with L.W. v. Skrmetti, a 2023 case heard by the U.S. Supreme Court concerning bans on gender-affirming care for transgender minors, to analyze how physician experts have referenced neuroimaging and genetic-sequencing studies to support the biological foundations of transgender identity. Transgender advocates have similarly expressed concerns about the medicalization of their identities, criticizing these studies as limited with regard to capturing the diversity and complexity of transgender experiences. Through analysis of historical and contemporary court cases, this article identifies shifting evidence-based methods for studying sex, understanding gender identity, and evaluating gender-affirming care, as well as the rising prominence of patient-centered approaches that seek to move beyond medicalized conceptions of gender identity as key themes clinicians should consider in their advocacy for their transgender patients.
147. Comparison of an Energy-Reduced Mediterranean Diet and Physical Activity Versus an Ad Libitum Mediterranean Diet in the Prevention of Type 2 Diabetes : A Secondary Analysis of a Randomized Controlled Trial.
作者: Miguel Ruiz-Canela.;Dolores Corella.;Miguel Ángel Martínez-González.;Nancy Babio.;J Alfredo Martínez.;Luis Forga.;Ángel M Alonso-Gómez.;Julia Wärnberg.;Jesús Vioque.;Dora Romaguera.;José López-Miranda.;Ramón Estruch.;José Manuel Santos-Lozano.;Luis Serra-Majem.;Aurora Bueno-Cavanillas.;Josep A Tur.;Vicente Martín-Sánchez.;Antoni Riera-Mestre.;Miguel Delgado-Rodríguez.;Pilar Matía-Martín.;Josep Vidal.;Clotilde Vázquez.;Lidia Daimiel.;Pilar Buil-Cosiales.;Sangeetha Shyam.;Jose V Sorlí.;Olga Castañer.;Antonio García-Rios.;Laura Torres-Collado.;Enrique Gómez-Gracia.;M Ángeles Zulet.;Jadwiga Konieczna.;Rosa Casas.;Naomi Cano-Ibáñez.;Lucas Tojal-Sierra.;Rosa M Bernal-López.;Estefanía Toledo.;Jesús García-Gavilán.;Rebeca Fernández-Carrión.;Albert Goday.;Antonio P Arenas-Larriva.;Sandra González-Palacios.;Helmut Schröder.;Emilio Ros.;Montserrat Fitó.;Frank B Hu.;Francisco J Tinahones.;Jordi Salas-Salvadó.
来源: Ann Intern Med. 2025年178卷10期1378-1389页
Limited research has been done to evaluate the combined effect of energy reduction, Mediterranean diet (MedDiet), and physical activity on type 2 diabetes incidence.
149. High-Concentration Delta-9-Tetrahydrocannabinol Cannabis Products and Mental Health Outcomes : A Systematic Review.
作者: Thanitsara Rittiphairoj.;Louis Leslie.;Jean-Pierre Oberste.;Tsz Wing Yim.;Gregory Tung.;Lisa Bero.;Paula Riggs.;Kent Hutchison.;Jonathan Samet.;Tianjing Li.
来源: Ann Intern Med. 2025年178卷10期1429-1440页
Rapid changes in the legalized cannabis market have led to the predominance of high-concentration delta-9-tetrahydrocannabinol (THC) cannabis products.
153. Long-Term Routine Laboratory Toxicity Monitoring of Immunomodulatory Drugs in Rheumatoid Arthritis : A Retrospective Cohort Study.
作者: Evy Ulijn.;Nathan den Broeder.;Karen Bevers.;Rosalie Pruijs.;Bram van Es.;Tjebbe Tauber.;Robert Landewé.;Noortje van Herwaarden.;Alfons A den Broeder.
来源: Ann Intern Med. 2025年178卷10期1400-1408页
Scarcity of data on the value of long-term routine laboratory toxicity monitoring (lt-RLTM) during disease-modifying antirheumatic drug (DMARD) use results in frequent monitoring in clinical practice.
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