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141. Aspirin Discontinuation at 24 to 28 Weeks' Gestation in Pregnancies at High Risk of Preterm Preeclampsia: A Randomized Clinical Trial.
作者: Manel Mendoza.;Erika Bonacina.;Pablo Garcia-Manau.;Monica López.;Sara Caamiña.;Àngels Vives.;Eva Lopez-Quesada.;Marta Ricart.;Anna Maroto.;Laura de Mingo.;Elena Pintado.;Roser Ferrer-Costa.;Lourdes Martin.;Alicia Rodríguez-Zurita.;Esperanza Garcia.;Mar Pallarols.;Laia Vidal-Sagnier.;Mireia Teixidor.;Carmen Orizales-Lago.;Adela Pérez-Gomez.;Vanesa Ocaña.;Linda Puerto.;Pilar Millán.;Mercè Alsius.;Sonia Diaz.;Nerea Maiz.;Elena Carreras.;Anna Suy.
来源: JAMA. 2023年329卷7期542-550页
Aspirin reduces the incidence of preterm preeclampsia by 62% in pregnant individuals at high risk of preeclampsia. However, aspirin might be associated with an increased risk of peripartum bleeding, which could be mitigated by discontinuing aspirin before term (37 weeks of gestation) and by an accurate selection of individuals at higher risk of preeclampsia in the first trimester of pregnancy.
142. Effect of Low-Concentration Atropine Eyedrops vs Placebo on Myopia Incidence in Children: The LAMP2 Randomized Clinical Trial.
作者: Jason C Yam.;Xiu Juan Zhang.;Yuzhou Zhang.;Benjamin H K Yip.;Fangyao Tang.;Emily S Wong.;Christine H T Bui.;Ka Wai Kam.;Mandy P H Ng.;Simon T Ko.;Wilson W K Yip.;Alvin L Young.;Clement C Tham.;Li Jia Chen.;Chi Pui Pang.
来源: JAMA. 2023年329卷6期472-481页
Early onset of myopia is associated with high myopia later in life, and myopia is irreversible once developed.
143. Effect of Argatroban Plus Intravenous Alteplase vs Intravenous Alteplase Alone on Neurologic Function in Patients With Acute Ischemic Stroke: The ARAIS Randomized Clinical Trial.
作者: Hui-Sheng Chen.;Yu Cui.;Zhong-He Zhou.;Ying-Jie Dai.;Gao-Hua Li.;Zhao-Long Peng.;Yi Zhang.;Xiao-Dong Liu.;Zhi-Mei Yuan.;Chang-Hao Jiang.;Qing-Cheng Yang.;Ying-Jie Duan.;Guang-Bin Ma.;Li-Wei Zhao.;Rui-Xian Wang.;Yuan-Lin Sun.;Lei Shen.;Er-Qiang Wang.;Li-Hua Wang.;Ye-Fang Feng.;Feng-Yun Wang.;Ren-Lin Zou.;He-Ping Yang.;Kai Wang.;Duo-Lao Wang.;Yi-Long Wang.; .
来源: JAMA. 2023年329卷8期640-650页
Previous studies suggested a benefit of argatroban plus alteplase (recombinant tissue-type plasminogen activator) in patients with acute ischemic stroke (AIS). However, robust evidence in trials with large sample sizes is lacking.
145. Effect of Early High-Flow Nasal Oxygen vs Standard Oxygen Therapy on Length of Hospital Stay in Hospitalized Children With Acute Hypoxemic Respiratory Failure: The PARIS-2 Randomized Clinical Trial.
作者: Donna Franklin.;Franz E Babl.;Shane George.;Ed Oakley.;Meredith L Borland.;Jocelyn Neutze.;Jason Acworth.;Simon Craig.;Mark Jones.;Brenda Gannon.;Deborah Shellshear.;Hamish McCay.;Alexandra Wallace.;Tobias Hoeppner.;Mark Wildman.;Joerg Mattes.;Trang M T Pham.;Letitia Miller.;Amanda Williams.;Sharon O'Brien.;Shirley Lawrence.;Megan Bonisch.;Kristen Gibbons.;Susan Moloney.;John Waugh.;Sue Hobbins.;Simon Grew.;Rose Fahy.;Stuart R Dalziel.;Andreas Schibler.
来源: JAMA. 2023年329卷3期224-234页
Nasal high-flow oxygen therapy in infants with bronchiolitis and hypoxia has been shown to reduce the requirement to escalate care. The efficacy of high-flow oxygen therapy in children aged 1 to 4 years with acute hypoxemic respiratory failure without bronchiolitis is unknown.
146. Effect of Torsemide vs Furosemide After Discharge on All-Cause Mortality in Patients Hospitalized With Heart Failure: The TRANSFORM-HF Randomized Clinical Trial.
作者: Robert J Mentz.;Kevin J Anstrom.;Eric L Eisenstein.;Shelly Sapp.;Stephen J Greene.;Shelby Morgan.;Jeffrey M Testani.;Amanda H Harrington.;Vandana Sachdev.;Fassil Ketema.;Dong-Yun Kim.;Patrice Desvigne-Nickens.;Bertram Pitt.;Eric J Velazquez.; .
来源: JAMA. 2023年329卷3期214-223页
Although furosemide is the most commonly used loop diuretic in patients with heart failure, some studies suggest a potential benefit for torsemide.
147. Effect of Catheter Ablation Using Pulmonary Vein Isolation With vs Without Posterior Left Atrial Wall Isolation on Atrial Arrhythmia Recurrence in Patients With Persistent Atrial Fibrillation: The CAPLA Randomized Clinical Trial.
作者: Peter M Kistler.;David Chieng.;Hariharan Sugumar.;Liang-Han Ling.;Louise Segan.;Sonia Azzopardi.;Ahmed Al-Kaisey.;Ramanathan Parameswaran.;Robert D Anderson.;Joshua Hawson.;Sandeep Prabhu.;Aleksandr Voskoboinik.;Geoffrey Wong.;Joseph B Morton.;Bhupesh Pathik.;Alex J McLellan.;Geoffrey Lee.;Michael Wong.;Sue Finch.;Rajeev K Pathak.;Deep Chandh Raja.;Laurence Sterns.;Matthew Ginks.;Christopher M Reid.;Prashanthan Sanders.;Jonathan M Kalman.
来源: JAMA. 2023年329卷2期127-135页
Pulmonary vein isolation (PVI) alone is less effective in patients with persistent atrial fibrillation (AF) compared with paroxysmal AF. The left atrial posterior wall may contribute to maintenance of persistent AF, and posterior wall isolation (PWI) is a common PVI adjunct. However, PWI has not been subjected to randomized comparison.
148. Effect of Remifentanil vs Neuromuscular Blockers During Rapid Sequence Intubation on Successful Intubation Without Major Complications Among Patients at Risk of Aspiration: A Randomized Clinical Trial.
作者: Nicolas Grillot.;Gilles Lebuffe.;Olivier Huet.;Sigismond Lasocki.;Xavier Pichon.;Mathieu Oudot.;Nathalie Bruneau.;Jean-Stéphane David.;Pierre Bouzat.;Alexandra Jobert.;Martine Tching-Sin.;Fanny Feuillet.;Raphael Cinotti.;Karim Asehnoune.;Antoine Roquilly.; .
来源: JAMA. 2023年329卷1期28-38页
It is uncertain whether a rapid-onset opioid is noninferior to a rapid-onset neuromuscular blocker during rapid sequence intubation when used in conjunction with a hypnotic agent.
149. Effect of a Community Health Worker-Delivered Personal Sound Amplification Device on Self-Perceived Communication Function in Older Adults With Hearing Loss: A Randomized Clinical Trial.
作者: Carrie L Nieman.;Joshua Betz.;Emmanuel E Garcia Morales.;Jonathan J Suen.;Jami Trumbo.;Nicole Marrone.;Hae-Ra Han.;Sarah L Szanton.;Frank R Lin.
来源: JAMA. 2022年328卷23期2324-2333页
Age-related hearing loss that impairs daily communication is associated with adverse health outcomes, but use of hearing aids by older adults is low and disparities exist.
150. Effect of Pessary vs Surgery on Patient-Reported Improvement in Patients With Symptomatic Pelvic Organ Prolapse: A Randomized Clinical Trial.
作者: Lisa R van der Vaart.;Astrid Vollebregt.;Alfredo L Milani.;Antoine L Lagro-Janssen.;Ruben G Duijnhoven.;Jan-Paul W R Roovers.;Carl H van der Vaart.
来源: JAMA. 2022年328卷23期2312-2323页
Pelvic organ prolapse is a prevalent condition among women that negatively affects their quality of life. With increasing life expectancy, the global need for cost-effective care for women with pelvic organ prolapse will continue to increase.
151. Effect of a Biopsychosocial Intervention or Postural Therapy on Disability and Health Care Spending Among Patients With Acute and Subacute Spine Pain: The SPINE CARE Randomized Clinical Trial.
作者: Niteesh K Choudhry.;Sheila Fifer.;Constance P Fontanet.;Kristin R Archer.;Ellen Sears.;Gauri Bhatkhande.;Nancy Haff.;Roya Ghazinouri.;Rogelio A Coronado.;Byron J Schneider.;Susan W Butterworth.;Harvinder Deogun.;Angelina Cooper.;Eugene Hsu.;Shannon Block.;Claudia A Davidson.;Claude E Shackelford.;Parul Goyal.;Arnold Milstein.; .;Katherine Crum.;Jennifer Scott.;Keith Marton.;Flavio M Silva.;Sarah Obeidalla.;Payton E Robinette.;Mario Lorenzana-DeWitt.;Courtney A Bair.;Hana J Sadun.;Natalie Goldfield.;Luke M Hogewood.;Emma K Sterling.;Cole Pickney.;Emma J Koltun-Baker.;Andrew Swehla.;Vishvaas Ravikumar.;Sameeksha Malhotra.;Sabrina T Finney.;Lynn Holliday.;Karin C Moolman.;Shanita Coleman-Dockery.;Ilaben B Patel.;Federica B Angel.;Jennifer K Green.;Kevin Mitchell.;Mary R McBean.;Muteeb Ghaffar.;Sandra R Ermini.;Ana L Carr.;James MacDonald.
来源: JAMA. 2022年328卷23期2334-2344页
Low back and neck pain are often self-limited, but health care spending remains high.
152. Effect of a Remotely Delivered Self-directed Behavioral Intervention on Body Weight and Physical Health Status Among Adults With Obesity: The D-ELITE Randomized Clinical Trial.
作者: Katherine D Hoerster.;Rachel Hunter-Merrill.;Tanya Nguyen.;Peter Rise.;Anna E Barón.;Jennifer McDowell.;Lucas M Donovan.;Emily Gleason.;Amber Lane.;Robert Plumley.;Mary Schooler.;Linnaea Schuttner.;Margaret Collins.;David H Au.;Jun Ma.
来源: JAMA. 2022年328卷22期2230-2241页
The effectiveness of remotely delivered, self-directed, weight loss programs in routine clinical practice is largely unknown.
153. Effects of Mindfulness Training and Exercise on Cognitive Function in Older Adults: A Randomized Clinical Trial.
作者: Eric J Lenze.;Michelle Voegtle.;J Philip Miller.;Beau M Ances.;David A Balota.;Deanna Barch.;Colin A Depp.;Breno Satler Diniz.;Lisa T Eyler.;Erin R Foster.;Torie R Gettinger.;Denise Head.;Tamara Hershey.;Samuel Klein.;Jeanne F Nichols.;Ginger E Nicol.;Tomoyuki Nishino.;Bruce W Patterson.;Thomas L Rodebaugh.;Julie Schweiger.;Joshua S Shimony.;David R Sinacore.;Abraham Z Snyder.;Susan Tate.;Elizabeth W Twamley.;David Wing.;Gregory F Wu.;Lei Yang.;Michael D Yingling.;Julie Loebach Wetherell.
来源: JAMA. 2022年328卷22期2218-2229页
Episodic memory and executive function are essential aspects of cognitive functioning that decline with aging. This decline may be ameliorable with lifestyle interventions.
154. Effect of Diet and Exercise on Knee Pain in Patients With Osteoarthritis and Overweight or Obesity: A Randomized Clinical Trial.
作者: Stephen P Messier.;Daniel P Beavers.;Kate Queen.;Shannon L Mihalko.;Gary D Miller.;Elena Losina.;Jeffrey N Katz.;Richard F Loeser.;Paul DeVita.;David J Hunter.;Jovita J Newman.;Sara A Quandt.;Mary F Lyles.;Joanne M Jordan.;Leigh F Callahan.
来源: JAMA. 2022年328卷22期2242-2251页
Some weight loss and exercise programs that have been successful in academic center-based trials have not been evaluated in community settings.
155. Effect of Timing by Endometrial Receptivity Testing vs Standard Timing of Frozen Embryo Transfer on Live Birth in Patients Undergoing In Vitro Fertilization: A Randomized Clinical Trial.
作者: Nicole Doyle.;Samad Jahandideh.;Micah J Hill.;Eric A Widra.;Michael Levy.;Kate Devine.
来源: JAMA. 2022年328卷21期2117-2125页
Endometrial receptivity testing is purported to improve live birth following frozen embryo transfer by identifying the optimal embryo transfer time for an individual patient; however, data are conflicting.
156. Effect of Regular, Low-Dose, Extended-release Morphine on Chronic Breathlessness in Chronic Obstructive Pulmonary Disease: The BEAMS Randomized Clinical Trial.
作者: Magnus Ekström.;Diana Ferreira.;Sungwon Chang.;Sandra Louw.;Miriam J Johnson.;Danny J Eckert.;Belinda Fazekas.;Katherine J Clark.;Meera R Agar.;David C Currow.; .
来源: JAMA. 2022年328卷20期2022-2032页
Chronic breathlessness is common in people with chronic obstructive pulmonary disease (COPD). Regular, low-dose, extended-release morphine may relieve breathlessness, but evidence about its efficacy and dosing is needed.
157. Effect of Selective Decontamination of the Digestive Tract on Hospital Mortality in Critically Ill Patients Receiving Mechanical Ventilation: A Randomized Clinical Trial.
作者: .;John A Myburgh.;Ian M Seppelt.;Fiona Goodman.;Laurent Billot.;Maryam Correa.;Joshua S Davis.;Anthony C Gordon.;Naomi E Hammond.;Jon Iredell.;Qiang Li.;Sharon Micallef.;Jennene Miller.;Jayanthi Mysore.;Colman Taylor.;Paul J Young.;Brian H Cuthbertson.;Simon R Finfer.
来源: JAMA. 2022年328卷19期1911-1921页
Whether selective decontamination of the digestive tract (SDD) reduces mortality in critically ill patients remains uncertain.
158. Effect of Ivermectin vs Placebo on Time to Sustained Recovery in Outpatients With Mild to Moderate COVID-19: A Randomized Clinical Trial.
作者: Susanna Naggie.;David R Boulware.;Christopher J Lindsell.;Thomas G Stewart.;Nina Gentile.;Sean Collins.;Matthew William McCarthy.;Dushyantha Jayaweera.;Mario Castro.;Mark Sulkowski.;Kathleen McTigue.;Florence Thicklin.;G Michael Felker.;Adit A Ginde.;Carolyn T Bramante.;Alex J Slandzicki.;Ahab Gabriel.;Nirav S Shah.;Leslie A Lenert.;Sarah E Dunsmore.;Stacey J Adam.;Allison DeLong.;George Hanna.;April Remaly.;Rhonda Wilder.;Sybil Wilson.;Elizabeth Shenkman.;Adrian F Hernandez.; .
来源: JAMA. 2022年328卷16期1595-1603页
The effectiveness of ivermectin to shorten symptom duration or prevent hospitalization among outpatients in the US with mild to moderate symptomatic COVID-19 is unknown.
159. Extended Follow-up of Microbiome Therapeutic SER-109 Through 24 Weeks for Recurrent Clostridioides difficile Infection in a Randomized Clinical Trial.
作者: Stuart H Cohen.;Thomas J Louie.;Matthew Sims.;Elaine E L Wang.;Asli Memisoglu.;Barbara H McGovern.;Lisa von Moltke.
来源: JAMA. 2022年328卷20期2062-2064页 160. Effect of Spinal Cord Burst Stimulation vs Placebo Stimulation on Disability in Patients With Chronic Radicular Pain After Lumbar Spine Surgery: A Randomized Clinical Trial.
作者: Sozaburo Hara.;Hege Andresen.;Ole Solheim.;Sven M Carlsen.;Terje Sundstrøm.;Greger Lønne.;Vetle V Lønne.;Kristin Taraldsen.;Erling A Tronvik.;Lise R Øie.;Agnete M Gulati.;Lisa M Sagberg.;Asgeir S Jakola.;Tore K Solberg.;Øystein P Nygaard.;Øyvind O Salvesen.;Sasha Gulati.
来源: JAMA. 2022年328卷15期1506-1514页
The use of spinal cord stimulation for chronic pain after lumbar spine surgery is increasing, yet rigorous evidence of its efficacy is lacking.
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