当前位置: 首页 >> 检索结果
141. Family-Based Behavioral Treatment for Childhood Obesity Implemented in Pediatric Primary Care: A Randomized Clinical Trial.
作者: Leonard H Epstein.;Denise E Wilfley.;Colleen Kilanowski.;Teresa Quattrin.;Steven R Cook.;Ihuoma U Eneli.;Nancy Geller.;Daphne Lew.;Michael Wallendorf.;Peter Dore.;Rocco A Paluch.;Kenneth B Schechtman.
来源: JAMA. 2023年329卷22期1947-1956页
Intensive behavioral interventions for childhood overweight and obesity are recommended by national guidelines, but are currently offered primarily in specialty clinics. Evidence is lacking on their effectiveness in pediatric primary care settings.
142. Direct Oral Anticoagulants vs Low-Molecular-Weight Heparin and Recurrent VTE in Patients With Cancer: A Randomized Clinical Trial.
作者: Deborah Schrag.;Hajime Uno.;Rachel Rosovsky.;Cynthia Rutherford.;Kristen Sanfilippo.;John L Villano.;Monic Drescher.;Nagesh Jayaram.;Chris Holmes.;Lawrence Feldman.;Ottavia Zattra.;Haley Farrar-Muir.;Christine Cronin.;Ethan Basch.;Anna Weiss.;Jean M Connors.; .
来源: JAMA. 2023年329卷22期1924-1933页
In patients with cancer who have venous thromboembolism (VTE) events, long-term anticoagulation with low-molecular-weight heparin (LMWH) is recommended to prevent recurrent VTE. The effectiveness of a direct oral anticoagulant (DOAC) compared with LMWH for preventing recurrent VTE in patients with cancer is uncertain.
143. Reducing Opioid Use for Chronic Pain With a Group-Based Intervention: A Randomized Clinical Trial.
作者: Harbinder K Sandhu.;Katie Booth.;Andrea D Furlan.;Jane Shaw.;Dawn Carnes.;Stephanie J C Taylor.;Charles Abraham.;Sharisse Alleyne.;Shyam Balasubramanian.;Lauren Betteley.;Kirstie L Haywood.;Cynthia P Iglesias-Urrutia.;Sheeja Krishnan.;Ranjit Lall.;Andrea Manca.;Dipesh Mistry.;Sian Newton.;Jennifer Noyes.;Vivien Nichols.;Emma Padfield.;Anisur Rahman.;Kate Seers.;Nicole K Y Tang.;Colin Tysall.;Sam Eldabe.;Martin Underwood.
来源: JAMA. 2023年329卷20期1745-1756页
Opioid use for chronic nonmalignant pain can be harmful.
144. Effect of Prophylactic Antibiotics on Mortality in Severe Alcohol-Related Hepatitis: A Randomized Clinical Trial.
作者: Alexandre Louvet.;Julien Labreuche.;Thong Dao.;Thierry Thévenot.;Frédéric Oberti.;Christophe Bureau.;Thierry Paupard.;Eric Nguyen-Khac.;Anne Minello.;Brigitte Bernard-Chabert.;Rodolphe Anty.;Faustine Wartel.;Nicolas Carbonell.;Georges-Philippe Pageaux.;Marie-Noelle Hilleret.;Romain Moirand.;Pierre Nahon.;Camille Potey.;Alain Duhamel.;Philippe Mathurin.
来源: JAMA. 2023年329卷18期1558-1566页
The benefits of prophylactic antibiotics for hospitalized patients with severe alcohol-related hepatitis are unclear.
145. Prednisone vs Placebo and Live Birth in Patients With Recurrent Implantation Failure Undergoing In Vitro Fertilization: A Randomized Clinical Trial.
作者: Yun Sun.;Linlin Cui.;Yao Lu.;Jichun Tan.;Xi Dong.;Tianxiang Ni.;Junhao Yan.;Yichun Guan.;Guimin Hao.;Jia-Yin Liu.;Bo Zhang.;Daimin Wei.;Yan Hong.;Yaqiong He.;Jia Qi.;Bing Xu.;Juanjuan Lu.;Qian Zhang.;Shanshan Zhao.;Xiaowei Ji.;Xiaofang Du.;Jie Zhang.;Jinyong Liu.;Jing Wang.;Yingqin Huang.;Dongmei Huang.;Yanzhi Du.;Hugo Vankelecom.;Heping Zhang.;Zi-Jiang Chen.
来源: JAMA. 2023年329卷17期1460-1468页
Implantation failure remains a critical barrier to in vitro fertilization. Prednisone, as an immune-regulatory agent, is widely used to improve the probability of implantation and pregnancy, although the evidence for efficacy is inadequate.
146. Community Health Workers in Early Childhood Well-Child Care for Medicaid-Insured Children: A Randomized Clinical Trial.
作者: Tumaini R Coker.;Kendra Liljenquist.;Sarah J Lowry.;Kevin Fiscella.;Marcia R Weaver.;Janette Ortiz.;Rachel LaFontaine.;Javier Silva.;Taylor Salaguinto.;Gina Johnson.;Lisa Friesema.;Lorena Porras-Javier.;Laura J Sotelo Guerra.;Peter G Szilagyi.
来源: JAMA. 2023年329卷20期1757-1767页
An intervention model (the Parent-focused Redesign for Encounters, Newborns to Toddlers; the PARENT intervention) for well-child care that integrates a community health worker into preventive care services may enhance early childhood well-child care.
147. Panitumumab vs Bevacizumab Added to Standard First-line Chemotherapy and Overall Survival Among Patients With RAS Wild-type, Left-Sided Metastatic Colorectal Cancer: A Randomized Clinical Trial.
作者: Jun Watanabe.;Kei Muro.;Kohei Shitara.;Kentaro Yamazaki.;Manabu Shiozawa.;Hisatsugu Ohori.;Atsuo Takashima.;Mitsuru Yokota.;Akitaka Makiyama.;Naoya Akazawa.;Hitoshi Ojima.;Yasuhiro Yuasa.;Keisuke Miwa.;Hirofumi Yasui.;Eiji Oki.;Takeo Sato.;Takeshi Naitoh.;Yoshito Komatsu.;Takeshi Kato.;Masamitsu Hihara.;Junpei Soeda.;Toshihiro Misumi.;Kouji Yamamoto.;Kiwamu Akagi.;Atsushi Ochiai.;Hiroyuki Uetake.;Katsuya Tsuchihara.;Takayuki Yoshino.
来源: JAMA. 2023年329卷15期1271-1282页
For patients with RAS wild-type metastatic colorectal cancer, adding anti-epidermal growth factor receptor (anti-EGFR) or anti-vascular endothelial growth factor (anti-VEGF) monoclonal antibodies to first-line doublet chemotherapy is routine, but the optimal targeted therapy has not been defined.
148. VE303, a Defined Bacterial Consortium, for Prevention of Recurrent Clostridioides difficile Infection: A Randomized Clinical Trial.
作者: Thomas Louie.;Yoav Golan.;Sahil Khanna.;Dmitri Bobilev.;Nathalie Erpelding.;Candida Fratazzi.;Meg Carini.;Rajita Menon.;Mary Ruisi.;Jason M Norman.;Jeremiah J Faith.;Bernat Olle.;Minran Li.;Jeffrey L Silber.;Darrell S Pardi.
来源: JAMA. 2023年329卷16期1356-1366页
The effect of rationally defined nonpathogenic, nontoxigenic, commensal strains of Clostridia on prevention of Clostridioides difficile infection (CDI) is unknown.
149. Heterogeneity in Blood Pressure Response to 4 Antihypertensive Drugs: A Randomized Clinical Trial.
作者: Johan Sundström.;Lars Lind.;Shamim Nowrouzi.;Emil Hagström.;Claes Held.;Per Lytsy.;Bruce Neal.;Kerstin Marttala.;Ollie Östlund.
来源: JAMA. 2023年329卷14期1160-1169页
Hypertension is the leading risk factor for premature death worldwide. Multiple blood pressure-lowering therapies are available but the potential for maximizing benefit by personalized targeting of drug classes is unknown.
150. Effect of Angiotensin-Converting Enzyme Inhibitor and Angiotensin Receptor Blocker Initiation on Organ Support-Free Days in Patients Hospitalized With COVID-19: A Randomized Clinical Trial.
作者: .;Patrick R Lawler.;Lennie P G Derde.;Frank L van de Veerdonk.;Bryan J McVerry.;David T Huang.;Lindsay R Berry.;Elizabeth Lorenzi.;Roland van Kimmenade.;Frank Gommans.;Muthiah Vaduganathan.;David E Leaf.;Rebecca M Baron.;Edy Y Kim.;Claudia Frankfurter.;Slava Epelman.;Yvonne Kwan.;Richard Grieve.;Stephen O'Neill.;Zia Sadique.;Michael Puskarich.;John C Marshall.;Alisa M Higgins.;Paul R Mouncey.;Kathryn M Rowan.;Farah Al-Beidh.;Djillali Annane.;Yaseen M Arabi.;Carly Au.;Abi Beane.;Wilma van Bentum-Puijk.;Marc J M Bonten.;Charlotte A Bradbury.;Frank M Brunkhorst.;Aidan Burrell.;Adrian Buzgau.;Meredith Buxton.;Maurizio Cecconi.;Allen C Cheng.;Matthew Cove.;Michelle A Detry.;Lise J Estcourt.;Justin Ezekowitz.;Mark Fitzgerald.;David Gattas.;Lucas C Godoy.;Herman Goossens.;Rashan Haniffa.;David A Harrison.;Thomas Hills.;Christopher M Horvat.;Nao Ichihara.;Francois Lamontagne.;Kelsey M Linstrum.;Daniel F McAuley.;Anna McGlothlin.;Shay P McGuinness.;Zoe McQuilten.;Srinivas Murthy.;Alistair D Nichol.;David R J Owen.;Rachael L Parke.;Jane C Parker.;Katrina M Pollock.;Luis Felipe Reyes.;Hiroki Saito.;Marlene S Santos.;Christina T Saunders.;Christopher W Seymour.;Manu Shankar-Hari.;Vanessa Singh.;Alexis F Turgeon.;Anne M Turner.;Ryan Zarychanski.;Cameron Green.;Roger J Lewis.;Derek C Angus.;Scott Berry.;Anthony C Gordon.;Colin J McArthur.;Steve A Webb.
来源: JAMA. 2023年329卷14期1183-1196页
Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
152. Early vs Interval Postpartum Intrauterine Device Placement: A Randomized Clinical Trial.
作者: Sarah Averbach.;Gennifer Kully.;Erica Hinz.;Arnab Dey.;Holly Berkley.;Marisa Hildebrand.;Florin Vaida.;Sadia Haider.;Lisa G Hofler.
来源: JAMA. 2023年329卷11期910-917页
The early postpartum period, 2 to 4 weeks after birth, may be a convenient time for intrauterine device (IUD) placement; the placement could then coincide with early postpartum or well-baby visits.
153. Efficacy and Safety of Early Administration of 4-Factor Prothrombin Complex Concentrate in Patients With Trauma at Risk of Massive Transfusion: The PROCOAG Randomized Clinical Trial.
作者: Pierre Bouzat.;Jonathan Charbit.;Paer-Selim Abback.;Delphine Huet-Garrigue.;Nathalie Delhaye.;Marc Leone.;Guillaume Marcotte.;Jean-Stéphane David.;Albrice Levrat.;Karim Asehnoune.;Julien Pottecher.;Jacques Duranteau.;Elie Courvalin.;Anais Adolle.;Dimitri Sourd.;Jean-Luc Bosson.;Bruno Riou.;Tobias Gauss.;Jean-François Payen.; .
来源: JAMA. 2023年329卷16期1367-1375页
Optimal transfusion strategies in traumatic hemorrhage are unknown. Reports suggest a beneficial effect of 4-factor prothrombin complex concentrate (4F-PCC) on blood product consumption.
155. Effect of Intrapartum Azithromycin vs Placebo on Neonatal Sepsis and Death: A Randomized Clinical Trial.
作者: Anna Roca.;Bully Camara.;Joel D Bognini.;Usman N Nakakana.;Athasana M Somé.;Nathalie Beloum.;Toussaint Rouamba.;Fatoumata Sillah.;Madikoi Danso.;Joquina C Jones.;Shashu Graves.;Isatou Jagne.;Pauline Getanda.;Saffiatou Darboe.;Marc C Tahita.;Ebrahim Ndure.;Hien S Franck.;Sawadogo Y Edmond.;Bai L Dondeh.;Wilfried G J Nassa.;Zakaria Garba.;Abdoulie Bojang.;Yusupha Njie.;Christian Bottomley.;Halidou Tinto.;Umberto D'Alessandro.; .
来源: JAMA. 2023年329卷9期716-724页
Neonatal sepsis is a leading cause of neonatal mortality. New interventions are needed to decrease neonatal sepsis and mortality in regions with highest burden.
156. Effect of Induction Therapy With Olamkicept vs Placebo on Clinical Response in Patients With Active Ulcerative Colitis: A Randomized Clinical Trial.
作者: Shenghong Zhang.;Baili Chen.;Bangmao Wang.;Hong Chen.;Yan Li.;Qian Cao.;Jie Zhong.;Ming-Jium Shieh.;Zhihua Ran.;Tongyu Tang.;Ming Yang.;Beibei Xu.;Qiang Wang.;Yunjie Liu.;Lijia Ma.;Xiaolin Wang.;Nan Zhang.;Su Zhang.;Wenyu Guo.;Liang Huang.;Stefan Schreiber.;Minhu Chen.
来源: JAMA. 2023年329卷9期725-734页
Olamkicept, a soluble gp130-Fc-fusion-protein, selectively inhibits interleukin 6 (IL-6) trans-signaling by binding the soluble IL-6 receptor/IL-6 complex. It has anti-inflammatory activities in inflammatory murine models without immune suppression.
157. Treat-to-Target or High-Intensity Statin in Patients With Coronary Artery Disease: A Randomized Clinical Trial.
作者: Sung-Jin Hong.;Yong-Joon Lee.;Seung-Jun Lee.;Bum-Kee Hong.;Woong Chol Kang.;Jong-Young Lee.;Jin-Bae Lee.;Tae-Hyun Yang.;Junghan Yoon.;Chul-Min Ahn.;Jung-Sun Kim.;Byeong-Keuk Kim.;Young-Guk Ko.;Donghoon Choi.;Yangsoo Jang.;Myeong-Ki Hong.; .
来源: JAMA. 2023年329卷13期1078-1087页
In patients with coronary artery disease, some guidelines recommend initial statin treatment with high-intensity statins to achieve at least a 50% reduction in low-density lipoprotein cholesterol (LDL-C). An alternative approach is to begin with moderate-intensity statins and titrate to a specific LDL-C goal. These alternatives have not been compared head-to-head in a clinical trial involving patients with known coronary artery disease.
158. Coordinated Care to Optimize Cardiovascular Preventive Therapies in Type 2 Diabetes: A Randomized Clinical Trial.
作者: Neha J Pagidipati.;Adam J Nelson.;Lisa A Kaltenbach.;Monica Leyva.;Darren K McGuire.;Rodica Pop-Busui.;Matthew A Cavender.;Vanita R Aroda.;Melissa L Magwire.;Caroline R Richardson.;Ildiko Lingvay.;Julienne K Kirk.;Hussein R Al-Khalidi.;Laura Webb.;Tanya Gaynor.;Jonathan Pak.;Cagri Senyucel.;Renato D Lopes.;Jennifer B Green.;Christopher B Granger.; .
来源: JAMA. 2023年329卷15期1261-1270页
Evidence-based therapies to reduce atherosclerotic cardiovascular disease risk in adults with type 2 diabetes are underused in clinical practice.
159. Endovascular Ultrasound Renal Denervation to Treat Hypertension: The RADIANCE II Randomized Clinical Trial.
作者: Michel Azizi.;Manish Saxena.;Yale Wang.;J Stephen Jenkins.;Chandan Devireddy.;Florian Rader.;Naomi D L Fisher.;Roland E Schmieder.;Felix Mahfoud.;Jason Lindsey.;Kintur Sanghvi.;Thomas M Todoran.;John Pacella.;John Flack.;Joost Daemen.;Andrew S P Sharp.;Philipp Lurz.;Michael J Bloch.;Michael A Weber.;Melvin D Lobo.;Jan Basile.;Lisa Claude.;Helen Reeve-Stoffer.;Candace K McClure.;Ajay J Kirtane.; .
来源: JAMA. 2023年329卷8期651-661页
Two initial sham-controlled trials demonstrated that ultrasound renal denervation decreases blood pressure (BP) in patients with mild to moderate hypertension and hypertension that is resistant to treatment.
160. Aspirin Discontinuation at 24 to 28 Weeks' Gestation in Pregnancies at High Risk of Preterm Preeclampsia: A Randomized Clinical Trial.
作者: Manel Mendoza.;Erika Bonacina.;Pablo Garcia-Manau.;Monica López.;Sara Caamiña.;Àngels Vives.;Eva Lopez-Quesada.;Marta Ricart.;Anna Maroto.;Laura de Mingo.;Elena Pintado.;Roser Ferrer-Costa.;Lourdes Martin.;Alicia Rodríguez-Zurita.;Esperanza Garcia.;Mar Pallarols.;Laia Vidal-Sagnier.;Mireia Teixidor.;Carmen Orizales-Lago.;Adela Pérez-Gomez.;Vanesa Ocaña.;Linda Puerto.;Pilar Millán.;Mercè Alsius.;Sonia Diaz.;Nerea Maiz.;Elena Carreras.;Anna Suy.
来源: JAMA. 2023年329卷7期542-550页
Aspirin reduces the incidence of preterm preeclampsia by 62% in pregnant individuals at high risk of preeclampsia. However, aspirin might be associated with an increased risk of peripartum bleeding, which could be mitigated by discontinuing aspirin before term (37 weeks of gestation) and by an accurate selection of individuals at higher risk of preeclampsia in the first trimester of pregnancy.
|