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1462. The Science of Sleep in Medieval Arabic Medicine: Part 2: Sleep Theory and Practice After Ibn Sīnā.
In this second article on medieval Arabic medical discussions on sleep, I show that Ibn Sīnā's pneumatic paradigm of sleep opened up new research pathways for subsequent physicians in Islamic societies. Opposing those who posit a decline in scientific activity post-1200 in these societies, I show that Ibn al-Nafīs (d. 1288), Ibn al-Quff (d. 1286), and Quṭb al-Dīn al-Shīrāzī (d. 1311), among others, raised and answered new questions to highlight the (possible) active role played by the brain in sleep onset and the strengthening of certain brain activities during sleep. They also continued to investigate the (three) stages of sleep and paid attention to different breathing patterns, in addition to pulse, during each stage. Finally, they also applied the pneumatic paradigm in new ways to understand the broader impact of certain medical conditions on sleep.
1473. Reducing Pulmonary Capillary Wedge Pressure During Exercise Exacerbates Exertional Dyspnea in Patients With Heart Failure With Preserved Ejection Fraction: Implications for V˙/Q˙ Mismatch.
作者: Bryce N Balmain.;Andrew R Tomlinson.;James P MacNamara.;Linda S Hynan.;Denis J Wakeham.;Benjamin D Levine.;Satyam Sarma.;Tony G Babb.
来源: Chest. 2023年164卷3期686-699页
The primary cause of dyspnea on exertion in heart failure with preserved ejection fraction (HFpEF) is presumed to be the marked rise in pulmonary capillary wedge pressure during exercise; however, this hypothesis has never been tested directly. Therefore, we evaluated invasive exercise hemodynamics and dyspnea on exertion in patients with HFpEF before and after acute nitroglycerin (NTG) treatment to lower pulmonary capillary wedge pressure.
1474. Complications and Practice Variation in the Use of Peripherally Inserted Central Venous Catheters in People With Cystic Fibrosis: The Prospective Study of Peripherally Inserted Venous Catheters in People With Cystic Fibrosis Study.
作者: Alex H Gifford.;Alexandra C Hinton.;Shijing Jia.;Samya Z Nasr.;Joel D Mermis.;Thomas Lahiri.;Edith T Zemanick.;Charlotte C Teneback.;Patrick A Flume.;Emily A DiMango.;Hossein Sadeghi.;Deepika Polineni.;Rebecca H Dezube.;Natalie E West.;Elliott C Dasenbrook.;F Lee Lucas.;Jonathan B Zuckerman.
来源: Chest. 2023年164卷3期614-624页
Peripherally inserted central catheters (PICCs) are used commonly to administer antibiotics to people with cystic fibrosis (CF), but their use can be complicated by venous thrombosis and catheter occlusion.
1475. Prediction Models for Mediastinal Metastasis and Its Detection by Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration in Potentially Operable Non-Small Cell Lung Cancer: A Prospective Study.
作者: Hyun Sung Chung.;Ho Il Yoon.;Bin Hwangbo.;Eun Young Park.;Chang-Min Choi.;Young Sik Park.;Kyungjong Lee.;Wonjun Ji.;Sohee Park.;Geon Kook Lee.;Tae Sung Kim.;Hyae Young Kim.;Moon Soo Kim.;Jong Mog Lee.
来源: Chest. 2023年164卷3期770-784页
Prediction models for mediastinal metastasis and its detection by endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) have not been developed using a prospective cohort of potentially operable patients with non-small cell lung cancer (NSCLC).
1477. Valaciclovir for Epstein-Barr Virus Suppression in Moderate-to-Severe COPD: A Randomized Double-Blind Placebo-Controlled Trial.
作者: Dermot A Linden.;Hong Guo-Parke.;Michael C McKelvey.;Gisli G Einarsson.;Andrew J Lee.;Derek J Fairley.;Vanessa Brown.;Gavin Lundy.;Christina Campbell.;Danielle Logan.;Margaret McFarland.;Dave Singh.;Daniel F McAuley.;Clifford C Taggart.;Joseph C Kidney.
来源: Chest. 2023年164卷3期625-636页
Epstein-Barr virus (EBV) frequently is measured at high levels in COPD using sputum quantitative polymerase chain reaction, whereas airway immunohistochemistry analysis has shown EBV detection to be common in severe disease.
1478. The Fungal Microbiome of the Upper Airway Is Associated With Future Loss of Asthma Control and Exacerbation Among Children With Asthma.
作者: Hanshu Yuan.;Zhongmao Liu.;Jinhong Dong.;Leonard B Bacharier.;Daniel Jackson.;David Mauger.;Homer Boushey.;Mario Castro.;Juliana Durack.;Yvonne J Huang.;Robert F Lemanske.;Gregory A Storch.;George M Weinstock.;Kristine Wylie.;Ronina Covar.;Anne M Fitzpatrick.;Wanda Phipatanakul.;Rachel G Robison.;Avraham Beigelman.;Yanjiao Zhou.
来源: Chest. 2023年164卷2期302-313页
Accumulating evidence suggests that the upper airway bacterial microbiota is implicated in asthma inception, severity, and exacerbation. Unlike bacterial microbiota, the role of the upper airway fungal microbiome (mycobiome) in asthma control is poorly understood.
1479. Albuterol-Budesonide Pressurized Metered Dose Inhaler in Patients With Mild-to-Moderate Asthma: Results of the DENALI Double-Blind Randomized Controlled Trial.
作者: Bradley E Chipps.;Elliot Israel.;Richard Beasley.;Reynold A Panettieri.;Frank C Albers.;Robert Rees.;Lynn Dunsire.;Anna Danilewicz.;Eva Johnsson.;Christy Cappelletti.;Alberto Papi.
来源: Chest. 2023年164卷3期585-595页
In the phase 3 MANDALA trial, as-needed albuterol-budesonide pressurized metered-dose inhaler significantly reduced severe exacerbation risk vs as-needed albuterol in patients with moderate-to-severe asthma receiving inhaled corticosteroid-containing maintenance therapy. This study (DENALI) was conducted to address the US Food and Drug Administration combination rule, which requires a combination product to demonstrate that each component contributes to its efficacy.
1480. BAL Fluid Eosinophilia Associates With Chronic Lung Allograft Dysfunction Risk: A Multicenter Study.
作者: Jamie L Todd.;Jeremy M Weber.;Francine L Kelly.;Megan L Neely.;Hillary Mulder.;Courtney W Frankel.;Andrew Nagler.;Christopher McCrae.;Paul Newbold.;Jim Kreindler.;Scott M Palmer.
来源: Chest. 2023年164卷3期670-681页
Chronic lung allograft dysfunction (CLAD) is the leading cause of death among lung transplant recipients. Eosinophils, effector cells of type 2 immunity, are implicated in the pathobiology of many lung diseases, and prior studies suggest their presence associates with acute rejection or CLAD after lung transplantation.
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