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1401. Understanding the Complex Genetics of Spontaneous Coronary Artery Dissection: A Guide for Clinicians.
作者: Lucy McGrath-Cadell.;Stephanie Hesselson.;David W M Muller.;Jason C Kovacic.;Eleni Giannoulatou.;Robert M Graham.
来源: Circ Genom Precis Med. 2024年17卷6期e004800页 1403. Polygenic Prediction of Recurrent Events After Early-Onset Myocardial Infarction.
作者: Maddalena Ardissino.;Elvezia Maria Paraboschi.;Samuel A Lambert.;Lois G Kim.;Martin Kelemen.;Giuseppe Maglietta.;Antonio Crocamo.;Giulia Magnani.;Serena Bricoli.;Luigi Vignali.;Giampaolo Niccoli.;Marco Tubaro.;Libor Pastika.;Arunashis Sau.;Fu Siong Ng.;Antonio de Marvao.;Michael C Honigberg.;Pradeep Natarajan.;Adam J Nelson.;Michael Inouye.;Emanuele Di Angelantonio.;Rosanna Asselta.;Diego Ardissino.;Adam S Butterworth.
来源: Circ Genom Precis Med. 2024年17卷6期e004687页
Myocardial infarction (MI) is a complex disease caused by both lifestyle and genetic factors. This study aims to investigate the predictive value of genetic risk, in addition to traditional cardiovascular risk factors, for recurrent events following early-onset MI.
1404. Electrophysiological Phenotype-Genotype Study of Sustained Monomorphic Ventricular Tachycardia in Inherited, High Arrhythmic Risk, Left Ventricular Cardiomyopathy.
作者: Eva Cabrera-Borrego.;Francisco J Bermúdez-Jiménez.;Alessio Gasperetti.;Harikrishna Tandri.;Pablo J Sánchez-Millán.;Manuel Molina-Lerma.;Ivo Roca-Luque.;Sara Vázquez-Calvo.;Paolo Compagnucci.;Michela Casella.;Claudio Tondo.;Petr Peichl.;Giovani Peretto.;Elena Paiotti.;Ardan M Saguner.;Víctor Castro-Urda.;Nerea Mora-Ayestarán.;José M Larrañaga-Moreira.;Pablo Fernández de-Aspe.;Roberto Barriales-Villa.;Carmen Muñoz-Esparza.;Esther Zorio.;Julia Martínez-Solé.;Luis R Lopes.;Johanna B Tonko.;Pier D Lambiase.;Perry M Elliott.;Moisés Rodríguez-Mañero.;Victoria Cañadas-Godoy.;Sebastian Giacoman.;Miguel Álvarez-López.;Rosa Macías-Ruiz.;William J McKenna.;Luis Tercedor-Sánchez.;Juan Jiménez-Jáimez.
来源: Circ Arrhythm Electrophysiol. 2024年17卷12期e013145页
Among inherited cardiomyopathies involving the left ventricle, whether dilated or not, certain genotypes carry a well-established arrhythmic risk, notably manifested as sustained monomorphic ventricular tachycardia (SMVT). Nonetheless, the precise localization and electrophysiological profile of this substrate remain undisclosed across different genotypes.
1405. Unraveling Comorbidities Contribution to Cardiac Diastolic Dysfunction and Heart Failure.
作者: María Villalba-Orero.;Marina López-Olañeta.;Belén Campos-Olmo.;Daniel Jimenez-Carretero.;Lucía Sánchez.;Fátima Sánchez-Cabo.;Antonella Ausiello.;Rodrigo Cañas-Álvaro.;Emilio Camafeita.;Jesús Vázquez.;Pablo García-Pavía.;Domingo Pascual-Figal.;Enrique Lara-Pezzi.
来源: Circ Heart Fail. 2025年18卷1期e011724页
Heart failure with preserved ejection fraction (HFpEF) is a major public health problem characterized by multiple simultaneous comorbidities whose specific contribution is challenging to disentangle in humans, leading to a generalized therapeutic approach that may not account for the underlying pathology.
1406. Sex-Specific Association Between Genetic Risk of Psychiatric Disorders and Cardiovascular Diseases.
作者: Jiayue-Clara Jiang.;Kritika Singh.;Rachana Nitin.;Lea K Davis.;Naomi R Wray.;Sonia Shah.
来源: Circ Genom Precis Med. 2024年17卷6期e004685页
Though epidemiological studies show increased cardiovascular disease (CVD) risks among individuals with psychiatric disorders, findings on sex differences in comorbidity have been inconsistent.
1408. Lesion Morphometry of the Pentaspline Pulsed Field Ablation Catheter: Understanding Catheter Pose, Rotation, and Dosing.
作者: Keita Watanabe.;Moritz Nies.;Vivek Y Reddy.;Jacob S Koruth.
来源: Circ Arrhythm Electrophysiol. 2024年17卷12期e013208页
The pentaspline pulsed field ablation catheter achieves pulmonary vein isolation using 8 stacked, pose-specific applications with rotation. The morphology of pose-specific, single or double applications has not been described.
1409. Hepatic Tissue Alterations in ST-Elevation Myocardial Infarction: Determinants and Prognostic Implications.
作者: Ivan Lechner.;Martin Reindl.;Sebastian von der Emde.;Alina Desheva.;Fritz Oberhollenzer.;Christina Tiller.;Magdalena Holzknecht.;Thomas Kremser.;Julian Faccini.;Can Gollmann-Tepeköylü.;Christian Kremser.;Agnes Mayr.;Axel Bauer.;Bernhard Metzler.;Sebastian J Reinstadler.
来源: Circ Cardiovasc Imaging. 2024年17卷12期e017041页
The presence and clinical significance of hepatic tissue alterations as assessed by cardiac magnetic resonance imaging in patients with ST-segment-elevation myocardial infarction (STEMI), are unclear. This study aimed to investigate associations of hepatic T1 patterns with myocardial tissue damage and clinical outcomes in patients suffering from STEMI.
1410. Comparison of Procedural Outcomes of Lumenless Fixed-Helix Versus Stylet-Driven Extendable-Helix Lead Systems in Left Bundle Branch Pacing: COMPARE LBBP.
作者: Jenish P Shroff.;Anugrah Nair.;Deep Chandh Raja.;Sreevilasam P Abhilash.;Simon Fiorese.;Jonathan P Ariyaratnam.;Walter P Abhayaratna.;Prashanthan Sanders.;Pugazhendhi Vijayaraman.;Rajeev K Pathak.
来源: Circ Arrhythm Electrophysiol. 2024年17卷12期e013385页
Left bundle branch pacing (LBBP) has emerged as a safe and effective alternative to right ventricular pacing. Traditionally, LBBP is performed with lumenless lead (LLL); however, the use of stylet-driven lead (SDL) is on rise. We aimed to assess acute success and procedural outcomes of SDL versus LLL for LBBP.
1411. His-Ventricular Interval and Incident Pacemaker Implant in Over 3000 Ambulatory Patients Undergoing Invasive Electrophysiologic Procedures.
作者: Daniel Pipilas.;Thomas Sommers.;Gregory F Michaud.;Patrick T Ellinor.;Shaan Khurshid.
来源: Circ Arrhythm Electrophysiol. 2024年17卷12期e013285页 1412. Neutrophil CRACR2A Promotes Neutrophil Recruitment in Sterile Inflammation and Ischemic Stroke.
作者: Jingu Lee.;Brett Balzraine.;Alexis Schweizer.;Vasilisa Kuzmanova.;Yousang Gwack.;Babak Razani.;Jin-Moo Lee.;Deane F Mosher.;Jaehyung Cho.
来源: Circulation. 2025年151卷10期696-715页
Ca2+ release-activated Ca2+ channel regulator 2A (CRACR2A) has been linked to immunodeficiency attributable to T-cell dysfunction in humans. We discovered that neutrophil CRACR2A promotes neutrophil adhesive and migratory functions by facilitating Ca2+ mobilization and β2 integrin activation.
1413. Antithrombotic Strategies When Using Epicardial Carbon Dioxide Insufflation During Percutaneous Epicardial Access.
作者: Corentin Chaumont.;Adrian M Petzl.;Alireza Oraii.;Kristine Conn.;Frederic Anselme.;Francis E Marchlinski.;Matthew C Hyman.
来源: Circ Arrhythm Electrophysiol. 2024年17卷12期e013310页 1414. Self-Administered Etripamil Nasal Spray Relieved Symptoms, Decreased Heart Rate, and Reduced Medical Interventions During Atrioventricular Nodal-Dependent Paroxysmal Supraventricular Tachycardia.
作者: Bruce S Stambler.;Benoit Coutu.;James E Ip.;Blandine Mondésert.;A Shekhar Pandey.;Philip T Sager.;Doug Wight.;Francis Plat.;Silvia Shardonofsky.;David B Bharucha.;A John Camm.
来源: Circ Arrhythm Electrophysiol. 2024年17卷12期e011681页 1415. Tumescent Local Anesthesia During Cardiac Implantable Electronic Device Implantation to Reduce Postoperative Pain.
作者: Balaram Krishna Hanumanthu.;Jason Wink.;Gustavo Guandalini.;Francis E Marchlinski.;David S Frankel.;Timothy M Markman.
来源: Circ Arrhythm Electrophysiol. 2024年17卷12期e013168页 1416. Abdominal Compared With Coronary Artery Calcification and Incident Cardiovascular Events and Mortality in Black Adults.
作者: Temidayo A Abe.;Fengxia Yan.;Titilope Olanipekun.;Michael Blaha.;Valery Effoe.;Ndausung Udongwo.;Robert J Mentz.;Adebamike Oshunbade.;James G Terry.;Jalal K Ghali.;Wondwosen K Yimer.;Chukwuemezie Kamanu.;Ifeoma Onuorah.;Michael Hall.;Anekwe Onwuanyi.;Adolfo Correa.;Melvin Echols.
来源: Circ Cardiovasc Imaging. 2024年17卷12期e016775页
Black adults show heightened cardiovascular risk compared with other groups despite comparable or lower coronary artery calcium (CAC) scores, indicating potential cardiovascular risk underestimation by CAC. Abdominal aortic calcification (AAC), preceding CAC, may predict cardiovascular events better in Black adults who are prone to early atherosclerotic cardiovascular disease and excess events at low CAC scores.
1418. Eclipsed Mitral Regurgitation as an Early Sign of Myocardial Ischemia Due to Coronary Vasospasm.
作者: Cristina Garcia-Sebastian.;Ana García-Martín.;Ángel Sánchez-Recalde.;Paloma Remior-Pérez.;Luisa Salido-Tahoces.;Sara Fernandez-Santos.;Covadonga Fernández-Golfin.;José Luis Zamorano.
来源: Circ Cardiovasc Imaging. 2025年18卷5期e017521页 1419. Declining Trend of Sudden Cardiac Death in Younger Individuals: A 20-Year Nationwide Study.
作者: Carl Johann Hansen.;Jesper Svane.;Peder Emil Warming.;Thomas Hadberg Lynge.;Rodrigue Garcia.;Carolina Malta Hansen.;Christian Torp-Pedersen.;Jytte Banner.;Bo Gregers Winkel.;Jacob Tfelt-Hansen.
来源: Circulation. 2025年151卷8期537-547页
Declining cardiovascular mortality rates have been well-documented, yet temporal trends of sudden cardiac death (SCD) in young individuals remain unclear. We provide contemporary nationwide estimates of the temporal trends of SCD in young individuals (1-35 years of age) from 2000 through 2019 and correlate these trends to changes in out-of-hospital cardiac arrest (OHCA) patterns, rates of inherited cardiac diseases, and implantations of implantable cardioverter defibrillators (ICD).
1420. Pulsed Field Ablation as First-Line Therapy for Atrial Fibrillation: A Substudy of the EU-PORIA Registry.
作者: Anna Füting.;Kars Neven.;Stefano Bordignon.;Tobias Reichlin.;Yuri Blaauw.;Jim Hansen.;Raquel Adelino.;Alexandre Ouss.;Laurent Roten.;Bart A Mulder.;Martin H Ruwald.;Roberto Mené.;Pepijn van der Voort.;Nico Reinsch.;Thomas Kueffer.;Serge Boveda.;Elizabeth M Albrecht.;Jonathan D Raybuck.;Brad Sutton.;Kyoung Ryul Julian Chun.;Boris Schmidt.
来源: Circ Arrhythm Electrophysiol. 2024年17卷12期e013088页
Recent studies have demonstrated the benefit of early ablation in preventing the progression of atrial fibrillation (AF). Clinical practice has reflected this shift in AF management and no longer requires patients to fail antiarrhythmic drugs (AADs) before receiving ablation. However, there is limited evidence on outcomes with pulsed field ablation (PFA) as a first-line therapy. Examination of real-world data may shed light on clinical practices and the effectiveness of PFA with and without a prior history of AAD usage.
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