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121. Effect of High-Intensity vs Low-Intensity Noninvasive Positive Pressure Ventilation on the Need for Endotracheal Intubation in Patients With an Acute Exacerbation of Chronic Obstructive Pulmonary Disease: The HAPPEN Randomized Clinical Trial.
作者: Zujin Luo.;Yichong Li.;Wenjun Li.;Ying Li.;Qingrong Nie.;Yu Shi.;Juan Wang.;Qiuling Ji.;Xuefeng Han.;Sijie Liu.;Dongmei Li.;ShaSha Wang.;Zhijun Li.;Dong Jia.;Huiqing Ge.;Peifeng Xu.;Zhijun Feng.;Fengjie Li.;Fucheng An.;Na Tai.;Lili Yue.;Hongwei Xie.;Xiuhong Jin.;Hongru Liu.;Qiang Dang.;Yongxiang Zhang.;Li Sun.;Jinxiang Wang.;He Huang.;Liang Chen.;Yingmin Ma.;Zhixin Cao.;Chen Wang.; .
来源: JAMA. 2024年332卷20期1709-1722页
The effect of high-intensity noninvasive positive pressure ventilation (NPPV) on the need for endotracheal intubation in patients with an acute exacerbation of chronic obstructive pulmonary disease (COPD) is unknown.
123. Tenecteplase vs Alteplase for Patients With Acute Ischemic Stroke: The ORIGINAL Randomized Clinical Trial.
作者: Xia Meng.;Shuya Li.;Hongguo Dai.;Guozhi Lu.;Weiwei Wang.;Fengyuan Che.;Yu Geng.;Minghui Sun.;Xiyan Li.;Hao Li.;Yongjun Wang.
来源: JAMA. 2024年332卷17期1437-1445页
Tenecteplase is a bioengineered variant of alteplase with greater fibrin specificity and a longer half-life, allowing single-bolus administration. Evidence on the treatment effect of tenecteplase 0.25 mg/kg in Chinese patients with acute ischemic stroke (AIS) is limited.
126. Telehealth vs In-Person Early Palliative Care for Patients With Advanced Lung Cancer: A Multisite Randomized Clinical Trial.
作者: Joseph A Greer.;Jennifer S Temel.;Areej El-Jawahri.;Simone Rinaldi.;Mihir Kamdar.;Elyse R Park.;Nora K Horick.;Kedie Pintro.;Dustin J Rabideau.;Lee Schwamm.;Josephine Feliciano.;Isaac Chua.;Konstantinos Leventakos.;Stacy M Fischer.;Toby C Campbell.;Michael W Rabow.;Finly Zachariah.;Laura C Hanson.;Sara F Martin.;Maria Silveira.;Laura Shoemaker.;Marie Bakitas.;Jessica Bauman.;Lori Spoozak.;Carl Grey.;Leslie Blackhall.;Kimberly Curseen.;Sean O'Mahony.;Melanie M Smith.;Ramona Rhodes.;Amelia Cullinan.;Vicki Jackson.; .
来源: JAMA. 2024年332卷14期1153-64页
Numerous studies show that early palliative care improves quality of life and other key outcomes in patients with advanced cancer and their caregivers, although most lack access to this evidence-based model of care.
129. Combined Whole Eye and Face Transplant: Microsurgical Strategy and 1-Year Clinical Course.
作者: Daniel J Ceradini.;David L Tran.;Vaidehi S Dedania.;Bruce E Gelb.;Oriana D Cohen.;Roberto L Flores.;Jamie P Levine.;Pierre B Saadeh.;David A Staffenberg.;Zakia Ben Youss.;Patryk Filipiak.;Steven H Baete.;Eduardo D Rodriguez.
来源: JAMA. 2024年332卷18期1551-1558页
Catastrophic facial injury with globe loss remains a formidable clinical problem with no previous reports of reconstruction by whole eye or combined whole eye and facial transplant.
130. Balloon Angioplasty vs Medical Management for Intracranial Artery Stenosis: The BASIS Randomized Clinical Trial.
作者: Xuan Sun.;Yiming Deng.;Yong Zhang.;Ming Yang.;Dapeng Sun.;Thanh N Nguyen.;Xu Tong.;Guangge Peng.;Aihua Liu.;Yun Xu.;Yunhu Wu.;Xiaokun Geng.;Yang Wang.;Tianxiao Li.;Shihui Xing.;Wei Wu.;Yunxiang Ji.;Hua Yang.;Shouchun Wang.;Xiaoping Gao.;Weimin Yang.;Xingquan Zhao.;Liping Liu.;Ning Ma.;Feng Gao.;Dapeng Mo.;Xiaochuan Huo.;Ligang Song.;Xiaoqing Li.;Jingbo Zhang.;Hongwei He.;Ming Lv.;Shiqing Mu.;Wengui Yu.;David S Liebeskind.;Sepideh Amin-Hanjani.;Yongjun Wang.;Yilong Wang.;Zhongrong Miao.; .
来源: JAMA. 2024年332卷13期1059-1069页
Previous randomized clinical trials did not demonstrate the superiority of endovascular stenting over aggressive medical management for patients with symptomatic intracranial atherosclerotic stenosis (sICAS). However, balloon angioplasty has not been investigated in a randomized clinical trial.
133. Pulmonary Vein Isolation vs Sham Intervention in Symptomatic Atrial Fibrillation: The SHAM-PVI Randomized Clinical Trial.
作者: Rajdip Dulai.;Neil Sulke.;Nick Freemantle.;Pier D Lambiase.;David Farwell.;Neil T Srinivasan.;Stuart Tan.;Nikhil Patel.;Adam Graham.;Rick A Veasey.
来源: JAMA. 2024年332卷14期1165-73页
There are concerns that pulmonary vein isolation for atrial fibrillation may have a profound placebo effect, but no double-blind randomized clinical trials have been conducted.
134. Potassium Supplementation and Prevention of Atrial Fibrillation After Cardiac Surgery: The TIGHT K Randomized Clinical Trial.
作者: Benjamin O'Brien.;Niall G Campbell.;Elizabeth Allen.;Zahra Jamal.;Joanna Sturgess.;Julie Sanders.;Charles Opondo.;Neil Roberts.;Jonathan Aron.;Maria Rita Maccaroni.;Richard Gould.;Bilal H Kirmani.;Ben Gibbison.;Gudrun Kunst.;Alexander Zarbock.;Maren Kleine-Brüggeney.;Christian Stoppe.;Keith Pearce.;Mark Hughes.;Laura Van Dyck.;Richard Evans.;Hugh E Montgomery.;Diana Elbourne.; .
来源: JAMA. 2024年332卷12期979-988页
Supplementing potassium in an effort to maintain high-normal serum concentrations is a widespread strategy used to prevent atrial fibrillation after cardiac surgery (AFACS), but is not evidence-based, carries risks, and is costly.
136. Low-Dose Triple-Pill vs Standard-Care Protocols for Hypertension Treatment in Nigeria: A Randomized Clinical Trial.
作者: Dike B Ojji.;Abdul Salam.;Mahmoud U Sani.;Okechukwu S Ogah.;Aletta E Schutte.;Mark D Huffman.;Rashmi Pant.;Arpita Ghosh.;Rupasvi Dhurjati.;Josyula K Lakshmi.;Nanna R Ripiye.;Ikechukwu A Orji.;Shehu A Kana.;Tijjani Abdussalam.;Abdulgafar L Olawumi.;Isiaka M Alfa.;Olanike Allison Orimolade.;Moses O Ajayi.;Anthony Rodgers.
来源: JAMA. 2024年332卷13期1070-1079页
With the high burden of hypertension in sub-Saharan Africa, there is a need for effective, safe and scalable treatment strategies.
137. Continuation vs Discontinuation of Renin-Angiotensin System Inhibitors Before Major Noncardiac Surgery: The Stop-or-Not Randomized Clinical Trial.
作者: Matthieu Legrand.;Jérémy Falcone.;Bernard Cholley.;Hélène Charbonneau.;Amélie Delaporte.;Adrien Lemoine.;Matthias Garot.;Alexandre Joosten.;Claude Meistelman.;Delphine Cheron-Leroy.;Jean-Philippe Rives.;Bruno Pastene.;Antoine Dewitte.;Stéphanie Sigaut.;Marc Danguy des Deserts.;Cyrille Truc.;Matthieu Boisson.;Sigismond Lasocki.;Philippe Cuvillon.;Ugo Schiff.;Samir Jaber.;Morgan Le Guen.;Anaïs Caillard.;Stéphane Bar.;Edmundo Pereira de Souza Neto.;Vincent Colas.;Florin Dimache.;Thibaut Girardot.;Elsa Jozefowicz.;Simon Viquesnel.;Francis Berthier.;Eric Vicaut.;Etienne Gayat.; .
来源: JAMA. 2024年332卷12期970-978页
Before surgery, the best strategy for managing patients who are taking renin-angiotensin system inhibitors (RASIs) (angiotensin-converting enzyme inhibitors or angiotensin receptor blockers) is unknown. The lack of evidence leads to conflicting guidelines.
138. Characterizing Long COVID in Children and Adolescents.
作者: Rachel S Gross.;Tanayott Thaweethai.;Lawrence C Kleinman.;Jessica N Snowden.;Erika B Rosenzweig.;Joshua D Milner.;Kelan G Tantisira.;Kyung E Rhee.;Terry L Jernigan.;Patricia A Kinser.;Amy L Salisbury.;David Warburton.;Sindhu Mohandas.;John C Wood.;Jane W Newburger.;Dongngan T Truong.;Valerie J Flaherman.;Torri D Metz.;Elizabeth W Karlson.;Lori B Chibnik.;Deepti B Pant.;Aparna Krishnamoorthy.;Richard Gallagher.;Michelle F Lamendola-Essel.;Denise C Hasson.;Stuart D Katz.;Shonna Yin.;Benard P Dreyer.;Megan Carmilani.;K Coombs.;Megan L Fitzgerald.;Nick Güthe.;Mady Hornig.;Rebecca J Letts.;Aimee K Peddie.;Brittany D Taylor.;Venkataraman Balaraman.;Amanda Bogie.;Hulya Bukulmez.;Allen J Dozor.;Daniel Eckrich.;Amy J Elliott.;Danielle N Evans.;Jonathan S Farkas.;E Vincent S Faustino.;Laura Fischer.;Sunanda Gaur.;Ashraf S Harahsheh.;Uzma N Hasan.;Daniel S Hsia.;Gredia Huerta-Montañez.;Kathy D Hummel.;Matt P Kadish.;David C Kaelber.;Sankaran Krishnan.;Jessica S Kosut.;Jerry Larrabee.;Peter Paul C Lim.;Ian C Michelow.;Carlos R Oliveira.;Hengameh Raissy.;Zaira Rosario-Pabon.;Judith L Ross.;Alice I Sato.;Michelle D Stevenson.;Maria M Talavera-Barber.;Ronald J Teufel.;Kathryn E Weakley.;Emily Zimmerman.;Marie-Abele C Bind.;James Chan.;Zoe Guan.;Richard E Morse.;Harrison T Reeder.;Natascha Akshoomoff.;Judy L Aschner.;Rakesh Bhattacharjee.;Lesley A Cottrell.;Kelly Cowan.;Viren A D'Sa.;Alexander G Fiks.;Maria L Gennaro.;Katherine Irby.;Manaswitha Khare.;Jeremy Landeo Guttierrez.;Russell J McCulloh.;Shalu Narang.;Manette Ness-Cochinwala.;Sheila Nolan.;Paul Palumbo.;Julie Ryu.;Juan C Salazar.;Rangaraj Selvarangan.;Cheryl R Stein.;Alan Werzberger.;William T Zempsky.;Robin Aupperle.;Fiona C Baker.;Marie T Banich.;Deanna M Barch.;Arielle Baskin-Sommers.;James M Bjork.;Susan Y Bookheimer.;Sandra A Brown.;B J Casey.;Linda Chang.;Duncan B Clark.;Anders M Dale.;Mirella Dapretto.;Thomas M Ernst.;Damien A Fair.;Sarah W Feldstein Ewing.;John J Foxe.;Edward G Freedman.;Naomi P Friedman.;Hugh Garavan.;Dylan G Gee.;Raul Gonzalez.;Kevin M Gray.;Mary M Heitzeg.;Megan M Herting.;Joanna Jacobus.;Angela R Laird.;Christine L Larson.;Krista M Lisdahl.;Monica Luciana.;Beatriz Luna.;Pamela A F Madden.;Erin C McGlade.;Eva M Müller-Oehring.;Bonnie J Nagel.;Michael C Neale.;Martin P Paulus.;Alexandra S Potter.;Perry F Renshaw.;Elizabeth R Sowell.;Lindsay M Squeglia.;Susan Tapert.;Lucina Q Uddin.;Sylia Wilson.;Deborah A Yurgelun-Todd.;Andrea S Foulkes.;Melissa S Stockwell.; .; .
来源: JAMA. 2024年332卷14期1174-88页
Most research to understand postacute sequelae of SARS-CoV-2 infection (PASC), or long COVID, has focused on adults, with less known about this complex condition in children. Research is needed to characterize pediatric PASC to enable studies of underlying mechanisms that will guide future treatment.
140. Renal Cell Carcinoma: A Review.
Renal cell carcinoma (RCC) is a common malignancy, with an estimated 434 840 incident cases worldwide in 2022. In the US, it is the sixth most common cancer among males and ninth among females.
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