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123. Add-On Treatment With Zilebesiran for Inadequately Controlled Hypertension: The KARDIA-2 Randomized Clinical Trial.
作者: Akshay S Desai.;Adam D Karns.;Jolita Badariene.;Ahmad Aswad.;Joel M Neutel.;Farhana Kazi.;Wansu Park.;Daniel Stiglitz.;Nune Makarova.;Andrea Havasi.;Dion H Zappe.;Manish Saxena.; .
来源: JAMA. 2025年334卷1期46-55页
In prior monotherapy studies of patients with hypertension, single subcutaneous doses of zilebesiran, an investigational RNA interference therapeutic, reduced serum angiotensinogen levels and systolic blood pressure (SBP) at 3 and 6 months.
124. Long-Term Follow-Up of Extracranial-Intracranial Bypass Surgery for Symptomatic Cerebral Artery Occlusion.
作者: Yan Ma.;Tao Wang.;Wei Ni.;Haibo Wang.;Delin Liu.;Xinyi Sun.;Xiaoguang Tong.;Liyong Zhang.;Zhiyong Tong.;Yufeng Wang.;Yiling Cai.;Jun Ren.;Donghai Wang.;Lian Duan.;Aisha Maimaitili.;Chunhua Hang.;Jiasheng Yu.;Feng Ling.;Yangfeng Wu.;Colin P Derdeyn.;Yuxiang Gu.;Guoguang Zhao.;Liqun Jiao.; .
来源: JAMA. 2025年334卷4期358-360页 126. Dexmedetomidine- or Clonidine-Based Sedation Compared With Propofol in Critically Ill Patients: The A2B Randomized Clinical Trial.
作者: Timothy S Walsh.;Richard A Parker.;Leanne M Aitken.;Cathrine A McKenzie.;Lydia Emerson.;Julia Boyd.;Alix Macdonald.;Gayle Beveridge.;Annabel Giddings.;David Hope.;Sîan Irvine.;Sharon Tuck.;Nazir I Lone.;Kalliopi Kydonaki.;John Norrie.;David Brealey.;David Antcliffe.;Michael Reay.;Alan Williams.;Jeremy Bewley.;Benedict Creagh-Brown.;Daniel F McAuley.;Paul Dark.;Matt P Wise.;Anthony C Gordon.;Gavin D Perkins.;Michael C Reade.;Bronagh Blackwood.;Alasdair MacLullich.;Robert Glen.;Valerie J Page.;Christopher J Weir.; .
来源: JAMA. 2025年334卷1期32-45页
Whether α2-adrenergic receptor agonist-based sedation, compared with propofol-based sedation, reduces time to extubation in patients receiving mechanical ventilation in the intensive care unit (ICU) is uncertain.
127. A Multidimensional Diagnostic Approach for Chronic Obstructive Pulmonary Disease.
作者: .;Surya P Bhatt.;Ehsan Abadi.;Antonio Anzueto.;Sandeep Bodduluri.;Richard Casaburi.;Peter J Castaldi.;Michael H Cho.;Alejandro P Comellas.;Douglas J Conrad.;Jeffrey L Curtis.;Chandra Dass.;Dawn L DeMeo.;Mark T Dransfield.;Raul San José Estépar.;Eric L Flenaugh.;Marilyn G Foreman.;Spyridon Fortis.;Arnav Gupta.;MeiLan K Han.;Nicola A Hanania.;Craig P Hersh.;John E Hokanson.;Stephen M Humphries.;Miranda Kirby.;Ken M Kunisaki.;Pei Zhi Li.;David A Lynch.;Neil R MacIntyre.;Barry J Make.;David M Mannino.;Fernando J Martinez.;Charlene E McEvoy.;Bruce E Miller.;Matthew Moll.;Arie Nakhmani.;John D Newell.;Katherine A Pratte.;Elizabeth A Regan.;Joseph M Reinhardt.;Stephen I Rennard.;Harry B Rossiter.;Matthew J Strand.;Rajat Suri.;Emily S Wan.;Christine H Wendt.;Gloria E Westney.;Carla G Wilson.;Robert A Wise.;Kendra A Young.;Wan C Tan.;Edwin K Silverman.;James D Crapo.
来源: JAMA. 2025年333卷24期2164-2175页
Individuals at risk for chronic obstructive pulmonary disease (COPD) but without spirometric airflow obstruction can have respiratory symptoms and structural lung disease on chest computed tomography. Current guidelines recommend COPD diagnostic schemas that do not incorporate imaging abnormalities.
132. Spironolactone vs Amiloride for Resistant Hypertension: A Randomized Clinical Trial.
作者: Chan Joo Lee.;Sang-Hyun Ihm.;Dong-Ho Shin.;Jin-Ok Jeong.;Ju Han Kim.;Kyeong-Hyeon Chun.;JiWung Ryu.;Hae-Young Lee.;Seonghoon Choi.;Eun Mi Lee.;Jung Hyun Choi.;Kwang-Il Kim.;Jinho Shin.;Wook Bum Pyun.;Dae-Hee Kim.;Sungha Park.;Bryan Williams.
来源: JAMA. 2025年333卷23期2073-2082页
Amiloride has been proposed as an alternative to spironolactone for treating resistant hypertension. However, no randomized clinical trials have compared the efficacy of spironolactone and amiloride in patients with resistant hypertension.
133. Screening for Syphilis Infection During Pregnancy: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force.
作者: Gary N Asher.;Meera Viswanathan.;Afua Takyi.;Jennifer Cook Middleton.;Claire Baker.;Leila C Kahwati.
来源: JAMA. 2025年333卷22期2015-2017页 136. Antihypertensive Medication Timing and Cardiovascular Events and Death: The BedMed Randomized Clinical Trial.
作者: Scott R Garrison.;Jeffrey A Bakal.;Michael R Kolber.;Christina S Korownyk.;Lee A Green.;Jessica E M Kirkwood.;Finlay A McAlister.;Raj S Padwal.;Richard Lewanczuk.;Michael D Hill.;Alexander G Singer.;Alan Katz.;Michael D Kelmer.;Armine Gayayan.;Farah N Campbell.;Ana Vucenovic.;Nathan R Archibald.;Jack M S Yeung.;Erik R E Youngson.;Kimberlyn McGrail.;Braden G O'Neill.;Michelle Greiver.;Donna P Manca.;Roni Y Kraut.;Ting Wang.;Braden J Manns.;Dee A Mangin.;Cathy MacLean.;James McCormack.;Sabrina T Wong.;Colleen Norris.;G Michael Allan.
来源: JAMA. 2025年333卷23期2061-2072页
Whether administration of blood pressure medications at bedtime instead of in the morning reduces cardiovascular risk is unknown, as findings from large clinical trials have not been consistent. There is also concern that bedtime antihypertensive use could induce glaucoma-related visual loss or other hypotensive/ischemic adverse effects.
139. Immunogenicity and Safety of Influenza and COVID-19 Multicomponent Vaccine in Adults ≥50 Years: A Randomized Clinical Trial.
作者: Amanda K Rudman Spergel.;Iris Wu.;Weiping Deng.;Jose Cardona.;Kimball Johnson.;Ivette Espinosa-Fernandez.;Melissa Sinkiewicz.;Veronica Urdaneta.;Lizbeth Carmona.;Kristin Schaefers.;Bethany Girard.;Yamuna D Paila.;Darshan Mehta.;Benoit Callendret.;Lusine Kostanyan.;Jintanat Ananworanich.;Jacqueline Miller.;Rituparna Das.;Christine A Shaw.
来源: JAMA. 2025年333卷22期1977-1987页
Uptake of recommended seasonal influenza and COVID-19 vaccines remains suboptimal.
140. Association of Stratified Benchmarks With Financial Penalties in the ESRD Treatment Choices Model.
作者: Sri Lekha Tummalapalli.;Yuvaram N V Reddy.;Yueming Zhao.;Nuo Chen.;Seojeong Hong.;Yuntian Shi.;Zhimeng Yan.;Amol S Navathe.
来源: JAMA. 2025年334卷1期85-87页 |