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122. Optimal Vasopressin Initiation in Septic Shock: The OVISS Reinforcement Learning Study.
作者: Alexandre Kalimouttou.;Jason N Kennedy.;Jean Feng.;Harvineet Singh.;Suchi Saria.;Derek C Angus.;Christopher W Seymour.;Romain Pirracchio.
来源: JAMA. 2025年333卷19期1688-98页
Norepinephrine is the first-line vasopressor for patients with septic shock. When and whether a second agent, such as vasopressin, should be added is unknown.
123. Inhaled Sedation in Acute Respiratory Distress Syndrome: The SESAR Randomized Clinical Trial.
作者: Matthieu Jabaudon.;Jean-Pierre Quenot.;Julio Badie.;Jules Audard.;Samir Jaber.;Benjamin Rieu.;Caroline Varillon.;Antoine Monsel.;François Thouy.;Julien Lorber.;Joël Cousson.;Stéphanie Bulyez.;Jérémy Bourenne.;Ghada Sboui.;Claire Lhommet.;Virginie Lemiale.;Belaïd Bouhemad.;Clément Brault.;Sigismond Lasocki.;François Legay.;Thomas Lebouvier.;Arthur Durand.;Julien Pottecher.;Alexandre Conia.;Delphine Brégeaud.;Lionel Velly.;Arnaud W Thille.;Fabien Lambiotte.;Erwan L'Her.;Mehran Monchi.;Antoine Roquilly.;Aziz Berrouba.;Franck Verdonk.;Russell Chabanne.;Thomas Godet.;Marc Garnier.;Raiko Blondonnet.;Jérémy Vernhes.;Vincent Sapin.;Lucile Borao.;Emmanuel Futier.;Bruno Pereira.;Jean-Michel Constantin.; .
来源: JAMA. 2025年333卷18期1608-1617页
Whether the use of inhaled or intravenous sedation affects outcomes differentially in mechanically ventilated adults with acute respiratory distress syndrome (ARDS) is unknown.
126. Chronic Myeloid Leukemia: A Review.
Chronic myeloid leukemia (CML) has an annual incidence of 2 cases per 100 000 people and is newly diagnosed in approximately 9300 individuals per year in the US. Approximately 150 000 people in the US and 5 million worldwide have CML.
134. Atezolizumab in High-Risk Locally Advanced Squamous Cell Carcinoma of the Head and Neck: A Randomized Clinical Trial.
作者: Robert Haddad.;Jérôme Fayette.;Maria Teixeira.;Kumar Prabhash.;Ricard Mesia.;Andrzej Kawecki.;Arunee Dechaphunkul.;José Dinis.;Ye Guo.;Muneyuki Masuda.;Ching-Yun Hsieh.;Maria Grazia Ghi.;Claudia Vaz de Melo Sette.;Kevin Harrington.;Makoto Tahara.;Nabil F Saba.;Agnes Lau.;Tao Jiang.;Yibing Yan.;Marcus Ballinger.;Monika Kaul.;Christina Matheny.;Vaikunth Cuchelkar.;Deborah J Wong.
来源: JAMA. 2025年333卷18期1599-1607页
Treating locally advanced squamous cell carcinoma of the head and neck (LA SCCHN) involves any combination of surgery, radiation, and chemotherapy, followed by routine monitoring for local recurrence or distant metastases. Given the poor patient outcomes, a significant unmet clinical need for improved treatment options remains.
136. Adjuvant PD-1 Blockade With Camrelizumab for Nasopharyngeal Carcinoma: The DIPPER Randomized Clinical Trial.
作者: Ye-Lin Liang.;Xu Liu.;Liang-Fang Shen.;Guang-Yuan Hu.;Guo-Rong Zou.;Ning Zhang.;Chuan-Ben Chen.;Xiao-Zhong Chen.;Xiao-Dong Zhu.;Ya-Wei Yuan.;Kun-Yu Yang.;Feng Jin.;Wei-Han Hu.;Fang-Yun Xie.;Ying Huang.;Fei Han.;Ling-Long Tang.;Yan-Ping Mao.;Li-Xia Lu.;Rui Sun.;Yu-Xiang He.;Yang-Ying Zhou.;Guo-Xian Long.;Jie Tang.;Lu-Si Chen.;Jing-Feng Zong.;Ting Jin.;Ling Li.;Jie Lin.;Jing Huang.;Xiu-Yun Gong.;Guan-Qun Zhou.;Lei Chen.;Wen-Fei Li.;Yu-Pei Chen.;Cheng Xu.;Li Lin.;Shao-Hui Huang.;Sai-Wei Huang.;Ya-Qin Wang.;Cheng-Long Huang.;Hui-Xia Feng.;Min Hou.;Chun-Hua Chen.;Su-Fen Zheng.;Ying-Qing Li.;Shu-Bin Hong.;Yu-Sheng Jie.;Hao Li.;Jing-Ping Yun.;Sheng-Bing Zang.;Song-Ran Liu.;Qing-Guang Lin.;Hao-Jiang Li.;Li Tian.;Li-Zhi Liu.;Hong-Yun Zhao.;Ji-Bin Li.;Ai-Hua Lin.;Na Liu.;Yuan Zhang.;Rui Guo.;Jun Ma.;Ying Sun.
来源: JAMA. 2025年333卷18期1589-1598页
Approximately 20% to 30% of patients with locoregionally advanced nasopharyngeal carcinoma (NPC) experience disease relapse despite definitive chemoradiotherapy. The programmed cell death 1 (PD-1) blockade camrelizumab has demonstrated considerable value in recurrent or metastatic NPC, while its role in locoregionally advanced NPC is unclear.
140. CNM-Au8 in Amyotrophic Lateral Sclerosis: The HEALEY ALS Platform Trial.
作者: .;James D Berry.;Nicholas J Maragakis.;Eric A Macklin.;Lori B Chibnik.;Melanie Quintana.;Benjamin R Saville.;Michelle A Detry.;Matteo Vestrucci.;Joseph Marion.;Anna McGlothlin.;Elijah W Stommel.;Marianne Chase.;Lindsay Pothier.;Brittney A Harkey.;Hong Yu.;Alex Sherman.;Jeremy Shefner.;Meghan Hall.;Gale Kittle.;Suma Babu.;Jinsy Andrews.;Derek D'Agostino.;Eric Tustison.;Erica Scirocco.;Elisa Giacomelli.;Gustavo Alameda.;Eduardo Locatelli.;Doreen Ho.;Adam Quick.;Senda Ajroud-Driss.;Jonathan Katz.;Daragh Heitzman.;Stanley H Appel.;Sheetal Shroff.;Kevin J Felice.;Zachary Simmons.;Timothy Miller.;Nicholas Olney.;Michael D Weiss.;Stephen A Goutman.;Joseph Americo Fernandes.;Omar Jawdat.;Margaret Ayo Owegi.;Laura Foster.;Tuan Vu.;Hristelina Ilieva.;Daniel S Newman.;Ximena Arcila-Londono.;Carlayne Jackson.;Shafeeq Ladha.;Terry Heiman-Patterson.;James Caress.;Andrea Swenson.;Amanda Peltier.;Richard Lewis.;Dominic Fee.;Matthew Elliott.;Richard Bedlack.;Edward J Kasarskis.;Lauren Elman.;Jeffrey Rosenfeld.;David Walk.;Courtney E McIlduff.;Paul Twydell.;Eufrosina Young.;Kristin Johnson.;Kourosh Rezania.;Namita A Goyal.;Jeffrey A Cohen.;Michael Benatar.;Vovanti Jones.;Jonathan Glass.;Jaimin Shah.;Said R Beydoun.;James P Wymer.;Lindsay Zilliox.;Shakti Nayar.;Gary L Pattee.;Jennifer Martinez-Thompson.;Austin Rynders.;Jacob Evan.;Jeremy Evan.;Alan Hartford.;Marjan Sepassi.;Karen S Ho.;Robert Glanzman.;Benjamin Greenberg.;Michael T Hotchkin.;Sabrina Paganoni.;Merit E Cudkowicz.; .
来源: JAMA. 2025年333卷13期1138-49页
Bioenergetic failure has been proposed as a driver of amyotrophic lateral sclerosis (ALS). CNM-Au8 is a suspension of gold nanocrystals that catalyzes the conversion of nicotinamide adenine dinucleotide hydride into NAD+, resulting in an increase of cellular adenosine triphosphate production.
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