Metabolic dysfunction-associated steatotic liver disease (MASLD) affects a quarter of the population. Although multiple studies have investigated the mechanisms underlying steatohepatitis and MASLD progression, little attention has been paid to milder cases, particularly those with normal enzyme levels. Our objective was to evaluate the molecular events in patients with MASLD and normal enzyme levels.

The worldwide increase in acute diverticulitis (AD) prevalence and the resulting growing economic burden on the healthcare system have driven the scientific community towards standardizing a methodological approach to obtain a prompt diagnosis, optimized treatment, and thus containing costs. By the analysis of currently available evidence, this review could provide effective strategies for efficient AD clinical management and highlights possible innovative therapeutic strategies.

Crohn's disease (CD) is a chronic inflammatory disorder of the gastrointestinal tract, characterized by heterogeneous manifestations with significant morbidities. Diagnosing and managing CD remains challenging due to its variable clinical presentation, complexities in assessing disease extent and activity, and lack of a definitive diagnostic marker. Over the last years, there has been a switch towards a treat-to-target approach in the management of inflammatory bowel disease (IBD). Capsule endoscopy (CE) has emerged as a non-invasive, complementary tool for CD diagnosis and monitoring. CE is patient friendly being wireless and enables direct visualization of the entire small bowel in one sitting. CE plays a role in the diagnostic workup of suspected CD and in cases of in IBD unclassified (IBDU). In established CD, CE plays a role in monitoring mucosal healing, a key therapeutic target linked to improved long-term outcomes. CE findings significantly influence treatment strategies, leading to therapy escalation, adjustment, or avoidance of unnecessary surgical interventions. Moreover, CE disease activity assessment by means of the Lewis score is able to predict disease flares, thus having also a prognostic role. In conclusion, the non-invasive nature of CE, combined with its diagnostic, prognostic, and therapeutic implications, establishes it as an essential tool in the comprehensive management of CD across all disease stages. This review provides a comprehensive update on CE's evolving role in optimizing care of patients with CD.

The gallstone disease is gradually becoming a burden of healthcare systems throughout world. The frequency of gallstone disease in Ethiopia has been the subject of few investigations and to the best of our knowledge, limited evidence of published research has examined the risk factors linked with gallstone disease. The main objective of the current study was to assess the prevalence of gallstone disease and associated factors among patients who visited the surgical department of Debre Birhan Comprehensive Specialization Hospital.

To identify the clinical and molecular factors that effectively predict pathological complete response (pCR) and assess the safety of patients receiving neoadjuvant combination immunotherapy.

Early identification of strangulation in adhesive small bowel obstruction (SBO) is crucial for emergency triage and immediate surgical intervention. This study aimed to explore the predictive value of the immature granulocyte (IG) count in assessing strangulation in adhesive SBO.

Pancreatic cancer (PC) is characterized by an extremely poor prognosis and a high mortality rate, posing a significant burden on society.