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121. Iron Chelation in Transfusion-Dependent Patients With Low- to Intermediate-1-Risk Myelodysplastic Syndromes: A Randomized Trial.
作者: Emanuele Angelucci.;Junmin Li.;Peter Greenberg.;Depei Wu.;Ming Hou.;Efreen Horacio Montano Figueroa.;Maria Guadalupe Rodriguez.;Xunwei Dong.;Jagannath Ghosh.;Miguel Izquierdo.;Guillermo Garcia-Manero.; .
来源: Ann Intern Med. 2020年172卷8期513-522页
Iron chelation therapy (ICT) in patients with lower-risk myelodysplastic syndromes (MDS) has not been evaluated in randomized studies.
122. Effects of Interleukin-1β Inhibition on Incident Anemia: Exploratory Analyses From a Randomized Trial.
作者: Mounica Vallurupalli.;Jean G MacFadyen.;Robert J Glynn.;Tom Thuren.;Peter Libby.;Nancy Berliner.;Paul M Ridker.
来源: Ann Intern Med. 2020年172卷8期523-532页
Inflammatory cytokines, such as interleukin (IL)-1β, alter iron homeostasis and erythropoiesis, resulting in anemia, but whether inhibition of IL-1β can reverse these effects is unclear.
123. Immunogenicity, Safety, and Efficacy of a Standalone Universal Influenza Vaccine, FLU-v, in Healthy Adults: A Randomized Clinical Trial.
作者: Olga Pleguezuelos.;Joep Dille.;Sofie de Groen.;Fredrik Oftung.;Hubert G M Niesters.;Md Atiqul Islam.;Lisbeth Meyer Næss.;Olav Hungnes.;Nuhoda Aldarij.;Demi L Idema.;Ana Fernandez Perez.;Emma James.;Henderik W Frijlink.;Gregory Stoloff.;Paul Groeneveld.;Eelko Hak.
来源: Ann Intern Med. 2020年172卷7期453-462页
FLU-v is a broad-spectrum influenza vaccine that induces antibodies and cell-mediated immunity.
124. Adverse Effects of Low-Dose Methotrexate: A Randomized Trial.
作者: Daniel H Solomon.;Robert J Glynn.;Elizabeth W Karlson.;Fengxin Lu.;Cassandra Corrigan.;Josh Colls.;Chang Xu.;Jean MacFadyen.;Medha Barbhaiya.;Nancy Berliner.;Paul F Dellaripa.;Brendan M Everett.;Aruna D Pradhan.;Sarah P Hammond.;Meredith Murray.;Deepak A Rao.;Susan Y Ritter.;Anna Rutherford.;Jeffrey A Sparks.;Jackie Stratton.;Dong H Suh.;Sara K Tedeschi.;Kathleen M M Vanni.;Nina P Paynter.;Paul M Ridker.
来源: Ann Intern Med. 2020年172卷6期369-380页
Low-dose methotrexate (LD-MTX) is the most commonly used drug for systemic rheumatic diseases worldwide and is the recommended first-line agent for rheumatoid arthritis. Despite extensive clinical use for more than 30 years, few data on adverse event (AE) rates derive from randomized, placebo-controlled trials, where both causality and magnitude of risk can be inferred.
125. Poxvirus Vectored Cytomegalovirus Vaccine to Prevent Cytomegalovirus Viremia in Transplant Recipients: A Phase 2, Randomized Clinical Trial.
作者: Ibrahim Aldoss.;Corinna La Rosa.;Lindsey R Baden.;Jeffrey Longmate.;Ella J Ariza-Heredia.;Wasima N Rida.;Chetan Raj Lingaraju.;Qiao Zhou.;Joy Martinez.;Teodora Kaltcheva.;Andy Dagis.;Nicola Hardwick.;Nicolas C Issa.;Len Farol.;Auayporn Nademanee.;Monzr M Al Malki.;Stephen Forman.;Ryotaro Nakamura.;Don J Diamond.; .
来源: Ann Intern Med. 2020年172卷5期306-316页
Triplex vaccine was developed to enhance cytomegalovirus (CMV)-specific T cells and prevent CMV reactivation early after hematopoietic stem cell transplant (HCT).
126. Addition of Maraviroc Versus Placebo to Standard Antiretroviral Therapy for Initial Treatment of Advanced HIV Infection: A Randomized Trial.
作者: Yves Lévy.;Jean-Daniel Lelièvre.;Lambert Assoumou.;Esther Aznar.;Federico Pulido.;Giuseppe Tambussi.;Manuel Crespo.;Agnès Meybeck.;Jean-Michel Molina.;Constance Delaugerre.;Jacques Izopet.;Gilles Peytavin.;Fanny Cardon.;Alpha Diallo.;Rémi Lancar.;Lydie Béniguel.;Dominique Costagliola.
来源: Ann Intern Med. 2020年172卷5期297-305页
Patients diagnosed with advanced HIV infection have a poor prognosis despite initiation of combined antiretroviral therapy (c-ART).
127. Disease-Modifying Effects of a Novel Cathepsin K Inhibitor in Osteoarthritis: A Randomized Controlled Trial.
作者: Philip G Conaghan.;Michael A Bowes.;Sarah R Kingsbury.;Alan Brett.;Gwenael Guillard.;Biljana Rizoska.;Niclas Sjögren.;Philippa Graham.;Åsa Jansson.;Cecilia Wadell.;Richard Bethell.;John Öhd.
来源: Ann Intern Med. 2020年172卷2期86-95页
MIV-711 is a novel selective cathepsin K inhibitor with beneficial effects on bone and cartilage in preclinical osteoarthritis models.
128. Hospital-Level Care at Home for Acutely Ill Adults: A Randomized Controlled Trial.
作者: David M Levine.;Kei Ouchi.;Bonnie Blanchfield.;Agustina Saenz.;Kimberly Burke.;Mary Paz.;Keren Diamond.;Charles T Pu.;Jeffrey L Schnipper.
来源: Ann Intern Med. 2020年172卷2期77-85页
Substitutive hospital-level care in a patient's home may reduce cost, health care use, and readmissions while improving patient experience, although evidence from randomized controlled trials in the United States is lacking.
129. Effect of Electronic Health Record-Based Coaching on Weight Maintenance: A Randomized Trial.
作者: Molly B Conroy.;Kathleen M McTigue.;Cindy L Bryce.;Dana Tudorascu.;Bethany Barone Gibbs.;Jonathan Arnold.;Diane Comer.;Rachel Hess.;Kimberly Huber.;Laurey R Simkin-Silverman.;Gary S Fischer.
来源: Ann Intern Med. 2019年171卷11期777-784页
Weight regain after intentional loss is common. Most evidence-based weight management programs focus on short-term loss rather than long-term maintenance.
130. Rivaroxaban Versus Vitamin K Antagonist in Antiphospholipid Syndrome: A Randomized Noninferiority Trial.
作者: Josep Ordi-Ros.;Luis Sáez-Comet.;Mercedes Pérez-Conesa.;Xavier Vidal.;Antoni Riera-Mestre.;Antoni Castro-Salomó.;Jordi Cuquet-Pedragosa.;Vera Ortiz-Santamaria.;Montserrat Mauri-Plana.;Cristina Solé.;Josefina Cortés-Hernández.
来源: Ann Intern Med. 2019年171卷10期685-694页
The potential role of new oral anticoagulants in antiphospholipid antibody syndrome (APS) remains uncertain.
131. Menopausal Estrogen-Alone Therapy and Health Outcomes in Women With and Without Bilateral Oophorectomy: A Randomized Trial.
作者: JoAnn E Manson.;Aaron K Aragaki.;Shari S Bassuk.;Rowan T Chlebowski.;Garnet L Anderson.;Jacques E Rossouw.;Barbara V Howard.;Cynthia A Thomson.;Marcia L Stefanick.;Andrew M Kaunitz.;Carolyn J Crandall.;Charles B Eaton.;Victor W Henderson.;Simin Liu.;Juhua Luo.;Thomas Rohan.;Aladdin H Shadyab.;Gretchen Wells.;Jean Wactawski-Wende.;Ross L Prentice.; .
来源: Ann Intern Med. 2019年171卷6期406-414页
Whether health outcomes of menopausal estrogen therapy differ between women with and without bilateral salpingo-oophorectomy (BSO) is unknown.
133. Continuous Anticoagulation and Cold Snare Polypectomy Versus Heparin Bridging and Hot Snare Polypectomy in Patients on Anticoagulants With Subcentimeter Polyps: A Randomized Controlled Trial.
作者: Yoji Takeuchi.;Katsuhiro Mabe.;Yuichi Shimodate.;Shinji Yoshii.;Shinya Yamada.;Mineo Iwatate.;Takuji Kawamura.;Kinichi Hotta.;Koji Nagaike.;Nobuaki Ikezawa.;Tomoaki Yamasaki.;Yoriaki Komeda.;Satoshi Asai.;Yasuhiro Abe.;Takuji Akamatsu.;Yuko Sakakibara.;Hisatomo Ikehara.;Yuzuru Kinjo.;Takashi Ohta.;Yoko Kitamura.;Takashi Shono.;Takuya Inoue.;Yoshio Ohda.;Nozomu Kobayashi.;Tokuma Tanuma.;Ryu Sato.;Taku Sakamoto.;Naohiko Harada.;Akiko Chino.;Hideki Ishikawa.;Masanori Nojima.;Toshio Uraoka.; .
来源: Ann Intern Med. 2019年171卷4期229-237页
Management of anticoagulants for patients undergoing polypectomy is still controversial. Cold snare polypectomy (CSP) is reported to cause less bleeding than hot snare polypectomy (HSP).
134. Long-Term Weight Loss With Metformin or Lifestyle Intervention in the Diabetes Prevention Program Outcomes Study.
作者: John W Apolzan.;Elizabeth M Venditti.;Sharon L Edelstein.;William C Knowler.;Dana Dabelea.;Edward J Boyko.;Xavier Pi-Sunyer.;Rita R Kalyani.;Paul W Franks.;Preethi Srikanthan.;Kishore M Gadde.; .
来源: Ann Intern Med. 2019年170卷10期682-690页
Identifying reliable predictors of long-term weight loss (LTWL) could lead to improved weight management.
135. Intensive Models of Hepatitis C Care for People Who Inject Drugs Receiving Opioid Agonist Therapy: A Randomized Controlled Trial.
作者: Matthew J Akiyama.;Brianna L Norton.;Julia H Arnsten.;Linda Agyemang.;Moonseong Heo.;Alain H Litwin.
来源: Ann Intern Med. 2019年170卷9期594-603页
Many people who inject drugs (PWID) are denied treatment for hepatitis C virus (HCV) infection, even if they are receiving opioid agonist therapy (OAT). Research suggests that HCV in PWID may be treated effectively, but optimal models of care for promoting adherence and sustained virologic response (SVR) have not been evaluated in the direct-acting antiviral (DAA) era.
136. Medical Graphic Narratives to Improve Patient Comprehension and Periprocedural Anxiety Before Coronary Angiography and Percutaneous Coronary Intervention: A Randomized Trial.
作者: Anna Brand.;Linde Gao.;Alexandra Hamann.;Claudia Crayen.;Hannah Brand.;Susan M Squier.;Karl Stangl.;Friederike Kendel.;Verena Stangl.
来源: Ann Intern Med. 2019年170卷8期579-581页 137. B-Lymphocyte Depletion in Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial.
作者: Øystein Fluge.;Ingrid G Rekeland.;Katarina Lien.;Hanne Thürmer.;Petter C Borchgrevink.;Christoph Schäfer.;Kari Sørland.;Jörg Aßmus.;Irini Ktoridou-Valen.;Ingrid Herder.;Merethe E Gotaas.;Øivind Kvammen.;Katarzyna A Baranowska.;Louis M L J Bohnen.;Sissel S Martinsen.;Ann E Lonar.;Ann-Elise H Solvang.;Arne E S Gya.;Ove Bruland.;Kristin Risa.;Kine Alme.;Olav Dahl.;Olav Mella.
来源: Ann Intern Med. 2019年170卷9期585-593页
Previous phase 2 trials indicated benefit from B-lymphocyte depletion in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).
138. Thyroidectomy Versus Medical Management for Euthyroid Patients With Hashimoto Disease and Persisting Symptoms: A Randomized Trial.
作者: Ivar Guldvog.;Laurens Cornelus Reitsma.;Lene Johnsen.;Andromeda Lauzike.;Charlotte Gibbs.;Eivind Carlsen.;Tone Hoel Lende.;Jon Kristian Narvestad.;Roald Omdal.;Jan Terje Kvaløy.;Geir Hoff.;Tomm Bernklev.;Håvard Søiland.
来源: Ann Intern Med. 2019年170卷7期453-464页
Hashimoto disease is a chronic autoimmune thyroiditis. Despite adequate hormone substitution, some patients have persistent symptoms that may be the result of immunologic pathophysiology.
139. Comparative Efficacy of Therapies for Treatment of Depression for Patients Undergoing Maintenance Hemodialysis: A Randomized Clinical Trial.
作者: Rajnish Mehrotra.;Daniel Cukor.;Mark Unruh.;Tessa Rue.;Patrick Heagerty.;Scott D Cohen.;Laura M Dember.;Yaminette Diaz-Linhart.;Amelia Dubovsky.;Tom Greene.;Nancy Grote.;Nancy Kutner.;Madhukar H Trivedi.;Davin K Quinn.;Nisha Ver Halen.;Steven D Weisbord.;Bessie A Young.;Paul L Kimmel.;S Susan Hedayati.
来源: Ann Intern Med. 2019年170卷6期369-379页
Although depression is common among patients receiving maintenance hemodialysis, data on their acceptance of treatment and on the comparative efficacy of various therapies are limited.
140. Effects of a Personalized Web-Based Decision Aid for Surrogate Decision Makers of Patients With Prolonged Mechanical Ventilation: A Randomized Clinical Trial.
作者: Christopher E Cox.;Douglas B White.;Catherine L Hough.;Derek M Jones.;Jeremy M Kahn.;Maren K Olsen.;Carmen L Lewis.;Laura C Hanson.;Shannon S Carson.
来源: Ann Intern Med. 2019年170卷5期285-297页
Treatment decisions commonly have to be made in intensive care units (ICUs). These decisions are difficult for surrogate decision makers and often lead to decisional conflict, psychological distress, and treatments misaligned with patient preferences.
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