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121. Early Metformin in Gestational Diabetes: A Randomized Clinical Trial.
作者: Fidelma Dunne.;Christine Newman.;Alberto Alvarez-Iglesias.;John Ferguson.;Andrew Smyth.;Marie Browne.;Paula O'Shea.;Declan Devane.;Paddy Gillespie.;Delia Bogdanet.;Oratile Kgosidialwa.;Aoife Egan.;Yvonne Finn.;Geraldine Gaffney.;Aftab Khattak.;Derek O'Keeffe.;Aaron Liew.;Martin O'Donnell.
来源: JAMA. 2023年330卷16期1547-1556页
Gestational diabetes is a common complication of pregnancy and the optimal management is uncertain.
123. Atrial Fibrillation Catheter Ablation vs Medical Therapy and Psychological Distress: A Randomized Clinical Trial.
作者: Ahmed M Al-Kaisey.;Ramanathan Parameswaran.;Christina Bryant.;Robert D Anderson.;Joshua Hawson.;David Chieng.;Louise Segan.;Aleksandr Voskoboinik.;Hariharan Sugumar.;Geoffrey R Wong.;Sue Finch.;Stephen A Joseph.;Alex McLellan.;Liang-Han Ling.;Joseph Morton.;Paul Sparks.;Prashanthan Sanders.;Geoffrey Lee.;Peter M Kistler.;Jonathan M Kalman.
来源: JAMA. 2023年330卷10期925-933页
The impact of atrial fibrillation (AF) catheter ablation on mental health outcomes is not well understood.
124. Two-Year Outcomes After Minimally Invasive Surfactant Therapy in Preterm Infants: Follow-Up of the OPTIMIST-A Randomized Clinical Trial.
作者: Peter A Dargaville.;C Omar F Kamlin.;Francesca Orsini.;Xiaofang Wang.;Antonio G De Paoli.;H Gozde Kanmaz Kutman.;Merih Cetinkaya.;Lilijana Kornhauser-Cerar.;Matthew Derrick.;Hilal Özkan.;Christian V Hulzebos.;Georg M Schmölzer.;Ajit Aiyappan.;Brigitte Lemyre.;Sheree Kuo.;Victor S Rajadurai.;Joyce O'Shea.;Manoj Biniwale.;Rangasamy Ramanathan.;Alla Kushnir.;David Bader.;Mark R Thomas.;Mallinath Chakraborty.;Mariam J Buksh.;Risha Bhatia.;Carol L Sullivan.;Eric S Shinwell.;Amanda Dyson.;David P Barker.;Amir Kugelman.;Tim J Donovan.;Kevin C W Goss.;Markus K Tauscher.;Vadivelam Murthy.;Sanoj K M Ali.;Howard W Clark.;Roger F Soll.;Samantha Johnson.;Jeanie L Y Cheong.;John B Carlin.;Peter G Davis.; .
来源: JAMA. 2023年330卷11期1054-1063页
The long-term effects of surfactant administration via a thin catheter (minimally invasive surfactant therapy [MIST]) in preterm infants with respiratory distress syndrome remain to be definitively clarified.
125. Blood Pressure Management After Endovascular Therapy for Acute Ischemic Stroke: The BEST-II Randomized Clinical Trial.
作者: Eva A Mistry.;Kimberly W Hart.;Larry T Davis.;Yue Gao.;Charles J Prestigiacomo.;Shilpi Mittal.;Tapan Mehta.;Hayden LaFever.;Pablo Harker.;Hilary E Wilson-Perez.;Kalli A Beasley.;Neeharika Krothapalli.;Emily Lippincott.;Heather Stefek.;Michael Froehler.;Rohan Chitale.;Matthew Fusco.;Aaron Grossman.;Peyman Shirani.;Matthew Smith.;Matthew N Jaffa.;Sharon D Yeatts.;Gregory W Albers.;Jonathan P Wanderer.;Juliana Tolles.;Christopher J Lindsell.;Roger J Lewis.;Gordon R Bernard.;Pooja Khatri.
来源: JAMA. 2023年330卷9期821-831页
The effects of moderate systolic blood pressure (SBP) lowering after successful recanalization with endovascular therapy for acute ischemic stroke are uncertain.
126. Intensive vs Conventional Blood Pressure Lowering After Endovascular Thrombectomy in Acute Ischemic Stroke: The OPTIMAL-BP Randomized Clinical Trial.
作者: Hyo Suk Nam.;Young Dae Kim.;JoonNyung Heo.;Hyungwoo Lee.;Jae Wook Jung.;Jin Kyo Choi.;Il Hyung Lee.;In Hwan Lim.;Soon-Ho Hong.;Minyoul Baik.;Byung Moon Kim.;Dong Joon Kim.;Na-Young Shin.;Bang-Hoon Cho.;Seong Hwan Ahn.;Hyungjong Park.;Sung-Il Sohn.;Jeong-Ho Hong.;Tae-Jin Song.;Yoonkyung Chang.;Gyu Sik Kim.;Kwon-Duk Seo.;Kijeong Lee.;Jun Young Chang.;Jung Hwa Seo.;Sukyoon Lee.;Jang-Hyun Baek.;Han-Jin Cho.;Dong Hoon Shin.;Jinkwon Kim.;Joonsang Yoo.;Kyung-Yul Lee.;Yo Han Jung.;Yang-Ha Hwang.;Chi Kyung Kim.;Jae Guk Kim.;Chan Joo Lee.;Sungha Park.;Hye Sun Lee.;Sun U Kwon.;Oh Young Bang.;Craig S Anderson.;Ji Hoe Heo.; .
来源: JAMA. 2023年330卷9期832-842页
Optimal blood pressure (BP) control after successful reperfusion with endovascular thrombectomy (EVT) for patients with acute ischemic stroke is unclear.
127. Muvalaplin, an Oral Small Molecule Inhibitor of Lipoprotein(a) Formation: A Randomized Clinical Trial.
作者: Stephen J Nicholls.;Steven E Nissen.;Cynthia Fleming.;Shweta Urva.;Jeffrey Suico.;Paul H Berg.;Helle Linnebjerg.;Giacomo Ruotolo.;P Kellie Turner.;Laura F Michael.
来源: JAMA. 2023年330卷11期1042-1053页
Lipoprotein(a) (Lp[a]) is associated with atherosclerotic disease and aortic stenosis. Lp(a) forms by bonding between apolipoprotein(a) (apo[a]) and apo B100. Muvalaplin is an orally administered small molecule that inhibits Lp(a) formation by blocking the apo(a)-apo B100 interaction while avoiding interaction with a homologous protein, plasminogen.
128. Extracranial-Intracranial Bypass and Risk of Stroke and Death in Patients With Symptomatic Artery Occlusion: The CMOSS Randomized Clinical Trial.
作者: Yan Ma.;Tao Wang.;Haibo Wang.;Sepideh Amin-Hanjani.;Xiaoguang Tong.;Jiyue Wang.;Zhiyong Tong.;Dong Kuai.;Yiling Cai.;Jun Ren.;Donghai Wang.;Lian Duan.;Aisha Maimaitili.;Chunhua Hang.;Jiasheng Yu.;Xuesong Bai.;William J Powers.;Colin P Derdeyn.;Yangfeng Wu.;Feng Ling.;Yuxiang Gu.;Liqun Jiao.; .
来源: JAMA. 2023年330卷8期704-714页
Prior trials of extracranial-intracranial (EC-IC) bypass surgery showed no benefit for stroke prevention in patients with atherosclerotic occlusion of the internal carotid artery (ICA) or middle cerebral artery (MCA), but there have been subsequent improvements in surgical techniques and patient selection.
129. Perioperative Vaginal Estrogen as Adjunct to Native Tissue Vaginal Apical Prolapse Repair: A Randomized Clinical Trial.
作者: David D Rahn.;Holly E Richter.;Vivian W Sung.;Jessica E Pruszynski.;Linda S Hynan.
来源: JAMA. 2023年330卷7期615-625页
Surgical repairs of apical/uterovaginal prolapse are commonly performed using native tissue pelvic ligaments as the point of attachment for the vaginal cuff after a hysterectomy. Clinicians may recommend vaginal estrogen in an effort to reduce prolapse recurrence, but the effects of intravaginal estrogen on surgical prolapse management are uncertain.
130. Prenatal Intravenous Magnesium at 30-34 Weeks' Gestation and Neurodevelopmental Outcomes in Offspring: The MAGENTA Randomized Clinical Trial.
作者: Caroline A Crowther.;Pat Ashwood.;Philippa F Middleton.;Andrew McPhee.;Thach Tran.;Jane E Harding.; .
来源: JAMA. 2023年330卷7期603-614页
Intravenous magnesium sulfate administered to pregnant individuals before birth at less than 30 weeks' gestation reduces the risk of death and cerebral palsy in their children. The effects at later gestational ages are unclear.
131. Manchester Procedure vs Sacrospinous Hysteropexy for Treatment of Uterine Descent: A Randomized Clinical Trial.
作者: Rosa A Enklaar.;Sascha F M Schulten.;Hugo W F van Eijndhoven.;Mirjam Weemhoff.;Sanne A L van Leijsen.;Marijke C van der Weide.;Jeroen van Bavel.;Anna C Verkleij-Hagoort.;Eddy M M Adang.;Kirsten B Kluivers.; .
来源: JAMA. 2023年330卷7期626-635页
In many countries, sacrospinous hysteropexy is the most commonly practiced uterus-preserving technique in women undergoing a first operation for pelvic organ prolapse. However, there are no direct comparisons of outcomes after sacrospinous hysteropexy vs an older technique, the Manchester procedure.
132. Atorvastatin for Anthracycline-Associated Cardiac Dysfunction: The STOP-CA Randomized Clinical Trial.
作者: Tomas G Neilan.;Thiago Quinaglia.;Takeshi Onoue.;Syed S Mahmood.;Zsofia D Drobni.;Hannah K Gilman.;Amanda Smith.;Julius C Heemelaar.;Priya Brahmbhatt.;Jor Sam Ho.;Supraja Sama.;Jakub Svoboda.;Donna S Neuberg.;Jeremy S Abramson.;Ephraim P Hochberg.;Jefferey A Barnes.;Philippe Armand.;Eric D Jacobsen.;Caron A Jacobson.;Austin I Kim.;Jacob D Soumerai.;Yuchi Han.;Robb S Friedman.;Ann S Lacasce.;Bonnie Ky.;Dan Landsburg.;Sunita Nasta.;Raymond Y Kwong.;Michael Jerosch-Herold.;Robert A Redd.;Lanqi Hua.;James L Januzzi.;Aarti Asnani.;Negareh Mousavi.;Marielle Scherrer-Crosbie.
来源: JAMA. 2023年330卷6期528-536页
Anthracyclines treat a broad range of cancers. Basic and retrospective clinical data have suggested that use of atorvastatin may be associated with a reduction in cardiac dysfunction due to anthracycline use.
133. Upfront Radiosurgery vs a Wait-and-Scan Approach for Small- or Medium-Sized Vestibular Schwannoma: The V-REX Randomized Clinical Trial.
作者: Dhanushan Dhayalan.;Øystein Vesterli Tveiten.;Monica Finnkirk.;Anette Storstein.;Karl Ove Hufthammer.;Frederik Kragerud Goplen.;Morten Lund-Johansen.; .
来源: JAMA. 2023年330卷5期421-431页
Current guidelines for treating small- to medium-sized vestibular schwannoma recommend either upfront radiosurgery or waiting to treat until tumor growth has been detected radiographically.
134. Cervical Pessary for Prevention of Preterm Birth in Individuals With a Short Cervix: The TOPS Randomized Clinical Trial.
作者: Matthew K Hoffman.;Rebecca G Clifton.;Joseph R Biggio.;George R Saade.;Lynda G Ugwu.;Monica Longo.;Sabine Z Bousleiman.;Kelly Clark.;William A Grobman.;Heather A Frey.;Suneet P Chauhan.;Lorraine Dugoff.;Tracy A Manuck.;Edward K Chien.;Dwight J Rouse.;Hyagriv N Simhan.;M Sean Esplin.;George A Macones.; .
来源: JAMA. 2023年330卷4期340-348页
A short cervix as assessed by transvaginal ultrasound is an established risk factor for preterm birth. Study findings for a cervical pessary to prevent preterm delivery in singleton pregnancies with transvaginal ultrasound evidence of a short cervix have been conflicting.
135. Identifying Children Likely to Benefit From Antibiotics for Acute Sinusitis: A Randomized Clinical Trial.
作者: Nader Shaikh.;Alejandro Hoberman.;Timothy R Shope.;Jong-Hyeon Jeong.;Marcia Kurs-Lasky.;Judith M Martin.;Sonika Bhatnagar.;Gysella B Muniz.;Stan L Block.;Melissa Andrasko.;Matthew C Lee.;Kumaravel Rajakumar.;Ellen R Wald.
来源: JAMA. 2023年330卷4期349-358页
The large overlap between symptoms of acute sinusitis and viral upper respiratory tract infection suggests that certain subgroups of children being diagnosed with acute sinusitis, and subsequently treated with antibiotics, derive little benefit from antibiotic use.
136. Cytisinicline for Smoking Cessation: A Randomized Clinical Trial.
作者: Nancy A Rigotti.;Neal L Benowitz.;Judith Prochaska.;Scott Leischow.;Mitchell Nides.;Brent Blumenstein.;Anthony Clarke.;Daniel Cain.;Cindy Jacobs.
来源: JAMA. 2023年330卷2期152-160页
Cytisinicline (cytisine) is a plant-based alkaloid that, like varenicline, binds selectively to α4β2 nicotinic acetylcholine receptors, which mediate nicotine dependence. Although not licensed in the US, cytisinicline is used in some European countries to aid smoking cessation, but its traditional dosing regimen and treatment duration may not be optimal.
137. Dual Antiplatelet Therapy vs Alteplase for Patients With Minor Nondisabling Acute Ischemic Stroke: The ARAMIS Randomized Clinical Trial.
作者: Hui-Sheng Chen.;Yu Cui.;Zhong-He Zhou.;Hong Zhang.;Li-Xia Wang.;Wei-Zhong Wang.;Li-Ying Shen.;Li-Yan Guo.;Er-Qiang Wang.;Rui-Xian Wang.;Jing Han.;Yu-Ling Dong.;Jing Li.;Yong-Zhong Lin.;Qing-Cheng Yang.;Li Zhang.;Jing-Yu Li.;Jin Wang.;Lei Xia.;Guang-Bin Ma.;Jiang Lu.;Chang-Hao Jiang.;Shu-Man Huang.;Li-Shu Wan.;Xiang-Yu Piao.;Zhuo Li.;Yan-Song Li.;Kui-Hua Yang.;Duo-Lao Wang.;Thanh N Nguyen.; .
来源: JAMA. 2023年329卷24期2135-2144页
Intravenous thrombolysis is increasingly used in patients with minor stroke, but its benefit in patients with minor nondisabling stroke is unknown.
138. Once-Weekly Insulin Icodec vs Once-Daily Insulin Degludec in Adults With Insulin-Naive Type 2 Diabetes: The ONWARDS 3 Randomized Clinical Trial.
作者: Ildiko Lingvay.;Marisse Asong.;Cyrus Desouza.;Pierre Gourdy.;Soumitra Kar.;André Vianna.;Tina Vilsbøll.;Siri Vinther.;Yiming Mu.
来源: JAMA. 2023年330卷3期228-237页
Once-weekly insulin icodec could provide a simpler dosing alternative to daily basal insulin in people with type 2 diabetes.
139. Six-Month Follow-up of a Trial of Spinal Cord Burst Stimulation vs Placebo Stimulation and Disability in Patients With Chronic Radicular Pain After Lumbar Spine Surgery.
作者: Sozaburo Hara.;Hege Andresen.;Ole Solheim.;Sven M Carlsen.;Asgeir S Jakola.;Øyvind O Salvesen.;Sasha Gulati.
来源: JAMA. 2023年329卷22期1985-1986页 140. Minithoracotomy vs Conventional Sternotomy for Mitral Valve Repair: A Randomized Clinical Trial.
作者: Enoch F Akowuah.;Rebecca H Maier.;Helen C Hancock.;Ehsan Kharatikoopaei.;Luke Vale.;Cristina Fernandez-Garcia.;Emmanuel Ogundimu.;Janelle Wagnild.;Ayesha Mathias.;Zoe Walmsley.;Nicola Howe.;Adetayo Kasim.;Richard Graham.;Gavin J Murphy.;Joseph Zacharias.; .
来源: JAMA. 2023年329卷22期1957-1966页
The safety and effectiveness of mitral valve repair via thoracoscopically-guided minithoracotomy (minithoracotomy) compared with median sternotomy (sternotomy) in patients with degenerative mitral valve regurgitation is uncertain.
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