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121. Atrioventricular Synchrony Delivered by a Dual-Chamber Leadless Pacemaker System.
作者: James E Ip.;Mayer Rashtian.;Derek V Exner.;Vivek Y Reddy.;Rahul Doshi.;Nima Badie.;Jordan R Nevo.;Aditya Goil.;Pascal Defaye.;Robert Canby.;Maria Grazia Bongiorni.;Morio Shoda.;Gerhard Hindricks.;Reinoud E Knops.
来源: Circulation. 2024年150卷6期439-450页
A dual-chamber leadless pacemaker system has been designed for atrioventricular synchronous pacing using wireless, beat-to-beat, implant-to-implant (i2i) communication between distinct atrial and ventricular leadless pacemakers. The atrioventricular synchrony achieved across various ambulatory scenarios has yet to be systematically evaluated.
122. Effect of Apixaban on Clinical Outcomes in Outpatients With COVID-19: The APOLLO Randomized Clinical Trial.
作者: Pedro Gabriel Melo de Barros E Silva.;Ariane Vieira Scarlatelli Macedo.;Bruna Bronhara.;Lucas Petri Damiani.;Lilian Mazza Barbosa.;Nathália Rodrigues Lopes.;Mayra Akimi Suiama.;Murillo O Antunes.;Mariana Raquel Gonçalves.;Otávio Celso Eluf Gebara.;Priscilla de Aquino Martins.;Mariana Galvão Ribeiro.;João Batista de Moura Xavier de Moraes.;Valéria Cristina Resende Aguiar.;Alexandre B Cavalcanti.;Regis G Rosa.;Otavio Berwanger.;Viviane C Veiga.;Luciano C P Azevedo.;Eduardo Ramacciotti.;Christopher B Granger.;John H Alexander.;Alvaro Avezum.;Renato D Lopes.; .
来源: Circulation. 2024年150卷1期82-85页 123. Tadalafil for Treatment of Combined Postcapillary and Precapillary Pulmonary Hypertension in Patients With Heart Failure and Preserved Ejection Fraction: A Randomized Controlled Phase 3 Study.
作者: Marius M Hoeper.;Britta Oerke.;Max Wissmüller.;Hanno Leuchte.;Christian Opitz.;Michael Halank.;Hans-Juergen Seyfarth.;Stephan Baldus.;Johann Bauersachs.;Michael Böhm.;Hossein-Ardeschir Ghofrani.;Stavros Konstantinides.;Karen M Olsson.;Rolf Wachter.;Carolyn S P Lam.;Behnaz Aminossadati.;Stephan Rosenkranz.
来源: Circulation. 2024年150卷8期600-610页
We assessed the efficacy and safety of tadalafil, a phosphodiesterase type 5 inhibitor, in patients with heart failure with preserved ejection fraction and combined postcapillary and precapillary pulmonary hypertension.
124. Effects of an Intervention to Improve Evidence-Based Care for People With Diabetes and Cardiovascular Disease Across Sex, Race, and Ethnicity Subgroups: Insights From the COORDINATE-Diabetes Trial.
作者: Manasi Tannu.;Lisa Kaltenbach.;Neha J Pagidipati.;Darren K McGuire.;Vanita R Aroda.;Rodica Pop-Busui.;Nitin Kondamudi.;Hussein R Al-Khalidi.;Renato D Lopes.;Matthew A Cavender.;Adam J Nelson.;Julienne Kirk.;Ildiko Lingvay.;Melissa Magwire.;Caroline Regina Richardson.;Laura Webb.;Monica Leyva.;Ambarish Pandey.;Alana Washington.;Jonathan Pak.;Tanya Gaynor.;Waqar Khan.;Patrick Weston.;Christopher B Granger.;Jennifer Green.
来源: Circulation. 2024年150卷3期180-189页
Results from the COORDINATE-Diabetes trial (Coordinating Cardiology Clinics Randomized Trial of Interventions to Improve Outcomes - Diabetes) demonstrated that a multifaceted, clinic-based intervention increased prescription of evidence-based medical therapies to participants with type 2 diabetes and atherosclerotic cardiovascular disease. This secondary analysis assessed whether intervention success was consistent across sex, race, and ethnicity.
125. Implementation of First-Trimester Screening and Prevention of Preeclampsia: A Stepped Wedge Cluster-Randomized Trial in Asia.
作者: Long Nguyen-Hoang.;Linh Thuy Dinh.;Angela S T Tai.;Duy-Anh Nguyen.;Ritsuko K Pooh.;Arihiro Shiozaki.;Mingming Zheng.;Yali Hu.;Bin Li.;Aditya Kusuma.;Piengbulan Yapan.;Arundhati Gosavi.;Mayumi Kaneko.;Suchaya Luewan.;Tung-Yao Chang.;Noppadol Chaiyasit.;Tongta Nanthakomon.;Huishu Liu.;Steven W Shaw.;Wing Cheong Leung.;Zaleha Abdullah Mahdy.;Angela Aguilar.;Hillary H Y Leung.;Nikki M W Lee.;So Ling Lau.;Isabella Y M Wah.;Xiaohong Lu.;Daljit S Sahota.;Marc K C Chong.;Liona C Poon.; .
来源: Circulation. 2024年150卷16期1223-1235页
This trial aimed to assess the efficacy, acceptability, and safety of a first-trimester screen-and-prevent strategy for preterm preeclampsia in Asia.
126. Health Coaching Improves Outcomes of Informal Caregivers of Adults With Chronic Heart Failure: A Randomized Controlled Trial.
作者: Barbara Riegel.;Ryan Quinn.;Karen B Hirschman.;Gladys Thomas.;Rebecca Ashare.;Michael A Stawnychy.;Kathryn H Bowles.;Subhash Aryal.;Joyce W Wald.
来源: Circ Heart Fail. 2024年17卷7期e011475页
Caring for someone with heart failure takes an emotional and physical toll. Engaging in self-care may decrease stress and improve the health of informal caregivers. We conducted a randomized controlled trial testing the efficacy of a virtual health coaching intervention, compared with health information alone, on the self-care, stress, coping, and health status of heart failure caregivers.
127. Myocardial Blood Flow by Magnetic Resonance in Patients With Suspected Coronary Stenosis: Comparison to PET and Invasive Physiology.
作者: Laust Dupont Rasmussen.;Theodore Murphy.;Xenios Milidonis.;Ashkan Eftekhari.;Salma Raghad Karim.;Jelmer Westra.;Jonathan Nørtoft Dahl.;Christin Isaksen.;Lau Brix.;June Anita Ejlersen.;Mette Nyegaard.;Jane Kirk Johansen.;Hanne Maare Søndergaard.;Jesper Mortensen.;Lars Christian Gormsen.;Evald Høj Christiansen.;Amedeo Chiribiri.;Steffen E Petersen.;Morten Bøttcher.;Simon Winther.
来源: Circ Cardiovasc Imaging. 2024年17卷6期e016635页
Despite recent guideline recommendations, quantitative perfusion (QP) estimates of myocardial blood flow from cardiac magnetic resonance (CMR) have only been sparsely validated. Furthermore, the additional diagnostic value of utilizing QP in addition to the traditional visual expert interpretation of stress-perfusion CMR remains unknown. The aim was to investigate the correlation between myocardial blood flow measurements estimated by CMR, positron emission tomography, and invasive coronary thermodilution. The second aim is to investigate the diagnostic performance of CMR-QP to identify obstructive coronary artery disease (CAD).
128. Text Messages to Promote Physical Activity in Patients With Cardiovascular Disease: A Micro-Randomized Trial of a Just-In-Time Adaptive Intervention.
作者: Jessica R Golbus.;Jieru Shi.;Kashvi Gupta.;Rachel Stevens.;V Swetha E Jeganathan.;Evan Luff.;Thomas Boyden.;Bhramar Mukherjee.;Sarah Kohnstamm.;Vlad Taralunga.;Vik Kheterpal.;Sachin Kheterpal.;Kenneth Resnicow.;Susan Murphy.;Walter Dempsey.;Predrag Klasnja.;Brahmajee K Nallamothu.
来源: Circ Cardiovasc Qual Outcomes. 2024年17卷7期e010731页
Text messages may enhance physical activity levels in patients with cardiovascular disease, including those enrolled in cardiac rehabilitation. However, the independent and long-term effects of text messages remain uncertain.
129. Health-Status Outcomes in Older Patients With Myocardial Infarction: Physiology-Guided Complete Revascularization Versus Culprit-Only Strategy.
作者: Gianluca Campo.;Vincenzo Guiducci.;Javier Escaned.;Raul Moreno.;Gianni Casella.;Caterina Cavazza.;Enrico Cerrato.;Marco Contarini.;Marco Arena.;Andres Iniguez Romo.;Enrique Gutiérrez Ibañes.;Roberto Scarsini.;Giuseppe Vadalà.;Giuseppe Andò.;Gerlando Pilato.;Sergio Musto d'Amore.;Alessandro Capecchi.;Ramiro Trillo Nouche.;Elisabetta Moscarella.;Alfonso Gambino.;Marco Pavani.;Anna Zanetti.;Nicola Pesenti.;Dariusz Dudek.;Emanuele Barbato.;Matteo Tebaldi.;Simone Biscaglia.
来源: Circ Cardiovasc Qual Outcomes. 2024年17卷7期e010490页
The FIRE trial (Functional Assessment in Elderly Myocardial Infarction Patients With Multivessel Disease) enrolled 1445 older (aged ≥75 years) patients with myocardial infarction and multivessel disease in Italy, Spain, and Poland. Patients were randomized to physiology-guided complete revascularization or treatment of the only culprit lesion. Physiology-guided complete revascularization significantly reduced ischemic adverse events at 1 year. This prespecified analysis investigated the changes between the 2 study groups in angina status, quality of life, physical performance, and frailty.
130. Randomized Trial for Evaluation in Secondary Prevention Efficacy of Combination Therapy-Statin and Eicosapentaenoic Acid (RESPECT-EPA).
作者: Katsumi Miyauchi.;Hiroshi Iwata.;Yuji Nishizaki.;Teruo Inoue.;Atsushi Hirayama.;Kazuo Kimura.;Yukio Ozaki.;Toyoaki Murohara.;Kenji Ueshima.;Yoshihiro Kuwabara.;Sachiko Tanaka-Mizuno.;Naotake Yanagisawa.;Tosiya Sato.;Hiroyuki Daida.; .
来源: Circulation. 2024年150卷6期425-434页
Low plasma levels of eicosapentaenoic acid (EPA) are associated with cardiovascular events. This trial aimed to assess the clinical benefits of icosapent ethyl in patients with coronary artery disease, a low EPA/arachidonic acid (AA) ratio, and statin treatment.
131. Safety and Tolerability of Angiotensin Receptor-Neprilysin Inhibitor Initiation in High-Risk Acute Myocardial Infarction Relative to Care Setting: A Subgroup Analysis of the PARADISE-MI Trial.
作者: Carmine G De Pasquale.;Brian Claggett.;Karola Jering.;John J V McMurray.;Douglas Mann.;Zi Michael Miao.;Christopher B Granger.;Lars Køber.;Aldo P Maggioni.;Jean-Lucien Rouleau.;Scott D Solomon.;Philippe Gabriel Steg.;Peter van der Meer.;Eugene Braunwald.;Marc A Pfeffer.
来源: Circ Heart Fail. 2024年17卷7期e011393页 132. Assisting Black Patients With Decision-Making for Implantable Cardioverter Defibrillator Therapy: Qualitative Findings From the Videos to Reduce Racial Disparities in ICD Therapy via Innovative Designs (VIVID) Trial.
作者: Larry R Jackson.;Kevin McKenna.;Amy Corneli.;Carrie Dombeck.;Kathleen Brelsford.;Kevin L Thomas.
来源: Circ Cardiovasc Qual Outcomes. 2024年17卷7期e010550页
The VIVID (Videos for Addressing Racial Disparities in Implantable Cardioverter Defibrillator Therapy via Innovative Designs) study was a multicenter, randomized controlled trial aimed at evaluating the effectiveness of a video-based decision support tool in enhancing informed consent for implantable cardioverter defibrillator (ICD) implantation among Black patients who met guideline criteria for primary prevention ICDs. Within the broader VIVID randomized trial, a qualitative investigation was conducted to elucidate the decisional factors among Black individuals considering ICD implantation for the primary prevention of sudden cardiac arrest.
133. Impact of Blood Pressure Targets in Patients With Heart Failure Undergoing Postresuscitation Care: A Subgroup Analysis From a Randomized Controlled Trial.
作者: Johannes Grand.;Christian Hassager.;Henrik Schmidt.;Simon Mølstrøm.;Benjamin Nyholm.;Laust E R Obling.;Martin A S Meyer.;Emma Illum.;Jakob Josiassen.;Rasmus P Beske.;Henrik Høigaard Frederiksen.;Jordi S Dahl.;Jacob E Møller.;Jesper Kjaergaard.
来源: Circ Heart Fail. 2024年17卷6期e011437页
To assess the effect of targeting higher or lower blood pressure during postresucitation intensive care among comatose patients with out-of-hospital cardiac arrest with a history of heart failure.
134. Effect of Sacubitril/Valsartan on Cognitive Function in Patients With Heart Failure With Preserved Ejection Fraction: A Prespecified Analysis of PARAGON-HF.
作者: Pooja Dewan.;Li Shen.;João Pedro Ferreira.;Pardeep S Jhund.;Inder S Anand.;Alvin Chandra.;Lu-May Chiang.;Brian Claggett.;Akshay S Desai.;Jianjian Gong.;Carolyn S P Lam.;Martin P Lefkowitz.;Aldo P Maggioni.;Felipe Martinez.;Milton Packer.;Margaret M Redfield.;Jean L Rouleau.;Dirk J van Veldhuisen.;Faiez Zannad.;Michael R Zile.;Scott D Solomon.;John J V McMurray.
来源: Circulation. 2024年150卷4期272-282页
A hypothetical concern has been raised that sacubitril/valsartan might cause cognitive impairment because neprilysin is one of several enzymes degrading amyloid-β peptides in the brain, some of which are neurotoxic and linked to Alzheimer-type dementia. To address this, we examined the effect of sacubitril/valsartan compared with valsartan on cognitive function in patients with heart failure with preserved ejection fraction in a prespecified substudy of PARAGON-HF (Prospective Comparison of Angiotensin Receptor Neprilysin Inhibitor With Angiotensin Receptor Blocker Global Outcomes in Heart Failure With Preserved Ejection Fraction).
135. Application of the Win Ratio Method in the ENGAGE AF-TIMI 48 Trial Comparing Edoxaban With Warfarin in Patients With Atrial Fibrillation.
作者: Brian A Bergmark.;Jeong-Gun Park.;Rose A Hamershock.;Giorgio E M Melloni.;Raffaele De Caterina.;Elliott M Antman.;Christian T Ruff.;Howard Rutman.;Michele F Mercuri.;Hans-Joachim Lanz.;Eugene Braunwald.;Robert P Giugliano.
来源: Circ Cardiovasc Qual Outcomes. 2024年17卷7期e010561页
Cardiovascular trials often use a composite end point and a time-to-first event model. We sought to compare edoxaban versus warfarin using the win ratio, which offers data complementary to time-to-first event analysis, emphasizing the most severe clinical events.
136. Atorvastatin Effect on Aortic Dilatation and Valvular Calcification Progression in Bicuspid Aortic Valve (BICATOR): A Randomized Clinical Trial.
作者: Arturo Evangelista.;Laura Galian-Gay.;Andrea Guala.;Gisela Teixido-Tura.;Francisco Calvo-Iglesias.;Teresa Sevilla.;Javier Bermejo.;Irene Méndez.;Violeta Sánchez.;Juan M Robledo Carmona.;Josep M Alegret.;Elena Ferrer-Sistach.;Daniel Saura.;Aroa Ruiz-Muñoz.;Lydia Dux-Santoy.;María Ángeles Carmona.;Marina Huguet.;Hug Cuellar-Calabria.;Augusto Sao-Avilés.;Ignacio Ferreira-González.;Jose F Rodríguez-Palomares.
来源: Circulation. 2024年149卷25期1938-1948页
Ascending aorta dilation and aortic valve degeneration are common complications in patients with bicuspid aortic valve. Several retrospective studies have suggested the benefit of statins in reducing these complications. This study aimed to determine whether atorvastatin treatment is effective in reducing the growth of aortic diameters in bicuspid aortic valve and if it slows the progression of valve calcification.
137. Biodegradable Polymer Versus Polymer-Free Ultrathin Sirolimus-Eluting Stents: Analysis of the Stent Arm Registry From the HOST-IDEA Randomized Trial.
作者: Jung-Kyu Han.;Seokhun Yang.;Doyeon Hwang.;Sang-Hyeon Park.;Jeehoon Kang.;Han-Mo Yang.;Kyung Woo Park.;Hyun-Jae Kang.;Bon-Kwon Koo.;Jin-Man Cho.;Janghyun Cho.;Duk Won Bang.;Jae-Hwan Lee.;Han Cheol Lee.;Kyung-Jin Kim.;Woo Jung Chun.;Won-Woo Seo.;Woo-Jung Park.;Sang Min Park.;Jin Won Kim.;Hyo-Soo Kim.
来源: Circ Cardiovasc Interv. 2024年17卷7期e013585页
The efficacy and safety of each third-generation drug-eluting stent with ultrathin struts and advanced polymer technology remain unclear. We investigated the clinical outcomes of percutaneous coronary intervention using the Coroflex ISAR polymer-free sirolimus-eluting stent (SES) or Orsiro biodegradable polymer SES.
138. Three-Year Outcomes With Fractional Flow Reserve-Guided or Angiography-Guided Multivessel Percutaneous Coronary Intervention for Myocardial Infarction.
作者: Etienne Puymirat.;Guillaume Cayla.;Tabassome Simon.;Philippe Gabriel Steg.;Gilles Montalescot.;Isabelle Durand-Zaleski.;Fabiola Ngaleu Siaha.;Romain Gallet.;Khalife Khalife.;Jean-François Morelle.;Pascal Motreff.;Gilles Lemesle.;Jean-Guillaume Dillinger.;Thibault Lhermusier.;Johanne Silvain.;Vincent Roule.;Jean-Noel Labèque.;Grégoire Rangé.;Grégory Ducrocq.;Yves Cottin.;Didier Blanchard.;Anaïs Charles Nelson.;Juliette Djadi-Prat.;Gilles Chatellier.;Nicolas Danchin.; .
来源: Circ Cardiovasc Interv. 2024年17卷6期e013913页
In patients with multivessel disease with successful primary percutaneous coronary intervention for ST-segment-elevation myocardial infarction, the FLOWER-MI trial (Flow Evaluation to Guide Revascularization in Multivessel ST-Elevation Myocardial Infarction) showed that a fractional flow reserve (FFR)-guided strategy was not superior to an angiography-guided strategy for treatment of noninfarct-related artery lesions regarding the 1-year risk of death from any cause, myocardial infarction, or unplanned hospitalization leading to urgent revascularization. The extension phase of the trial was planned using the same primary outcome to determine whether a difference in outcomes would be observed with a longer follow-up.
139. Clinical Value of Single-Projection Angiography-Derived FFR in Noninfarct-Related Artery.
作者: Woochan Kwon.;Ki Hong Choi.;Seung Hun Lee.;David Hong.;Doosup Shin.;Hyun Kuk Kim.;Keun Ho Park.;Eun Ho Choo.;Chan Joon Kim.;Min Chul Kim.;Young Joon Hong.;Sung Gyun Ahn.;Joon-Hyung Doh.;Sang Yeub Lee.;Sang Don Park.;Hyun-Jong Lee.;Min Gyu Kang.;Jin-Sin Koh.;Yun-Kyeong Cho.;Chang-Wook Nam.;Hyun Sung Joh.;Taek Kyu Park.;Jeong Hoon Yang.;Young Bin Song.;Seung-Hyuk Choi.;Myung Ho Jeong.;Hyeon-Cheol Gwon.;Joo-Yong Hahn.;Joo Myung Lee.; .
来源: Circ Cardiovasc Interv. 2024年17卷5期e013844页
The Murray law-based quantitative flow ratio (μFR) is an emerging technique that requires only 1 projection of coronary angiography with similar accuracy to quantitative flow ratio (QFR). However, it has not been validated for the evaluation of noninfarct-related artery (non-IRA) in acute myocardial infarction (AMI) settings. Therefore, our study aimed to evaluate the diagnostic accuracy of μFR and the safety of deferring non-IRA lesions with μFR >0.80 in the setting of AMI.
140. Early Versus Late Initiation of Direct Oral Anticoagulants After Ischemic Stroke in People With Atrial Fibrillation and Hemorrhagic Transformation: Prespecified Subanalysis of the Randomized Controlled ELAN Trial.
作者: Roman Rohner.;Markus Kneihsl.;Martina B Goeldlin.;Arsany Hakim.;Mattia Branca.;Stefanie Abend.;Waldo Valenzuela Pinilla.;Sabine Fenzl.;Beata Rezny-Kasprzak.;Daniel Strbian.;Sven Trelle.;Maurizio Paciaroni.;Götz Thomalla.;Patrik Michel.;Krassen Nedeltchev.;Thomas Gattringer.;Else C Sandset.;Leo Bonati.;Diana Aguiar de Sousa.;P N Sylaja.;George Ntaios.;Masatoshi Koga.;Zuzana Gdovinova.;Robin Lemmens.;Natan M Bornstein.;Peter Kelly.;Mira Katan.;Thomas Horvath.;Jesse Dawson.;Urs Fischer.; .
来源: Circulation. 2024年150卷1期19-29页
Whether hemorrhagic transformation (HT) modifies the treatment effect of early compared with late initiation of direct oral anticoagulation in people with ischemic stroke and atrial fibrillation is unknown.
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