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1341. Testicular Germ Cell Tumors: A Review.
作者: Nirmish Singla.;Aditya Bagrodia.;Ezra Baraban.;Christian D Fankhauser.;Yasser M A Ged.
来源: JAMA. 2025年333卷9期793-803页
Testicular cancer is the most common solid malignancy among males aged 15 to 40 years in the US, with approximately 10 000 new cases diagnosed each year. Between 90% and 95% of testicular cancers are germ cell tumors (GCTs).
1358. Adjuvant Atezolizumab for Early Triple-Negative Breast Cancer: The ALEXANDRA/IMpassion030 Randomized Clinical Trial.
作者: Michail Ignatiadis.;Andrew Bailey.;Heather McArthur.;Sarra El-Abed.;Evandro de Azambuja.;Otto Metzger.;Stephen Y Chui.;Max Dieterich.;Thomas Perretti.;Esther Shearer-Kang.;Luciana Molinero.;Günther G Steger.;Jacek Jassem.;Soo Chin Lee.;Michaela Higgins.;Jose Zarba.;Marcus Schmidt.;Henry Gomez.;Angel Guerrero Zotano.;Luca Moscetti.;Joanne Chiu.;Elisabetta Munzone.;Noa Efrat Ben-Baruch.;Emilio Bajetta.;Shinji Ohno.;Seock-Ah Im.;Gustavo Werutsky.;Einav Nili Gal-Yam.;Xavier Gonzalez Farre.;Ling-Ming Tseng.;William Jacot.;Oleg Gluz.;Zhimin Shao.;Yaroslav Shparyk.;Anastasia Zimina.;Eric Winer.;David A Cameron.;Giuseppe Viale.;Shigehira Saji.;Richard Gelber.;Martine Piccart.
来源: JAMA. 2025年333卷13期1150-60页
Triple-negative breast cancer is an aggressive subtype with a high incidence in young patients, a high incidence in non-Hispanic Black women, and a high risk of progression to metastatic cancer, a devastating sequela with a 12- to 18-month life expectancy. Until recently, one strategy for treating early-stage triple-negative breast cancer was chemotherapy after surgery. However, it was not known whether the addition of immune therapy to postsurgery chemotherapy would be beneficial.
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