1221. Infection prevention in acute nonlymphocytic leukemia. Laminar air flow room reverse isolation with oral, nonabsorbable antibiotic prophylaxis.
作者: S C Schimpff.;W H Greene.;V M Young.;C L Fortner.;N Cusack.;J B Block.;P H Wiernik.
来源: Ann Intern Med. 1975年82卷3期351-8页
Reverse isolation and prophylactic oral nonabsorbable antibiotics were evaluated among 64 consecutive noninfected adults with acute nonlymphocytic leukemia admitted for remission induction. Patients were randomly allocated to laminar air flow room reverse isolation with oral nonabsorbable antibiotics (LAF plus A), routine hospital ward care with antibiotics (W plus A), or ward care alone (W). The LAF plus A patients had a significantly decreased incidence of total infection, bacteremias, pneumonias, rectal abscesses, urinary tract infection, and pharyngitis. Infectious deaths were reduced in the LAF plus A group and the time to the first infection or to fatal infection was delayed. The W plus A patients who regularly ingested the antibiotics had a reduction in infections similar to that of the LAF plus A patients but those who could not tolerate the antibiotics had an incidence of infection comparable to the ward patients. The LAF plus A and the W plus A patients also had higher complete remission rates and longer median survival than the unprotected ward patients.
1222. Diazepam and paraldehyde for treatment of severe delirium tremens. A controlled trial.
Thirty-four patients with severe delirium tremens were allocated randomly to treatment with paraldehyde (10 ml rectally very 30 minutes) or diazepam (10 mg then 5 mg intravenously every 5 minutes) until they were calm but awake. Diazepam-treated patients became calm in one half the time needed to calm patients with paraldehyde. Half of the patients had delirium tremens in association with pneumonia, pancreatitis, or alcoholic hepatitis; these patients required twice as much paraldehyde or diazepam for initial calming as patients with delirium tremens alone. Maintenance of a calm state was accomplished easily with either diazepam, intramuscularly, or paraldehyde, rectally. Adverse reactions occurred in nine patients, all of whom had been treated with paraldehyde; these patients had greater degrees of fever, tachypnea, and tachycardia and required three times longer for initial calming than patients without adverse reactions. Diazepam given under this regimen is a safe and effective sedative for management of combative patients with severe delirium tremens.
1237. Combination chemotherapy in advanced Hodgkin's disease. Induction and maintenance of remission.
作者: E Frei.;J K Luce.;J F Gamble.;C A Coltman.;J J Constanzi.;R W Talley.;R W Monto.;H E Wilson.;J S Hewlett.;F C Delaney.;E A Gehan.
来源: Ann Intern Med. 1973年79卷3期376-82页 1238. Cholestyramine in type II hyperlipoproteinemia. A double-blind trial.
作者: R I Levy.;D S Fredrickson.;N J Stone.;D W Bilheimer.;W V Brown.;C J Glueck.;A M Gotto.;P N Herbert.;P O Kwiterovich.;T Langer.;J LaRosa.;S E Lux.;A K Rider.;R S Shulman.;H R Sloan.
来源: Ann Intern Med. 1973年79卷1期51-8页 |