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1201. Quantitative assessment of left ventricular size and function: side-by-side comparison of real-time three-dimensional echocardiography and computed tomography with magnetic resonance reference.
作者: Lissa Sugeng.;Victor Mor-Avi.;Lynn Weinert.;Johannes Niel.;Christian Ebner.;Regina Steringer-Mascherbauer.;Frank Schmidt.;Christian Galuschky.;Georg Schummers.;Roberto M Lang.;Hans-Joachim Nesser.
来源: Circulation. 2006年114卷7期654-61页
Cardiac CT (CCT) and real-time 3D echocardiography (RT3DE) are being used increasingly in clinical cardiology. CCT offers superb spatial and contrast resolution, resulting in excellent endocardial definition. RT3DE has the advantages of low cost, portability, and live 3D imaging without offline reconstruction. We sought to compare both CCT and RT3DE measurements of left ventricular size and function with the standard reference technique, cardiac MR (CMR).
1202. Transapical transcatheter aortic valve implantation in humans: initial clinical experience.
作者: Samuel V Lichtenstein.;Anson Cheung.;Jian Ye.;Christopher R Thompson.;Ronald G Carere.;Sanjeevan Pasupati.;John G Webb.
来源: Circulation. 2006年114卷6期591-6页
Aortic valve replacement with cardiopulmonary bypass is currently the treatment of choice for symptomatic aortic stenosis but carries a significant risk of morbidity and mortality, particularly in patients with comorbidities. Recently, percutaneous transfemoral aortic valve implantation has been proposed as a viable alternative in selected patients. We describe our experience with a new, minimally invasive, catheter-based approach to aortic valve implantation via left ventricular apical puncture without cardiopulmonary bypass or sternotomy.
1203. Prognostic utility of heart-type fatty acid binding protein in patients with acute coronary syndromes.
作者: Michelle O'Donoghue.;James A de Lemos.;David A Morrow.;Sabina A Murphy.;Jacqueline L Buros.;Christopher P Cannon.;Marc S Sabatine.
来源: Circulation. 2006年114卷6期550-7页
Heart-type fatty acid binding protein (H-FABP) is a cytosolic protein that is released rapidly from the cardiomyocyte in response to myocardial injury. Although it has been investigated as an early marker of acute myocardial infarction, its prognostic utility in acute coronary syndromes has not been established.
1204. In vivo evidence for nitric oxide-mediated calcium-activated potassium-channel activation during human endotoxemia.
作者: Peter Pickkers.;Mirrin J Dorresteijn.;Martijn P W J M Bouw.;Johannes G van der Hoeven.;Paul Smits.
来源: Circulation. 2006年114卷5期414-21页
During septic shock, the vasoconstrictor response to norepinephrine is seriously blunted. Animal experiments suggest that hyperpolarization of smooth muscle cells by opening of potassium (K) channels underlies this phenomenon. In the present study, we examined whether K-channel blockers and/or nitric oxide (NO) synthase inhibition could restore norepinephrine sensitivity during experimental human endotoxemia.
1205. Effects of digoxin on morbidity and mortality in diastolic heart failure: the ancillary digitalis investigation group trial.
作者: Ali Ahmed.;Michael W Rich.;Jerome L Fleg.;Michael R Zile.;James B Young.;Dalane W Kitzman.;Thomas E Love.;Wilbert S Aronow.;Kirkwood F Adams.;Mihai Gheorghiade.
来源: Circulation. 2006年114卷5期397-403页
About half of the 5 million heart failure patients in the United States have diastolic heart failure (clinical heart failure with normal or near-normal ejection fraction). Except for candesartan, no drugs have been tested in randomized clinical trials in these patients. Although digoxin was tested in an appreciable number of diastolic heart failure patients in the Digitalis Investigation Group ancillary trial, detailed findings from this important study have not previously been published.
1206. Clinical relevance of C-reactive protein during follow-up of patients with acute coronary syndromes in the Aggrastat-to-Zocor Trial.
作者: David A Morrow.;James A de Lemos.;Marc S Sabatine.;Stephen D Wiviott.;Michael A Blazing.;Amy Shui.;Nader Rifai.;Robert M Califf.;Eugene Braunwald.
来源: Circulation. 2006年114卷4期281-8页
Elevated levels of high-sensitivity C-reactive protein (hsCRP) are associated with higher risk of adverse outcomes in patients at risk for or with established coronary artery disease. Retrospective analyses suggest that this risk may be modified with statin therapy. However, a role for hsCRP in monitoring the success of therapy remains uncertain.
1207. Comparative impact of multiple biomarkers and N-Terminal pro-brain natriuretic peptide in the context of conventional risk factors for the prediction of recurrent cardiovascular events in the Heart Outcomes Prevention Evaluation (HOPE) Study.
作者: Stefan Blankenberg.;Matthew J McQueen.;Marek Smieja.;Janice Pogue.;Cynthia Balion.;Eva Lonn.;Hans J Rupprecht.;Christoph Bickel.;Laurence Tiret.;Francois Cambien.;Hertzel Gerstein.;Thomas Münzel.;Salim Yusuf.; .
来源: Circulation. 2006年114卷3期201-8页
Individual markers of inflammation may add incremental predictive value in the context of conventionally available risk factors. We evaluated the ability of 9 inflammatory biomarkers, microalbuminuria, and N-terminal pro-brain natriuretic peptide (Nt-proBNP) to improve cardiovascular risk prediction beyond that obtained from traditional risk factors in a secondary-prevention population.
1208. Mitral valve repair with Carpentier-McCarthy-Adams IMR ETlogix annuloplasty ring for ischemic mitral regurgitation: early echocardiographic results from a multi-center study.
作者: Masao Daimon.;Shota Fukuda.;David H Adams.;Patrick M McCarthy.;A Marc Gillinov.;Alain Carpentier.;Farzan Filsoufi.;Vivian M Abascal.;Vera H Rigolin.;Sacha Salzberg.;Anna Huskin.;Michelle Langenfeld.;Takahiro Shiota.
来源: Circulation. 2006年114卷1 Suppl期I588-93页
Ischemic mitral regurgitation (IMR) is associated with asymmetric changes in annular and ventricular geometry. Surgical repair with standard symmetric annuloplasty rings results in a high incidence of residual or recurrent mitral regurgitation (MR). The Carpentier-McCarthy-Adams (CMA) IMR ETlogix annuloplasty ring is the first remodeling ring specifically designed to treat asymmetric leaflet tethering and annular dilatation. We used quantitative 2-dimensional echo to examine early results of mitral valve (MV) repair with the CMA IMR ETlogix annuloplasty ring in patients with IMR.
1209. Are stentless valves superior to modern stented valves? A prospective randomized trial.
作者: Ayyaz Ali.;James C Halstead.;Fay Cafferty.;Linda Sharples.;Fiona Rose.;Richard Coulden.;Evelyn Lee.;John Dunning.;Vincenzo Argano.;Steven Tsui.
来源: Circulation. 2006年114卷1 Suppl期I535-40页
It is presumed that stentless aortic bioprostheses are hemodynamically superior to stented bioprostheses. A prospective randomized controlled trial was undertaken to compare stentless versus modern stented valves.
1210. Mitral valve repair versus revascularization alone in the treatment of ischemic mitral regurgitation.
作者: Duk-Hyun Kang.;Mi-Jeong Kim.;Soo-Jin Kang.;Jong-Min Song.;Hyun Song.;Myeong-Ki Hong.;Kee-Joon Choi.;Jae-Kwan Song.;Jae-Won Lee.
来源: Circulation. 2006年114卷1 Suppl期I499-503页
For patients with ischemic mitral regurgitation (MR), it is not clear whether adjunctive mitral valve (MV) repair at the time of coronary artery bypass graft surgery (CABG) is beneficial. We sought to test the hypothesis that MV repair with CABG is superior to CABG alone in improving MR without increasing operative or long-term mortality.
1211. Coronary revascularization (surgical or percutaneous) decreases mortality after the first year in diabetic subjects but not in nondiabetic subjects with multivessel disease: an analysis from the Medicine, Angioplasty, or Surgery Study (MASS II).
作者: Paulo R Soares.;Whady A Hueb.;Pedro A Lemos.;Neuza Lopes.;Eulógio E Martinez.;Luis A M Cesar.;Sergio A Oliveira.;Jose A F Ramires.
来源: Circulation. 2006年114卷1 Suppl期I420-4页
It is currently unknown whether revascularization procedures are associated with an improvement in mortality among diabetic subjects, as compared with a more conservative medical treatment.
1212. Endothelial Protection, AT1 blockade and Cholesterol-Dependent Oxidative Stress: the EPAS trial.
作者: Henning Morawietz.;Sandra Erbs.;Jürgen Holtz.;Andreas Schubert.;Michael Krekler.;Winfried Goettsch.;Oliver Kuss.;Volker Adams.;Karsten Lenk.;Friedrich W Mohr.;Gerhard Schuler.;Rainer Hambrecht.
来源: Circulation. 2006年114卷1 Suppl期I296-301页
Statins and angiotensin type 1 (AT1) receptor blockers reduce cardiovascular mortality and morbidity. In the Endothelial Protection, AT1 blockade and Cholesterol-Dependent Oxidative Stress (EPAS) trial, impact of independent or combined statin and AT1 receptor blocker therapy on endothelial expression of anti-atherosclerotic and proatherosclerotic genes and endothelial function in arteries of patients with coronary artery disease were tested.
1213. Glucose-insulin-potassium and tri-iodothyronine individually improve hemodynamic performance and are associated with reduced troponin I release after on-pump coronary artery bypass grafting.
作者: Aaron M Ranasinghe.;David W Quinn.;Domenico Pagano.;Nicola Edwards.;Muzzafar Faroqui.;Timothy R Graham.;Bruce E Keogh.;Jorge Mascaro.;David W Riddington.;Stephen J Rooney.;John N Townend.;Ian C Wilson.;Robert S Bonser.
来源: Circulation. 2006年114卷1 Suppl期I245-50页
Both glucose-insulin-potassium (GIK) and tri-iodothyronine (T3) may improve cardiovascular performance after coronary artery surgery (CABG) but their effects have not been directly compared and the effects of combined treatment are unknown.
1214. Differential effect of intracoronary infusion of mobilized peripheral blood stem cells by granulocyte colony-stimulating factor on left ventricular function and remodeling in patients with acute myocardial infarction versus old myocardial infarction: the MAGIC Cell-3-DES randomized, controlled trial.
作者: Hyun-Jae Kang.;Hae-Young Lee.;Sang-Hoon Na.;Sung-A Chang.;Kyung-Woo Park.;Hyung-Kwan Kim.;Song-Yi Kim.;Ho-Joon Chang.;Whal Lee.;Won Jun Kang.;Bon-Kwon Koo.;Yong-Jin Kim.;Dong Soo Lee.;Dae-Won Sohn.;Kyou-Sup Han.;Byung-Hee Oh.;Young-Bae Park.;Hyo-Soo Kim.
来源: Circulation. 2006年114卷1 Suppl期I145-51页
The efficacy of intracoronary infusion of granulocyte colony-stimulating factor (G-CSF) mobilized peripheral blood stem cells (PBSCs) has not been compared between patients with acute (AMI) versus old myocardial infarction (OMI). In addition, the potential risk of restenosis associated with G-CSF-based stem cell therapy has not been evaluated in the setting of drug eluting stent (DES) implantation.
1215. Clinical application of tissue engineered human heart valves using autologous progenitor cells.
作者: Serghei Cebotari.;Artur Lichtenberg.;Igor Tudorache.;Andres Hilfiker.;Heike Mertsching.;Rainer Leyh.;Thomas Breymann.;Klaus Kallenbach.;Liviu Maniuc.;Aurel Batrinac.;Oleg Repin.;Oxana Maliga.;Anatol Ciubotaru.;Axel Haverich.
来源: Circulation. 2006年114卷1 Suppl期I132-7页
Tissue engineering (TE) of heart valves reseeded with autologous cells has been successfully performed in vitro. Here, we report our first clinical implantation of pulmonary heart valves (PV) engineered with autologous endothelial progenitor cells (EPCs) and the results of 3.5 years of follow-up.
1216. The impact of the capability of circulating progenitor cell to differentiate on myocardial salvage in patients with primary acute myocardial infarction.
作者: Yasushi Numaguchi.;Takahito Sone.;Kenji Okumura.;Masakazu Ishii.;Yasuhiro Morita.;Ryuji Kubota.;Kazuhiko Yokouchi.;Hajime Imai.;Mitsunori Harada.;Hiroyuki Osanai.;Takahisa Kondo.;Toyoaki Murohara.
来源: Circulation. 2006年114卷1 Suppl期I114-9页
Circulating endothelial progenitor cells (EPCs) are known to be involved in vasculogenesis and mobilized after acute myocardial infarction (AMI). To test the hypothesis that the angiogenic function of EPCs affects post-myocardial infarction (MI) myocardial salvage, we evaluated the number and potential differentiation of EPCs and compared these data with clinical parameters 6 months after MI.
1217. Skeletal myoblast transplantation in ischemic heart failure: long-term follow-up of the first phase I cohort of patients.
作者: Albert A Hagège.;Jean-Pierre Marolleau.;Jean-Thomas Vilquin.;Armelle Alhéritière.;Séverine Peyrard.;Denis Duboc.;Eric Abergel.;Emmanuel Messas.;Elie Mousseaux.;Ketty Schwartz.;Michel Desnos.;Philippe Menasché.
来源: Circulation. 2006年114卷1 Suppl期I108-13页
Skeletal myoblast (SM) transplantation (Tx) in a post-myocardial infarction (MI) scar experimentally improves left ventricular (LV) ejection fraction (EF). Short-term follow-up (FU) studies have suggested that a similar benefit could clinically occur despite an increased risk of LV arrhythmias.
1218. Recovery of regional but not global contractile function by the direct intramyocardial autologous bone marrow transplantation: results from a randomized controlled clinical trial.
作者: Marc Hendrikx.;Karen Hensen.;Christel Clijsters.;Hanne Jongen.;Remco Koninckx.;Eric Bijnens.;Michel Ingels.;Axel Jacobs.;Robert Geukens.;Paul Dendale.;Johan Vijgen.;Dagmara Dilling.;Paul Steels.;Urbain Mees.;Jean-Luc Rummens.
来源: Circulation. 2006年114卷1 Suppl期I101-7页
Recent trials have shown that intracoronary infusion of bone marrow cells (BMCs) improves functional recovery after acute myocardial infarction. However, whether this treatment is effective in heart failure as a consequence of remodeling after organized infarcts remains unclear. In this randomized trial, we assessed the hypothesis that direct intramyocardial injection of autologous mononuclear bone marrow cells during coronary artery bypass graft (CABG) could improve global and regional left ventricular ejection fraction (LVEF) at 4-month follow-up.
1219. Intravenous administration of metoprolol is more effective than oral administration in the prevention of atrial fibrillation after cardiac surgery.
作者: Jari Halonen.;Tapio Hakala.;Tommi Auvinen.;Jari Karjalainen.;Anu Turpeinen.;Ari Uusaro.;Pirjo Halonen.;Juha Hartikainen.;Mikko Hippeläinen.
来源: Circulation. 2006年114卷1 Suppl期I1-4页
Atrial fibrillation (AF) is the most common arrhythmia to occur after cardiac surgery, with an incidence of 20% to 40%. AF is associated with postoperative complications, including increased risk of stroke and need of additional treatment, as well as prolonged hospital stay and increased costs. It has been shown that prophylactic oral administration of beta-blocker therapy reduces the incidence of postoperative AF after cardiac surgery. However, it is possible that absorption of drugs is impaired after cardiopulmonary perfusion associated with cardiac surgery. The purpose of this prospective, controlled, randomized trial was to study compare intravenous and per oral metoprolol administration in the prevention of AF after cardiac surgery.
1220. Effect of amiodarone and sotalol on ventricular defibrillation threshold: the optimal pharmacological therapy in cardioverter defibrillator patients (OPTIC) trial.
作者: Stefan H Hohnloser.;Paul Dorian.;Robin Roberts.;Michael Gent.;Carsten W Israel.;Eric Fain.;Jean Champagne.;Stuart J Connolly.
来源: Circulation. 2006年114卷2期104-9页
Many patients with implanted cardioverter defibrillators (ICDs) receive adjunctive antiarrhythmic drug therapy, most commonly amiodarone or sotalol. The effects of these drugs on defibrillation energy requirements have not been previously assessed in a randomized controlled trial.
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