106. Restrictive vs Liberal Physical Restraint Strategies in Critically Ill Patients: The R2D2-ICU Randomized Clinical Trial.
作者: Romain Sonneville.;Camille Couffignal.;Florian Sigaud.;Michael Thy.;Virginie Godard.;Juliette Audibert.;Damien Contou.;Adam Celier.;Michel Djibré.;Thomas Rambaud.;Pierre Jaquet.;Armand Mekontso Dessap.;Claire Bourel.;Romane Belot.;Carine Roy.;Fariza Nait Sidenas.;Fatiha Essardy.;Jean-François Timsit.;Renaud Cornic.;Lila Bouadma.; .
来源: JAMA. 2026年
The effect of wrist-strap physical restraints on outcomes in patients receiving mechanical ventilation in the intensive care unit (ICU) remains uncertain.
117. Tumor Debulking in Combination With Chemotherapy in Multiorgan Metastatic Colorectal Cancer: The ORCHESTRA Randomized Clinical Trial.
作者: Elske C Gootjes.;Lotte Bakkerus.;Anviti A Adhin.;Barbara M Zonderhuis.;Kathelijn S Versteeg.;Jurriaan B Tuynman.;Martijn R Meijerink.;Cornelis J A Haasbeek.;Johannes H W de Wilt.;Dirk J Grunhagen.;Ewoud J Smit.;John M Primrose.;John Bridgewater.;Esther van Meerten.;Jan-Willem B de Groot.;Mathijs P Hendriks.;Esther Oomen-de Hoop.;Tineke E Buffart.;Cornelis Verhoef.;Henk M W Verheul.; .
来源: JAMA. 2026年
Local therapy, including surgery, radiation, and ablation, is increasingly used in patients with multiorgan metastatic colorectal cancer (mCRC). However, prospective evidence for a survival benefit of tumor debulking is lacking.
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