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101. Macitentan for Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Pulmonary Vascular Disease: Results of the SERENADE Randomized Clinical Trial and Open-Label Extension Study.
作者: Sanjiv J Shah.;Diana Bonderman.;Barry A Borlaug.;John G F Cleland.;Gabriela Lack.;Wentao Lu.;Adriaan A Voors.;Faiez Zannad.;Mark T Gladwin.
来源: Circ Heart Fail. 2025年18卷3期e011381页
Despite favorable hemodynamic and neurohormonal effects, endothelin receptor antagonists have not improved outcomes in patients with heart failure (HF), possibly because they cause fluid retention.
102. Patent Foramen Ovale Closure in Patients With and Without Nickel Hypersensitivity: A Randomized Trial.
作者: Anastasios Apostolos.;Stamatios Gregoriou.;Maria Drakopoulou.;Georgios Trantalis.;Aikaterini Tsiogka.;Nikolaos Ktenopoulos.;Konstantina Aggeli.;Alexander Stratigos.;Konstantinos Tsioufis.;Konstantinos Toutouzas.
来源: Circ Cardiovasc Interv. 2025年18卷4期e015228页
Nickel-containing devices, such as the Amplatzer PFO Occluder and Gore Cardioform Septal Occluder, are used for transcatheter patent foramen ovale closure. However, the impact of nickel hypersensitivity on postprocedural outcomes remains poorly understood. This study aimed to evaluate the risk of adverse events in patients with nickel hypersensitivity undergoing patent foramen ovale closure.
103. Heart Rate Reduction Is Associated With Reverse Left Ventricular Remodeling and Mechanism-Specific Molecular Phenotypes in Dilated Cardiomyopathy.
作者: Natasha L Altman.;Edward A Gill.;Rami Kahwash.;Leslie K Meyer.;Jessica A Wagner.;Anis Karimpour-Fard.;Amber A Berning.;Wayne A Minobe.;Ian A Carroll.;Eric R Jonas.;Dobromir Slavov.;Sitaramesh Emani.;William T Abraham.;Alexa R Gollah.;Samuel L Ellis.;Matthew R G Taylor.;Sharon L Graw.;Luisa Mestroni.;Timothy A McKinsey.;Peter M Buttrick.;David P Kao.;Michael R Bristow.
来源: Circ Heart Fail. 2025年18卷4期e012484页
Heart rate (HR) affects heart failure outcomes, via uncertain mechanisms that may include left ventricular remodeling. However, in human ventricular myocardium, HR change has not been associated with a particular remodeling molecular phenotype.
104. Evaluating the Appropriate Use Criteria for Coronary Revascularization in Stable Ischemic Heart Disease Using Randomized Data From the ISCHEMIA Trial.
作者: James Slater.;David J Maron.;Philip G Jones.;Sripal Bangalore.;Harmony R Reynolds.;Zhuxuan Fu.;Gregg W Stone.;Ruth Kirby.;Judith S Hochman.;John A Spertus.; .
来源: Circ Cardiovasc Qual Outcomes. 2025年18卷3期e010849页
The appropriate use criteria for revascularization of stable ischemic heart disease have not been evaluated using randomized data. Using data from the randomized ISCHEMIA trial (International Study of Comparative Health Effectiveness with Medical and Invasive Approaches; July 2012 to January 2018, 37 countries), the health status benefits of an invasive strategy over a conservative one were examined within appropriate use criteria scenarios.
105. Left Ventricular Entry to Reduce Brain Lesions During Catheter Ablation: A Randomized Trial.
作者: Gregory M Marcus.;Roderick Tung.;Edward P Gerstenfeld.;Trisha F Hue.;Feng Lin.;Jing Cheng.;J Peter Weiss.;Wendy S Tzou.;Henry Hsia.;Ashkan Ehdaie.;Daniel H Cooper.;T Jared Bunch.;Jeffrey Arkles.;Babak Nazer.;Adam Lee.;Alexios Hadjis.;Duy T Nguyen.;Mihail G Chelu.;Joshua Moss.;Jonathan C Hsu.;Miguel Valderrábano.;Prashant D Bhave.;Andrew D Beaser.;Arvindh Kanagasundram.;Oussama Wazni.;Jason Bradfield.;Grace Wall.;Kathleen Chang.;Michelle Yang.;Gabrielle Montenegro.;Sabrina Jarrott.;Joel H Kramer.;Anthony S Kim.;Yvonne M Morris.;William P Dillon.
来源: Circulation. 2025年151卷15期1051-1059页
Catheter ablation of ventricular arrhythmias, one of the most rapidly growing procedures in cardiac electrophysiology, is associated with magnetic resonance imaging-detected brain lesions in more than half of cases. Although a retrograde aortic approach is conventional, modern tools enable entry through a transseptal approach that may avoid embolization of debris from the arterial system. We sought to test the hypothesis that a transseptal puncture would mitigate brain injury compared with a retrograde aortic approach.
106. Reactivation of Oxidized Soluble Guanylate Cyclase as a Novel Treatment Strategy to Slow Progression of Calcific Aortic Valve Stenosis: Preclinical and Randomized Clinical Trials to Assess Safety and Efficacy.
作者: Bin Zhang.;Maurice Enriquez-Sarano.;Hartzell V Schaff.;Hector I Michelena.;Carolyn M Roos.;Michael A Hagler.;Heyu Zhang.;Grace Casaclang-Verzosa.;Runqing Huang.;Anna Bartoo.;Sushant Ranadive.;Michael J Joyner.;Sorin Pislaru.;Vuyisile T Nkomo.;Walter K Kremers.;Philip A Araoz.;Gurpreet Singh.;Michael A Walters.;Jon Hawkinson.;Kevin Y Cunningham.;Jaeyun Sung.;Brandon Dunagan.;Zi Ye.;Jordan D Miller.
来源: Circulation. 2025年151卷13期913-930页
Pharmacological treatments for fibrocalcific aortic valve stenosis (FCAVS) have been elusive for >50 years. Here, we tested the hypothesis that reactivation of oxidized sGC (soluble guanylate cyclase), the primary receptor for nitric oxide, with ataciguat is a safe and efficacious strategy to slow progression of FCAVS.
107. Intravascular Imaging Predictors Associated With Cardiovascular Events After Complex PCIs.
作者: Joo Myung Lee.;Sang Yoon Lee.;Woochan Kwon.;Seung-Jae Lee.;Jong-Young Lee.;Seung Hun Lee.;Doosup Shin.;Sang Yeub Lee.;Sang Min Kim.;Kyeong Ho Yun.;Jae Young Cho.;Chan Joon Kim.;Hyo-Suk Ahn.;Chang-Wook Nam.;Hyuck-Jun Yoon.;Yong Hwan Park.;Wang Soo Lee.;Ki Hong Choi.;Taek Kyu Park.;Jeong Hoon Yang.;Seung-Hyuk Choi.;Hyeon-Cheol Gwon.;Young Bin Song.;Joo-Yong Hahn.; .
来源: Circ Cardiovasc Interv. 2025年18卷2期e014920页
Intravascular imaging-guided percutaneous coronary intervention (PCI) has been shown to improve clinical outcomes in patients with complex coronary artery lesions compared with angiography-guided PCI. However, the prognostic impact of suboptimal findings on intravascular imaging such as stent underexpansion, malapposition, or dissection is unclear in the era of contemporary drug-eluting stents.
108. Effect of Balloon Pulmonary Angioplasty and Riociguat on Right Ventricular Afterload and Function in CTEPH: Insights From the RACE Trial.
作者: Christian Gerges.;Mitja Jevnikar.;Philippe Brenot.;Laurent Savale.;Antoine Beurnier.;Hélène Bouvaist.;Olivier Sitbon.;Elie Fadel.;Athénaïs Boucly.;Denis Chemla.;Gérald Simonneau.;Marc Humbert.;David Montani.;Xavier Jaïs.; .
来源: Circ Cardiovasc Interv. 2025年18卷2期e014785页
Riociguat and balloon pulmonary angioplasty (BPA) improve hemodynamics in inoperable chronic thromboembolic pulmonary hypertension. Importantly, comparative effects of riociguat and BPA on different components of right ventricular (RV) afterload and function remain not fully elucidated.
109. Stepwise Provisional Versus Systematic Dual-Stent Strategies for Treatment of True Left Main Coronary Bifurcation Lesions.
作者: Sandeep Arunothayaraj.;Mohaned Egred.;Adrian P Banning.;Philippe Brunel.;Miroslaw Ferenc.;Thomas Hovasse.;Adrian Wlodarczak.;Manuel Pan.;Thomas Schmitz.;Marc Silvestri.;Andreis Erglis.;Evgeny Kretov.;Jens Flensted Lassen.;Alaide Chieffo.;Thierry Lefèvre.;Francesco Burzotta.;James Cockburn.;Olivier Darremont.;Goran Stankovic.;Marie-Claude Morice.;Yves Louvard.;David Hildick-Smith.
来源: Circulation. 2025年151卷9期612-622页
The optimal coronary stenting technique for true left main bifurcation lesions is uncertain. EBC MAIN (European Bifurcation Club Left Main Trial) aimed to evaluate clinical outcomes of a stepwise provisional strategy compared with a systematic dual-stent approach.
110. Efficacy of Irbesartan in Celiprolol-Treated Patients With Vascular Ehlers-Danlos Syndrome.
作者: Xavier Jeunemaitre.;Elie Mousseaux.;Michael Frank.;Salma Adham.;Francesca Pitocco.;Clarisse Billon.;Molka Ben Yakhlef.;Mohamed El Hachmi.;Alessandra Bura-Rivière.;François-Xavier Lapébie.;Claire Le Hello.;Damien Laneelle.;Christophe Seinturier.;Klaus Dieterich.;Marc Lambert.;Sophie Dupuis-Girod.;Stéphane Zuily.;Laurence Bal-Theoleyre.;Carine Boulon.;Pierrick Henneton.;Estelle Lu.;Nicolas Denarié.;Pierre Boutouyrie.;Tristan Mirault.;Gilles Chatellier.;Michel Azizi.
来源: Circulation. 2025年151卷10期686-695页
Vascular Ehlers-Danlos syndrome is a rare genetic disorder characterized by defective type III collagen and a high risk of arterial morbidity and mortality. Several cardiovascular drugs are used for treatment, including celiprolol, but no controlled trial in this condition has been conducted to date. We hypothesized the benefit of the addition of an angiotensin II receptor blocker.
111. Economic Outcomes With Precision Diagnostic Testing Versus Usual Testing in Stable Chest Pain: Results From the PRECISE Randomized Trial.
作者: Derek S Chew.;Daniel B Mark.;Yanhong Li.;Michael G Nanna.;Michelle D Kelsey.;Melanie R Daniels.;Linda Davidson-Ray.;Khaula N Baloch.;Campbell Rogers.;Manesh R Patel.;Kevin J Anstrom.;Nick Curzen.;Sreekanth Vemulapalli.;Pamela S Douglas.; .
来源: Circ Cardiovasc Qual Outcomes. 2025年18卷2期e011008页
The PRECISE (Prospective Randomized Trial of the Optimal Evaluation of Cardiac Symptoms and Revascularization) demonstrated that a precision diagnostic strategy reduced the primary composite of death, nonfatal myocardial infarction, or catheterization without obstructive coronary artery disease by 65% in patients with nonacute chest pain compared with usual testing. Medical cost was a prespecified secondary end point.
112. Quality of Life Outcomes With a Risk-Based Precision Testing Strategy Versus Usual Testing in Stable Patients With Suspected Coronary Disease: Results From the PRECISE Randomized Trial.
作者: Daniel B Mark.;Yanhong Li.;Michael G Nanna.;Michelle D Kelsey.;Melanie R Daniels.;Campbell Rogers.;Manesh R Patel.;Khaula N Baloch.;Benjamin J W Chow.;Kevin J Anstrom.;Sreekanth Vemulapalli.;Jonathan R Weir-McCall.;Gregg W Stone.;Derek S Chew.;Pamela S Douglas.; .
来源: Circ Cardiovasc Qual Outcomes. 2025年18卷2期e011414页
The PRECISE (Prospective Randomized Trial of the Optimal Evaluation of Cardiac Symptoms and Revascularization) trial compared an investigational precision diagnostic testing strategy (n=1057) with usual testing (n=1046) in patients with stable chest pain and suspected coronary artery disease. Quality of life (QOL) outcomes were a prespecified secondary end point.
113. Impaired Exercise Capacity in High-Risk Diabetic Cardiomyopathy: The ARISE-HF Cardiopulmonary Exercise Testing Subanalysis.
作者: W H Wilson Tang.;Yuxi Liu.;Javed Butler.;Stefano Del Prato.;Justin A Ezekowitz.;Nasrien E Ibrahim.;Carolyn S P Lam.;Thomas H Marwick.;Riccardo Perfetti.;Julio Rosenstock.;Scott D Solomon.;Faiez Zannad.;James L Januzzi.;Gregory D Lewis.
来源: Circ Heart Fail. 2025年18卷3期e012200页
Objective indices of functional capacity in patients with diabetic cardiomyopathy and stage B heart failure (HF) have not been comprehensively defined. We sought to characterize the cardiopulmonary exercise characteristics of individuals with diabetic cardiomyopathy at high risk for overt HF.
114. Three-Dimensional CT for Preprocedural Planning of PCI for Ostial Right Coronary Artery Lesions: A Randomized Controlled Pilot Trial.
作者: Deborah M F van den Buijs.;Ella M Poels.;Endry Willems.;Daan Cottens.;Kevin Dotremont.;Karen De Leener.;Evelyne Meekers.;Bert Ferdinande.;Mathias Vrolix.;Joseph Dens.;Koen Ameloot.
来源: Circ Cardiovasc Interv. 2025年18卷2期e013584页
Geographic stent-ostium mismatch is an important predictor of target lesion failure after percutaneous coronary intervention of an aorto-ostial right coronary artery lesion. Optimal visualization of the aorto-ostial plane is crucial for precise stent implantation at the level of the ostium. This study investigates whether preprocedural 3-dimensional computed tomography (3DCT), with determination of the optimal viewing angle, would allow for more precise stent implantation and reduce procedure time, contrast, and radiation dose.
115. Aspirin Plus Rivaroxaban Versus Rivaroxaban Alone for the Prevention of Venous Stent Thrombosis Among Patients With Post-Thrombotic Syndrome: The Multicenter, Multinational, Randomized, Open-Label ARIVA Trial.
作者: Stefano Barco.;Houman Jalaie.;Tim Sebastian.;Simon Wolf.;Riccardo M Fumagalli.;Michael Lichtenberg.;Thomas Zeller.;Christian Erbel.;Oliver Schlager.;Nils Kucher.
来源: Circulation. 2025年151卷12期835-846页
In patients with post-thrombotic syndrome, stent recanalization of iliofemoral veins or the inferior vena cava can restore venous patency and improve functional outcomes. The risk of stent thrombosis is particularly increased during the first 6 months after intervention. The ARIVA trial (Aspirin Plus Rivaroxaban Versus Rivaroxaban Alone for the Prevention of Venous Stent Thrombosis in Patients With PTS) tested whether 100 mg of daily aspirin plus 20 mg of rivaroxaban is superior to 20 mg of rivaroxaban alone to prevent stent thrombosis within 6 months after stent placement for post-thrombotic syndrome.
116. Optimal Predilatation Treatment Before Implantation of a Magmaris Bioresorbable Scaffold in Coronary Artery Stenosis: The OPTIMIS Trial.
作者: Kirstine Nørregaard Hansen.;Jens Trøan.;Akiko Maehara.;Manijeh Noori.;Mikkel Hougaard.;Julia Ellert-Gregersen.;Karsten Tange Veien.;Anders Junker.;Henrik Steen Hansen.;Jens Flensted Lassen.;Lisette Okkels Jensen.
来源: Circ Cardiovasc Interv. 2025年18卷1期e014665页
Bioresorbable scaffolds (BRS) were developed to overcome limitations related to late stent failures of drug-eluting stents, but lumen reductions over time after implantation of BRS have been reported. This study aimed to investigate if lesion preparation with a scoring balloon compared with a standard noncompliant balloon minimizes lumen reduction after implantation of a Magmaris BRS assessed with optical coherence tomography and intravascular ultrasound.
117. Impact of Bifurcation Lesions on Outcomes After FFR-Guided PCI or CABG.
作者: Daimy M M Dillen.;Hisao Otsuki.;Kuniaki Takahashi.;Yuhei Kobayashi.;Zsolt Piroth.;Nicolas Noiseux.;Badih El Nakadi.;Gintaras Kalinauskas.;Laszlo Szekely.;Giedrius Davidavičius.;Koen Teeuwen.;Pim A L Tonino.;Nico H J Pijls.;Bernard De Bruyne.;William F Fearon.;Frederik M Zimmermann.
来源: Circ Cardiovasc Interv. 2025年18卷1期e014610页
In the era of first-generation drug-eluting stents and angiography-guided percutaneous coronary intervention (PCI), the presence of a bifurcation lesion was associated with adverse outcomes after PCI. In contrast, the presence of a bifurcation lesion had no impact on outcomes following coronary artery bypass grafting (CABG). Therefore, the presence of a coronary bifurcation lesion requires special attention when choosing between CABG and PCI. The aim of this study is to assess whether the presence of a bifurcation lesion still influences clinical outcomes after contemporary PCI using second-generation drug-eluting stent and fractional flow reserve (FFR) guidance versus CABG.
118. Cryoballoon Pulmonary Vein Isolation With Versus Without Additional Right Atrial Linear Ablation for Persistent Atrial Fibrillation: The CRALAL Randomized Clinical Trial.
作者: Daehoon Kim.;Hee Tae Yu.;Jaemin Shim.;Junbeom Park.;Yong-Soo Baek.;Sang Won Park.;Dae-Kyeong Kim.;Young-Ah Park.;Tae-Hoon Kim.;Jae-Sun Uhm.;Boyoung Joung.;Moon-Hyoung Lee.;Hui-Nam Pak.
来源: Circ Arrhythm Electrophysiol. 2025年18卷1期e013408页
Pulmonary vein isolation (PVI) alone is less effective in patients with persistent atrial fibrillation (AF) compared with those with paroxysmal AF. We investigate whether additional linear ablation from the superior vena cava to the right atrial septum and cavotricuspid isthmus ablation improves the rhythm outcome of patients with persistent AF undergoing cryoballoon PVI (Cryo-PVI).
119. Nurse-Led Multicomponent Behavioral Activation Intervention for Patients With Atrial Fibrillation: A Randomized Controlled Trial.
Patients with atrial fibrillation (AF) are often ill-equipped for shared decision-making. This study investigated the effects of a patient empowerment care model on patient-reported health outcomes and treatment decision-making in patients with AF.
120. Relationship Between Severity of Ischemia and Coronary Artery Disease for Different Stress Test Modalities in the ISCHEMIA Trial.
作者: Harmony R Reynolds.;Courtney B Page.;Leslee J Shaw.;Daniel S Berman.;Bernard R Chaitman.;Michael H Picard.;Raymond Y Kwong.;James K Min.;Jonathon Leipsic.;G B John Mancini.;Matthew J Budoff.;Cameron J Hague.;Roxy Senior.;Hanna Szwed.;Balram Bhargava.;Jelena Celutkiene.;Milind Gadkari.;Kevin R Bainey.;Rolf Doerr.;Ruben B Ramos.;Peter Ong.;Sudhir R Naik.;Philippe Gabriel Steg.;Kaatje Goetschalckx.;Benjamin J W Chow.;Marielle Scherrer-Crosbie.;Lawrence Phillips.;Daniel B Mark.;John A Spertus.;Karen P Alexander.;Sean M O'Brien.;William E Boden.;Sripal Bangalore.;Gregg W Stone.;David J Maron.;Judith S Hochman.; .
来源: Circ Cardiovasc Interv. 2024年17卷12期e013743页
The relationship between the extent and severity of stress-induced ischemia and the extent and severity of anatomic coronary artery disease (CAD) in patients with obstructive CAD is multifactorial and includes the intensity of stress achieved, type of testing used, presence and extent of prior infarction, collateral blood flow, plaque characteristics, microvascular disease, coronary vasomotor tone, and genetic factors. Among chronic coronary disease participants with site-determined moderate or severe ischemia, we investigated associations between ischemia severity on stress testing and the extent of CAD on coronary computed tomography angiography.
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