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101. Subclinical thyroid dysfunction and fracture risk: a meta-analysis.
作者: Manuel R Blum.;Douglas C Bauer.;Tinh-Hai Collet.;Howard A Fink.;Anne R Cappola.;Bruno R da Costa.;Christina D Wirth.;Robin P Peeters.;Bjørn O Åsvold.;Wendy P J den Elzen.;Robert N Luben.;Misa Imaizumi.;Alexandra P Bremner.;Apostolos Gogakos.;Richard Eastell.;Patricia M Kearney.;Elsa S Strotmeyer.;Erin R Wallace.;Mari Hoff.;Graziano Ceresini.;Fernando Rivadeneira.;André G Uitterlinden.;David J Stott.;Rudi G J Westendorp.;Kay-Tee Khaw.;Arnuf Langhammer.;Luigi Ferrucci.;Jacobijn Gussekloo.;Graham R Williams.;John P Walsh.;Peter Jüni.;Drahomir Aujesky.;Nicolas Rodondi.; .
来源: JAMA. 2015年313卷20期2055-65页
Associations between subclinical thyroid dysfunction and fractures are unclear and clinical trials are lacking.
102. Prevalence of amyloid PET positivity in dementia syndromes: a meta-analysis.
作者: Rik Ossenkoppele.;Willemijn J Jansen.;Gil D Rabinovici.;Dirk L Knol.;Wiesje M van der Flier.;Bart N M van Berckel.;Philip Scheltens.;Pieter Jelle Visser.; .;Sander C J Verfaillie.;Marissa D Zwan.;Sofie M Adriaanse.;Adriaan A Lammertsma.;Frederik Barkhof.;William J Jagust.;Bruce L Miller.;Howard J Rosen.;Susan M Landau.;Victor L Villemagne.;Christopher C Rowe.;Dong Y Lee.;Duk L Na.;Sang W Seo.;Marie Sarazin.;Catherine M Roe.;Osama Sabri.;Henryk Barthel.;Norman Koglin.;John Hodges.;Cristian E Leyton.;Rik Vandenberghe.;Koen van Laere.;Alexander Drzezga.;Stefan Forster.;Timo Grimmer.;Pascual Sánchez-Juan.;Jose M Carril.;Vincent Mok.;Vincent Camus.;William E Klunk.;Ann D Cohen.;Philipp T Meyer.;Sabine Hellwig.;Andrew Newberg.;Kristian S Frederiksen.;Adam S Fleisher.;Mark A Mintun.;David A Wolk.;Agneta Nordberg.;Juha O Rinne.;Gaël Chételat.;Alberto Lleo.;Rafael Blesa.;Juan Fortea.;Karine Madsen.;Karen M Rodrigue.;David J Brooks.
来源: JAMA. 2015年313卷19期1939-49页
Amyloid-β positron emission tomography (PET) imaging allows in vivo detection of fibrillar plaques, a core neuropathological feature of Alzheimer disease (AD). Its diagnostic utility is still unclear because amyloid plaques also occur in patients with non-AD dementia.
103. Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis.
作者: Willemijn J Jansen.;Rik Ossenkoppele.;Dirk L Knol.;Betty M Tijms.;Philip Scheltens.;Frans R J Verhey.;Pieter Jelle Visser.; .;Pauline Aalten.;Dag Aarsland.;Daniel Alcolea.;Myriam Alexander.;Ina S Almdahl.;Steven E Arnold.;Inês Baldeiras.;Henryk Barthel.;Bart N M van Berckel.;Kristen Bibeau.;Kaj Blennow.;David J Brooks.;Mark A van Buchem.;Vincent Camus.;Enrica Cavedo.;Kewei Chen.;Gael Chetelat.;Ann D Cohen.;Alexander Drzezga.;Sebastiaan Engelborghs.;Anne M Fagan.;Tormod Fladby.;Adam S Fleisher.;Wiesje M van der Flier.;Lisa Ford.;Stefan Förster.;Juan Fortea.;Nadia Foskett.;Kristian S Frederiksen.;Yvonne Freund-Levi.;Giovanni B Frisoni.;Lutz Froelich.;Tomasz Gabryelewicz.;Kiran Dip Gill.;Olymbia Gkatzima.;Estrella Gómez-Tortosa.;Mark Forrest Gordon.;Timo Grimmer.;Harald Hampel.;Lucrezia Hausner.;Sabine Hellwig.;Sanna-Kaisa Herukka.;Helmut Hildebrandt.;Lianna Ishihara.;Adrian Ivanoiu.;William J Jagust.;Peter Johannsen.;Ramesh Kandimalla.;Elisabeth Kapaki.;Aleksandra Klimkowicz-Mrowiec.;William E Klunk.;Sebastian Köhler.;Norman Koglin.;Johannes Kornhuber.;Milica G Kramberger.;Koen Van Laere.;Susan M Landau.;Dong Young Lee.;Mony de Leon.;Viviana Lisetti.;Alberto Lleó.;Karine Madsen.;Wolfgang Maier.;Jan Marcusson.;Niklas Mattsson.;Alexandre de Mendonça.;Olga Meulenbroek.;Philipp T Meyer.;Mark A Mintun.;Vincent Mok.;José Luis Molinuevo.;Hanne M Møllergård.;John C Morris.;Barbara Mroczko.;Stefan Van der Mussele.;Duk L Na.;Andrew Newberg.;Agneta Nordberg.;Arto Nordlund.;Gerald P Novak.;George P Paraskevas.;Lucilla Parnetti.;Gayan Perera.;Oliver Peters.;Julius Popp.;Sudesh Prabhakar.;Gil D Rabinovici.;Inez H G B Ramakers.;Lorena Rami.;Catarina Resende de Oliveira.;Juha O Rinne.;Karen M Rodrigue.;Eloy Rodríguez-Rodríguez.;Catherine M Roe.;Uros Rot.;Christopher C Rowe.;Eckart Rüther.;Osama Sabri.;Páscual Sanchez-Juan.;Isabel Santana.;Marie Sarazin.;Johannes Schröder.;Christin Schütte.;Sang W Seo.;Femke Soetewey.;Hilkka Soininen.;Luiza Spiru.;Hanne Struyfs.;Charlotte E Teunissen.;Magda Tsolaki.;Rik Vandenberghe.;Marcel M Verbeek.;Victor L Villemagne.;Stephanie J B Vos.;Linda J C van Waalwijk van Doorn.;Gunhild Waldemar.;Anders Wallin.;Åsa K Wallin.;Jens Wiltfang.;David A Wolk.;Marzena Zboch.;Henrik Zetterberg.
来源: JAMA. 2015年313卷19期1924-38页
Cerebral amyloid-β aggregation is an early pathological event in Alzheimer disease (AD), starting decades before dementia onset. Estimates of the prevalence of amyloid pathology in persons without dementia are needed to understand the development of AD and to design prevention studies.
104. Blood pressure lowering in type 2 diabetes: a systematic review and meta-analysis.
作者: Connor A Emdin.;Kazem Rahimi.;Bruce Neal.;Thomas Callender.;Vlado Perkovic.;Anushka Patel.
来源: JAMA. 2015年313卷6期603-15页
Lowering blood pressure (BP) is widely used to reduce vascular risk in individuals with diabetes.
105. Association of sickle cell trait with chronic kidney disease and albuminuria in African Americans.
作者: Rakhi P Naik.;Vimal K Derebail.;Morgan E Grams.;Nora Franceschini.;Paul L Auer.;Gina M Peloso.;Bessie A Young.;Guillaume Lettre.;Carmen A Peralta.;Ronit Katz.;Hyacinth I Hyacinth.;Rakale C Quarells.;Megan L Grove.;Alexander G Bick.;Pierre Fontanillas.;Stephen S Rich.;Joshua D Smith.;Eric Boerwinkle.;Wayne D Rosamond.;Kaoru Ito.;Sophie Lanzkron.;Josef Coresh.;Adolfo Correa.;Gloria E Sarto.;Nigel S Key.;David R Jacobs.;Sekar Kathiresan.;Kirsten Bibbins-Domingo.;Abhijit V Kshirsagar.;James G Wilson.;Alexander P Reiner.
来源: JAMA. 2014年312卷20期2115-25页
The association between sickle cell trait (SCT) and chronic kidney disease (CKD) is uncertain.
106. Association between vancomycin minimum inhibitory concentration and mortality among patients with Staphylococcus aureus bloodstream infections: a systematic review and meta-analysis.
作者: Andre C Kalil.;Trevor C Van Schooneveld.;Paul D Fey.;Mark E Rupp.
来源: JAMA. 2014年312卷15期1552-64页
Staphylococcus aureus bacteremia (SAB) is a worldwide problem. It is unclear whether higher-vancomycin minimum inhibitory concentration (MIC) is associated with mortality. This potential association has direct consequences for patients and public health.
107. Accuracy of FDG-PET to diagnose lung cancer in areas with infectious lung disease: a meta-analysis.
作者: Stephen A Deppen.;Jeffrey D Blume.;Clark D Kensinger.;Ashley M Morgan.;Melinda C Aldrich.;Pierre P Massion.;Ronald C Walker.;Melissa L McPheeters.;Joe B Putnam.;Eric L Grogan.
来源: JAMA. 2014年312卷12期1227-36页
Positron emission tomography (PET) combined with fludeoxyglucose F 18 (FDG) is recommended for the noninvasive diagnosis of pulmonary nodules suspicious for lung cancer. In populations with endemic infectious lung disease, FDG-PET may not accurately identify malignant lesions.
108. Clinical and safety outcomes associated with treatment of acute venous thromboembolism: a systematic review and meta-analysis.
作者: Lana A Castellucci.;Chris Cameron.;Grégoire Le Gal.;Marc A Rodger.;Doug Coyle.;Philip S Wells.;Tammy Clifford.;Esteban Gandara.;George Wells.;Marc Carrier.
来源: JAMA. 2014年312卷11期1122-35页
Many anticoagulant strategies are available for the treatment of acute venous thromboembolism, yet little guidance exists regarding which drug is most effective and safe.
109. Comparison of weight loss among named diet programs in overweight and obese adults: a meta-analysis.
作者: Bradley C Johnston.;Steve Kanters.;Kristofer Bandayrel.;Ping Wu.;Faysal Naji.;Reed A Siemieniuk.;Geoff D C Ball.;Jason W Busse.;Kristian Thorlund.;Gordon Guyatt.;Jeroen P Jansen.;Edward J Mills.
来源: JAMA. 2014年312卷9期923-33页
Many claims have been made regarding the superiority of one diet or another for inducing weight loss. Which diet is best remains unclear.
110. Does this adult patient have early HIV infection?: The Rational Clinical Examination systematic review.
作者: Evan Wood.;Thomas Kerr.;Greg Rowell.;Julio S G Montaner.;Peter Phillips.;P Todd Korthuis.;David L Simel.
来源: JAMA. 2014年312卷3期278-85页
Timely identification of human immunodeficiency virus (HIV) infection in adults can contribute to reduced mortality and likelihood of further HIV transmission. During the first 6 months after infection, known as early HIV infection, patients often report a well-described constellation of symptoms and signs. However, the literature examining utility of the clinical examination in identifying early infection has not been systematically assessed.
111. Thrombolysis for pulmonary embolism and risk of all-cause mortality, major bleeding, and intracranial hemorrhage: a meta-analysis.
作者: Saurav Chatterjee.;Anasua Chakraborty.;Ido Weinberg.;Mitul Kadakia.;Robert L Wilensky.;Partha Sardar.;Dharam J Kumbhani.;Debabrata Mukherjee.;Michael R Jaff.;Jay Giri.
来源: JAMA. 2014年311卷23期2414-21页
Thrombolytic therapy may be beneficial in the treatment of some patients with pulmonary embolism. To date, no analysis has had adequate statistical power to determine whether thrombolytic therapy is associated with improved survival, compared with conventional anticoagulation.
112. Decline in estimated glomerular filtration rate and subsequent risk of end-stage renal disease and mortality.
作者: Josef Coresh.;Tanvir Chowdhury Turin.;Kunihiro Matsushita.;Yingying Sang.;Shoshana H Ballew.;Lawrence J Appel.;Hisatomi Arima.;Steven J Chadban.;Massimo Cirillo.;Ognjenka Djurdjev.;Jamie A Green.;Gunnar H Heine.;Lesley A Inker.;Fujiko Irie.;Areef Ishani.;Joachim H Ix.;Csaba P Kovesdy.;Angharad Marks.;Takayoshi Ohkubo.;Varda Shalev.;Anoop Shankar.;Chi Pang Wen.;Paul E de Jong.;Kunitoshi Iseki.;Benedicte Stengel.;Ron T Gansevoort.;Andrew S Levey.
来源: JAMA. 2014年311卷24期2518-2531页
The established chronic kidney disease (CKD) progression end point of end-stage renal disease (ESRD) or a doubling of serum creatinine concentration (corresponding to a change in estimated glomerular filtration rate [GFR] of −57% or greater) is a late event.
113. Pharmacotherapy for adults with alcohol use disorders in outpatient settings: a systematic review and meta-analysis.
作者: Daniel E Jonas.;Halle R Amick.;Cynthia Feltner.;Georgiy Bobashev.;Kathleen Thomas.;Roberta Wines.;Mimi M Kim.;Ellen Shanahan.;C Elizabeth Gass.;Cassandra J Rowe.;James C Garbutt.
来源: JAMA. 2014年311卷18期1889-900页
Alcohol use disorders cause substantial morbidity and early mortality yet remain greatly undertreated. Medications are considerably underused.
114. Maternal body mass index and the risk of fetal death, stillbirth, and infant death: a systematic review and meta-analysis.
作者: Dagfinn Aune.;Ola Didrik Saugstad.;Tore Henriksen.;Serena Tonstad.
来源: JAMA. 2014年311卷15期1536-46页
Evidence suggests that maternal obesity increases the risk of fetal death, stillbirth, and infant death; however, the optimal body mass index (BMI) for prevention is not known.
115. Epidermal growth factor receptor tyrosine kinase inhibitors vs conventional chemotherapy in non-small cell lung cancer harboring wild-type epidermal growth factor receptor: a meta-analysis.
作者: June-Koo Lee.;Seokyung Hahn.;Dong-Wan Kim.;Koung Jin Suh.;Bhumsuk Keam.;Tae Min Kim.;Se-Hoon Lee.;Dae Seog Heo.
来源: JAMA. 2014年311卷14期1430-7页
Current guidelines recommend both epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) and cytotoxic chemotherapy drugs as standard treatment options for patients with wild-type (WT) EGFR who were previously treated for non-small cell lung cancer (NSCLC). However, it is not clear that EGFR TKIs are as efficacious as chemotherapy in patients with WT EGFR.
116. Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis.
作者: Jeffrey M Rohde.;Derek E Dimcheff.;Neil Blumberg.;Sanjay Saint.;Kenneth M Langa.;Latoya Kuhn.;Andrew Hickner.;Mary A M Rogers.
来源: JAMA. 2014年311卷13期1317-26页
The association between red blood cell (RBC) transfusion strategies and health care-associated infection is not fully understood.
117. Association between influenza vaccination and cardiovascular outcomes in high-risk patients: a meta-analysis.
作者: Jacob A Udell.;Rami Zawi.;Deepak L Bhatt.;Maryam Keshtkar-Jahromi.;Fiona Gaughran.;Arintaya Phrommintikul.;Andrzej Ciszewski.;Hossein Vakili.;Elaine B Hoffman.;Michael E Farkouh.;Christopher P Cannon.
来源: JAMA. 2013年310卷16期1711-20页
Among nontraditional cardiovascular risk factors, recent influenzalike infection is associated with fatal and nonfatal atherothrombotic events.
119. Lateral wedge insoles as a conservative treatment for pain in patients with medial knee osteoarthritis: a meta-analysis.
作者: Matthew J Parkes.;Nasimah Maricar.;Mark Lunt.;Michael P LaValley.;Richard K Jones.;Neil A Segal.;Kayoko Takahashi-Narita.;David T Felson.
来源: JAMA. 2013年310卷7期722-30页
There is no consensus regarding the efficacy of lateral wedge insoles as a treatment for pain in medial knee osteoarthritis.
120. Does this patient with shoulder pain have rotator cuff disease?: The Rational Clinical Examination systematic review.
作者: Job Hermans.;Jolanda J Luime.;Duncan E Meuffels.;Max Reijman.;David L Simel.;Sita M A Bierma-Zeinstra.
来源: JAMA. 2013年310卷8期837-47页
Rotator cuff disease (RCD) is the most common cause of shoulder pain seen by physicians.
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