1161. Influenza-Associated Acute Necrotizing Encephalopathy in US Children.
作者: .;Andrew Silverman.;Rachel Walsh.;Jonathan D Santoro.;Katherine Thomas.;Elizabeth Ballinger.;Kristen S Fisher.;Ajay X Thomas.;Brian Appavu.;Michael C Kruer.;Derek Neilson.;Jasmine Knoll.;April N Sharp.;Hannah E Edelman.;Scott Otallah.;Alexandra Morgan.;Aniela Grzezulkowska.;John Nguyen.;Lekha M Rao.;Shaina M Hecht.;Laura Catalano.;Hunter Daigle.;Catherine Kronfol.;Jessica Wharton.;David Adams.;Adam Z Kalawi.;Michael Kung.;Janetta L Arellano.;Lauren Smith.;Devorah Segal.;Kristina Feja.;Eileen Broomall.;Anuj Jayakar.;Sandra R Arnold.;Hanna Retallack.;Craig A Press.;Grace Gombolay.;Madeleine H McLaughlin.;Varun Kannan.;Kavita Thakkar.;Tasmia Rezwan.;Erin Hulfish.;Dalia Eid.;Jennifer Meylor.;Diane Peng.;Ryan Hurtado.;Taylor Nickerson.;Iris Mandell.;Abigail U Carbonell.;Mallory Kerner-Rossi.;Divya Jayaraman.;Mallory Davis.;Rosemary Olivero.;Neel Shah.;Christina M Osborne.;Bo Zhang.;Christopher Cortina.;Adrienne G Randolph.;Suchitra Rao.;Thomas LaRocca.;Keith P Van Haren.;Molly Wilson-Murphy.
来源: JAMA. 2025年334卷8期692-701页
Acute necrotizing encephalopathy (ANE) is a rare, but severe, neurologic condition for which epidemiologic and management data remain limited. During the 2024-2025 US influenza season, clinicians at large pediatric centers anecdotally reported an increased number of children with influenza-associated ANE, prompting this national investigation.
1169. Structured vs Self-Guided Multidomain Lifestyle Interventions for Global Cognitive Function: The US POINTER Randomized Clinical Trial.
作者: Laura D Baker.;Mark A Espeland.;Rachel A Whitmer.;Heather M Snyder.;Xiaoyan Leng.;Laura Lovato.;Kathryn V Papp.;Melissa Yu.;Miia Kivipelto.;Ashley S Alexander.;Susan Antkowiak.;Maryjo Cleveland.;Claire Day.;Richard Elbein.;Sarah Tomaszewski Farias.;Deborah Felton.;Katelyn R Garcia.;Darren R Gitelman.;Sarah Graef.;Marjorie Howard.;Jeffrey Katula.;Katherine Lambert.;Olivia Matongo.;Anne Marie McDonald.;Valory Pavlik.;Rema Raman.;Stephen Salloway.;Christy Tangney.;Jennifer Ventrelle.;Sharon Wilmoth.;Benjamin J Willliams.;Rena Wing.;Nancy Woolard.;Maria C Carrillo.
来源: JAMA. 2025年334卷8期681-691页
Identifying new interventions to slow and prevent cognitive decline associated with dementia is critical. Nonpharmacological interventions targeting modifiable risk factors are promising, relatively low-cost, accessible, and safe approaches.
1175. Patent Foramen Ovale and Stroke: A Review.
A patent foramen ovale (PFO), an opening between the right and left atria during normal fetal development that fails to close after birth, is present in approximately 25% of all adults. Paradoxical embolism, a venous thromboembolism that travels to the systemic circulation typically through a PFO, accounts for about 5% of all strokes and 10% of strokes in younger patients.
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