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1161. Stage at Diagnosis Following Delay to Interval Scans for Indeterminate Nodules in Lung Cancer Screening: An Observational Study Examining the Outcomes of CHEST Expert Panel Recommendations.
作者: Andrew W Creamer.;Carolyn Horst.;Jennifer L Dickson.;Sophie Tisi.;Helen Hall.;Priyam Verghese.;Ruth Prendecki.;Amyn Bhamani.;Chuen R Khaw.;John McCabe.;Tanita Limani.;Kylie Gyertson.;Anne-Marie Hacker.;J Teague.;L Farrelly.;Shrinkhala Dawadi.;Allan Hackshaw.;Anand Devaraj.;Arjun Nair.;Sam M Janes.; .
来源: Chest. 2024年165卷4期1020-1024页 1162. Epigenetic Fingerprint of the SARS-CoV-2 Infection in the Lung of Lethal COVID-19.
作者: Aleix Noguera-Castells.;Jerónimo Parra.;Veronica Davalos.;Carlos A García-Prieto.;Yoana Veselinova.;Belén Pérez-Miés.;Tamara Caniego-Casas.;José Palacios.;Xavier Saenz-Sardà.;Elisabet Englund.;Eva Musulen.;Manel Esteller.
来源: Chest. 2024年165卷4期820-824页 1163. Management of Critically Ill Patients Receiving Medications for Opioid Use Disorder.
Critical care clinicians are likely to see an increasing number of patients admitted to the ICU who are receiving US Food and Drug Administration-approved medications for opioid use disorder (MOUDs) given the well-documented benefits of these agents. Oral methadone, multiple formulations of buprenorphine, and extended-release naltrexone are the three types of MOUD most likely to be encountered by ICU clinicians; however, these drugs vary with respect to formulations, pharmacokinetics, and adverse effects.
1164. Access to Lung Cancer Screening Among American Indian and Alaska Native Adults: A Qualitative Study.
作者: Allison C Welch.;Sara M London.;Candice L Wilshire.;Christopher R Gilbert.;Dedra Buchwald.;Gary Ferguson.;Cole Allick.;Jed A Gorden.
来源: Chest. 2024年165卷3期716-724页
Lung cancer is the leading cause of cancer mortality among American Indian and Alaska Native populations. American Indian and Alaska Native people use commercial tobacco products at higher rates compared with all other races and ethnicities. Moreover, they show lower adherence to cancer screening guidelines.
1165. Use and Outcomes of Peripheral Vasopressors in Early Sepsis-Induced Hypotension Across Michigan Hospitals: A Retrospective Cohort Study.
作者: Elizabeth S Munroe.;Megan E Heath.;Mousab Eteer.;Hayley B Gershengorn.;Jennifer K Horowitz.;Jessica Jones.;Scott Kaatz.;Maximiliano Tamae Kakazu.;Elizabeth McLaughlin.;Scott A Flanders.;Hallie C Prescott.
来源: Chest. 2024年165卷4期847-857页
Vasopressors traditionally are administered via central access, but newer data suggest that peripheral administration may be safe and may avoid delays and complications associated with central line placement.
1166. Ozanimod Therapy in Patients With COVID-19 Requiring Oxygen Support: A Randomized Open-Label Pilot Trial.
作者: François Lellouche.;Pascale Blais-Lecours.;François Maltais.;Jean-François Sarrazin.;Philippe Rola.;Tuyen Nguyen.;Nathalie Châteauvert.;David Marsolais.
来源: Chest. 2024年165卷4期810-819页
Sphingosine-1-phosphate receptor ligands (SRLs) dampen immunopathologic damages in models of viral pneumonia.
1167. Etiology-Based Prognosis of Extracorporeal CPR Recipients After Out-of-Hospital Cardiac Arrest: A Retrospective Multicenter Cohort Study.
作者: Toru Takiguchi.;Naoki Tominaga.;Takuro Hamaguchi.;Tomohisa Seki.;Jun Nakata.;Takeshi Yamamoto.;Takashi Tagami.;Akihiko Inoue.;Toru Hifumi.;Tetsuya Sakamoto.;Yasuhiro Kuroda.;Shoji Yokobori.; .
来源: Chest. 2024年165卷4期858-869页
A better understanding of the relative contributions of various factors to patient outcomes is essential for optimal patient selection for extracorporeal CPR (ECPR) therapy for patients with out-of-hospital cardiac arrest (OHCA). However, evidence on the prognostic comparison based on the etiologies of cardiac arrest is limited.
1168. High-Resolution CT Scan Fibrotic Patterns in Stage IV Pulmonary Sarcoidosis: Impact on Pulmonary Function and Survival.
作者: Ogugua Ndili Obi.;Shehabaldin Alqalyoobi.;Veeranna Maddipati.;Elyse E Lower.;Robert P Baughman.
来源: Chest. 2024年165卷4期892-907页
Different patterns of fibrosis on high-resolution CT scans (HRCT) have been associated with reduced survival in some interstitial lung diseases. Nothing is known about HRCT scan patterns and survival in sarcoidosis.
1169. Exploring the Association of Male Sex With Adverse Outcomes in Severe Bronchopulmonary Dysplasia: A Retrospective, Multicenter Cohort Study.
作者: J D Hammond.;Matthew J Kielt.;Sara Conroy.;Krithika Lingappan.;Eric D Austin.;Laurie C Eldredge.;William E Truog.;Steven H Abman.;Leif D Nelin.;Milenka Cuevas Guaman.
来源: Chest. 2024年165卷3期610-620页
Bronchopulmonary dysplasia (BPD) is a significant contributor to morbidity and death in infants who are born premature. Male sex is an independent risk factor for the development of BPD. However, whether male sex is associated with adverse outcomes that occur after formal diagnosis of severe BPD prior to hospital discharge remains unclear.
1170. Associations of Plasma Omega-3 Fatty Acids With Progression and Survival in Pulmonary Fibrosis.
作者: John S Kim.;Shwu-Fan Ma.;Jennie Z Ma.;Yong Huang.;Catherine A Bonham.;Justin M Oldham.;Ayodeji Adegunsoye.;Mary E Strek.;Kevin R Flaherty.;Emma Strickland.;Inemesit Udofia.;Joshua J Mooney.;Shrestha Ghosh.;Krishnarao Maddipati.;Imre Noth.
来源: Chest. 2024年165卷3期621-631页
Preclinical experiments suggest protective effects of omega-3 fatty acids and their metabolites in lung injury and fibrosis. Whether higher intake of omega-3 fatty acids is associated with disease progression and survival in humans with pulmonary fibrosis is unknown.
1171. Individual Risk Factors of PM2.5 Associated With Wintertime Mortality in Urban Patients With COPD.
作者: Jordan Aron.;Arianne K Baldomero.;Austin Rau.;Mark B Fiecas.;Christine H Wendt.;Jesse D Berman.
来源: Chest. 2024年165卷4期825-835页
Air pollution contributes to premature mortality, but potential impacts differ in populations with existing disease, particularly for individuals with multiple risk factors. Although COPD increases vulnerability to air pollution, individuals with COPD and other individual risk factors are at the intersection of multiple risks and may be especially susceptible to the effect of acute outdoor air pollution.
1172. Creation and Validation of a Massive Hemoptysis Simulator.
作者: Melissa L New.;Timothy Amass.;Anna Neumeier.;Nicholas M Jacobson.;Tristan J Huie.
来源: Chest. 2024年165卷3期636-644页
Simulation for the management of massive hemoptysis is limited by the absence of a commercially available simulator to practice procedural skills necessary for management.
1173. Massive Hemoptysis Simulation Curriculum Improves Performance.
Massive hemoptysis is a rare, high-acuity presentation, which requires the integration of both cognitive and procedural skills. Simulation has been recommended to improve preparation for high-acuity, low-occurrence procedures; however, the effect of a simulation curriculum for massive hemoptysis management has never been investigated.
1174. A Deep Learning-Based Radiomic Classifier for Usual Interstitial Pneumonia.
作者: Jonathan H Chung.;Lydia Chelala.;Janelle Vu Pugashetti.;Jennifer M Wang.;Ayodeji Adegunsoye.;Alexander W Matyga.;Lauren Keith.;Kai Ludwig.;Sahar Zafari.;Sahand Ghodrati.;Ahmadreza Ghasemiesfe.;Henry Guo.;Eleanor Soo.;Stephen Lyen.;Charles Sayer.;Charles Hatt.;Justin M Oldham.
来源: Chest. 2024年165卷2期371-380页
Because chest CT scan has largely supplanted surgical lung biopsy for diagnosing most cases of interstitial lung disease (ILD), tools to standardize CT scan interpretation are urgently needed.
1175. The Effect of Pressure Changes During Mechanical Insufflation-Exsufflation on Respiratory and Airway Physiology.
作者: Neeraj M Shah.;Chloe Apps.;Georgios Kaltsakas.;Sophie Madden-Scott.;Eui-Sik Suh.;Rebecca F D'Cruz.;Gill Arbane.;Maxime Patout.;Elodie Lhuillier.;Nicholas Hart.;Patrick B Murphy.
来源: Chest. 2024年165卷4期929-941页
Respiratory muscle weakness can impair cough function, leading to lower respiratory tract infections. These infections are an important contributor to morbidity and mortality in patients with neuromuscular disease. Mechanical insufflation-exsufflation (MIE) is used to augment cough function in these patients. Although MIE is widely used, there are few data to advise on the optimal technique. Since the introduction of MIE, the recommended pressures to be delivered have increased. There are concerns regarding the use of higher pressures and their potential to cause lung derecruitment and upper airway closure.
1176. Legionnaires Disease in Solid Organ Transplant Recipients: A Decade-Long Nationwide Study in France.
作者: Guillaume Thizy.;Adrien Flahault.;Anne Scemla.;Olivier Roux.;Sophie Jarraud.;David Lebeaux.;Jacques Pouchot.;Gabriela Gautier-Vargas.;Paolo Malvezzi.;Marlene Murris.;Fanny Vuotto.;Sophie Girerd.;Nathalie Pansu.;Teresa Antonini.;Laure Elkrief.;Benoit Barrou.;Camille Besch.;Mathieu Blot.;Aude Boignard.;Henri Brenier.;Audrey Coilly.;Corentin Gouezel.;Kaminski Hannah.;Pauline Housssel-Debry.;Jerome Jouan.;Hervé Lecuyer.;Anne Limelette.;Charles Edouard Luyt.;Boris Melloni.;Christophe Pison.;Cédric Rafat.;Jean-Michel Rebibou.;Eric Savier.;Betoul Schvartz.;Olivier Scatton.;Fatouma Toure.;Shaida Varnous.;Pauline Vidal.;Emilie Savoye.;Florence Ader.;Olivier Lortholary.;Fanny Lanternier.;Emmanuel Lafont.
来源: Chest. 2024年165卷3期507-520页
Legionnaires disease (LD) is a rare, life-threatening opportunistic bacterial infection that poses a significant risk to patients with impaired cell-mediated immunity such as solid organ transplant recipients. However, the epidemiologic features, clinical presentation, and outcomes of LD in this population are poorly described.
1177. The Association Between Prepandemic ICU Performance and Mortality Variation in COVID-19: A Multicenter Cohort Study of 35,619 Critically Ill Patients.
作者: Leonardo S L Bastos.;Silvio Hamacher.;Pedro Kurtz.;Otavio T Ranzani.;Fernando G Zampieri.;Marcio Soares.;Fernando A Bozza.;Jorge I F Salluh.
来源: Chest. 2024年165卷4期870-880页
During the COVID-19 pandemic, ICUs remained under stress and observed elevated mortality rates and high variations of outcomes. A knowledge gap exists regarding whether an ICU performing best during nonpandemic times would still perform better when under high pressure compared with the least performing ICUs.
1178. Historic Use of Race-Based Spirometry Values Lowered Transplant Priority for Black Patients.
作者: Daniel Colon Hidalgo.;Kathleen J Ramos.;Emily A Harlan.;Fernando Holguin.;Erick Forno.;Daniel J Weiner.;Matthew F Griffith.
来源: Chest. 2024年165卷2期381-388页
The lung allocation score (LAS) is a tool used to prioritize patients for lung transplantation. For patients with interstitial lung diseases (ILDs), spirometry data are used for the LAS calculation. Spirometry values such as a FVC are subjected to race-specific equations that determine expected values. The effect of race-specific equations in LAS score remains unknown.
1179. Changes in Respiratory Mechanics With Trunk Inclination Differs Between Patients With ARDS With and Without Obesity.
Studies investigating the effect of trunk inclination on respiratory mechanics in mechanically ventilated patients with ARDS have reported postural differences in partition respiratory mechanics. Compared with more upright positions, the supine-flat position provided lower lung and chest wall elastance, allowing reduced driving pressures and end-inspiratory transpulmonary pressure. However, the effect of trunk inclination on respiratory mechanics in patients with obesity and ARDS is uncertain.
1180. External Validation of the BACES Score in Canadian Patients With Nontuberculous Mycobacterial Pulmonary Disease.
作者: Marie Yan.;Brooke Fraser.;Eric McArthur.;Matty Mehrabi.;Sarah K Brode.;Theodore K Marras.
来源: Chest. 2024年165卷3期521-528页
The clinical course of nontuberculous mycobacterial pulmonary disease (NTM-PD) can be variable and difficult to predict. Recently, the BACES score was developed as a tool to predict all-cause mortality in patients with NTM-PD. This score is calculated based on five patient characteristics (BMI, age, cavity, erythrocyte sedimentation rate, and sex), and higher scores portend worse prognosis. Although the BACES score has been validated in a cohort of South Korean patients, it has not yet been validated in other settings or ethnic groups.
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