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1141. Immunogenicity and reactogenicity of alternative schedules of HPV vaccine in Vietnam: a cluster randomized noninferiority trial.
作者: Kathleen M Neuzil.;Do Gia Canh.;Vu Dinh Thiem.;Amynah Janmohamed.;Vu Minh Huong.;Yuxiao Tang.;Nguyen Thi Ngoc Diep.;Vivien Tsu.;D Scott LaMontagne.
来源: JAMA. 2011年305卷14期1424-31页
Human papillomavirus (HPV) vaccine programs may decrease the morbidity and mortality due to cervical cancer seen among women in low-resource countries. However, the 3-dose schedule over a 6-month period is a potential barrier to vaccine introduction in such settings.
1142. Efficacy and safety of a 4-drug fixed-dose combination regimen compared with separate drugs for treatment of pulmonary tuberculosis: the Study C randomized controlled trial.
作者: Christian Lienhardt.;Sharlette V Cook.;Marcos Burgos.;Victoria Yorke-Edwards.;Leen Rigouts.;Gladys Anyo.;Sang-Jae Kim.;Amina Jindani.;Don A Enarson.;Andrew J Nunn.; .
来源: JAMA. 2011年305卷14期1415-23页
Fixed-dose combinations (FDCs) of drugs for treatment of tuberculosis have been advocated to prevent the emergence of drug resistance.
1143. Health outcomes after stopping conjugated equine estrogens among postmenopausal women with prior hysterectomy: a randomized controlled trial.
作者: Andrea Z LaCroix.;Rowan T Chlebowski.;JoAnn E Manson.;Aaron K Aragaki.;Karen C Johnson.;Lisa Martin.;Karen L Margolis.;Marcia L Stefanick.;Robert Brzyski.;J David Curb.;Barbara V Howard.;Cora E Lewis.;Jean Wactawski-Wende.; .
来源: JAMA. 2011年305卷13期1305-14页
The Women's Health Initiative Estrogen-Alone Trial was stopped early after a mean of 7.1 years of follow-up because of an increased risk of stroke and little likelihood of altering the balance of risk to benefit by the planned trial termination date. Postintervention health outcomes have not been reported.
1144. Hydrocortisone therapy for patients with multiple trauma: the randomized controlled HYPOLYTE study.
作者: Antoine Roquilly.;Pierre Joachim Mahe.;Philippe Seguin.;Christophe Guitton.;Hervé Floch.;Anne Charlotte Tellier.;Laurent Merson.;Benoît Renard.;Yannick Malledant.;Laurent Flet.;Véronique Sebille.;Christelle Volteau.;Damien Masson.;Jean Michel Nguyen.;Corinne Lejus.;Karim Asehnoune.
来源: JAMA. 2011年305卷12期1201-9页
The role of stress-dose hydrocortisone in the management of trauma patients is currently unknown.
1145. Standard- vs high-dose clopidogrel based on platelet function testing after percutaneous coronary intervention: the GRAVITAS randomized trial.
作者: Matthew J Price.;Peter B Berger.;Paul S Teirstein.;Jean-François Tanguay.;Dominick J Angiolillo.;Douglas Spriggs.;Sanjeev Puri.;Mark Robbins.;Kirk N Garratt.;Olivier F Bertrand.;Michael E Stillabower.;Joseph R Aragon.;David E Kandzari.;Curtiss T Stinis.;Michael S Lee.;Steven V Manoukian.;Christopher P Cannon.;Nicholas J Schork.;Eric J Topol.; .
来源: JAMA. 2011年305卷11期1097-105页
High platelet reactivity while receiving clopidogrel has been linked to cardiovascular events after percutaneous coronary intervention (PCI), but a treatment strategy for this issue is not well defined.
1146. Nitric oxide for inhalation in the acute treatment of sickle cell pain crisis: a randomized controlled trial.
作者: Mark T Gladwin.;Gregory J Kato.;Debra Weiner.;Onyinye C Onyekwere.;Carlton Dampier.;Lewis Hsu.;R Ward Hagar.;Thomas Howard.;Rachelle Nuss.;Maureen M Okam.;Carole K Tremonti.;Brian Berman.;Anthony Villella.;Lakshmanan Krishnamurti.;Sophie Lanzkron.;Oswaldo Castro.;Victor R Gordeuk.;Wynona A Coles.;Marlene Peters-Lawrence.;James Nichols.;Mary K Hall.;Mariana Hildesheim.;William C Blackwelder.;James Baldassarre.;James F Casella.; .
来源: JAMA. 2011年305卷9期893-902页
Inhaled nitric oxide has shown evidence of efficacy in mouse models of sickle cell disease (SCD), case series of patients with acute chest syndrome, and 2 small placebo-controlled trials for treatment of vaso-occlusive pain crisis (VOC).
1147. Effects of cell phone radiofrequency signal exposure on brain glucose metabolism.
作者: Nora D Volkow.;Dardo Tomasi.;Gene-Jack Wang.;Paul Vaska.;Joanna S Fowler.;Frank Telang.;Dave Alexoff.;Jean Logan.;Christopher Wong.
来源: JAMA. 2011年305卷8期808-13页
The dramatic increase in use of cellular telephones has generated concern about possible negative effects of radiofrequency signals delivered to the brain. However, whether acute cell phone exposure affects the human brain is unclear.
1148. Effect of nitroglycerin ointment on bone density and strength in postmenopausal women: a randomized trial.
作者: Sophie A Jamal.;Celeste J Hamilton.;Richard Eastell.;Steven R Cummings.
来源: JAMA. 2011年305卷8期800-7页
Nitroglycerin stimulates bone formation and inhibits bone resorption, is inexpensive, and is widely available. Its effects on bone density, bone structure, and bone strength are unknown.
1149. Axillary dissection vs no axillary dissection in women with invasive breast cancer and sentinel node metastasis: a randomized clinical trial.
作者: Armando E Giuliano.;Kelly K Hunt.;Karla V Ballman.;Peter D Beitsch.;Pat W Whitworth.;Peter W Blumencranz.;A Marilyn Leitch.;Sukamal Saha.;Linda M McCall.;Monica Morrow.
来源: JAMA. 2011年305卷6期569-75页
Sentinel lymph node dissection (SLND) accurately identifies nodal metastasis of early breast cancer, but it is not clear whether further nodal dissection affects survival.
1150. A multifaceted intervention for quality improvement in a network of intensive care units: a cluster randomized trial.
作者: Damon C Scales.;Katie Dainty.;Brigette Hales.;Ruxandra Pinto.;Robert A Fowler.;Neill K J Adhikari.;Merrick Zwarenstein.
来源: JAMA. 2011年305卷4期363-72页
Evidence-based practices improve intensive care unit (ICU) outcomes, but eligible patients may not receive them. Community hospitals treat most critically ill patients but may have few resources dedicated to quality improvement.
1151. Efficacy of escitalopram for hot flashes in healthy menopausal women: a randomized controlled trial.
作者: Ellen W Freeman.;Katherine A Guthrie.;Bette Caan.;Barbara Sternfeld.;Lee S Cohen.;Hadine Joffe.;Janet S Carpenter.;Garnet L Anderson.;Joseph C Larson.;Kristine E Ensrud.;Susan D Reed.;Katherine M Newton.;Sheryl Sherman.;Mary D Sammel.;Andrea Z LaCroix.
来源: JAMA. 2011年305卷3期267-74页
Concerns regarding the risks associated with estrogen and progesterone to manage menopausal symptoms have resulted in its declining use and increased interest in nonhormonal treatments with demonstrated efficacy for hot flashes.
1152. Radial artery grafts vs saphenous vein grafts in coronary artery bypass surgery: a randomized trial.
作者: Steven Goldman.;Gulshan K Sethi.;William Holman.;Hoang Thai.;Edward McFalls.;Herbert B Ward.;Rosemary F Kelly.;Birger Rhenman.;Gareth H Tobler.;Faisal G Bakaeen.;Joseph Huh.;Ernesto Soltero.;Mohammed Moursi.;Miguel Haime.;Michael Crittenden.;Vigneshwar Kasirajan.;Michelle Ratliff.;Stewart Pett.;Anand Irimpen.;William Gunnar.;Donald Thomas.;Stephen Fremes.;Thomas Moritz.;Domenic Reda.;Lynn Harrison.;Todd H Wagner.;Yajie Wang.;Lori Planting.;Meredith Miller.;Yvette Rodriguez.;Elizabeth Juneman.;Douglass Morrison.;Mary Kaye Pierce.;Sandra Kreamer.;Mei-Chiung Shih.;Kelvin Lee.
来源: JAMA. 2011年305卷2期167-74页
Arterial grafts are thought to be better conduits than saphenous vein grafts for coronary artery bypass grafting (CABG) based on experience with using the left internal mammary artery to bypass the left anterior descending coronary artery. The efficacy of the radial artery graft is less clear.
1153. Behavioral therapy with or without biofeedback and pelvic floor electrical stimulation for persistent postprostatectomy incontinence: a randomized controlled trial.
作者: Patricia S Goode.;Kathryn L Burgio.;Theodore M Johnson.;Olivio J Clay.;David L Roth.;Alayne D Markland.;Jeffrey H Burkhardt.;Muta M Issa.;L Keith Lloyd.
来源: JAMA. 2011年305卷2期151-9页
Although behavioral therapy has been shown to improve postoperative recovery of continence, there have been no controlled trials of behavioral therapy for postprostatectomy incontinence persisting more than 1 year.
1154. Prenatal micronutrient supplementation and intellectual and motor function in early school-aged children in Nepal.
作者: Parul Christian.;Laura E Murray-Kolb.;Subarna K Khatry.;Joanne Katz.;Barbara A Schaefer.;Pamela M Cole.;Steven C Leclerq.;James M Tielsch.
来源: JAMA. 2010年304卷24期2716-23页
Iron and zinc are important for the development of both intellectual and motor skills. Few studies have examined whether iron and zinc supplementation during gestation, a critical period of central nervous system development, affects children's later functioning.
1155. Effect of a lung protective strategy for organ donors on eligibility and availability of lungs for transplantation: a randomized controlled trial.
作者: Luciana Mascia.;Daniela Pasero.;Arthur S Slutsky.;M Jose Arguis.;Maurizio Berardino.;Salvatore Grasso.;Marina Munari.;Silvia Boifava.;Giuseppe Cornara.;Francesco Della Corte.;Nicoletta Vivaldi.;Paolo Malacarne.;Paolo Del Gaudio.;Sergio Livigni.;Elisabeth Zavala.;Claudia Filippini.;Erica L Martin.;Pier Paolo Donadio.;Ilaria Mastromauro.;V Marco Ranieri.
来源: JAMA. 2010年304卷23期2620-7页
Many potential donor lungs deteriorate between the time of brain death and evaluation for transplantation suitability, possibly because of the ventilatory strategy used after brain death.
1156. Weight lifting for women at risk for breast cancer-related lymphedema: a randomized trial.
作者: Kathryn H Schmitz.;Rehana L Ahmed.;Andrea B Troxel.;Andrea Cheville.;Lorita Lewis-Grant.;Rebecca Smith.;Cathy J Bryan.;Catherine T Williams-Smith.;Jesse Chittams.
来源: JAMA. 2010年304卷24期2699-705页
Clinical guidelines for breast cancer survivors without lymphedema advise against upper body exercise, preventing them from obtaining established health benefits of weight lifting.
1157. Integrating tobacco cessation into mental health care for posttraumatic stress disorder: a randomized controlled trial.
作者: Miles McFall.;Andrew J Saxon.;Carol A Malte.;Bruce Chow.;Sara Bailey.;Dewleen G Baker.;Jean C Beckham.;Kathy D Boardman.;Timothy P Carmody.;Anne M Joseph.;Mark W Smith.;Mei-Chiung Shih.;Ying Lu.;Mark Holodniy.;Philip W Lavori.; .
来源: JAMA. 2010年304卷22期2485-93页
Most smokers with mental illness do not receive tobacco cessation treatment.
1158. Effects of aerobic and resistance training on hemoglobin A1c levels in patients with type 2 diabetes: a randomized controlled trial.
作者: Timothy S Church.;Steven N Blair.;Shannon Cocreham.;Neil Johannsen.;William Johnson.;Kimberly Kramer.;Catherine R Mikus.;Valerie Myers.;Melissa Nauta.;Ruben Q Rodarte.;Lauren Sparks.;Angela Thompson.;Conrad P Earnest.
来源: JAMA. 2010年304卷20期2253-62页
Exercise guidelines for individuals with diabetes include both aerobic and resistance training although few studies have directly examined this exercise combination.
1159. Mediastinoscopy vs endosonography for mediastinal nodal staging of lung cancer: a randomized trial.
作者: Jouke T Annema.;Jan P van Meerbeeck.;Robert C Rintoul.;Christophe Dooms.;Ellen Deschepper.;Olaf M Dekkers.;Paul De Leyn.;Jerry Braun.;Nicholas R Carroll.;Marleen Praet.;Frederick de Ryck.;Johan Vansteenkiste.;Frank Vermassen.;Michel I Versteegh.;Maud Veseliç.;Andrew G Nicholson.;Klaus F Rabe.;Kurt G Tournoy.
来源: JAMA. 2010年304卷20期2245-52页
Mediastinal nodal staging is recommended for patients with resectable non-small cell lung cancer (NSCLC). Surgical staging has limitations, which results in the performance of unnecessary thoracotomies. Current guidelines acknowledge minimally invasive endosonography followed by surgical staging (if no nodal metastases are found by endosonography) as an alternative to immediate surgical staging.
1160. Doxorubicin plus sorafenib vs doxorubicin alone in patients with advanced hepatocellular carcinoma: a randomized trial.
作者: Ghassan K Abou-Alfa.;Philip Johnson.;Jennifer J Knox.;Marinela Capanu.;Irina Davidenko.;Juan Lacava.;Thomas Leung.;Bolorsukh Gansukh.;Leonard B Saltz.
来源: JAMA. 2010年304卷19期2154-60页
In a randomized phase 3 trial, 400 mg of sorafenib twice daily prolonged overall survival of patients with advanced hepatocellular carcinoma (HCC) and Child-Pugh A disease. In a phase 1 study, sorafenib combined with doxorubicin, 60 mg/m(2), was well tolerated by patients with refractory solid tumors. The combination of sorafenib and doxorubicin in patients with advanced HCC has not been evaluated in a phase 2 or 3 trial.
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