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1121. Enteral omega-3 fatty acid, gamma-linolenic acid, and antioxidant supplementation in acute lung injury.
作者: Todd W Rice.;Arthur P Wheeler.;B Taylor Thompson.;Bennett P deBoisblanc.;Jay Steingrub.;Peter Rock.; .
来源: JAMA. 2011年306卷14期1574-81页
The omega-3 (n-3) fatty acids docosahexaenoic acid and eicosapentaenoic acid, along with γ-linolenic acid and antioxidants, may modulate systemic inflammatory response and improve oxygenation and outcomes in patients with acute lung injury.
1122. Effect of increasing doses of saw palmetto extract on lower urinary tract symptoms: a randomized trial.
作者: Michael J Barry.;Sreelatha Meleth.;Jeannette Y Lee.;Karl J Kreder.;Andrew L Avins.;J Curtis Nickel.;Claus G Roehrborn.;E David Crawford.;Harris E Foster.;Steven A Kaplan.;Andrew McCullough.;Gerald L Andriole.;Michael J Naslund.;O Dale Williams.;John W Kusek.;Catherine M Meyers.;Joseph M Betz.;Alan Cantor.;Kevin T McVary.; .
来源: JAMA. 2011年306卷12期1344-51页
Saw palmetto fruit extracts are widely used for treating lower urinary tract symptoms attributed to benign prostatic hyperplasia (BPH); however, recent clinical trials have questioned their efficacy, at least at standard doses (320 mg/d).
1123. Cognitive behavior therapy augmentation of pharmacotherapy in pediatric obsessive-compulsive disorder: the Pediatric OCD Treatment Study II (POTS II) randomized controlled trial.
作者: Martin E Franklin.;Jeffrey Sapyta.;Jennifer B Freeman.;Muniya Khanna.;Scott Compton.;Daniel Almirall.;Phoebe Moore.;Molly Choate-Summers.;Abbe Garcia.;Aubrey L Edson.;Edna B Foa.;John S March.
来源: JAMA. 2011年306卷11期1224-32页
The extant literature on the treatment of pediatric obsessive-compulsive disorder (OCD) indicates that partial response to serotonin reuptake inhibitors (SRIs) is the norm and that augmentation with short-term OCD-specific cognitive behavior therapy (CBT) may provide additional benefit.
1124. Intra-aortic balloon counterpulsation and infarct size in patients with acute anterior myocardial infarction without shock: the CRISP AMI randomized trial.
作者: Manesh R Patel.;Richard W Smalling.;Holger Thiele.;Huiman X Barnhart.;Yi Zhou.;Praveen Chandra.;Derek Chew.;Marc Cohen.;John French.;Divaka Perera.;E Magnus Ohman.
来源: JAMA. 2011年306卷12期1329-37页
Intra-aortic balloon counterpulsation (IABC) is an adjunct to revascularization in patients with cardiogenic shock and reduces infarct size when placed prior to reperfusion in animal models.
1125. Effect of a dietary portfolio of cholesterol-lowering foods given at 2 levels of intensity of dietary advice on serum lipids in hyperlipidemia: a randomized controlled trial.
作者: David J A Jenkins.;Peter J H Jones.;Benoit Lamarche.;Cyril W C Kendall.;Dorothea Faulkner.;Luba Cermakova.;Iris Gigleux.;Vanu Ramprasath.;Russell de Souza.;Chris Ireland.;Darshna Patel.;Korbua Srichaikul.;Shahad Abdulnour.;Balachandran Bashyam.;Cheryl Collier.;Sandy Hoshizaki.;Robert G Josse.;Lawrence A Leiter.;Philip W Connelly.;Jiri Frohlich.
来源: JAMA. 2011年306卷8期831-9页
Combining foods with recognized cholesterol-lowering properties (dietary portfolio) has proven highly effective in lowering serum cholesterol under metabolically controlled conditions.
1126. Efficacy and tolerability of pegloticase for the treatment of chronic gout in patients refractory to conventional treatment: two randomized controlled trials.
作者: John S Sundy.;Herbert S B Baraf.;Robert A Yood.;N Lawrence Edwards.;Sergio R Gutierrez-Urena.;Edward L Treadwell.;Janitzia Vázquez-Mellado.;William B White.;Peter E Lipsky.;Zeb Horowitz.;William Huang.;Allan N Maroli.;Royce W Waltrip.;Steven A Hamburger.;Michael A Becker.
来源: JAMA. 2011年306卷7期711-20页
Patients with chronic disabling gout refractory to conventional urate-lowering therapy need timely treatment to control disease manifestations related to tissue urate crystal deposition. Pegloticase, monomethoxypoly(ethylene glycol)-conjugated mammalian recombinant uricase, was developed to fulfill this need.
1127. Community-implemented trauma therapy for former child soldiers in Northern Uganda: a randomized controlled trial.
作者: Verena Ertl.;Anett Pfeiffer.;Elisabeth Schauer.;Thomas Elbert.;Frank Neuner.
来源: JAMA. 2011年306卷5期503-12页
The psychological rehabilitation of former child soldiers and their successful reintegration into postconflict society present challenges. Despite high rates of impairment, there have been no randomized controlled trials examining the feasibility and efficacy of mental health interventions for former child soldiers.
1128. Adjunctive risperidone treatment for antidepressant-resistant symptoms of chronic military service-related PTSD: a randomized trial.
作者: John H Krystal.;Robert A Rosenheck.;Joyce A Cramer.;Jennifer C Vessicchio.;Karen M Jones.;Julia E Vertrees.;Rebecca A Horney.;Grant D Huang.;Christopher Stock.; .
来源: JAMA. 2011年306卷5期493-502页
Serotonin reuptake-inhibiting (SRI) antidepressants are the only FDA-approved pharmacotherapies for the treatment of posttraumatic stress disorder (PTSD).
1129. Effect of the gonadotropin-releasing hormone analogue triptorelin on the occurrence of chemotherapy-induced early menopause in premenopausal women with breast cancer: a randomized trial.
作者: Lucia Del Mastro.;Luca Boni.;Andrea Michelotti.;Teresa Gamucci.;Nina Olmeo.;Stefania Gori.;Monica Giordano.;Ornella Garrone.;Paolo Pronzato.;Claudia Bighin.;Alessia Levaggi.;Sara Giraudi.;Nicola Cresti.;Emanuela Magnolfi.;Tiziana Scotto.;Carlo Vecchio.;Marco Venturini.
来源: JAMA. 2011年306卷3期269-76页
Premenopausal patients with breast cancer are at high risk of premature ovarian failure induced by systemic treatments, but no standard strategies for preventing this adverse effect are yet available.
1130. Effect of bronchoalveolar lavage-directed therapy on Pseudomonas aeruginosa infection and structural lung injury in children with cystic fibrosis: a randomized trial.
作者: Claire E Wainwright.;Suzanna Vidmar.;David S Armstrong.;Catherine A Byrnes.;John B Carlin.;Joyce Cheney.;Peter J Cooper.;Keith Grimwood.;Marj Moodie.;Colin F Robertson.;Harm A Tiddens.; .
来源: JAMA. 2011年306卷2期163-71页
Early pulmonary infection in children with cystic fibrosis leads to increased morbidity and mortality. Despite wide use of oropharyngeal cultures to identify pulmonary infection, concerns remain over their diagnostic accuracy. While bronchoalveolar lavage (BAL) is an alternative diagnostic tool, evidence for its clinical benefit is lacking.
1131. KIT as a therapeutic target in metastatic melanoma.
作者: Richard D Carvajal.;Cristina R Antonescu.;Jedd D Wolchok.;Paul B Chapman.;Ruth-Ann Roman.;Jerrold Teitcher.;Katherine S Panageas.;Klaus J Busam.;Bartosz Chmielowski.;Jose Lutzky.;Anna C Pavlick.;Anne Fusco.;Lauren Cane.;Naoko Takebe.;Swapna Vemula.;Nancy Bouvier.;Boris C Bastian.;Gary K Schwartz.
来源: JAMA. 2011年305卷22期2327-34页
Some melanomas arising from acral, mucosal, and chronically sun-damaged sites harbor activating mutations and amplification of the type III transmembrane receptor tyrosine kinase KIT. We explored the effects of KIT inhibition using imatinib mesylate in this molecular subset of disease.
1132. Effect of screening on ovarian cancer mortality: the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Randomized Controlled Trial.
作者: Saundra S Buys.;Edward Partridge.;Amanda Black.;Christine C Johnson.;Lois Lamerato.;Claudine Isaacs.;Douglas J Reding.;Robert T Greenlee.;Lance A Yokochi.;Bruce Kessel.;E David Crawford.;Timothy R Church.;Gerald L Andriole.;Joel L Weissfeld.;Mona N Fouad.;David Chia.;Barbara O'Brien.;Lawrence R Ragard.;Jonathan D Clapp.;Joshua M Rathmell.;Thomas L Riley.;Patricia Hartge.;Paul F Pinsky.;Claire S Zhu.;Grant Izmirlian.;Barnett S Kramer.;Anthony B Miller.;Jian-Lun Xu.;Philip C Prorok.;John K Gohagan.;Christine D Berg.; .
来源: JAMA. 2011年305卷22期2295-303页
Screening for ovarian cancer with cancer antigen 125 (CA-125) and transvaginal ultrasound has an unknown effect on mortality.
1133. Oral vs intratympanic corticosteroid therapy for idiopathic sudden sensorineural hearing loss: a randomized trial.
作者: Steven D Rauch.;Christopher F Halpin.;Patrick J Antonelli.;Seilesh Babu.;John P Carey.;Bruce J Gantz.;Joel A Goebel.;Paul E Hammerschlag.;Jeffrey P Harris.;Brandon Isaacson.;Daniel Lee.;Christopher J Linstrom.;Lorne S Parnes.;Helen Shi.;William H Slattery.;Steven A Telian.;Jeffrey T Vrabec.;Domenic J Reda.
来源: JAMA. 2011年305卷20期2071-9页
Idiopathic sudden sensorineural hearing loss has been treated with oral corticosteroids for more than 30 years. Recently, many patients' symptoms have been managed with intratympanic steroid therapy. No satisfactory comparative effectiveness study to support this practice exists.
1134. Effects of vitamin A or beta carotene supplementation on pregnancy-related mortality and infant mortality in rural Bangladesh: a cluster randomized trial.
作者: Keith P West.;Parul Christian.;Alain B Labrique.;Mahbubur Rashid.;Abu Ahmed Shamim.;Rolf D W Klemm.;Allan B Massie.;Sucheta Mehra.;Kerry J Schulze.;Hasmot Ali.;Barkat Ullah.;Lee S F Wu.;Joanne Katz.;Hashina Banu.;Halida H Akhter.;Alfred Sommer.
来源: JAMA. 2011年305卷19期1986-95页
Maternal vitamin A deficiency is a public health concern in the developing world. Its prevention may improve maternal and infant survival.
1135. Laparoscopic antireflux surgery vs esomeprazole treatment for chronic GERD: the LOTUS randomized clinical trial.
作者: Jean-Paul Galmiche.;Jan Hatlebakk.;Stephen Attwood.;Christian Ell.;Roberto Fiocca.;Stefan Eklund.;Göran Långström.;Tore Lind.;Lars Lundell.; .
来源: JAMA. 2011年305卷19期1969-77页
Gastroesophageal reflux disease (GERD) is a chronic, relapsing disease with symptoms that have negative effects on daily life. Two treatment options are long-term medication or surgery.
1136. Intravenous erythropoietin in patients with ST-segment elevation myocardial infarction: REVEAL: a randomized controlled trial.
作者: Samer S Najjar.;Sunil V Rao.;Chiara Melloni.;Subha V Raman.;Thomas J Povsic.;Laura Melton.;Gregory W Barsness.;Kristi Prather.;John F Heitner.;Rakhi Kilaru.;Luis Gruberg.;Vic Hasselblad.;Adam B Greenbaum.;Manesh Patel.;Raymond J Kim.;Mark Talan.;Luigi Ferrucci.;Dan L Longo.;Edward G Lakatta.;Robert A Harrington.; .
来源: JAMA. 2011年305卷18期1863-72页
Acute ST-segment elevation myocardial infarction (STEMI) is a leading cause of morbidity and mortality. In experimental models of MI, erythropoietin reduces infarct size and improves left ventricular (LV) function.
1137. Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: the TONIC randomized controlled trial.
作者: Joel E Lavine.;Jeffrey B Schwimmer.;Mark L Van Natta.;Jean P Molleston.;Karen F Murray.;Philip Rosenthal.;Stephanie H Abrams.;Ann O Scheimann.;Arun J Sanyal.;Naga Chalasani.;James Tonascia.;Aynur Ünalp.;Jeanne M Clark.;Elizabeth M Brunt.;David E Kleiner.;Jay H Hoofnagle.;Patricia R Robuck.; .
来源: JAMA. 2011年305卷16期1659-68页
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in US children and adolescents and can present with advanced fibrosis or nonalcoholic steatohepatitis (NASH). No treatment has been established.
1138. Safety and immunogenicity of 4 intramuscular double doses and 4 intradermal low doses vs standard hepatitis B vaccine regimen in adults with HIV-1: a randomized controlled trial.
作者: Odile Launay.;Diane van der Vliet.;Arielle R Rosenberg.;Marie-Louise Michel.;Lionel Piroth.;David Rey.;Nathalie Colin de Verdière.;Laurence Slama.;Karine Martin.;Olivier Lortholary.;Fabrice Carrat.; .
来源: JAMA. 2011年305卷14期1432-40页
Alternative schedules more immunogenic than the standard hepatitis B vaccine regimen are needed in patients with human immunodeficiency virus 1 (HIV-1) infection.
1139. Immunogenicity and reactogenicity of alternative schedules of HPV vaccine in Vietnam: a cluster randomized noninferiority trial.
作者: Kathleen M Neuzil.;Do Gia Canh.;Vu Dinh Thiem.;Amynah Janmohamed.;Vu Minh Huong.;Yuxiao Tang.;Nguyen Thi Ngoc Diep.;Vivien Tsu.;D Scott LaMontagne.
来源: JAMA. 2011年305卷14期1424-31页
Human papillomavirus (HPV) vaccine programs may decrease the morbidity and mortality due to cervical cancer seen among women in low-resource countries. However, the 3-dose schedule over a 6-month period is a potential barrier to vaccine introduction in such settings.
1140. Efficacy and safety of a 4-drug fixed-dose combination regimen compared with separate drugs for treatment of pulmonary tuberculosis: the Study C randomized controlled trial.
作者: Christian Lienhardt.;Sharlette V Cook.;Marcos Burgos.;Victoria Yorke-Edwards.;Leen Rigouts.;Gladys Anyo.;Sang-Jae Kim.;Amina Jindani.;Don A Enarson.;Andrew J Nunn.; .
来源: JAMA. 2011年305卷14期1415-23页
Fixed-dose combinations (FDCs) of drugs for treatment of tuberculosis have been advocated to prevent the emergence of drug resistance.
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