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1061. Appendicitis: should diagnostic imaging be performed if the clinical presentation is highly suggestive of the disease?
作者: Thomas Rettenbacher.;Alois Hollerweger.;Norbert Gritzmann.;Thaddaeus Gotwald.;Klaus Schwamberger.;Hanno Ulmer.;Dieter Zur Nedden.
来源: Gastroenterology. 2002年123卷4期992-8页
Our aim was to investigate whether diagnostic imaging is required if the clinical presentation suggests acute appendicitis with high probability.
1062. Budesonide treatment for collagenous colitis: a randomized, double-blind, placebo-controlled, multicenter trial.
作者: Stephan Miehlke.;Peter Heymer.;Birgit Bethke.;Elke Bästlein.;Eberhard Meier.;Hans-Peter Bartram.;Günther Wilhelms.;Norbert Lehn.;Gian Dorta.;Joachim DeLarive.;Andreas Tromm.;Ekkehard Bayerdörffer.;Manfred Stolte.
来源: Gastroenterology. 2002年123卷4期978-84页
Collagenous colitis is an idiopathic microscopic colitis characterized by chronic watery diarrhea, a typical subepithelial collagen layer, and lymphoplasmacellular infiltration. We investigated the effect of budesonide on symptoms and histology in patients with collagenous colitis in a randomized, double-blind, placebo-controlled multicenter trial.
1063. Condition-specific deactivation of brain regions by 5-HT3 receptor antagonist Alosetron.
作者: Steven M Berman.;Lin Chang.;Brandall Suyenobu.;Stuart W Derbyshire.;Jean Stains.;Leah Fitzgerald.;Mark Mandelkern.;Lynn Hamm.;Brent Vogt.;Bruce D Naliboff.;Emeran A Mayer.
来源: Gastroenterology. 2002年123卷4期969-77页
The 5-HT3 receptor (5-HT3R) antagonist Alosetron (Alos) reduces the symptoms of female patients with diarrhea-predominant irritable bowel syndrome (IBS); yet, the mechanism(s) underlying this effect remains incompletely understood. We determined the effect of Alos on regional cerebral blood flow (rCBF) in the absence and presence of rectal or sigmoid stimulation to evaluate 2 hypothesized mechanisms of therapeutic action: peripheral antinociception and inhibition of emotional motor system (EMS) regions in the brain.
1064. Primary prophylaxis of variceal hemorrhage: a randomized controlled trial comparing band ligation, propranolol, and isosorbide mononitrate.
作者: Hock F Lui.;Adrian J Stanley.;Ewan H Forrest.;Rajiv Jalan.;W Stuart Hislop.;Peter R Mills.;Niall D C Finlayson.;Alastair J Macgilchrist.;Peter C Hayes.
来源: Gastroenterology. 2002年123卷3期735-44页
This randomized controlled trial compared variceal band ligation (VBL), propranolol (PPL), and isosorbide-5-mononitrate (ISMN) in the prevention of first esophageal variceal bleed.
1065. Banding ligation versus nadolol and isosorbide mononitrate for the prevention of esophageal variceal rebleeding.
作者: Gin-Ho Lo.;Wen-Chi Chen.;Mei-Hsiu Chen.;Ping-I Hsu.;Chiun-Ku Lin.;Wei-Lun Tsai.;Kwok-Hung Lai.
来源: Gastroenterology. 2002年123卷3期728-34页
beta-blockers and banding ligation are effective in the prevention of variceal rebleeding. However, the relative efficacy and safety remains unresolved.
1066. Lipid-induced intestinal gas retention in irritable bowel syndrome.
作者: Jordi Serra.;Beatrice Salvioli.;Fernando Azpiroz.;Juan-R Malagelada.
来源: Gastroenterology. 2002年123卷3期700-6页
We hypothesized that lipids, which induce various motor and sensory effects on the gut, modulate intestinal gas dynamics and that alteration of this regulatory mechanism may result in impaired gas transit in patients with irritable bowel syndrome (IBS).
1067. Randomized trial of medical or endoscopic therapy to prevent recurrent ulcer hemorrhage in patients with adherent clots.
作者: Dennis M Jensen.;Thomas O G Kovacs.;Rome Jutabha.;Gustavo A Machicado.;Ian M Gralnek.;Thomas J Savides.;James Smith.;Mary Ellen Jensen.;Gwen Alofaituli.;Jeff Gornbein.
来源: Gastroenterology. 2002年123卷2期407-13页
Treatment of high-risk patients with nonbleeding adherent clots on ulcers is controversial. In a previous randomized trial, there was no benefit to endoscopic therapies compared with medical therapy for prevention of ulcer rebleeding. Our purpose was to test the hypothesis that patients treated with combination endoscopic therapy would have significantly lower rebleeding rates than those treated with medical therapy.
1068. Safety and efficacy of recombinant factor VIIa in patients with liver disease undergoing laparoscopic liver biopsy.
作者: Lennox Jeffers.;Naga Chalasani.;Luis Balart.;Nikolaos Pyrsopoulos.;Elisabeth Erhardtsen.
来源: Gastroenterology. 2002年123卷1期118-26页
Activated recombinant factor VII (rFVIIa) has been shown to be effective in correcting prolonged prothrombin time (PT) in cirrhotic patients. The main objective of this study was to evaluate the effect of 4 (5, 20, 80, and 120 microg/kg) doses of rFVIIa on correction of PT and the time to achieve hemostasis in cirrhotic patients with coagulopathy who are undergoing laparoscopic liver biopsy.
1069. Rofecoxib inhibits cyclooxygenase 2 expression and activity and reduces cell proliferation in Barrett's esophagus.
作者: Baljeet S Kaur.;Niloufar Khamnehei.;Mohamed Iravani.;Sai S Namburu.;Otto Lin.;George Triadafilopoulos.
来源: Gastroenterology. 2002年123卷1期60-7页
Cyclooxygenase 2 (COX-2) is overexpressed in Barrett's esophagus and adenocarcinoma and up-regulated by acid or bile salt exposure. COX-2 inhibition with the selective inhibitor rofecoxib may be important in chemoprevention of esophageal adenocarcinoma by decreasing cell proliferation.
1070. Ileal losses of nitrogen and amino acids in humans and their importance to the assessment of amino acid requirements.
作者: Claire Gaudichon.;Cécile Bos.;Céline Morens.;Klaus J Petzke.;François Mariotti.;Julia Everwand.;Robert Benamouzig.;Sophie Daré.;Daniel Tomé.;Cornelia C Metges.
来源: Gastroenterology. 2002年123卷1期50-9页
Irreversible amino acid losses at the human ileum are not taken into account when tracer-derived amino acid requirements are calculated because the data available are scarce. We have investigated amino acid losses at the ileal level in humans after ingestion of a protein meal.
1071. Combined budesonide and antibiotic therapy for active Crohn's disease: a randomized controlled trial.
作者: A Hillary Steinhart.;Brian G Feagan.;Cindy J Wong.;Margaret Vandervoort.;Shelley Mikolainis.;Kenneth Croitoru.;Ernest Seidman.;Desmond J Leddin.;Alain Bitton.;Eric Drouin.;Albert Cohen.;Gordon R Greenberg.
来源: Gastroenterology. 2002年123卷1期33-40页
Although antibiotics are frequently used to treat Crohn's disease, this practice is not supported by strong evidence from randomized trials.
1072. Erythromycin intravenous bolus infusion in acute upper gastrointestinal bleeding: a randomized, controlled, double-blind trial.
作者: Jean Louis Frossard.;Laurent Spahr.;Pierre Edouard Queneau.;Emiliano Giostra.;Beat Burckhardt.;Gaëlle Ory.;Philippe De Saussure.;Berj Armenian.;Raymond De Peyer.;Antoine Hadengue.
来源: Gastroenterology. 2002年123卷1期17-23页
Emergency endoscopy may be difficult in upper gastrointestinal bleeding when blood obscures the visibility. Erythromycin, a motilin agonist, induces gastric emptying. We investigated whether an intravenous bolus infusion of erythromycin would improve the yield of endoscopy in these patients.
1073. Gastroenterologist-administered propofol versus meperidine and midazolam for advanced upper endoscopy: a prospective, randomized trial.
作者: John J Vargo.;Gregory Zuccaro.;John A Dumot.;Kenneth M Shermock.;J Brad Morrow.;Darwin L Conwell.;Patricia A Trolli.;Walter G Maurer.
来源: Gastroenterology. 2002年123卷1期8-16页
Propofol is increasingly used for gastrointestinal endoscopy because of its rapid recovery profile. There has been no prospective, randomized comparison of gastroenterologist-administered propofol to meperidine and midazolam for endoscopic retrograde cholangiopancreatography and endoscopic ultrasonography. Additionally, its cost-effectiveness has not been studied.
1074. A randomized controlled trial of preoperative oral supplementation with a specialized diet in patients with gastrointestinal cancer.
作者: Luca Gianotti.;Marco Braga.;Luca Nespoli.;Giovanni Radaelli.;Aldo Beneduce.;Valerio Di Carlo.
来源: Gastroenterology. 2002年122卷7期1763-70页
Perioperative nutrition with specialized enteral diets improves outcome when compared with standard formulas. A post-hoc analysis suggested preoperative administration as the most important period. Thus, we designed a study to understand prospectively whether preoperative supplementation could be as efficacious as the perioperative approach and superior to a conventional treatment (no artificial nutrition) in reducing postoperative infections and length of hospital stay.
1075. Prokinetic effects in patients with intestinal gas retention.
作者: Maria Pía Caldarella.;Jordi Serra.;Fernando Azpiroz.;Juan-Ramon Malagelada.
来源: Gastroenterology. 2002年122卷7期1748-55页
We have previously shown that patients with irritable bowel syndrome (IBS) have impaired transit of intestinal gas loads. Because abnormal gas retention can be experimentally reproduced in healthy subjects by pharmacological inhibition of gut motility, we hypothesized that impaired gas transit and retention can be reciprocally corrected by pharmacologically stimulating intestinal propulsion.
1076. Rehabilitation of swallowing by exercise in tube-fed patients with pharyngeal dysphagia secondary to abnormal UES opening.
作者: Reza Shaker.;Caryn Easterling.;Mark Kern.;Terilynn Nitschke.;Benson Massey.;Stephanie Daniels.;Barbara Grande.;Marta Kazandjian.;Karen Dikeman.
来源: Gastroenterology. 2002年122卷5期1314-21页
We evaluated the effect of a novel rehabilitative exercise on restoration of deglutition in a group of patients with deglutitive failure caused by abnormal upper esophageal sphincter (UES) opening manifested by postswallow residue and aspiration necessitating percutaneous tube feeding.
1077. Effects of long-term propranolol and octreotide on postprandial hemodynamics in cirrhosis: a randomized, controlled trial.
作者: Julio D Vorobioff.;Marcelo Gamen.;David Kravetz.;Eduardo Picabea.;Roberto Villavicencio.;Juan Bordato.;Andrés Ruf.;Fernando Bessone.;Gustavo Romero.;Jorge Palazzi.;Alicia Nicora.;María Passamonti.;Hugo Tanno.
来源: Gastroenterology. 2002年122卷4期916-22页
Postprandial increases in portal pressure may influence esophageal variceal rupture. The effects of chronic propranolol and octreotide (100 and 200 microg subcutaneously in a single dose) on postprandial hemodynamics were evaluated.
1078. 6-MP metabolite profiles provide a biochemical explanation for 6-MP resistance in patients with inflammatory bowel disease.
作者: Marla C Dubinsky.;Huiying Yang.;Philip V Hassard.;Ernest G Seidman.;Lori Y Kam.;Maria T Abreu.;Stephan R Targan.;Eric A Vasiliauskas.
来源: Gastroenterology. 2002年122卷4期904-15页
Approximately 40% of inflammatory bowel disease (IBD) patients fail to benefit from 6-mercaptopurine (6-MP)/azathioprine (AZA). Recent reports suggest 6-thioguanine nucleotide (6-TGN) levels (>235) independently correlate with remission. An inverse correlation between 6-TGN and thiopurine methyltransferase (TPMT) has been described. The objectives of this study were to determine whether dose escalation optimizes both 6-TGN levels and efficacy in patients failing therapy because of subtherapeutic 6-TGN levels and its effect on TPMT.
1080. Long-term treatment with sulindac in familial adenomatous polyposis: a prospective cohort study.
作者: Marcia Cruz-Correa.;Linda M Hylind.;Katherine E Romans.;Susan V Booker.;Francis M Giardiello.
来源: Gastroenterology. 2002年122卷3期641-5页
Management of patients with familial adenomatous polyposis (FAP) can consist of colectomy with ileorectal anastomosis (IRA). Sulindac, a nonsteroidal anti-inflammatory drug, causes regression of colorectal adenomas in the retained rectal segment of FAP patients, although long-term use of this therapy has not been studied. We evaluated the long-term effectiveness and toxicity of sulindac in attempting to maintain retained rectal segments free of adenomas.
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