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1021. Effect of long-term, low-dose erythromycin on pulmonary exacerbations among patients with non-cystic fibrosis bronchiectasis: the BLESS randomized controlled trial.
作者: David J Serisier.;Megan L Martin.;Michael A McGuckin.;Rohan Lourie.;Alice C Chen.;Barbara Brain.;Sally Biga.;Sanmarié Schlebusch.;Peter Dash.;Simon D Bowler.
来源: JAMA. 2013年309卷12期1260-7页
Macrolide antibiotics such as erythromycin may improve clinical outcomes in non-cystic fibrosis (CF) bronchiectasis, although associated risks of macrolide resistance are poorly defined.
1022. Effect of azithromycin maintenance treatment on infectious exacerbations among patients with non-cystic fibrosis bronchiectasis: the BAT randomized controlled trial.
作者: Josje Altenburg.;Casper S de Graaff.;Ymkje Stienstra.;Jacobus H Sloos.;Eric H J van Haren.;Ralph J H Koppers.;Tjip S van der Werf.;Wim G Boersma.
来源: JAMA. 2013年309卷12期1251-9页
Macrolide antibiotics have been shown beneficial in cystic fibrosis (CF) and diffuse panbronchiolitis, and earlier findings also suggest a benefit in non-CF bronchiectasis.
1023. Effect of disodium EDTA chelation regimen on cardiovascular events in patients with previous myocardial infarction: the TACT randomized trial.
作者: Gervasio A Lamas.;Christine Goertz.;Robin Boineau.;Daniel B Mark.;Theodore Rozema.;Richard L Nahin.;Lauren Lindblad.;Eldrin F Lewis.;Jeanne Drisko.;Kerry L Lee.; .
来源: JAMA. 2013年309卷12期1241-50页
Chelation therapy with disodium EDTA has been used for more than 50 years to treat atherosclerosis without proof of efficacy.
1024. Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: the ACCESS randomized trial.
作者: Steven M Opal.;Pierre-Francois Laterre.;Bruno Francois.;Steven P LaRosa.;Derek C Angus.;Jean-Paul Mira.;Xavier Wittebole.;Thierry Dugernier.;Dominique Perrotin.;Mark Tidswell.;Luis Jauregui.;Kenneth Krell.;Jan Pachl.;Takeshi Takahashi.;Claus Peckelsen.;Edward Cordasco.;Chia-Sheng Chang.;Sandra Oeyen.;Naoki Aikawa.;Tatsuya Maruyama.;Roland Schein.;Andre C Kalil.;Marc Van Nuffelen.;Melvyn Lynn.;Daniel P Rossignol.;Jogadish Gogate.;Mary B Roberts.;Janice L Wheeler.;Jean-Louis Vincent.; .
来源: JAMA. 2013年309卷11期1154-62页
Eritoran is a synthetic lipid A antagonist that blocks lipopolysaccharide (LPS) from binding at the cell surface MD2-TLR4 receptor. LPS is a major component of the outer membrane of gram-negative bacteria and is a potent activator of the acute inflammatory response.
1025. Effects of promoting longer-term and exclusive breastfeeding on adiposity and insulin-like growth factor-I at age 11.5 years: a randomized trial.
作者: Richard M Martin.;Rita Patel.;Michael S Kramer.;Lauren Guthrie.;Konstantin Vilchuck.;Natalia Bogdanovich.;Natalia Sergeichick.;Nina Gusina.;Ying Foo.;Tom Palmer.;Sheryl L Rifas-Shiman.;Matthew W Gillman.;George Davey Smith.;Emily Oken.
来源: JAMA. 2013年309卷10期1005-13页
Evidence that longer-term and exclusive breastfeeding reduces child obesity risk is based on observational studies that are prone to confounding.
1026. Primary care vs specialist sleep center management of obstructive sleep apnea and daytime sleepiness and quality of life: a randomized trial.
作者: Ching Li Chai-Coetzer.;Nick A Antic.;L Sharn Rowland.;Richard L Reed.;Adrian Esterman.;Peter G Catcheside.;Simon Eckermann.;Norman Vowles.;Helena Williams.;Sandra Dunn.;R Doug McEvoy.
来源: JAMA. 2013年309卷10期997-1004页
Due to increasing demand for sleep services, there has been growing interest in ambulatory models of care for patients with obstructive sleep apnea. With appropriate training and simplified management tools, primary care physicians are ideally positioned to take on a greater role in diagnosis and treatment.
1027. Effect of aliskiren on postdischarge mortality and heart failure readmissions among patients hospitalized for heart failure: the ASTRONAUT randomized trial.
作者: Mihai Gheorghiade.;Michael Böhm.;Stephen J Greene.;Gregg C Fonarow.;Eldrin F Lewis.;Faiez Zannad.;Scott D Solomon.;Fabio Baschiera.;Jaco Botha.;Tsushung A Hua.;Claudio R Gimpelewicz.;Xavier Jaumont.;Anastasia Lesogor.;Aldo P Maggioni.; .
来源: JAMA. 2013年309卷11期1125-35页
Hospitalizations for heart failure (HHF) represent a major health burden, with high rates of early postdischarge rehospitalization and mortality.
1028. Effect of phosphodiesterase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction: a randomized clinical trial.
作者: Margaret M Redfield.;Horng H Chen.;Barry A Borlaug.;Marc J Semigran.;Kerry L Lee.;Gregory Lewis.;Martin M LeWinter.;Jean L Rouleau.;David A Bull.;Douglas L Mann.;Anita Deswal.;Lynne W Stevenson.;Michael M Givertz.;Elizabeth O Ofili.;Christopher M O'Connor.;G Michael Felker.;Steven R Goldsmith.;Bradley A Bart.;Steven E McNulty.;Jenny C Ibarra.;Grace Lin.;Jae K Oh.;Manesh R Patel.;Raymond J Kim.;Russell P Tracy.;Eric J Velazquez.;Kevin J Anstrom.;Adrian F Hernandez.;Alice M Mascette.;Eugene Braunwald.; .
来源: JAMA. 2013年309卷12期1268-77页
Studies in experimental and human heart failure suggest that phosphodiesterase-5 inhibitors may enhance cardiovascular function and thus exercise capacity in heart failure with preserved ejection fraction (HFPEF).
1029. Effect of spironolactone on diastolic function and exercise capacity in patients with heart failure with preserved ejection fraction: the Aldo-DHF randomized controlled trial.
作者: Frank Edelmann.;Rolf Wachter.;Albrecht G Schmidt.;Elisabeth Kraigher-Krainer.;Caterina Colantonio.;Wolfram Kamke.;André Duvinage.;Raoul Stahrenberg.;Kathleen Durstewitz.;Markus Löffler.;Hans-Dirk Düngen.;Carsten Tschöpe.;Christoph Herrmann-Lingen.;Martin Halle.;Gerd Hasenfuss.;Götz Gelbrich.;Burkert Pieske.; .
来源: JAMA. 2013年309卷8期781-91页
Diastolic heart failure (ie, heart failure with preserved ejection fraction) is a common condition without established therapy, and aldosterone stimulation may contribute to its progression.
1030. Association between telomere length and experimentally induced upper respiratory viral infection in healthy adults.
作者: Sheldon Cohen.;Denise Janicki-Deverts.;Ronald B Turner.;Margaretha L Casselbrant.;Ha-Sheng Li-Korotky.;Elissa S Epel.;William J Doyle.
来源: JAMA. 2013年309卷7期699-705页
Although leukocyte telomere length is associated with mortality and many chronic diseases thought to be manifestations of age-related functional decline, it is not known whether it relates to acute disease in younger healthy populations.
1031. Risk of recurrent Helicobacter pylori infection 1 year after initial eradication therapy in 7 Latin American communities.
作者: Douglas R Morgan.;Javier Torres.;Rachael Sexton.;Rolando Herrero.;Eduardo Salazar-Martínez.;E Robert Greenberg.;Luis Eduardo Bravo.;Ricardo L Dominguez.;Catterina Ferreccio.;Eduardo C Lazcano-Ponce.;Maria Mercedes Meza-Montenegro.;Edgar M Peña.;Rodolfo Peña.;Pelayo Correa.;María Elena Martínez.;William D Chey.;Manuel Valdivieso.;Garnet L Anderson.;Gary E Goodman.;John J Crowley.;Laurence H Baker.
来源: JAMA. 2013年309卷6期578-86页
The long-term effectiveness of Helicobacter pylori eradication programs for preventing gastric cancer will depend on recurrence risk and individual and community factors.
1032. Tedizolid phosphate vs linezolid for treatment of acute bacterial skin and skin structure infections: the ESTABLISH-1 randomized trial.
作者: Philippe Prokocimer.;Carisa De Anda.;Edward Fang.;Purvi Mehra.;Anita Das.
来源: JAMA. 2013年309卷6期559-69页
Acute bacterial skin and skin structure infections (ABSSSIs), including cellulitis or erysipelas, major cutaneous abscesses, and wound infections, can be life-threatening and may require surgery and hospitalization. Increasingly, ABSSSIs are associated with drug-resistant pathogens, and many antimicrobial agents have adverse effects restricting their use. Tedizolid phosphate is a novel oxazolidinone in development for the treatment of ABSSSIs.
1033. Effect of corticosteroid injection, physiotherapy, or both on clinical outcomes in patients with unilateral lateral epicondylalgia: a randomized controlled trial.
作者: Brooke K Coombes.;Leanne Bisset.;Peter Brooks.;Asad Khan.;Bill Vicenzino.
来源: JAMA. 2013年309卷5期461-9页
Corticosteroid injection and physiotherapy, common treatments for lateral epicondylalgia, are frequently combined in clinical practice. However, evidence on their combined efficacy is lacking.
1034. Effect of ramipril on walking times and quality of life among patients with peripheral artery disease and intermittent claudication: a randomized controlled trial.
作者: Anna A Ahimastos.;Philip J Walker.;Christopher Askew.;Anthony Leicht.;Elise Pappas.;Peter Blombery.;Christopher M Reid.;Jonathan Golledge.;Bronwyn A Kingwell.
来源: JAMA. 2013年309卷5期453-60页
Approximately one-third of patients with peripheral artery disease experience intermittent claudication, with consequent loss of quality of life.
1035. Effect of pressure support vs unassisted breathing through a tracheostomy collar on weaning duration in patients requiring prolonged mechanical ventilation: a randomized trial.
作者: Amal Jubran.;Brydon J B Grant.;Lisa A Duffner.;Eileen G Collins.;Dorothy M Lanuza.;Leslie A Hoffman.;Martin J Tobin.
来源: JAMA. 2013年309卷7期671-7页
Patients requiring prolonged mechanical ventilation (>21 days) are commonly weaned at long-term acute care hospitals (LTACHs). The most effective method of weaning such patients has not been investigated.
1036. Effect of not monitoring residual gastric volume on risk of ventilator-associated pneumonia in adults receiving mechanical ventilation and early enteral feeding: a randomized controlled trial.
作者: Jean Reignier.;Emmanuelle Mercier.;Amelie Le Gouge.;Thierry Boulain.;Arnaud Desachy.;Frederic Bellec.;Marc Clavel.;Jean-Pierre Frat.;Gaetan Plantefeve.;Jean-Pierre Quenot.;Jean-Baptiste Lascarrou.; .
来源: JAMA. 2013年309卷3期249-56页
Monitoring of residual gastric volume is recommended to prevent ventilator-associated pneumonia (VAP) in patients receiving early enteral nutrition. However, studies have challenged the reliability and effectiveness of this measure.
1037. Effect of vitamin D supplementation on progression of knee pain and cartilage volume loss in patients with symptomatic osteoarthritis: a randomized controlled trial.
作者: Timothy McAlindon.;Michael LaValley.;Erica Schneider.;Melynn Nuite.;Ji Yeon Lee.;Lori Lyn Price.;Grace Lo.;Bess Dawson-Hughes.
来源: JAMA. 2013年309卷2期155-62页
Knee osteoarthritis (OA), a disorder of cartilage and periarticular bone, is a public health problem without effective medical treatments. Some studies have suggested that vitamin D may protect against structural progression.
1038. Effect of intravenous paracetamol on postoperative morphine requirements in neonates and infants undergoing major noncardiac surgery: a randomized controlled trial.
作者: Ilse Ceelie.;Saskia N de Wildt.;Monique van Dijk.;Margreeth M J van den Berg.;Gerbrich E van den Bosch.;Hugo J Duivenvoorden.;Tom G de Leeuw.;Ron Mathôt.;Catherijne A J Knibbe.;Dick Tibboel.
来源: JAMA. 2013年309卷2期149-54页
Continuous morphine infusion as standard postoperative analgesic therapy in young infants is associated with unwanted adverse effects such as respiratory depression.
1039. Association of an intensive lifestyle intervention with remission of type 2 diabetes.
作者: Edward W Gregg.;Haiying Chen.;Lynne E Wagenknecht.;Jeanne M Clark.;Linda M Delahanty.;John Bantle.;Henry J Pownall.;Karen C Johnson.;Monika M Safford.;Abbas E Kitabchi.;F Xavier Pi-Sunyer.;Rena R Wing.;Alain G Bertoni.; .
来源: JAMA. 2012年308卷23期2489-96页
The frequency of remission of type 2 diabetes achievable with lifestyle intervention is unclear.
1040. Effects of fructose vs glucose on regional cerebral blood flow in brain regions involved with appetite and reward pathways.
作者: Kathleen A Page.;Owen Chan.;Jagriti Arora.;Renata Belfort-Deaguiar.;James Dzuira.;Brian Roehmholdt.;Gary W Cline.;Sarita Naik.;Rajita Sinha.;R Todd Constable.;Robert S Sherwin.
来源: JAMA. 2013年309卷1期63-70页
Increases in fructose consumption have paralleled the increasing prevalence of obesity, and high-fructose diets are thought to promote weight gain and insulin resistance. Fructose ingestion produces smaller increases in circulating satiety hormones compared with glucose ingestion, and central administration of fructose provokes feeding in rodents, whereas centrally administered glucose promotes satiety.
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