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1001. Effect of soy protein isolate supplementation on biochemical recurrence of prostate cancer after radical prostatectomy: a randomized trial.
作者: Maarten C Bosland.;Ikuko Kato.;Anne Zeleniuch-Jacquotte.;Joanne Schmoll.;Erika Enk Rueter.;Jonathan Melamed.;Max Xiangtian Kong.;Virgilia Macias.;Andre Kajdacsy-Balla.;L H Lumey.;Hui Xie.;Weihua Gao.;Paul Walden.;Herbert Lepor.;Samir S Taneja.;Carla Randolph.;Michael J Schlicht.;Hiroko Meserve-Watanabe.;Ryan J Deaton.;Joanne A Davies.
来源: JAMA. 2013年310卷2期170-8页
Soy consumption has been suggested to reduce risk or recurrence of prostate cancer, but this has not been tested in a randomized trial with prostate cancer as the end point.
1002. Natriuretic peptide-based screening and collaborative care for heart failure: the STOP-HF randomized trial.
作者: Mark Ledwidge.;Joseph Gallagher.;Carmel Conlon.;Elaine Tallon.;Eoin O'Connell.;Ian Dawkins.;Chris Watson.;Rory O'Hanlon.;Margaret Bermingham.;Anil Patle.;Mallikarjuna R Badabhagni.;Gillian Murtagh.;Victor Voon.;Leslie Tilson.;Michael Barry.;Laura McDonald.;Brian Maurer.;Kenneth McDonald.
来源: JAMA. 2013年310卷1期66-74页
Prevention strategies for heart failure are needed.
1003. Home-based walking exercise intervention in peripheral artery disease: a randomized clinical trial.
作者: Mary M McDermott.;Kiang Liu.;Jack M Guralnik.;Michael H Criqui.;Bonnie Spring.;Lu Tian.;Kathryn Domanchuk.;Luigi Ferrucci.;Donald Lloyd-Jones.;Melina Kibbe.;Huimin Tao.;Lihui Zhao.;Yihua Liao.;W Jack Rejeski.
来源: JAMA. 2013年310卷1期57-65页
Clinical practice guidelines state there is insufficient evidence to support advising patients with peripheral artery disease (PAD) to participate in a home-based walking exercise program.
1004. Effect of home blood pressure telemonitoring and pharmacist management on blood pressure control: a cluster randomized clinical trial.
作者: Karen L Margolis.;Stephen E Asche.;Anna R Bergdall.;Steven P Dehmer.;Sarah E Groen.;Holly M Kadrmas.;Tessa J Kerby.;Krissa J Klotzle.;Michael V Maciosek.;Ryan D Michels.;Patrick J O'Connor.;Rachel A Pritchard.;Jaime L Sekenski.;JoAnn M Sperl-Hillen.;Nicole K Trower.
来源: JAMA. 2013年310卷1期46-56页
Only about half of patients with high blood pressure (BP) in the United States have their BP controlled. Practical, robust, and sustainable models are needed to improve BP control in patients with uncontrolled hypertension.
1005. Endosonography vs conventional bronchoscopy for the diagnosis of sarcoidosis: the GRANULOMA randomized clinical trial.
作者: Martin B von Bartheld.;Olaf M Dekkers.;Artur Szlubowski.;Ralf Eberhardt.;Felix J Herth.;Johannes C C M in 't Veen.;Ynze P de Jong.;Erik H F M van der Heijden.;Kurt G Tournoy.;Martin Claussen.;Bernt van den Blink.;Pallav L Shah.;Zaid Zoumot.;Paul Clementsen.;Celeste Porsbjerg.;Thais Mauad.;Fabiola D Bernardi.;Erik W van Zwet.;Klaus F Rabe.;Jouke T Annema.
来源: JAMA. 2013年309卷23期2457-64页
Tissue verification of noncaseating granulomas is recommended for the diagnosis of sarcoidosis. Bronchoscopy with transbronchial lung biopsies, the current diagnostic standard, has moderate sensitivity in assessing granulomas. Endosonography with intrathoracic nodal aspiration appears to be a promising diagnostic technique.
1006. Effects of the live attenuated measles-mumps-rubella booster vaccination on disease activity in patients with juvenile idiopathic arthritis: a randomized trial.
作者: Marloes W Heijstek.;Sylvia Kamphuis.;Wineke Armbrust.;Joost Swart.;Simone Gorter.;Lara D de Vries.;Gaby P Smits.;Pieter G van Gageldonk.;Guy A M Berbers.;Nico M Wulffraat.
来源: JAMA. 2013年309卷23期2449-56页
The immunogenicity and the effects of live attenuated measles-mumps-rubella (MMR) vaccination on disease activity in patients with juvenile idiopathic arthritis (JIA) are matters of concern, especially in patients treated with immunocompromising therapies.
1007. Effect of an outpatient antimicrobial stewardship intervention on broad-spectrum antibiotic prescribing by primary care pediatricians: a randomized trial.
作者: Jeffrey S Gerber.;Priya A Prasad.;Alexander G Fiks.;A Russell Localio.;Robert W Grundmeier.;Louis M Bell.;Richard C Wasserman.;Ron Keren.;Theoklis E Zaoutis.
来源: JAMA. 2013年309卷22期2345-52页
Antimicrobial stewardship programs have been effective for inpatients, often through prescribing audit and feedback. However, most antimicrobial use occurs in outpatients with acute respiratory tract infections (ARTIs).
1008. Roux-en-Y gastric bypass vs intensive medical management for the control of type 2 diabetes, hypertension, and hyperlipidemia: the Diabetes Surgery Study randomized clinical trial.
作者: Sayeed Ikramuddin.;Judith Korner.;Wei-Jei Lee.;John E Connett.;William B Inabnet.;Charles J Billington.;Avis J Thomas.;Daniel B Leslie.;Keong Chong.;Robert W Jeffery.;Leaque Ahmed.;Adrian Vella.;Lee-Ming Chuang.;Marc Bessler.;Michael G Sarr.;James M Swain.;Patricia Laqua.;Michael D Jensen.;John P Bantle.
来源: JAMA. 2013年309卷21期2240-9页
Controlling glycemia, blood pressure, and cholesterol is important for patients with diabetes. How best to achieve this goal is unknown.
1009. Effect of escitalopram on mental stress-induced myocardial ischemia: results of the REMIT trial.
作者: Wei Jiang.;Eric J Velazquez.;Maragatha Kuchibhatla.;Zainab Samad.;Stephen H Boyle.;Cynthia Kuhn.;Richard C Becker.;Thomas L Ortel.;Redford B Williams.;Joseph G Rogers.;Christopher O'Connor.
来源: JAMA. 2013年309卷20期2139-49页
Mental stress can induce myocardial ischemia and also has been implicated in triggering cardiac events. However, pharmacological interventions aimed at reducing mental stress-induced myocardial ischemia (MSIMI) have not been well studied.
1010. Effect of early vs late tracheostomy placement on survival in patients receiving mechanical ventilation: the TracMan randomized trial.
作者: Duncan Young.;David A Harrison.;Brian H Cuthbertson.;Kathy Rowan.; .
来源: JAMA. 2013年309卷20期2121-9页
Tracheostomy is a widely used intervention in adult critical care units. There is little evidence to guide clinicians regarding the optimal timing for this procedure.
1011. Short-term vs conventional glucocorticoid therapy in acute exacerbations of chronic obstructive pulmonary disease: the REDUCE randomized clinical trial.
作者: Jörg D Leuppi.;Philipp Schuetz.;Roland Bingisser.;Michael Bodmer.;Matthias Briel.;Tilman Drescher.;Ursula Duerring.;Christoph Henzen.;Yolanda Leibbrandt.;Sabrina Maier.;David Miedinger.;Beat Müller.;Andreas Scherr.;Christian Schindler.;Rolf Stoeckli.;Sebastien Viatte.;Christophe von Garnier.;Michael Tamm.;Jonas Rutishauser.
来源: JAMA. 2013年309卷21期2223-31页
International guidelines advocate a 7- to 14-day course of systemic glucocorticoid therapy in acute exacerbations of chronic obstructive pulmonary disease (COPD). However, the optimal dose and duration are unknown.
1012. Early parenteral nutrition in critically ill patients with short-term relative contraindications to early enteral nutrition: a randomized controlled trial.
作者: Gordon S Doig.;Fiona Simpson.;Elizabeth A Sweetman.;Simon R Finfer.;D Jamie Cooper.;Philippa T Heighes.;Andrew R Davies.;Michael O'Leary.;Tom Solano.;Sandra Peake.; .
来源: JAMA. 2013年309卷20期2130-8页
Systematic reviews suggest adult patients in intensive care units (ICUs) with relative contraindications to early enteral nutrition (EN) may benefit from parenteral nutrition (PN) provided within 24 hours of ICU admission.
1013. Effects of patient-directed music intervention on anxiety and sedative exposure in critically ill patients receiving mechanical ventilatory support: a randomized clinical trial.
作者: Linda L Chlan.;Craig R Weinert.;Annie Heiderscheit.;Mary Fran Tracy.;Debra J Skaar.;Jill L Guttormson.;Kay Savik.
来源: JAMA. 2013年309卷22期2335-44页
Alternatives to sedative medications, such as music, may alleviate the anxiety associated with ventilatory support.
1014. Long-term outcomes following abdominal sacrocolpopexy for pelvic organ prolapse.
作者: Ingrid Nygaard.;Linda Brubaker.;Halina M Zyczynski.;Geoffrey Cundiff.;Holly Richter.;Marie Gantz.;Paul Fine.;Shawn Menefee.;Beri Ridgeway.;Anthony Visco.;Lauren Klein Warren.;Min Zhang.;Susan Meikle.
来源: JAMA. 2013年309卷19期2016-24页
More than 225 000 surgeries are performed annually in the United States for pelvic organ prolapse (POP). Abdominal sacrocolpopexy is considered the most durable POP surgery, but little is known about safety and long-term effectiveness.
1015. Effect of long-detection interval vs standard-detection interval for implantable cardioverter-defibrillators on antitachycardia pacing and shock delivery: the ADVANCE III randomized clinical trial.
作者: Maurizio Gasparini.;Alessandro Proclemer.;Catherine Klersy.;Axel Kloppe.;Maurizio Lunati.;José Bautista Martìnez Ferrer.;Ahmad Hersi.;Marcin Gulaj.;Maurits C E F Wijfels.;Elisabetta Santi.;Laura Manotta.;Angel Arenal.
来源: JAMA. 2013年309卷18期1903-11页
Using more intervals to detect ventricular tachyarrhythmias has been associated with reducing unnecessary implantable cardioverter-defibrillator (ICD) therapies.
1016. Effects of targeting higher vs lower arterial oxygen saturations on death or disability in extremely preterm infants: a randomized clinical trial.
作者: Barbara Schmidt.;Robin K Whyte.;Elizabeth V Asztalos.;Diane Moddemann.;Christian Poets.;Yacov Rabi.;Alfonso Solimano.;Robin S Roberts.; .
来源: JAMA. 2013年309卷20期2111-20页
The goal of oxygen therapy is to deliver sufficient oxygen to the tissues while minimizing oxygen toxicity and oxidative stress. It remains uncertain what values of arterial oxygen saturations achieve this balance in preterm infants.
1017. Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial.
Oral supplementation with the Age-Related Eye Disease Study (AREDS) formulation (antioxidant vitamins C and E, beta carotene, and zinc) has been shown to reduce the risk of progression to advanced age-related macular degeneration (AMD). Observational data suggest that increased dietary intake of lutein + zeaxanthin (carotenoids), omega-3 long-chain polyunsaturated fatty acids (docosahexaenoic acid [DHA] + eicosapentaenoic acid [EPA]), or both might further reduce this risk.
1018. Immunogenicity of 2 doses of HPV vaccine in younger adolescents vs 3 doses in young women: a randomized clinical trial.
作者: Simon R M Dobson.;Shelly McNeil.;Marc Dionne.;Meena Dawar.;Gina Ogilvie.;Mel Krajden.;Chantal Sauvageau.;David W Scheifele.;Tobias R Kollmann.;Scott A Halperin.;Joanne M Langley.;Julie A Bettinger.;Joel Singer.;Deborah Money.;Dianne Miller.;Monika Naus.;Fawziah Marra.;Eric Young.
来源: JAMA. 2013年309卷17期1793-802页
Global use of human papillomavirus (HPV) vaccines to prevent cervical cancer is impeded by cost. A 2-dose schedule for girls may be possible.
1019. Effect of different dosages of oral vitamin D supplementation on vitamin D status in healthy, breastfed infants: a randomized trial.
作者: Sina Gallo.;Kathryn Comeau.;Catherine Vanstone.;Sherry Agellon.;Atul Sharma.;Glenville Jones.;Mary L'Abbé.;Ali Khamessan.;Celia Rodd.;Hope Weiler.
来源: JAMA. 2013年309卷17期1785-92页
Vitamin D supplementation in infancy is required to support healthy bone mineral accretion. A supplement of 400 IU of vitamin D per day is thought to support plasma 25-hydroxyvitamin D (25[OH]D) concentrations between 40 and 50 nmol/L; some advocate 75 to 150 nmol/L for bone health.
1020. Effect of shock wave-facilitated intracoronary cell therapy on LVEF in patients with chronic heart failure: the CELLWAVE randomized clinical trial.
作者: Birgit Assmus.;Dirk H Walter.;Florian H Seeger.;David M Leistner.;Julia Steiner.;Ina Ziegler.;Andreas Lutz.;Walaa Khaled.;Jens Klotsche.;Torsten Tonn.;Stefanie Dimmeler.;Andreas M Zeiher.
来源: JAMA. 2013年309卷15期1622-31页
The modest effects of clinical studies using intracoronary administration of autologous bone marrow-derived mononuclear cells (BMCs) in patients with chronic postinfarction heart failure may be attributed to impaired homing of BMCs to the target area. Extracorporeal shock wave treatment has been experimentally shown to increase homing factors in the target tissue, resulting in enhanced retention of applied BMCs.
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