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81. Radiology-guided percutaneous approach is superior to EUS for performing liver biopsies.
作者: Ji Young Bang.;Thomas J Ward.;Shady Guirguis.;Konrad Krall.;Francisco Contreras.;Nirag Jhala.;Udayakumar Navaneethan.;Robert H Hawes.;Shyam Varadarajulu.
来源: Gut. 2021年70卷12期2224-2226页 82. Long-term serological, virological and histological responses to RNA inhibition by ARC-520 in Chinese chronic hepatitis B patients on entecavir treatment.
作者: Man-Fung Yuen.;Danny Ka-Ho Wong.;Thomas Schluep.;Ching-Lung Lai.;Carlo Ferrari.;Stephen Locarnini.;Regina Cheuk-Lam Lo.;Robert G Gish.;James Hamilton.;Christine I Wooddell.;Lung Yi Mak.;Bruce D Given.
来源: Gut. 2022年71卷4期789-797页
We examined the serological, virological (in serum and liver) and histological profiles in chronic hepatitis B virus (HBV) patients during and after completion of multiple dose (MD) ARC-520.
83. Endoscopic radiofrequency ablation or surveillance in patients with Barrett's oesophagus with confirmed low-grade dysplasia: a multicentre randomised trial.
作者: Maximilien Barret.;Mathieu Pioche.;Benoit Terris.;Thierry Ponchon.;Franck Cholet.;Frank Zerbib.;Edouard Chabrun.;Marc Le Rhun.;Emmanuel Coron.;Marc Giovannini.;Fabrice Caillol.;René Laugier.;Jeremie Jacques.;Romain Legros.;Christian Boustiere.;Gabriel Rahmi.;Elodie Metivier-Cesbron.;Geoffroy Vanbiervliet.;Paul Bauret.;Jean Escourrou.;Julien Branche.;Lea Jilet.;Hendy Abdoul.;Nadira Kaddour.;Sarah Leblanc.;Michael Bensoussan.;Frederic Prat.;Stanislas Chaussade.
来源: Gut. 2021年70卷6期1014-1022页
Due to an annual progression rate of Barrett's oesophagus (BO) with low-grade dysplasia (LGD) between 9% and 13% per year endoscopic ablation therapy is preferred to surveillance. Since this recommendation is based on only one randomised trial, we aimed at checking these results by another multicentre randomised trial with a similar design.
84. Safety and efficacy of hydrothermal duodenal mucosal resurfacing in patients with type 2 diabetes: the randomised, double-blind, sham-controlled, multicentre REVITA-2 feasibility trial.
作者: Geltrude Mingrone.;Annieke Cg van Baar.;Jacques Devière.;David Hopkins.;Eduardo Moura.;Cintia Cercato.;Harith Rajagopalan.;Juan Carlos Lopez-Talavera.;Kelly White.;Vijeta Bhambhani.;Guido Costamagna.;Rehan Haidry.;Eduardo Grecco.;Manoel Galvao Neto.;Guruprasad Aithal.;Alessandro Repici.;Bu'Hussain Hayee.;Amyn Haji.;A John Morris.;Raf Bisschops.;Manil D Chouhan.;Naomi S Sakai.;Deepak L Bhatt.;Arun J Sanyal.;J J G H M Bergman.; .
来源: Gut. 2022年71卷2期254-264页
Hydrothermal duodenal mucosal resurfacing (DMR) is a safe, outpatient endoscopic procedure. REVITA-2, a double-blind, superiority randomised controlled trial, investigates safety and efficacy of DMR using the single catheter Revita system (Revita DMR (catheter and system)), on glycaemic control and liver fat content in type 2 diabetes (T2D).
85. Targeting cancer stem cells with a pan-BCL-2 inhibitor in preclinical and clinical settings in patients with gastroesophageal carcinoma.
作者: Shumei Song.;Qiongrong Chen.;Yuan Li.;Guang Lei.;Ailing Scott.;Longfei Huo.;Cordelia Y Li.;Jeannelyn Santiano Estrella.;Arlene Correa.;Melissa Pool Pizzi.;Lang Ma.;Jiankang Jin.;Bin Liu.;Ying Wang.;Lianchun Xiao.;Wayne L Hofstetter.;Jeffrey H Lee.;Brian Weston.;Manoop Bhutani.;Namita Shanbhag.;Randy L Johnson.;Boyi Gan.;Shaozhong Wei.;Jaffer A Ajani.
来源: Gut. 2021年70卷12期2238-2248页
Gastro-oesophageal cancers (GEC) are resistant to therapy and lead to poor prognosis. The cancer stem cells (CSCs) and antiapoptotic pathways often confer therapy resistance. We sought to elucidate the antitumour action of a BCL-2 inhibitor, AT101 in GEC in vitro, in vivo and in a clinical trial.
86. Effect of green-Mediterranean diet on intrahepatic fat: the DIRECT PLUS randomised controlled trial.
作者: Anat Yaskolka Meir.;Ehud Rinott.;Gal Tsaban.;Hila Zelicha.;Alon Kaplan.;Philip Rosen.;Ilan Shelef.;Ilan Youngster.;Aryeh Shalev.;Matthias Blüher.;Uta Ceglarek.;Michael Stumvoll.;Kieran Tuohy.;Camilla Diotallevi.;Urska Vrhovsek.;Frank Hu.;Meir Stampfer.;Iris Shai.
来源: Gut. 2021年70卷11期2085-2095页
To examine the effectiveness of green-Mediterranean (MED) diet, further restricted in red/processed meat, and enriched with green plants and polyphenols on non-alcoholic fatty liver disease (NAFLD), reflected by intrahepatic fat (IHF) loss.
87. Pneumatic dilation for persistent dysphagia after antireflux surgery, a multicentre single-blind randomised sham-controlled clinical trial.
作者: Jeroen M Schuitenmaker.;Froukje B van Hoeij.;Marlies P Schijven.;Jan Tack.;José M Conchillo.;Eric J Hazebroek.;André J P M Smout.;Albert J Bredenoord.
来源: Gut. 2022年71卷1期10-15页
There is no evidence-based treatment for persistent dysphagia after laparoscopic fundoplication. The aim of this study was to evaluate the effect of pneumatic dilation on persistent dysphagia after laparoscopic fundoplication.
88. Multicentre, prospective, randomised study comparing the diagnostic yield of colon capsule endoscopy versus CT colonography in a screening population (the TOPAZ study).
作者: Brooks D Cash.;Mark R Fleisher.;Steven Fern.;Elizabeth Rajan.;Robyn Haithcock.;David M Kastenberg.;David Pound.;Neofytos P Papageorgiou.;Ignacio Fernández-Urién.;Ira J Schmelkin.;Douglas K Rex.
来源: Gut. 2021年70卷11期2115-2122页
Colon capsule endoscopy (CCE) has shown promise for colorectal neoplasia detection compared with optical colonoscopy (OC), but has not been compared with other screening tests in average risk screening patients.
89. First-line treatment with infliximab versus conventional treatment in children with newly diagnosed moderate-to-severe Crohn's disease: an open-label multicentre randomised controlled trial.
作者: Maria M E Jongsma.;Martine A Aardoom.;Martinus A Cozijnsen.;Merel van Pieterson.;Tim de Meij.;Michael Groeneweg.;Obbe F Norbruis.;Victorien M Wolters.;Herbert M van Wering.;Iva Hojsak.;Kaija-Leena Kolho.;Thalia Hummel.;Janneke Stapelbroek.;Cathelijne van der Feen.;Patrick F van Rheenen.;Michiel P van Wijk.;Sarah T A Teklenburg-Roord.;Marco W J Schreurs.;Dimitris Rizopoulos.;Michail Doukas.;Johanna C Escher.;Janneke N Samsom.;Lissy de Ridder.
来源: Gut. 2022年71卷1期34-42页
In newly diagnosed paediatric patients with moderate-to-severe Crohn's disease (CD), infliximab (IFX) is initiated once exclusive enteral nutrition (EEN), corticosteroid and immunomodulator therapies have failed. We aimed to investigate whether starting first-line IFX (FL-IFX) is more effective to achieve and maintain remission than conventional treatment.
90. Endoscopic placement of covered versus uncovered self-expandable metal stents for palliation of malignant gastric outlet obstruction.
作者: Kentaro Yamao.;Masayuki Kitano.;Yasutaka Chiba.;Takeshi Ogura.;Takaaki Eguchi.;Ichiro Moriyama.;Yukitaka Yamashita.;Hironari Kato.;Takahisa Kayahara.;Noriyuki Hoki.;Yoshinobu Okabe.;Hideyuki Shiomi.;Yoshitaka Nakai.;Yoshinori Kushiyama.;Yoshifumi Fujimoto.;Shiro Hayashi.;Shigeki Bamba.;Yasushi Kudo.;Nobuaki Azemoto.;Toshiharu Ueki.;Norimitsu Uza.;Masanori Asada.;Kazuya Matsumoto.;Hiroko Nebiki.;Hiroshi Takihara.;Chisio Noguchi.;Hideki Kamada.;Kojiro Nakase.;Daisuke Goto.;Tsuyoshi Sanuki.;Tetsuya Koga.;Shinichi Hashimoto.;Hidefumi Nishikiori.;Masahiro Serikawa.;Keiji Hanada.;Ken Hirao.;Masaya Ohana.;Imakiire Kazuyuki.;Takao Kato.;Motoyuki Yoshida.;Hirofumi Kawamoto.
来源: Gut. 2021年70卷7期1244-1252页
Stenting is an established endoscopic therapy for malignant gastric outlet obstruction (mGOO). The choice of stent (covered vs uncovered) has been examined in prior randomised studies without clear results.
91. Multicentre randomised controlled trial on virtual chromoendoscopy in the detection of neoplasia during colitis surveillance high-definition colonoscopy (the VIRTUOSO trial).
作者: Kesavan Kandiah.;Sharmila Subramaniam.;Sreedhari Thayalasekaran.;Fergus Jq Chedgy.;Gaius Longcroft-Wheaton.;Carole Fogg.;James F Brown.;Samuel Cl Smith.;Marietta Iacucci.;Pradeep Bhandari.
来源: Gut. 2021年70卷9期1684-1690页
Longstanding colonic IBD increases the risk of developing colorectal cancer. The utility of chromoendoscopy with standard-definition white light technology has been established. However, the use of high-definition virtual chromoendoscopy (HDV) in colitis surveillance remains undefined.
92. EGFR amplification and outcome in a randomised phase III trial of chemotherapy alone or chemotherapy plus panitumumab for advanced gastro-oesophageal cancers.
作者: Elizabeth C Smyth.;Georgios Vlachogiannis.;Somaieh Hedayat.;Alice Harbery.;Sanna Hulkki-Wilson.;Massimiliano Salati.;Kyriakos Kouvelakis.;Javier Fernandez-Mateos.;George D Cresswell.;Elisa Fontana.;Therese Seidlitz.;Clare Peckitt.;Jens C Hahne.;Andrea Lampis.;Ruwaida Begum.;David Watkins.;Sheela Rao.;Naureen Starling.;Tom Waddell.;Alicia Okines.;Tom Crosby.;Was Mansoor.;Jonathan Wadsley.;Gary Middleton.;Matteo Fassan.;Andrew Wotherspoon.;Chiara Braconi.;Ian Chau.;Igor Vivanco.;Andrea Sottoriva.;Daniel E Stange.;David Cunningham.;Nicola Valeri.
来源: Gut. 2021年70卷9期1632-1641页
Epidermal growth factor receptor (EGFR) inhibition may be effective in biomarker-selected populations of advanced gastro-oesophageal adenocarcinoma (aGEA) patients. Here, we tested the association between outcome and EGFR copy number (CN) in pretreatment tissue and plasma cell-free DNA (cfDNA) of patients enrolled in a randomised first-line phase III clinical trial of chemotherapy or chemotherapy plus the anti-EGFR monoclonal antibody panitumumab in aGEA (NCT00824785).
93. Faecal microbiota transplantation halts progression of human new-onset type 1 diabetes in a randomised controlled trial.
作者: Pieter de Groot.;Tanja Nikolic.;Silvia Pellegrini.;Valeria Sordi.;Sultan Imangaliyev.;Elena Rampanelli.;Nordin Hanssen.;Ilias Attaye.;Guido Bakker.;Gaby Duinkerken.;Antoinette Joosten.;Andrei Prodan.;Evgeni Levin.;Han Levels.;Bartjan Potter van Loon.;Arianne van Bon.;Catherina Brouwer.;Sytze van Dam.;Suat Simsek.;Daniel van Raalte.;Frank Stam.;Victor Gerdes.;Roel Hoogma.;Martin Diekman.;Martin Gerding.;Cees Rustemeijer.;Bernadette de Bakker.;Joost Hoekstra.;Aeilko Zwinderman.;Jacques Bergman.;Frits Holleman.;Lorenzo Piemonti.;Willem De Vos.;Bart Roep.;Max Nieuwdorp.
来源: Gut. 2021年70卷1期92-105页
Type 1 diabetes (T1D) is characterised by islet autoimmunity and beta cell destruction. A gut microbiota-immunological interplay is involved in the pathophysiology of T1D. We studied microbiota-mediated effects on disease progression in patients with type 1 diabetes using faecal microbiota transplantation (FMT).
94. Faecal immunochemical test is superior to symptoms in predicting pathology in patients with suspected colorectal cancer symptoms referred on a 2WW pathway: a diagnostic accuracy study.
作者: Nigel D'Souza.;Theo Georgiou Delisle.;Michelle Chen.;Sally Benton.;Muti Abulafi.; .
来源: Gut. 2021年70卷6期1130-1138页
To assess whether a faecal immunochemical test (FIT) could be used to select patients with suspected colorectal cancer (CRC) symptoms for urgent investigation.
95. Multiplexed endoscopic imaging of Barrett's neoplasia using targeted fluorescent heptapeptides in a phase 1 proof-of-concept study.
作者: Jing Chen.;Yang Jiang.;Tse-Shao Chang.;Bishnu Joshi.;Juan Zhou.;Joel H Rubenstein.;Erik J Wamsteker.;Richard S Kwon.;Henry Appelman.;David G Beer.;Danielle K Turgeon.;Eric J Seibel.;Thomas D Wang.
来源: Gut. 2021年70卷6期1010-1013页 96. WASh multicentre randomised controlled trial: water-assisted sigmoidoscopy in English NHS bowel scope screening.
作者: Matthew D Rutter.;Rachel Evans.;Zoe Hoare.;Christian Von Wagner.;Jill Deane.;Shiran Esmaily.;Tony Larkin.;Rhiannon Edwards.;Seow Tien Yeo.;Llinos Haf Spencer.;Emily Holmes.;Brian P Saunders.;Colin J Rees.;Zacharias P Tsiamoulos.;Iosif Beintaris.; .
来源: Gut. 2021年70卷5期845-852页
The English Bowel Cancer Screening Programme invites 55 year olds for a sigmoidoscopy (Bowel Scope Screening (BSS)), aiming to resect premalignant polyps, thus reducing cancer incidence. A national patient survey indicated higher procedural pain than anticipated, potentially impacting on screening compliance and effectiveness. We aimed to assess whether water-assisted sigmoidoscopy (WAS), as opposed to standard CO2 technique, improved procedural pain and detection of adenomatous polyps.
97. Equivalent performance of single-use and reusable duodenoscopes in a randomised trial.
Single-use duodenoscopes have been recently developed to eliminate risk of infection transmission from contaminated reusable duodenoscopes. We compared performances of single-use and reusable duodenoscopes in patients undergoing endoscopic retrograde cholangiopancreatography (ERCP).
98. Development and validation of a model to predict survival in colorectal cancer using a gradient-boosted machine.
The success of treatment planning relies critically on our ability to predict the potential benefit of a therapy. In colorectal cancer (CRC), several nomograms are available to predict different outcomes based on the use of tumour specific features. Our objective is to provide an accurate and explainable prediction of the risk to die within 10 years after CRC diagnosis, by incorporating the tumour features and the patient medical and demographic information.
99. Metagenomics analysis of gut microbiota in response to diet intervention and gestational diabetes in overweight and obese women: a randomised, double-blind, placebo-controlled clinical trial.
作者: Kati Mokkala.;Niklas Paulin.;Noora Houttu.;Ella Koivuniemi.;Outi Pellonperä.;Sofia Khan.;Sami Pietilä.;Kristiina Tertti.;Laura L Elo.;Kirsi Laitinen.
来源: Gut. 2021年70卷2期309-318页
Gut microbiota and diet are known to contribute to human metabolism. We investigated whether the metagenomic gut microbiota composition and function changes over pregnancy are related to gestational diabetes mellitus (GDM) and can be modified by dietary supplements, fish oil and/or probiotics.
100. Major GI bleeding in older persons using aspirin: incidence and risk factors in the ASPREE randomised controlled trial.
作者: Suzanne E Mahady.;Karen L Margolis.;Andrew Chan.;Galina Polekhina.;Robyn L Woods.;Rory Wolfe.;Mark R Nelson.;Jessica E Lockery.;Erica M Wood.;Christopher Reid.;Michael E Ernst.;Anne Murray.;Ltp Thao.;John J McNeil.
来源: Gut. 2021年70卷4期717-724页
There is a lack of robust data on significant gastrointestinal bleeding in older people using aspirin. We calculated the incidence, risk factors and absolute risk using data from a large randomised, controlled trial.
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