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821. Phenotypic clusters of long-term damage in Sjögren's disease: a 15-year multicentre study.
作者: Giacomo Cafaro.;Beatrice Dei.;Roberto Dal Pozzolo.;Gaetano La Rocca.;Lorenza Bruno.;Giovanni Fulvio.;Francesco Ferro.;Carlo Perricone.;Marta Mosca.;Roberto Gerli.;Chiara Baldini.;Elena Bartoloni.
来源: Rheumatology (Oxford). 2025年64卷12期6259-6267页
To identify phenotypic damage pattern at 15 years and predictors of long-term damage at diagnosis in a multicentre Sjögren's disease (SjD) cohort.
822. Oesophageal dysmotility patterns are associated with distinct clinical phenotypes and prognosis in patients with systemic sclerosis.
作者: Luis G Alcala-Gonzalez.;Alfredo Guillen-Del-Castillo.;Ariadna Aguilar.;Claudia Barber.;Carolina Malagelada.;Laura Polo Figueras.;Laura Triginer.;Claudia Codina-Clavaguera.;Michael Hughes.;Jordi Serra.;Carmen P Simeón-Aznar.;Zsuzsanna H McMahan.
来源: Rheumatology (Oxford). 2025年64卷12期6250-6258页
Oesophageal dysmotility is a common manifestation of SSc, contributing to substantial morbidity. We sought to determine whether oesophageal dysmotility patterns by high-resolution oesophageal manometry were associated with distinct SSc clinical phenotypes and different outcomes.
823. Eye-openers for advanced management of elderly-onset rheumatoid arthritis.
作者: Hamit Harun Dag.;Selinde V J Snoeck Henkemans.;Agnes E M Looijen.;Judith W Heutz.;Radboud J E M Dolhain.;Pascal H P de Jong.
来源: Rheumatology (Oxford). 2025年64卷12期6241-6249页
To investigate whether clinical outcomes and patient-reported outcomes (PROs) differ over 2 years based on the age of onset of RA.
824. Exploration of health-related quality of life, anxiety and depression in antineutrophil cytoplasmic antibody-associated vasculitis.
作者: Annika Granath.;Sara Brolin.;Karuna Dahlberg.;Iva Gunnarsson.;Elisabet Welin.;Susanne Pettersson.
来源: Rheumatology (Oxford). 2025年64卷12期6233-6240页
To explore health-related quality of life (HRQoL), anxiety, depression and fatigue among persons with ANCA-associated vasculitis (AAV).
825. Eculizumab as rescue therapy in refractory anti-NXP2 dermatomyositis with digestive vasculitis and gastrointestinal perforation: report of two cases.
作者: Loraine Combemale.;Alexandre-Raphael Wery.;Gérôme Bohelay.;Mehdi Zerrari.;Julien Culerrier.;Robin Dhote.;Anissa Martins-Bexiga.;Armelle Bardier.;Antoine Diep.;Yves Allenbach.;Frédéric Caux.;Olivier Benveniste.
来源: Rheumatology (Oxford). 2025年64卷11期5998-6000页 826. Associations between dietary mineral intake and rheumatoid arthritis: evidence from UK Biobank and NHANES.
作者: Jingni Hui.;Xuena Yang.;Meijuan Kang.;Dan He.;Yifan Gou.;Ruixue Zhou.;Chen Liu.;Ye Liu.;Bingyi Wang.;Panxing Shi.;Shiqiang Cheng.;Chuyu Pan.;Boyue Zhao.;Jin Feng.;Wenming Wei.;Yumeng Jia.;Feng Zhang.
来源: Rheumatology (Oxford). 2026年65卷1期
The relationship between dietary mineral intakes and the risk of rheumatoid arthritis (RA) remains limited. This study aims to investigate the associations between dietary mineral intakes with RA.
827. Decreasing prevalence and cumulative incidence of scleroderma renal crisis over time: associated factors identified from the RESCLE registry.
作者: Xavier Pla-Salas.;Carles Tolosa-Vilella.;Maria Baldà-Masmiquel.;Alfredo Guillén-Del-Castillo.;Manuel Rubio-Rivas.;Ana Argibay-Filgueira.;Adela Marín-Ballvé.;Ignasi Rodríguez-Pintó.;Eduardo Callejas-Moraga.;Dolores Colunga-Argüelles.;Luís Sáez-Comet.;Cristina González-de-Echávarri.;Norberto Ortego-Centeno.;Begoña Marí-Alonso.;Jose Antonio Vargas-Hitos.;Jose Antonio Todolí-Parra.;Luís Trapiella-Martínez.;Maria Teresa Herranz-Marín.;Mayka Freire.;Antoni Castro-Salomó.;Isabel Perales-Fraile.;Ana Belén Madroñero-Vuelta.;Maria Esther Sánchez-García.;Andrés González-García.;Jorge Sánchez-Redondo.;Glória De-la-Red.;Alejandra Fernández-Luque.;A Muela-Molinero.;Gemma Lledó.;Antonio Javier Chamorro-Fernández.;Mónica Rodríguez-Carballeira.;Sabela Sánchez-Trigo.;Rafael Ángel Fernández-de-la-Puebla.;Isaac Pons-Martín-Del-Campo.;Vincent Fonollosa-Pla.;Carmen Pilar Simeón-Aznar.; .
来源: Rheumatology (Oxford). 2025年64卷12期6201-6212页
To determine the prevalence and incidence of scleroderma renal crisis (SRC) in patients with SSc over two time periods and to identify factors influencing potential epidemiological changes.
829. Risk of venous thromboembolism in people with RA: a population-based study in the UK.
作者: Mark D Russell.;Katie Bechman.;Mark Gibson.;Victoria Basey.;Michael Mclean.;Saqib Rana.;Anna Barkaway.;Simon de Lusignan.;Maya H Buch.;James B Galloway.
来源: Rheumatology (Oxford). 2025年64卷12期6224-6232页
To evaluate the absolute and relative risk of venous thromboembolism (VTE) in individuals with RA, with relation to age, sex, BMI, disease duration and exposure to exogenous oestrogens.
830. Self-reported cognitive dysfunction and memory impairment in Systemic Autoimmune Rheumatic Diseases (SARDs): a mixed methods analysis of the INSPIRE cohort.
作者: Avni Varshney.;Thomas A Pollak.;Arjoon Arunasalam.;Efthalia Massou.;Felix Naughton.;James A Bourgeois.;Lucy Calderwood.;Guy Leschziner.;Alessandra Bortoluzzi.;Alice Tunks.;Ellie Dalby.;Martha Piper.;Laura Andreoli.;Xiaofeng Yan.;Sharmilee Gnanapavan.;Arvind Kaul.;David D'Cruz.;Melanie Sloan.
来源: Rheumatology (Oxford). 2025年64卷12期6213-6223页
To explore self-reported cognitive dysfunction, including memory impairment, across systemic autoimmune rheumatic diseases (SARDs) and examine its impact and associations with demographic, clinical and psychosocial factors.
831. Crosstalk between macrophages and fibroblasts contributes to inflammation and damage in giant cell arteritis.
作者: Shuang Xu.;William F Jiemy.;Anqi Zhang.;Fokke Walinga.;Miranda Nijenhuis.;Elien Hensema.;Wayel Abdulahad.;Kornelis Sm van der Geest.;Peter Heeringa.;Annemieke Boots.;Elisabeth Brouwer.;Maria Sandovici.
来源: Rheumatology (Oxford). 2026年65卷3期
Giant cell arteritis (GCA) is a large vessel vasculitis characterized by arterial wall inflammation and remodelling. Macrophages and fibroblasts are abundantly present in arteries affected by GCA, but their crosstalk in GCA pathogenesis is largely unknown. Here we investigated the interaction between macrophages and fibroblasts in GCA-affected arteries and in vitro.
832. Anti-Mi2 autoantibodies target PHD fingers of SP140L and TIF1γ, while anti-TIF1γ autoantibodies primarily bind TIF1γ outside the PHD region.
作者: Iago Pinal-Fernandez.;Jon Musai.;Maria Casal-Dominguez.;Katherine Pak.;Mariana Kaplan.;Blake M Warner.;Lisa G Rider.;Rohit Aggarwal.;Chester V Oddis.;Siamak Moghadam-Kia.;Gloria Garrabou.;Albert Selva-O'Callaghan.;Jose C Milisenda.;John A Chiorini.;Andrew L Mammen.;Peter D Burbelo.
来源: Rheumatology (Oxford). 2025年64卷12期6371-6377页
Plant homeodomain (PHD) fingers are present in many chromatin-binding proteins. We recently discovered that anti-Mi2 autoantibodies recognize PHD fingers in Mi2 and AIRE. The purpose of this study was to characterize anti-Mi2 autoantibody recognition of PHD fingers in SP140L and TIF1γ as well as to explore recognition of TIF1γ by both anti-TIF1γ and anti-Mi2 autoantibodies.
833. Treatment and prognostic factors in PMR: a systematic literature review informing German, Austrian and Swiss guidelines.
作者: Zhivana Boyadzhieva.;Myriam Reisch.;Matthias Schneider.;Frank Buttgereit.;Christian Dejaco.
来源: Rheumatology (Oxford). 2025年64卷12期6036-6047页
To capture the current evidence on therapeutic interventions and prognostic factors in PMR informing a task force of the German, Austrian and Swiss rheumatology societies formulating the updated recommendations for the management of PMR.
834. Prevalence and functional characterization of anti-interferon autoantibodies in inflammatory myopathies.
作者: Iago Pinal-Fernandez.;Lindsey B Rosen.;Jose Luis Gomez-Vazquez.;Maria Casal-Dominguez.;Serena Lee.;Jose C Milisenda.;Katherine Pak.;Xavier Solanich.;Steven M Holland.;Albert Selva-O'Callaghan.;Andrew L Mammen.
来源: Rheumatology (Oxford). 2025年64卷12期6404-6408页
Functional autoantibodies targeting IFNs can lead to immunodeficiency and have been implicated in various autoimmune diseases. Despite the critical role of interferons in myositis pathogenesis, the significance of anti-IFN autoantibodies in inflammatory myopathies remains poorly understood. This study aimed to investigate the prevalence and functional impact of anti-IFN autoantibodies in patients with myositis.
835. Assessing the content validity of a Patient Reported Outcome Measure item pool for Rheumatoid Arthritis Disease Activity using cognitive interviews.
作者: Tim Pickles.;Rhiannon Phillips.;Mike Horton.;David Gillespie.;Janice Davies.;Susan Campbell.;Ernest Choy.
来源: Rheumatology (Oxford). 2025年64卷12期6176-6183页
Using Rasch measurement theory, an item pool of 12 questions has been identified, covering tenderness and swelling, disease activity, pain, physical functioning and stiffness for assessing the construct of RA disease activity. This study aimed to assess the content validity of this item pool using cognitive interviews.
836. Non-negligible risk of HBV reactivation among rheumatoid arthritis patients receiving JAK inhibitors: bridging the evidence gap.
作者: Ting-Yuan Lan.;Tai-Ju Lee.;Ting-Wei Chang.;Tai-Chung Tseng.;Pei-Hsinq Lai.;Chiao-Feng Cheng.;Jui-Hung Kao.;Kuan-Yen Lin.;Shao-Yu Pai.;Cheng-Han Wu.;Kung-Yu Wang.;Wei-Yung Lo.;Shang-Chin Huang.;Chieh-Yu Shen.;Cheng-Hsun Lu.;Hung-Chih Yang.;Song-Chou Hsieh.;Ko-Jen Li.
来源: Rheumatology (Oxford). 2025年64卷12期6168-6175页
HBV reactivation is a critical concern for patients with autoimmune disease undergoing immunosuppressive therapy. Despite data on HBV reactivation risks associated with biologics, the impact of the new targeted immunosuppressive agents-Janus kinase inhibitors (JAKis)-remains unclear. This study aimed to evaluate the risk of HBV reactivation among patients with RA treated with JAKis, compared with those receiving TNF inhibitors (TNFis) or rituximab.
838. Multimodal ultrasound in the assessment of muscle involvement in systemic sclerosis patients: results from a bicentric study.
作者: Riccardo Bixio.;Stefano Di Donato.;Maria Giovanna Lommano.;Gianluca Smerilli.;Sonia Farah.;Seda Çolak.;Marco Minerba.;Francesca Pistillo.;Richard J Wakefield.;Fausto Salaffi.;Ombretta Viapiana.;Rossella De Angelis.;Maurizio Rossini.;Edoardo Cipolletta.;Emilio Filippucci.;Luca Idolazzi.;Paul Emery.;Francesco Del Galdo.;Andrea Di Matteo.
来源: Rheumatology (Oxford). 2025年64卷12期6159-6167页
To investigate muscle mass, quality, and stiffness using ultrasound ('multimodal ultrasound') in systemic sclerosis (SSc) patients, compared with healthy controls (HCs), and examine their correlation with muscle strength, physical performance and disability.
839. Risk of ischaemic and non-ischaemic heart failure in patients with systemic sclerosis: a population-based study.
作者: Majd Bairkdar.;Jonas Faxén.;Elizabeth V Arkema.;Daniel C Andersson.;Marie Holmqvist.
来源: Rheumatology (Oxford). 2025年64卷12期6184-6191页
To investigate the risk of incident ischaemic and non-ischaemic heart failure (HF) in a population-based cohort of all patients with SSc in Sweden compared with the general population.
840. Avacopan is effective in inducing remission for MPA/GPA, regardless of changes in serum C5a levels: a single-center study in Japan.
作者: Yusuke Ushio.;Hiromi Shimada.;Risa Wakiya.;Shusaku Nakashima.;Taichi Miyagi.;Koichi Sugihara.;Rina Mino.;Mao Mizusaki.;Kanako Chujo.;Naoto Manabe.;Norimitsu Kadowaki.;Hiroaki Dobashi.
来源: BMC Rheumatol. 2025年9卷1期99页
Avacopan, a selective oral C5a receptor antagonist, was approved for the treatment of microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA) in 2021. However, there are still limited reports on its efficacy and safety in real-world settings, specifically regarding its impact on the Vasculitis Damage Index (VDI), and its effects on serum biomarkers are poorly understood. This study aimed to evaluate the efficacy and safety of avacopan in remission induction therapy for MPA/GPA in a real-world setting, as well as its effect on serum C5a levels.
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