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801. Clinical and laboratory profiles of systemic lupus erythematosus patients in a new rheumatology clinic in southwestern Nigeria.
作者: Gbenga Joshua Odunlami.;Adeola Ajibade.;Bolanle Aderonke Omotoso.;Muzamil Olamide Hassan.;Adeyemi Abiola Adefidipe.;Fatai Olatunde Olanrewaju.;Ademola Olusegun Enitan.;Tajudin Adesegun Adetunji.;Olumide Akinniyi Akinyele.;Oluyomi Okunola.
来源: Reumatologia. 2024年62卷2期83-93页
The aims were to study the sociodemographic characteristics of patients presenting to the clinic and to study the clinical and serological pattern of systemic lupus erythematosus (SLE) in a new rheumatology clinic of a predominantly Yoruba population.
802. Level of glial cell derived neurotrophic factor in the blood plasma of rheumatoid arthritis patients and its relationship with alexithymia.
Glial cell derived neurotrophic factor (GDNF) has an important role in the pathogenetic mechanisms and clinical manifestations of rheumatoid arthritis (RA). Alexithymia is associated with a severe clinical course and worse prognosis, while the relationship between alexithymia and GDNF in RA patients has not been investigated before. The aims of the study were to investigate the GDNF level in blood plasma in RA patients depending on the presence of alexithymia and to evaluate the relationship of GDNF level with clinical manifestation and quality of life.
803. Bilateral rapidly destructive coxopathy in rheumatoid arthritis.
作者: Stoimen Dimitrov.;Georgi Gerganov.;Simona Bogdanova.;Svetlana Hristova.;Rosina Moraliyska.;Svetoslav Dimitrov.;Zhaklin Apostolova.;Desislava Simeonova.;Tanya Shivacheva.;Tsvetoslav Georgiev.
来源: Reumatologia. 2024年62卷2期134-141页
Rapidly destructive coxopathy (RDC) is a rare type of coxarthritis marked by swift deterioration of the hip joint. Although its cause remains unclear, several pathophysiological mechanisms are proposed. To comprehensively analyze this poorly understood condition, a literature search was conducted focusing on associations of bilateral RDC and rheumatoid arthritis (RA). The problem of long-standing RA, bilateral RDC with a febrile episode that preceded a rapid decline in mobility and severe hip pain, with radiological assessment confirmed bilateral hip destruction, was presented. Rapidly destructive coxopathy, especially when linked to RA, poses diagnostic and therapeutic challenges. Our review confirmed by the clinical picture emphasizes the need for vigilance in RA patients with hip involvement and calls for further research to understand RDC's mechanisms and enhance clinical care.
804. Patterns and prevalence of psychiatric morbidity among individuals with rheumatoid arthritis.
作者: Ajaz Kariem Khan.;Junaid Nabi.;Ashaq Hussain Parrey.;Prasan Deep Rath.;Sanan Lone.
来源: Reumatologia. 2024年62卷2期115-120页
Rheumatoid arthritis (RA) is a chronic autoimmune disorder that affects the joints, causing inflammation, pain, and potential joint damage. Patients with RA are at high risk of developing psychiatric morbidity; it is important to recognize these psychiatric manifestations. The relationship between psychiatric symptoms and RA is complex and can involve various factors, including the impact of chronic pain, inflammation, medications, and the overall burden of managing a chronic illness.Aim of the study was to systematically investigate and analyze the patterns and prevalence of psychiatric morbidity among individuals diagnosed with RA, with the aim of identifying common mental health conditions, understanding the interplay between RA and psychiatric disorders, and providing valuable insights for improved holistic patient care.
805. Assessment of hematologic indices for diagnosis in juvenile systemic lupus erythematosus.
The aim was to present effective approaches utilizing novel hematological parameters for early diagnosis of juvenile-onset systemic lupus erythematosus (jSLE).
806. Indications, response, and side effects of biologic treatment in Behçet's disease: an 8-year study with follow-up.
作者: Saeedeh Shenavandeh.;Elham Aflaki.;Maryam Rasti Jahromi.;Afshin Borhani Haghighi.;Mohammad Ali Nazarinia.
来源: Reumatologia. 2024年62卷2期101-108页
The treatment of Behçet's disease has improved significantly with the introduction of biologic therapies. However, there is still a need for more information about their use. This study aimed to evaluate the indications, response, and side effects of biologic agents in patients with refractory or severe Behçet's disease in the south of Iran, their follow-up and reasons for changing the biologics.
807. Bone turnover markers and muscle decay indicator in patients with proximal femur fracture - a case-control study.
作者: Marcin Łapiński.;Krystian Żarnovsky.;Katarzyna Czarzasta.;Bartosz Maciąg.;Grzegorz Maciąg.;Olga Adamska.;Artur Mamcarz.;Artur Stolarczyk.
来源: Reumatologia. 2024年62卷2期121-127页
Fracture of the proximal femur is common in elderly patients, in fact threatening their lives. Age-related sarcopenia may be involved in the imbalance resulting in the injury. Handy and readily accessible biochemical tests would be useful to assess the musculoskeletal system condition in daily practice. The aim of the study was to determine whether there is any relation between muscle decay and fracture of the proximal femur and to assess bone quality in elderly patients.
808. Impact of acetabular roof's angle on precision of cup center of rotation reproduction and placement in total hip arthroplasty.
作者: Bartosz Maciąg.;Dawid Jegierski.;Bartłomiej Wilk.;Martyna Budzińska.;Grzegorz Maciąg.;Anna Kupczak.;Krystian Żarnovsky.;Marcin Łapiński.;Tomasz Kordyaczny.;Artur Stolarczyk.
来源: Reumatologia. 2024年62卷2期128-133页
Total hip arthroplasty (THA) is nowadays considered as the most effective treatment option for end-stage hip osteoarthritis (OA) and one of the most successful orthopedic procedures. Precise reproduction of the center of rotation (COR) is among the most important aspects of recreating native hip biomechanics after THA as it is strictly related to muscle tension and force distribution within the hip joint. Both vertical and horizontal shift in cup positioning and COR restoration are commonly observed radiological signs corresponding with lesser functional outcome. The aim of this study was to assess whether the superior border of the native acetabulum morphology has an impact on cup positioning and COR restoration in patients undergoing THA as treatment of primary OA of the hip.
809. Extracorporeal membrane oxygenation for acute lung injury in idiopathic inflammatory myopathies-a potential lifesaving intervention.
作者: Boyang Zheng.;Ellen Eline.;Lillian Xu.;Kun Huang.;Greet Hermans.;Michael Perch.;Gordan Samoukovic.;Ellen De Langhe.;Maryam Dastmalchi.;Lisa Christopher-Stine.;Louise Pyndt Diederichsen.;Valérie Leclair.
来源: Rheumatology (Oxford). 2025年64卷4期2204-2208页
Idiopathic inflammatory myopathies (IIM) can present with acute IIM-related lung injury and respiratory failure, leading to a high mortality risk in intensive care units (ICU). Extracorporeal membrane oxygenation (ECMO) in acute respiratory distress syndrome can be lifesaving. We aimed to report a case series of IIM patients that received ECMO.
810. Modifiable risk factors and inflammation-related proteins in polymyalgia rheumatica: genome-wide meta-analysis and Mendelian randomization.
作者: Sizheng Steven Zhao.;Sarah L Mackie.;Susanna C Larsson.;Stephen Burgess.;Shuai Yuan.
来源: Rheumatology (Oxford). 2025年64卷5期3012-3018页
PMR is an age-related inflammatory disease of unknown cause. We aimed to identify potentially modifiable risk factors and therapeutic targets for preventing or treating PMR.
811. Executive summary: British Society for Rheumatology guideline on management of adult and juvenile onset Sjögren disease.
作者: Elizabeth J Price.;Stuart Benjamin.;Michele Bombardieri.;Simon Bowman.;Sara Carty.;Coziana Ciurtin.;Bridget Crampton.;Annabel Dawson.;Benjamin A Fisher.;Ian Giles.;Peter Glennon.;Monica Gupta.;Katie L Hackett.;Genevieve Larkin.;Wan-Fai Ng.;Athimalaipet V Ramanan.;Saad Rassam.;Saaeha Rauz.;Guy Smith.;Nurhan Sutcliffe.;Anwar Tappuni.;Stephen B Walsh.
来源: Rheumatology (Oxford). 2025年64卷2期396-408页 812. Epidemiology and diagnosis of gout in sub-saharan Africa: a scoping review.
作者: Ayouba Tinni Ismael.;Kabore Fulgence.;Bayala Yannick Laurent Tchenadoyo.;Yameogo Wendyam Nadège.;Zabsonre/Tiendrebeogo Wendlassida Stéphanie Joelle.;Ouedraogo Aboubakar.;Zongo Yamyelle Enselme.;Traore Awa.;Bonkoungou Marcellin.;Ouedraogo Dieu-Donné.
来源: BMC Rheumatol. 2024年8卷1期21页
The episodic nature of gout and diagnostic uncertainty in the absence of microcrystal evidence make it particularly difficult to estimate the frequency of gout. Our aim was to review the literature on the epidemiological and diagnostic aspects of gout in sub-Saharan Africa.
814. Identifying key health system components associated with improved outcomes to inform the re-configuration of services for adults with rare autoimmune rheumatic diseases: a mixed-methods study.
作者: Rosemary J Hollick.;Warren R G James.;Avril Nicoll.;Louise Locock.;Corri Black.;Neeraj Dhaun.;Allyson C Egan.;Nicholas Fluck.;Lynn Laidlaw.;Peter C Lanyon.;Mark A Little.;Raashid Ahmed Luqmani.;Laura Moir.;Maureen McBain.;Neil Basu.
来源: Lancet Rheumatol. 2024年6卷6期e361-e373页
Adults with rare autoimmune rheumatic diseases face unique challenges and struggles to navigate health-care systems designed to manage common conditions. Evidence to inform an optimal service framework for their care is scarce. Using systemic vasculitis as an exemplar, we aimed to identify and explain the key service components underpinning effective care for rare diseases.
815. B cell depletion after treatment with rituximab predicts relapse of IgG4-related disease.
作者: Marco Lanzillotta.;Giuseppe Alvise Ramirez.;Raffaella Milani.;Lorenzo Dagna.;Emanuel Della-Torre.
来源: Rheumatology (Oxford). 2025年64卷4期2290-2294页
B cell depletion therapy with rituximab is effective in most patients with IgG4-related disease (IgG4-RD) but requires repeated cycles to prevent disease flares. We here aimed to assess B cells after rituximab to predict relapse of IgG4-RD and guide retreatment.
816. Prospective assessment of glucocorticoid toxicity in rheumatology practice: a focus on the glucocorticoid toxicity index.
作者: Melda Bahap-Kara.;Emine Sariyildiz.;Hatice Yagmur Zengin.;Omer Karadag.;Aygin Bayraktar-Ekincioglu.
来源: Rheumatology (Oxford). 2025年64卷3期1010-1018页
The glucocorticoid toxicity index (GTI) is developed to measure glucocorticoid (GC)-related morbidity over time. This study aimed to assess GC-toxicity in patients at a rheumatology outpatient clinic by using the GTI and to identify the factors that interfere with the GTI.
817. Disruption of memory B-cell trafficking by belimumab in patients with systemic lupus erythematosus.
作者: Eline J Arends.;Mihaela Zlei.;Christopher M Tipton.;Jasna Cotic.;Zgjim Osmani.;Fenna J de Bie.;Sylvia W A Kamerling.;Andre van Maurik.;Richard Dimelow.;Yun Irene Gregan.;Norma Lynn Fox.;Ton J Rabelink.;David A Roth.;Ignacio Sanz.;Jacques J M van Dongen.;Cees van Kooten.;Y K Onno Teng.
来源: Rheumatology (Oxford). 2024年63卷9期2387-2398页
Autoreactive memory B cells (MBCs) contribute to chronic and progressive courses in autoimmune diseases like SLE. The efficacy of belimumab (BEL), the first approved biologic treatment for SLE and LN, is generally attributed to depletion of activated naïve B cells and inhibition of B-cell activation. BEL's effect on MBCs is currently unexplained. We performed an in-depth cellular and transcriptomic analysis of BEL's impact on the blood MBC compartment in patients with SLE.
818. Low-density granulocytes and neutrophil extracellular trap formation are increased in incomplete systemic lupus erythematosus.
作者: Svenja Henning.;Tobias Reimers.;Wayel Abdulahad.;Juan J Fierro.;Berber Doornbos-van der Meer.;Hendrika Bootsma.;Barbara Horvath.;Karina de Leeuw.;Johanna Westra.
来源: Rheumatology (Oxford). 2025年64卷3期1234-1242页
To investigate the proportion of low-density granulocytes (LDGs), circulating plasma neutrophil extracellular traps (NETs) and serum-induced NET formation in patients with incomplete SLE (iSLE) and SLE.
819. Design of ANCHOR-RA: a multi-national cross-sectional study on screening for interstitial lung disease in patients with rheumatoid arthritis.
作者: Jeffrey A Sparks.;Philippe Dieudé.;Anna-Maria Hoffmann-Vold.;Gerd R Burmester.;Simon Lf Walsh.;Michael Kreuter.;Christian Stock.;Steven Sambevski.;Margarida Alves.;Paul Emery.
来源: BMC Rheumatol. 2024年8卷1期19页
Patients with rheumatoid arthritis (RA) are at risk of developing interstitial lung disease (ILD), which is associated with high mortality. Screening tools based on risk factors are needed to decide which patients with RA should be screened for ILD using high-resolution computed tomography (HRCT). The ANCHOR-RA study is a multi-national cross-sectional study that will develop a multivariable model for prediction of RA-ILD, which can be used to inform screening for RA-ILD in clinical practice.
820. Efficacy and safety of guselkumab in patients with active psoriatic arthritis who had inadequate efficacy and/or intolerance to one prior tumor necrosis factor inhibitor: study protocol for SOLSTICE, a phase 3B, multicenter, randomized, double-blind, placebo-controlled study.
作者: Alexis Ogdie.;Joseph F Merola.;Philip J Mease.;Christopher T Ritchlin.;Jose U Scher.;Kimberly Parnell Lafferty.;Daphne Chan.;Soumya D Chakravarty.;Wayne Langholff.;Yanli Wang.;Olivia Choi.;Yevgeniy Krol.;Alice B Gottlieb.
来源: BMC Rheumatol. 2024年8卷1期20页
Tumor necrosis factor inhibitors (TNFi) are frequently chosen as the first biologic for patients with psoriatic arthritis (PsA). Given that many patients with PsA are TNFi inadequate responders (TNF-IR; either inadequate efficacy or intolerance), treatments utilizing alternative mechanisms of action are needed. In phase 3 studies, the fully human interleukin (IL)-23p19 subunit-inhibitor, guselkumab, was efficacious in patients with active PsA, including TNFi-IR. Efficacy was generally consistent between TNFi-naïve and TNFi-experienced cohorts; however, in the latter, higher response rates have been observed with the Q4W dosing regimen relative to the Q8W dosing regimen for some endpoints, suggesting the need to evaluate whether more frequent dosing may provide an incremental clinical benefit for TNFi-IR patients.
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