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801. Distraction therapy with nature sights and sounds reduces pain during flexible bronchoscopy: a complementary approach to routine analgesia.
作者: Gregory B Diette.;Noah Lechtzin.;Edward Haponik.;Aline Devrotes.;Haya R Rubin.
来源: Chest. 2003年123卷3期941-8页
To determine whether distraction therapy with nature sights and sounds during flexible bronchoscopy (FB) reduces pain and anxiety.
802. A randomized, phase III, double-blind, placebo-controlled trial of intrapleural instillation of methylprednisolone acetate in the management of malignant pleural effusion.
作者: Scott A North.;Heather-Jane Au.;Steven B Halls.;Linda Tkachuk.;John R Mackey.
来源: Chest. 2003年123卷3期822-7页
To determine if intrapleural administration of methylprednisolone acetate (MA) after therapeutic thoracentesis for symptomatic malignant pleural effusion improved time to repeat thoracentesis for symptom control, quality of life (QOL), and dyspnea.
803. Efficacy and safety of azithromycin vs levofloxacin in the outpatient treatment of acute bacterial exacerbations of chronic bronchitis.
To compare the safety and efficacy of oral azithromycin and levofloxacin in the treatment of outpatients with acute bacterial exacerbations of chronic bronchitis (ABECB).
804. Evaluation of unattended automated titration to determine therapeutic continuous positive airway pressure in patients with obstructive sleep apnea.
作者: Romain Kessler.;Emmanuel Weitzenblum.;Ari Chaouat.;Carmen Iamandi.;Thierry Alliotte.
来源: Chest. 2003年123卷3期704-10页
Determination of the therapeutic pressure during continuous positive airway pressure (CPAP) therapy is usually performed by a technician during polysomnography. In recent years, several devices for automated adjustment of the therapeutic pressure by the means of computerized algorithms were developed. The aims of the present study were to compare two different devices for automated titration and to verify if unattended automated titration is a feasible strategy to determine the therapeutic CPAP.
805. A physiologic comparison of nasal and oral positive airway pressure.
作者: Philip L Smith.;Christopher P O'Donnell.;Lawrence Allan.;Alan R Schwartz.
来源: Chest. 2003年123卷3期689-94页
The effectiveness of nasal continuous positive airway pressure (CPAP) in treating obstructive sleep apnea (OSA) is based on raising the intramural pressure above a critical collapsing pressure of the oropharyngeal airway. It is currently unclear whether CPAP delivered orally is also capable of raising pressure in the oropharynx above the critical collapse pressure.
806. Warfarin dose reduction vs watchful waiting for mild elevations in the international normalized ratio.
作者: Gerald A Banet.;Amy D Waterman.;Paul E Milligan.;Susan K Gatchel.;Brian F Gage.
来源: Chest. 2003年123卷2期499-503页
Whether clinicians should decrease the warfarin dose in response to a mild, asymptomatic elevation in the international normalized ratio (INR) is unknown.
807. Nebulized 3% hypertonic saline solution treatment in hospitalized infants with viral bronchiolitis.
作者: Avigdor Mandelberg.;Guy Tal.;Michaela Witzling.;Eli Someck.;Sion Houri.;Ami Balin.;Israel E Priel.
来源: Chest. 2003年123卷2期481-7页
To determine the utility of inhaled hypertonic saline solution to treat infants hospitalized with viral bronchiolitis.
808. Intrahospital transport of critically ill patients using ventilator with patient-triggering function.
作者: Toshiaki Nakamura.;Yuji Fujino.;Akinori Uchiyama.;Takashi Mashimo.;Masaji Nishimura.
来源: Chest. 2003年123卷1期159-64页
To compare a new transport ventilator to manual ventilation in terms of maintaining the respiratory and hemodynamic levels of critically ill patients.
809. Efficiency of pulmonary administration of tobramycin solution for inhalation in cystic fibrosis using an improved drug delivery system.
作者: David E Geller.;Margaret Rosenfeld.;David A Waltz.;Robert W Wilmott.; .
来源: Chest. 2003年123卷1期28-36页
To determine whether tobramycin solution for inhalation (TSI) can be administered safely and more efficiently with a new-generation aerosol device, the AeroDose 5.5 RP inhaler (Aerogen; Mountain View, CA) than with the approved PARI LC PLUS nebulizer (PARI Respiratory Equipment; Monterey, CA) with Pulmo-Aide compressor (DeVilbiss Corp; Somerset, PA). Second, we wanted to ascertain which AeroDose-delivered tobramycin dose is equivalent to the standard 300-mg dose administered with the PARI LC PLUS.
810. Comparison of five bilevel pressure ventilators in patients with chronic ventilatory failure: a physiologic study.
作者: Michele Vitacca.;Luca Barbano.;Silvestro D'Anna.;Roberto Porta.;Luca Bianchi.;Nicolino Ambrosino.
来源: Chest. 2002年122卷6期2105-14页
To compare patient-ventilator interaction and comfort in patients with chronic ventilatory failure (CVF) who are undergoing noninvasive positive-pressure ventilation with five different commercial bilevel pressure home ventilators. Also, we wanted to evaluate the short-term effects of the five ventilators on physiologic variables, namely, breathing patterns and inspiratory muscles.
811. Effects of inspiratory flow waveforms on lung mechanics, gas exchange, and respiratory metabolism in COPD patients during mechanical ventilation.
The clinical usefulness of varying inspiratory flow waveforms during mechanical ventilation has not been adequately studied. The aim of this study was to compare the effects of three different respiratory waveforms on the pulmonary mechanics, gas exchange, and respiratory metabolism of ventilated patients with COPD.
812. Findings on the portable chest radiograph correlate with fluid balance in critically ill patients.
Fluid balance concerns occur daily in critically ill patients, complicated by difficulties assessing intravascular volume. Chest radiographs (CXRs) quantify pulmonary edema in acute lung injury (ALI) and total blood volume in normal subjects. We hypothesized that CXRs would reflect temporal changes in fluid balance in critically ill patients.
813. Carvedilol reduces the inappropriate increase of ventilation during exercise in heart failure patients.
作者: Piergiuseppe Agostoni.;Marco Guazzi.;Maurizio Bussotti.;Stefano De Vita.;Pietro Palermo.
来源: Chest. 2002年122卷6期2062-7页
To evaluate the effects of beta-blockers on ventilation in heart failure patients. Indeed, beta-blockers ameliorate the clinical condition and cardiac function of heart failure patients, but not exercise capacity. Because ventilation is inappropriately elevated in heart failure patients due to overactive reflexes from ergoreceptors and chemoreceptors, we hypothesized that beta-blockers can elicit their positive clinical effects through a reduction of ventilation.
814. Immunostimulation with OM-85 in children with recurrent infections of the upper respiratory tract: a double-blind, placebo-controlled multicenter study.
Recurrent upper respiratory tract infections (URTIs) are common illnesses in young children. As the immunoactive bacterial extract OM-85 has been shown to prevent these infections in both adults and children, the aim of the present trial was to investigate further its efficacy and safety in infection-prone children.
815. Nebulized 3% hypertonic saline solution treatment in ambulatory children with viral bronchiolitis decreases symptoms.
作者: E Michael Sarrell.;Guy Tal.;Michaela Witzling.;Eli Someck.;Sion Houri.;Herman A Cohen.;Avigdor Mandelberg.
来源: Chest. 2002年122卷6期2015-20页
To determine the utility of inhaled hypertonic saline solution to treat ambulatory infants with viral bronchiolitis.
816. Comparison of single 7.5-mg dose treatment vs sequential multidose 2.5-mg treatments with nebulized albuterol in the treatment of acute asthma.
作者: Rita K Cydulka.;E Regis McFadden.;Joshua H Sarver.;Charles L Emerman.
来源: Chest. 2002年122卷6期1982-7页
s: The purpose of the current trial was to compare the relief of airway obstruction from treatment with a single dose of albuterol,7.5 mg (single-dose group), with that from three sequential doses of albuterol, 2.5 mg, spaced 20 min apart (multidose group).
817. Effects of varying doses of fluticasone propionate on the physiology and bronchial wall immunopathology in mild-to-moderate asthma.
作者: Siobhán O'Sullivan.;Liam Cormican.;Maeve Murphy.;Leonard W Poulter.;Conor M Burke.
来源: Chest. 2002年122卷6期1966-72页
Inhaled corticosteroids (ICS) are typically associated with a flat dose-response curve when traditional efficacy values are examined (eg, FEV(1)). The aim of the present study was to investigate if a dose-response relationship exists for lung function and inflammatory cell numbers in bronchial biopsy specimens.
818. Efficacy and safety of beclomethasone dipropionate extrafine aerosol in childhood asthma: a 12-week, randomized, double-blind, placebo-controlled study.
作者: Anjuli Nayak.;Robert Lanier.;Steven Weinstein.;Patti Stampone.;Michael Welch.
来源: Chest. 2002年122卷6期1956-65页
Beclomethasone dipropionate (BDP) has been formulated as an extrafine aerosol (hydrofluoroalkane-134a [HFA]-BDP) [QVAR; 3M Pharmaceuticals; St Paul, MN], which gives improved lung deposition compared with chlorofluorocarbon (CFC)-BDP. The clinical efficacy of HFA-BDP has been established in adult asthma at a required dose below that of CFC-BDP, but has not been evaluated in children.
819. Low rate of venous thromboembolism after craniotomy for brain tumor using multimodality prophylaxis.
作者: Samuel Z Goldhaber.;Kelly Dunn.;Marie Gerhard-Herman.;John K Park.;Peter McL Black.
来源: Chest. 2002年122卷6期1933-7页
Venous thromboembolism (VTE) is the most frequent complication following craniotomy for brain tumors. At Brigham and Women's Hospital, VTE after craniotomy for brain tumor is the leading cause of deep vein thrombosis (DVT) and pulmonary embolism (PE) among patients hospitalized for conditions other than VTE.
820. A randomized controlled trial to evaluate the effect of informing patients about their pretreatment responses to two respiratory questionnaires.
作者: Holger J Schünemann.;Gordon H Guyatt.;Lauren Griffith.;David Stubbing.;Roger Goldstein.
来源: Chest. 2002年122卷5期1701-8页
Previous studies with short recall periods have suggested that informed administration (previous responses available) may improve the responsiveness and validity of health-related quality-of-life (HRQL) questionnaires in comparison to blind administration (previous responses unavailable). Informed administration may, however, have less impact in studies with longer recall periods. The objective of this randomized trial was to compare the validity and responsiveness of the blind and informed Chronic Respiratory Questionnaire (CRQ) and the St. George's Respiratory Questionnaire (SGRQ) with a 3-month interval between questionnaire completion.
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