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782. Achieving inactive disease state in men and women with axial spondyloarthritis: results from a multi-country prospective observational study.
作者: Denis Poddubnyy.;Joachim Sieper.;Servet Akar.;Santiago Muñoz-Fernández.;Hildrun Haibel.;Mikhail Protopopov.;Elisabeth Altmaier.;Fabiana Ganz.;Robert D Inman.
来源: Rheumatology (Oxford). 2025年64卷12期6337-6344页
To assess the probability of achieving low disease activity (LDA) and inactive disease (ID) in men vs women with recently diagnosed axial spondyloarthritis (axSpA).
783. High risk of bloodstream infections, diverse causal pathogens and association with haemodialysis and plasma exchange in ANCA-associated vasculitis.
作者: Nanna Thuesen Bruun.;Dea H Kofod.;Nicholas Carlson.;Mads Hornum.;Emil L Fosbøl.;Lauge Østergaard.;Marianne Volstedlund.;Stine H Finsen.;Claus Moser.;Casper Rydahl.;Per Ivarsen.;Jon Waarst Gregersen.;Martin Egfjord.;Wladimir M Szpirt.;Karl Emil Nelveg-Kristensen.; .
来源: Rheumatology (Oxford). 2025年64卷12期6328-6336页
Infections from immunosuppressive treatment are a major cause of hospitalization and mortality in ANCA-associated vasculitis (AAV). This study examines bloodstream infections (BSIs) in incident AAV patients, comparing incidence, bacterial distribution and risk to the general population, with emphasis on central venous catheters (CVCs).
784. Effectiveness and safety of upadacitinib in juvenile idiopathic arthritis: beyond the polyarticular subset in pediatric and adult patients.
作者: Stefania Costi.;Luca Ingrao.;Maria Giovanna Lommano.;Gilberto Cincinelli.;Francesco Baldo.;Achille Marino.;Roberto Caporali.;Cecilia Beatrice Chighizola.
来源: Rheumatology (Oxford). 2025年64卷12期6417-6419页 785. Clinical characteristics and outcomes of anti-MDA5 dermatomyositis: a retrospective study.
作者: Tulaton Sodsri.;Tananchai Petnak.;Thitiporn Suwatanapongched.;Chayanin Nitiwarangkul.;Nantakarn Pongtarakulpanit.;Pintip Ngamjanyaporn.
来源: BMC Rheumatol. 2025年9卷1期102页
Anti-MDA5 dermatomyositis (anti-MDA5 DM) is a rare but severe subtype of dermatomyositis associated with high mortality. This study aimed to describe clinical characteristics and identify variables associated with rapidly progressive interstitial lung disease (RP-ILD) and mortality among affected patients.
786. Inflammatory bowel disease does not confer higher disease activity or greater radiographic progression in axial spondyloarthritis.
作者: Patricia Remalante-Rayco.;Yassir Daghistani.;Tina Chim.;Zeynep Baskurt.;Sareh Keshavarzi.;Laura Passalent.;Denis Poddubnyy.;Robert D Inman.;Nigil Haroon.
来源: Rheumatology (Oxford). 2025年64卷12期6302-6308页
To examine whether inflammatory bowel disease (IBD) influences disease activity and radiographic progression in patients with axial spondyloarthritis (axSpA).
787. Tofacitinib in combination with glucocorticoids in the treatment of eosinophilic granulomatosis with polyangiitis: a pilot study of 11 cases.
作者: Yun Liu.;Minglang Zhan.;Rongyi Chen.;Xianting Sun.;Mengdi Li.;Huiyong Chen.;Lindi Jiang.
来源: Rheumatology (Oxford). 2025年64卷12期6294-6301页
Current treatment for eosinophilic granulomatosis with polyangiitis (EGPA) is not always satisfactory due to refractory disease, relapse and drug toxicity. This study aims to investigate the efficacy and safety of tofacitinib, a Janus kinase (JAK) inhibitor, in the treatment of EGPA.
788. Impaired humoral and T helper cell responses to toxic shock syndrome toxin-1 (TSST-1) in granulomatosis with polyangiitis.
作者: Hang Liao.;Abraham Rutgers.;Minke G Huitema.;Caroline Roozendaal.;Peter Heeringa.;Wayel H Abdulahad.
来源: Rheumatology (Oxford). 2025年64卷12期6309-6318页
Nasal carriage of toxic shock syndrome toxin-1 (TSST-1)-positive Staphylococcus aureus (SA) is associated with a high relapse rate in granulomatosis with polyangiitis (GPA), suggesting TSST-1's role in disease progression. This study investigated the immune response to S. aureus-derived TSST-1 and characterized TSST-1-specific Th cells in GPA patients.
789. Aquaporin-4 downregulation in dysphagic patients with idiopathic inflammatory myopathies: myofiber vulnerability and inflammation drivers.
作者: Marco Fornaro.;Margherita Giannini.;Dario D'Abbicco.;Maria L Fiorella.;Mariella Errede.;Daniela Virgintino.;Onofrio Valente.;Antonio Frigeri.;Florenzo Iannone.;Francesco Girolamo.
来源: Rheumatology (Oxford). 2025年64卷12期6378-6386页
To evaluate whether the impairment of aquaporin-4 (AQP4), a water channel protein important for muscle function, may be associated with dysphagia in idiopathic inflammatory myopathies (IIMs). Swallowing muscle inflammation in IIM has been documented in case reports, but direct correlations with limb muscles impairment are lacking.
790. Urinary soluble CD163 is useful to predict lupus nephritis activity and to monitor standard-of-care therapy response.
作者: Yves Renaudineau.;Emmanuel Treiner.;Magali Colombat.;Gregory Pugnet.;Laurent Sailler.;Antoine Huart.;Stanislas Faguer.;Julie Belliere.
来源: Rheumatology (Oxford). 2025年64卷12期6319-6327页
This study aims to assess urinary soluble CD163 normalized to creatinuria (usCD163/Cre) alongside conventional biomarkers as indicators of renal activity and therapeutic response in LN.
792. Local immune effector cell-associated toxicity syndrome in CAR T-cell treated patients with refractory systemic lupus erythematosus - Authors' reply.
作者: Melanie Hagen.;Fabian Müller.;Andreas Wirsching.;Soraya Kharboutli.;Silvia Spoerl.;Christina Düsing.;Tobias Krickau.;Markus Metzler.;Simon Völkl.;Michael Aigner.;Sascha Kretschmann.;Ingrid Vasova.;Marc Saake.;Stefan Schliep.;Torsten Kubacki.;Nicolas Hunzelmann.;Laura Bucci.;Jule Taubmann.;Christina Bergmann.;Andrea-Hermina Györfi.;Sascha Dietrich.;Jörg H W Distler.;Ricardo Grieshaber-Bouyer.;Andreas Mackensen.;Georg Schett.
来源: Lancet Rheumatol. 2025年7卷10期e667-e669页 796. Personalised gait retraining for medial compartment knee osteoarthritis: a randomised controlled trial.
作者: Scott D Uhlrich.;Valentina Mazzoli.;Amy Silder.;Andrea K Finlay.;Feliks Kogan.;Garry E Gold.;Scott L Delp.;Gary S Beaupre.;Julie A Kolesar.
来源: Lancet Rheumatol. 2025年7卷10期e708-e718页
Retraining individuals with medial compartment knee osteoarthritis to walk with a patient-specific change in their foot angle (ie, toe-in or toe-out angle) can reduce excessive joint loading related to disease progression. This study investigated the clinical, biomechanical, and structural efficacy of personalised foot progression angle modifications compared with sham treatment in patients with mild-to-moderate medial compartment knee osteoarthritis.
798. Effectiveness of intravenous infliximab versus subcutaneous adalimumab in Takayasu arteritis: a multicentre retrospective study.
作者: Arsène Mekinian.;Sarah Meneses.;Lucie Biard.;Lorenzo Dagna.;Pavel Novikov.;Carlo Salvarani.;Olivier Espitia.;Savino Sciscia.;Martin Michaud.;Marc Lambert.;José Hernández-Rodríguez.;Nicolas Schleinitz.;Abid Awisat.;Xavier Puéchal.;Achille Aouba.;Heloise Munoz Pons.;Ilya Smitienko.;Jean Baptiste Gaultier.;Le Mouel Edwige.;Ygal Benhamou.;Antoinette Perlat.;Patrick Jego.;Tiphaine Goulenok.;Karim Sacre.;Bertrand Lioger.;Nolan Hassold.;Jonathan Broner.;Virginie Dufrost.;Thomas Sene.;Julie Seguier.;Francois Maurier.;Sabine Berthier.;Alexandre Belot.;Faten Frikha.;Guillaume Denis.;Alexandra Audemard-Verger.;Isabelle Koné-Paut.;Sebastien Humbert.;Pascal Woaye-Hune.;Alessandro Tomelleri.;Elena Baldissera.;Masataka Kuwana.;Alberto Lo Gullo.;Vahan Mukuchyan.;Azeddine Dellal.;Francis Gaches.;Pierre Zeminsky.;Chiara Marvisi.;Moya Alvarado.;Luigi Boiardi.;Francesco Muratore.;Mathieu Vautier.;Corrado Campochiaro.;Sergey Moiseev.;Matheus Vieira.;Patrice Cacoub.;Olivier Fain.;David Saadoun.; .
来源: Rheumatology (Oxford). 2025年64卷12期6192-6200页
In this large multicentre study, we aimed to compare the effectiveness of intravenous infliximab (IFX) vs subcutaneous adalimumab (ADA) in patients with Takayasu arteritis (TAK).
800. A screening tool to detect interstitial lung disease in systemic sclerosis: the ILD-RISC score.
作者: Cosimo Bruni.;Lorenzo Tofani.;Håvard Fretheim.;Sophie I E Liem.;Arthiha Velauthapillai.;Hilde Bjørkekjær.;Imon Barua.;Ilaria Galetti.;Alexandru Garaiman.;Mike O Becker.;Anna-Maria Hoffmann-Vold.;Jeska de Vries-Bouwstra.;Madelon C Vonk.;Jörg H W Distler.;Marco Matucci-Cerinic.;Oliver Distler.
来源: Rheumatology (Oxford). 2025年64卷12期6285-6293页
As a screening tool for the presence of systemic sclerosis-associated interstitial lung disease (SSc-ILD) on high-resolution computed tomography (HRCT) is missing, we aimed to develop the ILD-RISC score, a risk algorithm to guide physicians in ordering HRCTs, with specific focus on follow-up visits.
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