This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/policies/article-withdrawal). This article has been retracted at the request of the authors over questions of data integrity and reproducibility. Following an investigation undertaken by the University of Liverpool into research misconduct by Dr Daniel Antoine (https://news.liverpool.ac.uk/2018/07/06/research-misconduct-update/), the remaining authors elected to reanalyze independent samples of the human serum from the patient cohorts originally studied. The human serum analysis had been undertaken by Daniel Antoine at the University of Liverpool for this manuscript (REF PMID: 26344055). The coauthors were unable to reproduce the findings of the human serum analysis (doi: https://doi.org/10.1101/2021.04.02.437789) and therefore no longer have confidence in the human data component of this manuscript. The authors requested that this paper be retracted in 2019, and the Editors of Gastroenterology agree that this manuscript should be retracted. Dr Daniel Antoine played no part in any other aspects of this manuscript, and the authors have confidence in all other data.

Heterozygous inactivating mutations of Serine Threonine Kinase 11/Liver Kinase B1 (LKB1) are causative to the Peutz-Jeghers syndrome (PJS), a hereditary disease characterized by gastrointestinal hamartomatous polyposis and increased cancer susceptibility. Although LKB1 loss-induced polyp formation has been ascribed to nonepithelial tissues, how LKB1 deficiency increases cancer risk of patients by altering the phenotypical landscape and hierarchical organization of epithelial tissues remains poorly understood.

To evaluate the effectiveness of a staged health education pathway in the perioperative care of patients with esophageal cancer.

Patients with advanced cirrhosis are at an elevated risk of mortality, underscoring the need for reliable prognostic markers. This study aims to evaluate the association between the lactate-to-glucose ratio (LGR) and all-cause mortality in critically ill patients with cirrhosis, providing insights into potential predictive indicators in this high-risk population.

Identifying acute pancreatitis (AP) patients at risk of severe progression remains a challenge. The National Early Warning Score (NEWS) has been shown to effectively predict adverse outcomes (intensive care unit (ICU) admission and mortality) in critically ill patients, including AP. The combined model of NEWS and serum calcium (NEWS-Calcium) is hypothesized to enhance predictive accuracy. This study evaluates the value of NEWS and NEWS-Calcium in predicting adverse outcomes in AP, and compares them with the Bedside Index for Severity in Acute Pancreatitis (BISAP).

Acute pancreatitis (AP) is a serious condition, and the current diagnostic systems for AP are often time-consuming, and challenging to use outside intensive care, as they involve multiple variables. The diagnostic value of the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII) for determining the severity of acute pancreatitis (AP) was investigated.

Barrett's esophagus (BE) is the only identifiable precursor to esophageal adenocarcinoma (EAC). Endoscopic surveillance has been proposed for early detection of BE-related neoplasia and reducing EAC mortality. This clinical practice guideline aims to inform clinicians and patients by providing evidence-based practice recommendations for surveillance in patients with BE.