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781. The efficacy and safety of fluticasone propionate (250 microg)/salmeterol (50 microg) combined in the Diskus inhaler for the treatment of COPD.
作者: Nicola A Hanania.;Patrick Darken.;Donald Horstman.;Colin Reisner.;Benjamin Lee.;Suzanne Davis.;Tushar Shah.
来源: Chest. 2003年124卷3期834-43页
To compare the efficacy and safety of the inhaled corticosteroid fluticasone propionate (FP) and the inhaled long-acting beta(2)-agonist salmeterol (SM), when administered together in a single device (Diskus; GlaxoSmithKline, Inc; Research Triangle Park, NC), with that of placebo and the individual agents alone in patients with COPD.
782. A randomized controlled trial of inhaled flunisolide in the management of acute asthma in children.
Inhaled corticosteroids (ICS) may provide benefit in the therapy of acute asthma. The purpose of this study was to test the hypothesis that ICS are as effective as oral corticosteroids (OCS) in the management of acute childhood asthma.
783. Snoring in preschool children: prevalence and association with nocturnal cough and asthma.
The association between snoring, nocturnal cough, and allergic symptoms in young children is not known.
784. Specific expiratory muscle training in COPD.
作者: Paltiel Weiner.;Rasmi Magadle.;Marinella Beckerman.;Margalit Weiner.;Noa Berar-Yanay.
来源: Chest. 2003年124卷2期468-73页
There are several reports showing that expiratory muscle strength and endurance can be impaired in patients with COPD. This muscle weakness may have clinically relevant implications. Expiratory muscle training tended to improve cough and to reduce the sensation of respiratory effort during exercise in patients other than those with COPD.
785. The effect of smoking intervention and an inhaled bronchodilator on airways reactivity in COPD: the Lung Health Study.
作者: Robert A Wise.;Richard E Kanner.;Paula Lindgren.;John E Connett.;Murray D Altose.;Paul L Enright.;Donald P Tashkin.; .
来源: Chest. 2003年124卷2期449-58页
The Lung Health Study (LHS), a 5-year, randomized, prospective clinical trial, studied the effects of smoking intervention and therapy with inhaled anticholinergic bronchodilators on FEV(1) in participants who were 35 to 60 years of age and had mild COPD. Participants were randomized into the following three groups: usual care; smoking cessation plus inhaled ipratropium bromide; and smoking cessation plus placebo inhaler. This report evaluates the effects of these interventions, demographic characteristics, smoking status, and FEV(1) changes on airway responsiveness (AR).
786. Peripheral muscle strength training in bed-bound patients with COPD receiving mechanical ventilation: effect of electrical stimulation.
To compare the effects of active limb mobilization (ALM) with or without electrical stimulation (ES) on muscle strength, respiratory rate (RR), heart rate, oxygen saturation, and time needed to transfer from bed to chair in two groups of patients with COPD.
787. Cardiopulmonary effects of lipid emulsions in patients with ARDS.
作者: Marion Faucher.;Fabienne Bregeon.;Marc Gainnier.;Xavier Thirion.;Jean-Pierre Auffray.;Laurent Papazian.
来源: Chest. 2003年124卷1期285-91页
Lipid emulsions have been suspected of inducing certain modifications in gas exchange and pulmonary hemodynamics. The aim of this prospective study was to evaluate the hemodynamic and pulmonary effects of two lipid emulsions.
788. Serious asthma exacerbations in asthmatics treated with high-dose formoterol.
作者: Marianne Mann.;Badrul Chowdhury.;Eugene Sullivan.;Richard Nicklas.;Raymond Anthracite.;Robert J Meyer.
来源: Chest. 2003年124卷1期70-4页
To review three prospective, randomized, placebo-controlled, double-blind clinical studies of formoterol (Foradil Aerolizer; Novartis Pharmaceuticals; Basel, Switzerland) at dosages of 12 microg and 24 microg bid for the treatment of patients with asthma.
789. Lack of long-term adverse adrenal effects from inhaled triamcinolone: Lung Health Study II.
作者: Michael S Eichenhorn.;Robert A Wise.;Thelma C Madhok.;Lynn B Gerald.;William C Bailey.;Donald P Tashkin.;Paul D Scanlon.; .
来源: Chest. 2003年124卷1期57-62页
Inhaled corticosteroids (ICS) are widely used in the treatment of COPD. One of the potential adverse effects of their use is the development of adrenal suppression. Our study aimed to determine the effects of ICS on adrenal function over 3 years of use in patients with COPD.
790. Airway tissue mast cells in persistent asthma: predictor of treatment failure when patients discontinue inhaled corticosteroids.
作者: Monica Kraft.;Richard J Martin.;Stephen C Lazarus.;John V Fahy.;Homer A Boushey.;Robert F Lemanske.;Stanley J Szefler.; .
来源: Chest. 2003年124卷1期42-50页
To determine if persistent airway tissue mast cells are associated with treatment failure when patients discontinue inhaled corticosteroids (ICS).
791. Triple inhaled drug protocol for the treatment of acute severe asthma.
This study tests the hypothesis that the administration of multiple doses of inhaled albuterol (A), ipratropium bromide (IB), and flunisolide (F) provides an additional benefit to adults with acute severe asthma compared with the administration of A plus IB (A/IB) or A plus F (A/F).
792. Cardiovascular safety of salmeterol in COPD.
作者: Gary T Ferguson.;Christian Funck-Brentano.;Tracy Fischer.;Patrick Darken.;Colin Reisner.
来源: Chest. 2003年123卷6期1817-24页
Patients with COPD have an increased risk of cardiovascular disease. Despite the clinical benefits of long-acting beta-agonist agents in the treatment of COPD, patients may be at an increased risk of cardiovascular toxicity, including tachyarrhythmia due to beta-adrenergic stimulation.
793. A comparison of the effects of salbutamol and ipratropium bromide on exercise endurance in patients with COPD.
作者: Toru Oga.;Koichi Nishimura.;Mitsuhiro Tsukino.;Susumu Sato.;Takashi Hajiro.;Michiaki Mishima.
来源: Chest. 2003年123卷6期1810-6页
Inhaled bronchodilators are the first-line pharmacotherapy against COPD. The purpose of the present study was to investigate the effects of beta(2)-agonists and anticholinergic agents on the exercise capacity of patients with COPD.
794. Utility of daily routine portable chest radiographs in mechanically ventilated patients in the medical ICU.
To determine whether there is any difference in diagnostic, therapeutic, and outcome efficacy between protocols utilizing daily (ie, routine) chest radiographs (CXRs) and those utilizing clinically indicated (ie, nonroutine) CXRs in mechanically ventilated patients.
795. Budesonide and formoterol in a single inhaler improves asthma control compared with increasing the dose of corticosteroid in adults with mild-to-moderate asthma.
作者: Umesh G Lalloo.;Jóseph Malolepszy.;Dezsó Kozma.;Kamil Krofta.;Jaro Ankerst.;Bjørn Johansen.;Neil C Thomson.
来源: Chest. 2003年123卷5期1480-7页
We evaluated the efficacy and safety of low-dose budesonide/formoterol, 80 micro g/4.5 micro g, bid in a single inhaler (Symbicort Turbuhaler; AstraZeneca; Lund, Sweden) compared with an increased dose of budesonide, 200 micro g bid, in adult patients with mild-to-moderate asthma not fully controlled on low doses of inhaled corticosteroid alone.
796. Comparison of acetazolamide and medroxyprogesterone as respiratory stimulants in hypercapnic patients with COPD.
作者: Michiel Wagenaar.;Petra Vos.;Yvonne Heijdra.;Luc Teppema.;Hans Folgering.
来源: Chest. 2003年123卷5期1450-9页
Acetazolamide and medroxyprogesterone acetate (MPA) are two respiratory stimulants that can be used in patients with stable hypercapnic COPD.
797. The contribution of blood cultures to the clinical management of adult patients admitted to the hospital with community-acquired pneumonia: a prospective observational study.
作者: Samuel G Campbell.;Thomas J Marrie.;Rosemary Anstey.;Garth Dickinson.;Stacy Ackroyd-Stolarz.
来源: Chest. 2003年123卷4期1142-50页
To assess the clinical usefulness of blood cultures (BCs) in the management of patients hospitalized with community-acquired pneumonia (CAP).
798. Clinical outcomes related to interface type in patients with obstructive sleep apnea/hypopnea syndrome who are using continuous positive airway pressure.
To evaluate the effect of interface on objective compliance, patient satisfaction, adverse effects, quality of life, and residual sleep-disordered breathing in patients with obstructive sleep apnea/hypopnea syndrome (OSAHS) using continuous positive airway pressure (CPAP).
799. A pilot prospective, randomized, placebo-controlled trial of bilevel positive airway pressure in acute asthmatic attack.
Noninvasive ventilation has been shown to be effective in patients with acute respiratory failure due to pulmonary edema and exacerbations of COPD. Its role in an acute asthmatic attack, however, is uncertain. The purpose of this pilot study was to compare conventional asthma treatment with nasal bilevel pressure ventilation (BPV) [BiPAP; Respironics; Murrysville, PA] plus conventional treatment in patients with a severe asthmatic attack admitted to the emergency department.
800. High-dose inhaled fluticasone and delayed hypersensitivity skin testing.
作者: Ronald W England.;Jeffrey S Nugent.;Kurt W Grathwohl.;Larry Hagan.;James M Quinn.
来源: Chest. 2003年123卷4期1014-7页
Systemic steroids have been associated with anergy. Treatment with high-dose inhaled steroids has many documented systemic side effects, including adrenal suppression, reduction in growth velocity, and increased bone metabolism; however, little is known about their effect on delayed-type hypersensitivity (DTH).
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