61. The clinical effectiveness of clarithromycin versus endoscopic sinus surgery for adults with chronic rhinosinusitis with and without nasal polyps (MACRO): a pragmatic, multicentre, three-arm, randomised, placebo-controlled phase 4 trial.
作者: Carl Philpott.;David J Beard.;Elnaz Saeedi.;Jonathan A Cook.;Stephen Jones.;Caroline S Clarke.;Lucinda Teoh.;Mike Thomas.;Paul Little.;Jane Vennik.;Valerie Lund.;Anne G M Schilder.;Fei Long.;Stephen Durham.;James Boardman.;Claire Hopkins.; .; .
来源: Lancet. 2025年406卷10506期926-939页
A paucity of evidence regarding use of endoscopic sinus surgery and antibiotics in managing chronic rhinosinusitis has contributed to a five-times variation in endoscopic sinus surgery rates, as well as variation in the use of antibiotics. The main aim of the present trial was to compare the clinical effectiveness of endoscopic sinus surgery or 3 months of clarithromycin treatment alongside intranasal medication in adults with chronic rhinosinusitis with or without nasal polyps.
62. Blood pressure-lowering efficacy of antihypertensive drugs and their combinations: a systematic review and meta-analysis of randomised, double-blind, placebo-controlled trials.
作者: Nelson Wang.;Abdul Salam.;Rashmi Pant.;Amit Kumar.;Rupasvi Dhurjati.;Faraidoon Haghdoost.;Kota Vidyasagar.;Prachi Kaistha.;Hariprasad Esam.;Sonali R Gnanenthiran.;Raju Kanukula.;Paul K Whelton.;Brent Egan.;Aletta E Schutte.;Kazem Rahimi.;Otavio Berwanger.;Anthony Rodgers.
来源: Lancet. 2025年406卷10506期915-925页
We aimed to quantify the blood pressure-lowering efficacy of antihypertensive drugs and their combinations from the five major drug classes.
79. Tackling cardiovascular disease in the Asia-Pacific region: a new Lancet Commission.
作者: Carolyn S P Lam.;F Aaysha Cader.;Nicholas W S Chew.;Clara K Chow.;Corina Grey.;Yuming Guo.;Adam J Nelson.;Anna Rolleston.;Mitsuaki Sawano.;Kathryn Choon Beng Tan.;Jasper Tromp.;Lijing L Yan.;Stephen J Nicholls.
来源: Lancet. 2025年406卷10507期988-989页 |