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61. Oral Muvalaplin for Lowering of Lipoprotein(a): A Randomized Clinical Trial.
作者: Stephen J Nicholls.;Wei Ni.;Grace M Rhodes.;Steven E Nissen.;Ann Marie Navar.;Laura F Michael.;Axel Haupt.;John H Krege.
来源: JAMA. 2025年333卷3期222-231页
Muvalaplin inhibits lipoprotein(a) formation. A 14-day phase 1 study demonstrated that muvalaplin was well tolerated and reduced lipoprotein(a) levels up to 65%. The effect of longer administration of muvalaplin on lipoprotein(a) levels in individuals at high cardiovascular risk remains uncertain.
62. Pulmonary Vein Isolation With Optimized Linear Ablation vs Pulmonary Vein Isolation Alone for Persistent AF: The PROMPT-AF Randomized Clinical Trial.
作者: Caihua Sang.;Qiang Liu.;Yiwei Lai.;Shijun Xia.;Ruhong Jiang.;Songnan Li.;Qi Guo.;Qifan Li.;Mingyang Gao.;Xueyuan Guo.;Lihong Huang.;Nian Liu.;Chenxi Jiang.;Song Zuo.;Xiaoxia Liu.;Mengmeng Li.;Weili Ge.;Shangming Song.;Lianghua Chen.;Shuanglun Xie.;Jiangang Zou.;Ke Chen.;Xiangfei Liu.;Hesheng Hu.;Xinhua Wang.;Jinlin Zhang.;Zhaojun Wang.;Chi Wang.;Liu He.;Chao Jiang.;Ribo Tang.;Ning Zhou.;Yunlong Wang.;Deyong Long.;Xin Du.;Chenyang Jiang.;Laurent Macle.;Jianzeng Dong.;Changsheng Ma.; .
来源: JAMA. 2025年333卷5期381-389页
Success rates of pulmonary vein isolation (PVI) are modest for persistent atrial fibrillation (AF). Additional linear ablation beyond PVI has not been proved superior to PVI alone in randomized trials. Ethanol infusion of the vein of Marshall (EIVOM) facilitates ablation at the mitral isthmus and may lead to improved effectiveness of a linear ablation strategy.
64. Evaluating Performance and Agreement of Coronary Heart Disease Polygenic Risk Scores.
作者: Sarah A Abramowitz.;Kristin Boulier.;Karl Keat.;Katie M Cardone.;Manu Shivakumar.;John DePaolo.;Renae Judy.;Francisca Bermudez.;Nour Mimouni.;Christopher Neylan.;Dokyoon Kim.;Daniel J Rader.;Marylyn D Ritchie.;Benjamin F Voight.;Bogdan Pasaniuc.;Michael G Levin.;Scott M Damrauer.; .
来源: JAMA. 2025年333卷1期60-70页
Polygenic risk scores (PRSs) for coronary heart disease (CHD) are a growing clinical and commercial reality. Whether existing scores provide similar individual-level assessments of disease susceptibility remains incompletely characterized.
66. Tenofovir and Hepatitis B Virus Transmission During Pregnancy: A Randomized Clinical Trial.
作者: Calvin Q Pan.;Erhei Dai.;Zhongfu Mo.;Hua Zhang.;Thomas Q Zheng.;Yuming Wang.;Yingxia Liu.;Tianyan Chen.;Suwen Li.;Cuili Yang.;Jinjuan Wu.;Xiuli Chen.;Huaibin Zou.;Shanshan Mei.;Lin Zhu.
来源: JAMA. 2025年333卷5期390-399页
Standard care for preventing mother-to-child transmission (MTCT) of hepatitis B virus (HBV) in highly viremic mothers consists of maternal antiviral prophylaxis beginning at gestational week 28 combined with an HBV vaccine series and HBV immune globulin (HBIG) at birth. However, HBIG is unavailable in some resource-limited areas.
67. Artemisinin Partial Resistance in Ugandan Children With Complicated Malaria.
作者: Ryan C Henrici.;Ruth Namazzi.;Giselle Lima-Cooper.;Charles Kato.;Sadati Aliwuya.;Jamille G Dombrowski.;Sade Pratt.;Susana Campino.;Andrea L Conroy.;Colin J Sutherland.;Chandy C John.;Robert O Opoka.
来源: JAMA. 2025年333卷1期83-84页 68. Symptom Screening Linked to Care Pathways for Pediatric Patients With Cancer: A Randomized Clinical Trial.
作者: L Lee Dupuis.;Emily Vettese.;Allison C Grimes.;Melissa P Beauchemin.;Lisa M Klesges.;Christina Baggott.;Jenna Demedis.;Catherine Aftandilian.;David R Freyer.;Nicole Crellin-Parsons.;Etan Orgel.;David Dickens.;Kara M Kelly.;Wade Kyono.;Alexandra Walsh.;Farha Sherani.;Daniel Cannone.;Andrea D Orsey.;Allison A King.;Lolie Yu.;Wendy Woods-Swafford.;Scott M Bradfield.;Michael E Roth.;Adam J Esbenshade.;Emi H Caywood.;Vibhuti Agarwal.;Ramamoorthy Nagasubramanian.;George A Tomlinson.;Lillian Sung.
来源: JAMA. 2024年332卷23期1981-1991页
Pediatric patients with cancer commonly experience severely bothersome symptoms. The effectiveness of routine symptom screening with symptom feedback and symptom management care pathways is unknown.
70. Intratracheal Budesonide Mixed With Surfactant for Extremely Preterm Infants: The PLUSS Randomized Clinical Trial.
作者: Brett J Manley.;C Omar F Kamlin.;Susan M Donath.;Kate L Francis.;Jeanie L Y Cheong.;Peter A Dargaville.;Jennifer A Dawson.;Susan E Jacobs.;Pita Birch.;Steven M Resnick.;Georg M Schmölzer.;Brenda Law.;Risha Bhatia.;Katinka P Bach.;Koert de Waal.;Javeed N Travadi.;Pieter J Koorts.;Mary J Berry.;Kei Lui.;Victor S Rajadurai.;Suresh Chandran.;Martin Kluckow.;Elza Cloete.;Margaret M Broom.;Michael J Stark.;Adrienne Gordon.;Vinayak Kodur.;Lex W Doyle.;Peter G Davis.;Christopher J D McKinlay.; .
来源: JAMA. 2024年332卷22期1889-1899页
Bronchopulmonary dysplasia (BPD) is a common adverse outcome in extremely preterm infants born at less than 28 weeks' gestation. Systemic corticosteroids are effective against BPD but may be associated with adverse outcomes. Corticosteroids given directly into the lungs may be effective and safer.
71. Online Retailer Nonadherence to Age Verification, Shipping, and Flavor Restrictions on E-Cigarettes.
作者: Raquel M Harati.;Shannon E Ellis.;Nora Satybaldiyeva.;Tomas Mejorado.;Gustavo Benitez.;Lisa Henriksen.;Eric C Leas.
来源: JAMA. 2024年332卷24期2113-2114页 73. Postmarketing Surveillance of Inferior Vena Cava Filters Among US Medicare Beneficiaries: The SAFE-IVC Study.
作者: Enrico G Ferro.;Julie B Mackel.;Renee D Kramer.;Rebecca Torguson.;Eleni M Whatley.;Gregory O'Connell.;Brian Pullin.;Nathan W Watson.;Siling Li.;Yang Song.;Anna K Krawisz.;Brett J Carroll.;Marc L Schermerhorn.;Jeffrey L Weinstein.;Andrew Farb.;Bram Zuckerman.;Robert W Yeh.;Eric A Secemsky.
来源: JAMA. 2024年332卷24期2091-2100页
Inferior vena cava filters (IVCFs) are commonly used to prevent pulmonary embolism in selected clinical scenarios, despite limited evidence to support their use. Current recommendations from professional societies and the US Food and Drug Administration endorse timely IVCF retrieval when clinically feasible. Current IVCF treatment patterns and outcomes remain poorly described.
75. CAR T Cells and T-Cell Therapies for Cancer: A Translational Science Review.
Chimeric antigen receptor (CAR) T cells are T lymphocytes that are genetically engineered to express a synthetic receptor that recognizes a tumor cell surface antigen and causes the T cell to kill the tumor cell. CAR T treatments improve overall survival for patients with large B-cell lymphoma and progression-free survival for patients with multiple myeloma.
76. A Digital Health Behavior Intervention to Prevent Childhood Obesity: The Greenlight Plus Randomized Clinical Trial.
作者: William J Heerman.;Russell L Rothman.;Lee M Sanders.;Jonathan S Schildcrout.;Kori B Flower.;Alan M Delamater.;Melissa C Kay.;Charles T Wood.;Rachel S Gross.;Aihua Bian.;Laura E Adams.;Evan C Sommer.;H Shonna Yin.;Eliana M Perrin.; .;Belen de la Barrera.;Malakha Bility.;Michelle Cruz Jimenez Smith.;Evelyn F Cruzatte.;Gabriela Guevara.;Janna B Howard.;Jacarra Lampkin.;Colin J Orr.;Jennifer Pilotos McBride.;Lourdes Quintana Forster.;Kimberly S Ramirez.;Javier Rodriguez.;Samantha Schilling.;W Elizabeth Shepard.;Altagracia Soto.;Jessica J Velazquez.;Shelby Wallace.
来源: JAMA. 2024年332卷24期2068-2080页
Infant growth predicts long-term obesity and cardiovascular disease. Previous interventions designed to prevent obesity in the first 2 years of life have been largely unsuccessful. Obesity prevalence is high among traditional racial and ethnic minority groups.
78. Differences in Drug Shortages in the US and Canada.
作者: Mina Tadrous.;Katherine Callaway Kim.;Inmaculada Hernandez.;Scott D Rothenberger.;Joshua W Devine.;Tina B Hershey.;Lisa M Maillart.;Walid F Gellad.;Katie J Suda.
来源: JAMA. 2024年332卷22期1912-1922页
Drug shortages are a persistent public health issue that increased during the COVID-19 pandemic. Both the US and Canada follow similar regulatory standards and require reporting of drug-related supply chain issues that may result in shortages. However, it is unknown what proportion are associated with meaningful shortages (defined by a significant decrease in drug supply) and whether differences exist between Canada and the US.
79. State Policies Regulating Law Enforcement Access to Prescription Drug Monitoring Program Testosterone Prescription Data.
作者: Katie McCreedy.;Jule von der Heydt.;Aanchalika Chauhan.;Rajvi Shah.;Sunyou Kang.;Elizabeth Platt.;Leo Beletsky.
来源: JAMA. 2024年332卷20期1754-1757页 80. Early Intervention in Patients With Asymptomatic Severe Aortic Stenosis and Myocardial Fibrosis: The EVOLVED Randomized Clinical Trial.
作者: Krithika Loganath.;Neil J Craig.;Russell J Everett.;Rong Bing.;Vasiliki Tsampasian.;Patrycja Molek.;Simona Botezatu.;Saadia Aslam.;Steff Lewis.;Catriona Graham.;Audrey C White.;Tom MacGillivray.;Christopher E Tuck.;Phillip Rayson.;Denise Cranley.;Sian Irvine.;Ruth Armstrong.;Lynsey Milne.;Calvin W L Chin.;Graham S Hillis.;Timothy Fairbairn.;John P Greenwood.;Richard Steeds.;Stephen J Leslie.;Chim C Lang.;Chiara Bucciarelli-Ducci.;Nikhil V Joshi.;Vijay Kunadian.;Vassilios S Vassiliou.;Jason N Dungu.;Sandeep S Hothi.;Nicholas Boon.;Sanjay K Prasad.;Niall G Keenan.;Dana Dawson.;Thomas A Treibel.;Mani Motwani.;Christopher A Miller.;Nicholas L Mills.;Ronak Rajani.;David P Ripley.;Gerry P McCann.;Bernard Prendergast.;Anvesha Singh.;David E Newby.;Marc R Dweck.; .
来源: JAMA. 2025年333卷3期213-221页
Development of myocardial fibrosis in patients with aortic stenosis precedes left ventricular decompensation and is associated with an adverse long-term prognosis.
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