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61. Stepped Palliative Care for Patients With Advanced Lung Cancer: A Randomized Clinical Trial.
作者: Jennifer S Temel.;Vicki A Jackson.;Areej El-Jawahri.;Simone P Rinaldi.;Laura A Petrillo.;Pallavi Kumar.;Kathryn A McGrath.;Thomas W LeBlanc.;Arif H Kamal.;Christopher A Jones.;Dustin J Rabideau.;Nora Horick.;Kedie Pintro.;Emily R Gallagher Medeiros.;Kathryn E Post.;Joseph A Greer.
来源: JAMA. 2024年332卷6期471-481页
Despite the evidence for early palliative care improving outcomes, it has not been widely implemented in part due to palliative care workforce limitations.
62. Ivonescimab Plus Chemotherapy in Non-Small Cell Lung Cancer With EGFR Variant: A Randomized Clinical Trial.
作者: .;Wenfeng Fang.;Yuanyuan Zhao.;Yongzhong Luo.;Runxiang Yang.;Yan Huang.;Zhiyong He.;Hui Zhao.;Mingjun Li.;Kai Li.;Qibing Song.;Xiaobo Du.;Yulan Sun.;Wei Li.;Fei Xu.;Zhiyu Wang.;Kunning Yang.;Yun Fan.;Baogang Liu.;Hongyun Zhao.;Ying Hu.;Li Jia.;Shen Xu.;Tienan Yi.;Dongqing Lv.;Haitao Lan.;Mengxia Li.;Wenhua Liang.;Yongsheng Wang.;Hui Yang.;Yuming Jia.;Yuan Chen.;Junguo Lu.;Jifeng Feng.;Chunling Liu.;Ming Zhou.;Jianya Zhou.;Xianling Liu.;Ningning Zhou.;Ming He.;Xiaorong Dong.;Hualin Chen.;Yongxing Chen.;Haichuan Su.;Xiaoling Li.;Zhihong Zhang.;Lei Yang.;Ying Cheng.;Likun Chen.;Xue Hou.;Yu Zhang.;Jun Guo.;Zhen Wang.;Hong Lu.;Di Wu.;Weineng Feng.;Wen Li.;Jianan Huang.;Yan Wang.;Xia Song.;Jiewen Peng.;Laiyu Liu.;Yubiao Guo.;Wenting Li.;Dongmei Lu.;Mingxiu Hu.;Zhongmin Maxwell Wang.;Baiyong Li.;Michelle Xia.;Li Zhang.
来源: JAMA. 2024年332卷7期561-570页
For patients with non-small cell lung cancer whose disease progressed while receiving EGFR tyrosine kinase inhibitor (EGFR-TKI) therapy, particularly third-generation TKIs, optimal treatment options remain limited.
63. Tirzepatide for Weight Reduction in Chinese Adults With Obesity: The SURMOUNT-CN Randomized Clinical Trial.
作者: Lin Zhao.;Zhifeng Cheng.;Yibing Lu.;Ming Liu.;Hong Chen.;Min Zhang.;Rui Wang.;Yuan Yuan.;Xiaoying Li.
来源: JAMA. 2024年332卷7期551-560页
Obesity has become a global public health concern and China has the largest number of affected people worldwide.
64. Krill Oil for Knee Osteoarthritis: A Randomized Clinical Trial.
作者: Laura L Laslett.;Lieke E J M Scheepers.;Benny Antony.;Anita E Wluka.;Guoqi Cai.;Catherine L Hill.;Lyn March.;Helen I Keen.;Petr Otahal.;Flavia M Cicuttini.;Graeme Jones.
来源: JAMA. 2024年331卷23期1997-2006页
Knee osteoarthritis is disabling, with few effective treatments. Preliminary evidence suggested that krill oil supplementation improved knee pain, but effects on knee osteoarthritis remain unclear.
65. Bisoprolol in Patients With Chronic Obstructive Pulmonary Disease at High Risk of Exacerbation: The BICS Randomized Clinical Trial.
作者: Graham Devereux.;Seonaidh Cotton.;Mintu Nath.;Nicola McMeekin.;Karen Campbell.;Rekha Chaudhuri.;Gourab Choudhury.;Anthony De Soyza.;Shona Fielding.;Simon Gompertz.;John Haughney.;Amanda J Lee.;Graeme MacLennan.;Alyn Morice.;John Norrie.;David Price.;Philip Short.;Jorgen Vestbo.;Paul Walker.;Jadwiga Wedzicha.;Andrew Wilson.;Olivia Wu.;Brian J Lipworth.
来源: JAMA. 2024年332卷6期462-470页
Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. Observational studies report that β-blocker use may be associated with reduced risk of COPD exacerbations. However, a recent trial reported that metoprolol did not reduce COPD exacerbations and increased COPD exacerbations requiring hospital admission.
66. Acetaminophen for Prevention and Treatment of Organ Dysfunction in Critically Ill Patients With Sepsis: The ASTER Randomized Clinical Trial.
作者: Lorraine B Ware.;D Clark Files.;Alpha Fowler.;Michael S Aboodi.;Neil R Aggarwal.;Roy G Brower.;Steven Y Chang.;Ivor S Douglas.;Scott Fields.;Andrea S Foulkes.;Adit A Ginde.;Estelle S Harris.;Gregory W Hendey.;R Duncan Hite.;Weixing Huang.;Poying Lai.;Kathleen D Liu.;B Taylor Thompson.;Michael A Matthay.; .
来源: JAMA. 2024年332卷5期390-400页
Acetaminophen (paracetamol) has many pharmacological effects that might be beneficial in sepsis, including inhibition of cell-free hemoglobin-induced oxidation of lipids and other substrates.
67. Pamrevlumab for Idiopathic Pulmonary Fibrosis: The ZEPHYRUS-1 Randomized Clinical Trial.
作者: Ganesh Raghu.;Luca Richeldi.;Evans R Fernández Pérez.;Maria Cristina De Salvo.;Rafael S Silva.;Jin Woo Song.;Takashi Ogura.;Zuo Jun Xu.;Elizabeth A Belloli.;Xueping Zhang.;Lorilyn L Seid.;Lona Poole.; .
来源: JAMA. 2024年332卷5期380-389页
Current treatments for idiopathic pulmonary fibrosis slow the rate of lung function decline, but may be associated with adverse events that affect medication adherence. In phase 2 trials, pamrevlumab (a fully human monoclonal antibody that binds to and inhibits connective tissue growth factor activity) attenuated the progression of idiopathic pulmonary fibrosis without substantial adverse events.
68. Text Messages With Financial Incentives for Men With Obesity: A Randomized Clinical Trial.
作者: Pat Hoddinott.;Catriona O'Dolan.;Lisa Macaulay.;Stephan U Dombrowski.;James Swingler.;Seonaidh Cotton.;Alison Avenell.;Abraham M Getaneh.;Cindy Gray.;Kate Hunt.;Frank Kee.;Alice MacLean.;Michelle McKinley.;Claire Torrens.;Katrina Turner.;Marjon van der Pol.;Graeme MacLennan.
来源: JAMA. 2024年332卷1期31-40页
Effective weight loss interventions are needed for men with obesity.
69. An Adaptive Behavioral Intervention for Weight Loss Management: A Randomized Clinical Trial.
作者: Bonnie Spring.;Angela F Pfammatter.;Laura Scanlan.;Elyse Daly.;Jean Reading.;Sam Battalio.;H Gene McFadden.;Don Hedeker.;Juned Siddique.;Inbal Nahum-Shani.
来源: JAMA. 2024年332卷1期21-30页
Lifestyle interventions for weight loss are difficult to implement in clinical practice. Self-managed mobile health implementations without or with added support after unsuccessful weight loss attempts could offer effective population-level obesity management.
70. Ponatinib vs Imatinib in Frontline Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: A Randomized Clinical Trial.
作者: Elias Jabbour.;Hagop M Kantarjian.;Ibrahim Aldoss.;Pau Montesinos.;Jessica T Leonard.;David Gómez-Almaguer.;Maria R Baer.;Carlo Gambacorti-Passerini.;James McCloskey.;Yosuke Minami.;Cristina Papayannidis.;Vanderson Rocha.;Philippe Rousselot.;Pankit Vachhani.;Eunice S Wang.;Bingxia Wang.;Meliessa Hennessy.;Alexander Vorog.;Niti Patel.;Tammie Yeh.;Jose-Maria Ribera.
来源: JAMA. 2024年331卷21期1814-1823页
In newly diagnosed Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL), disease progression due to acquired resistance to first- or second-generation BCR::ABL1 tyrosine kinase inhibitors is common. Ponatinib inhibits BCR::ABL1 and all single-mutation variants, including T315I.
71. Smoking Cessation After Initial Treatment Failure With Varenicline or Nicotine Replacement: A Randomized Clinical Trial.
作者: Paul M Cinciripini.;Charles E Green.;Sanjay Shete.;Jennifer A Minnix.;Jason D Robinson.;Yong Cui.;Seokhun Kim.;George Kypriotakis.;Diane Beneventi.;Janice A Blalock.;Francesco Versace.;Maher Karam-Hage.
来源: JAMA. 2024年331卷20期1722-1731页
Most people who smoke do not quit on their initial attempt.
72. Aspirin vs Placebo as Adjuvant Therapy for Breast Cancer: The Alliance A011502 Randomized Trial.
作者: Wendy Y Chen.;Karla V Ballman.;Ann H Partridge.;Olwen M Hahn.;Frederick M Briccetti.;William J Irvin.;Banu Symington.;Kala Visvanathan.;Paula R Pohlmann.;Thomas H Openshaw.;Anna Weiss.;Eric P Winer.;Lisa A Carey.;Michelle D Holmes.
来源: JAMA. 2024年331卷20期1714-1721页
Observational studies of survivors of breast cancer and prospective trials of aspirin for cardiovascular disease suggest improved breast cancer survival among aspirin users, but prospective studies of aspirin to prevent breast cancer recurrence are lacking.
73. Neurodevelopmental Outcomes After Late Preterm Antenatal Corticosteroids: The ALPS Follow-Up Study.
作者: Cynthia Gyamfi-Bannerman.;Rebecca G Clifton.;Alan T N Tita.;Sean C Blackwell.;Monica Longo.;Jessica A de Voest.;T Michael O'Shea.;Sabine Z Bousleiman.;Felecia Ortiz.;Dwight J Rouse.;Torri D Metz.;George R Saade.;Kara M Rood.;Kent D Heyborne.;John M Thorp.;Geeta K Swamy.;William A Grobman.;Kelly S Gibson.;Yasser Y El-Sayed.;George A Macones.; .
来源: JAMA. 2024年331卷19期1629-1637页
The Antenatal Late Preterm Steroids (ALPS) trial changed clinical practice in the United States by finding that antenatal betamethasone at 34 to 36 weeks decreased short-term neonatal respiratory morbidity. However, the trial also found increased risk of neonatal hypoglycemia after betamethasone. This follow-up study focused on long-term neurodevelopmental outcomes after late preterm steroids.
74. Stewardship Prompts to Improve Antibiotic Selection for Pneumonia: The INSPIRE Randomized Clinical Trial.
作者: Shruti K Gohil.;Edward Septimus.;Ken Kleinman.;Neha Varma.;Taliser R Avery.;Lauren Heim.;Risa Rahm.;William S Cooper.;Mandelin Cooper.;Laura E McLean.;Naoise G Nickolay.;Robert A Weinstein.;L Hayley Burgess.;Micaela H Coady.;Edward Rosen.;Selsebil Sljivo.;Kenneth E Sands.;Julia Moody.;Justin Vigeant.;Syma Rashid.;Rebecca F Gilbert.;Kim N Smith.;Brandon Carver.;Russell E Poland.;Jason Hickok.;S G Sturdevant.;Michael S Calderwood.;Anastasiia Weiland.;David W Kubiak.;Sujan Reddy.;Melinda M Neuhauser.;Arjun Srinivasan.;John A Jernigan.;Mary K Hayden.;Abinav Gowda.;Katyuska Eibensteiner.;Robert Wolf.;Jonathan B Perlin.;Richard Platt.;Susan S Huang.
来源: JAMA. 2024年331卷23期2007-2017页
Pneumonia is the most common infection requiring hospitalization and is a major reason for overuse of extended-spectrum antibiotics. Despite low risk of multidrug-resistant organism (MDRO) infection, clinical uncertainty often drives initial antibiotic selection. Strategies to limit empiric antibiotic overuse for patients with pneumonia are needed.
75. Stewardship Prompts to Improve Antibiotic Selection for Urinary Tract Infection: The INSPIRE Randomized Clinical Trial.
作者: Shruti K Gohil.;Edward Septimus.;Ken Kleinman.;Neha Varma.;Taliser R Avery.;Lauren Heim.;Risa Rahm.;William S Cooper.;Mandelin Cooper.;Laura E McLean.;Naoise G Nickolay.;Robert A Weinstein.;L Hayley Burgess.;Micaela H Coady.;Edward Rosen.;Selsebil Sljivo.;Kenneth E Sands.;Julia Moody.;Justin Vigeant.;Syma Rashid.;Rebecca F Gilbert.;Kim N Smith.;Brandon Carver.;Russell E Poland.;Jason Hickok.;S G Sturdevant.;Michael S Calderwood.;Anastasiia Weiland.;David W Kubiak.;Sujan Reddy.;Melinda M Neuhauser.;Arjun Srinivasan.;John A Jernigan.;Mary K Hayden.;Abinav Gowda.;Katyuska Eibensteiner.;Robert Wolf.;Jonathan B Perlin.;Richard Platt.;Susan S Huang.
来源: JAMA. 2024年331卷23期2018-2028页
Urinary tract infection (UTI) is the second most common infection leading to hospitalization and is often associated with gram-negative multidrug-resistant organisms (MDROs). Clinicians overuse extended-spectrum antibiotics although most patients are at low risk for MDRO infection. Safe strategies to limit overuse of empiric antibiotics are needed.
76. Single Ascending and Multiple-Dose Trial of Zerlasiran, a Short Interfering RNA Targeting Lipoprotein(a): A Randomized Clinical Trial.
作者: Steven E Nissen.;Kathy Wolski.;Gerald F Watts.;Michael J Koren.;Henry Fok.;Stephen J Nicholls.;David A Rider.;Leslie Cho.;Steven Romano.;Carrie Melgaard.;Curtis Rambaran.
来源: JAMA. 2024年331卷18期1534-1543页
Lipoprotein(a) is a causal risk factor for atherosclerotic cardiovascular disease (ASCVD) and calcific aortic stenosis, with no pharmacological treatments approved by regulatory authorities.
77. Prostate Cancer Screening With PSA, Kallikrein Panel, and MRI: The ProScreen Randomized Trial.
作者: Anssi Auvinen.;Teuvo L J Tammela.;Tuomas Mirtti.;Hans Lilja.;Teemu Tolonen.;Anu Kenttämies.;Irina Rinta-Kiikka.;Terho Lehtimäki.;Kari Natunen.;Jaakko Nevalainen.;Jani Raitanen.;Johanna Ronkainen.;Theodorus van der Kwast.;Jarno Riikonen.;Anssi Pétas.;Mika Matikainen.;Kimmo Taari.;Tuomas Kilpeläinen.;Antti S Rannikko.; .
来源: JAMA. 2024年331卷17期1452-1459页
Prostate-specific antigen (PSA) screening has potential to reduce prostate cancer mortality but frequently detects prostate cancer that is not clinically important.
78. Prostate-Specific Antigen Screening and 15-Year Prostate Cancer Mortality: A Secondary Analysis of the CAP Randomized Clinical Trial.
作者: Richard M Martin.;Emma L Turner.;Grace J Young.;Chris Metcalfe.;Eleanor I Walsh.;J Athene Lane.;Jonathan A C Sterne.;Sian Noble.;Peter Holding.;Yoav Ben-Shlomo.;Naomi J Williams.;Nora Pashayan.;Mai Ngoc Bui.;Peter C Albertsen.;Tyler M Seibert.;Anthony L Zietman.;Jon Oxley.;Jan Adolfsson.;Malcolm D Mason.;George Davey Smith.;David E Neal.;Freddie C Hamdy.;Jenny L Donovan.; .
来源: JAMA. 2024年331卷17期1460-1470页
The Cluster Randomized Trial of PSA Testing for Prostate Cancer (CAP) reported no effect of prostate-specific antigen (PSA) screening on prostate cancer mortality at a median 10-year follow-up (primary outcome), but the long-term effects of PSA screening on prostate cancer mortality remain unclear.
79. Integrated Hepatitis C-Opioid Use Disorder Care Through Facilitated Telemedicine: A Randomized Trial.
作者: Andrew H Talal.;Marianthi Markatou.;Anran Liu.;Ponni V Perumalswami.;Amreen M Dinani.;Jonathan N Tobin.;Lawrence S Brown.
来源: JAMA. 2024年331卷16期1369-1378页
Facilitated telemedicine may promote hepatitis C virus elimination by mitigating geographic and temporal barriers.
80. Pulmonary Vein Isolation With or Without Left Atrial Appendage Ligation in Atrial Fibrillation: The aMAZE Randomized Clinical Trial.
作者: Dhanunjaya R Lakkireddy.;David J Wilber.;Suneet Mittal.;David Tschopp.;Christopher R Ellis.;Abdi Rasekh.;Troy Hounshell.;Rudy Evonich.;Sheetal Chandhok.;Ronald D Berger.;Rodney Horton.;Michael H Hoskins.;Hugh Calkins.;Steven J Yakubov.;Pamela Simons.;Benjamin R Saville.;Randall J Lee.; .
来源: JAMA. 2024年331卷13期1099-1108页
Left atrial appendage elimination may improve catheter ablation outcomes for atrial fibrillation.
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