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61. Tranexamic Acid in Patients Undergoing Liver Resection: The HeLiX Randomized Clinical Trial.
作者: Paul J Karanicolas.;Yulia Lin.;Stuart A McCluskey.;Jordan Tarshis.;Kevin E Thorpe.;Alice Wei.;Elijah Dixon.;Geoff Porter.;Prosanto Chaudhury.;Sulaiman Nanji.;Leyo Ruo.;Melanie E Tsang.;Anton Skaro.;Gareth Eeson.;Sean Cleary.;Carol-Anne Moulton.;Chad G Ball.;Julie Hallet.;Natalie Coburn.;Pablo E Serrano.;Shiva Jayaraman.;Calvin Law.;Ved Tandan.;Gonzalo Sapisochin.;David Nagorney.;Douglas Quan.;Rory Smoot.;Steven Gallinger.;Peter Metrakos.;Trevor W Reichman.;Diederick Jalink.;Sean Bennett.;Francis Sutherland.;Edward Solano.;Michele Molinari.;Ephraim S Tang.;Susanne G Warner.;Oliver F Bathe.;Jeffrey Barkun.;Michael L Kendrick.;Mark Truty.;Rachel Roke.;Grace Xu.;Myriam Lafreniere-Roula.;Gordon Guyatt.; .
来源: JAMA. 2024年332卷13期1080-1089页
Tranexamic acid reduces bleeding and blood transfusion in many types of surgery, but its effect in patients undergoing liver resection for a cancer-related indication remains unclear.
62. Uterus Transplant in Women With Absolute Uterine-Factor Infertility.
作者: Giuliano Testa.;Greg J McKenna.;Anji Wall.;Johanna Bayer.;Anthony R Gregg.;Ann Marie Warren.;Seung Hee S Lee.;Eric Martinez.;Amar Gupta.;Robert Gunby.;Liza Johannesson.
来源: JAMA. 2024年332卷10期817-824页
Uterus transplant in women with absolute uterine-factor infertility offers the possibility of carrying their own pregnancy.
63. Edetate Disodium-Based Chelation for Patients With a Previous Myocardial Infarction and Diabetes: TACT2 Randomized Clinical Trial.
作者: Gervasio A Lamas.;Kevin J Anstrom.;Ana Navas-Acien.;Robin Boineau.;Hayley Nemeth.;Zhen Huang.;Jun Wen.;Yves Rosenberg.;Mario Stylianou.;Teresa L Z Jones.;Bonnie R Joubert.;Qilu Yu.;Regina M Santella.;Ana C Mon.;Francisco Ujueta.;Esteban Escolar.;David M Nathan.;Vivian A Fonseca.;Y Wady Aude.;Jonathan K Ehrman.;Thomas Elliott.;Rakesh Prashad.;Eldrin F Lewis.;Renato D Lopes.;Michael E Farkouh.;Anne-Marie Elliott.;Jonathan D Newman.;Daniel B Mark.; .
来源: JAMA. 2024年332卷10期794-803页
In 2013, the Trial to Assess Chelation Therapy (TACT) reported that edetate disodium (EDTA)-based chelation significantly reduced cardiovascular disease (CVD) events by 18% in 1708 patients with a prior myocardial infarction (MI).
64. A Vaping Cessation Text Message Program for Adolescent E-Cigarette Users: A Randomized Clinical Trial.
作者: Amanda L Graham.;Sarah Cha.;Megan A Jacobs.;Michael S Amato.;Anna L Funsten.;Giselle Edwards.;George D Papandonatos.
来源: JAMA. 2024年332卷9期713-721页
E-cigarettes are the most commonly used tobacco product among adolescents. Despite known harms of nicotine exposure among teens, there are no empirically tested vaping cessation interventions.
65. Effect of Cash Benefits on Health Care Utilization and Health: A Randomized Study.
Poverty is associated with greater barriers to health care and worse health outcomes, but it remains unclear whether income support can improve health.
66. Risankizumab for Ulcerative Colitis: Two Randomized Clinical Trials.
作者: Edouard Louis.;Stefan Schreiber.;Remo Panaccione.;Peter Bossuyt.;Luc Biedermann.;Jean-Frederic Colombel.;Gareth Parkes.;Laurent Peyrin-Biroulet.;Geert D'Haens.;Tadakazu Hisamatsu.;Britta Siegmund.;Kaichun Wu.;Brigid S Boland.;Gil Y Melmed.;Alessandro Armuzzi.;Phillip Levine.;Jasmina Kalabic.;Su Chen.;Ling Cheng.;Lei Shu.;W Rachel Duan.;Valerie Pivorunas.;Yuri Sanchez Gonzalez.;Ronilda D'Cunha.;Ezequiel Neimark.;Kori Wallace.;Raja Atreya.;Marc Ferrante.;Edward V Loftus.; .
来源: JAMA. 2024年332卷11期881-897页
The clinical effects of risankizumab (a monoclonal antibody that selectively targets the p19 subunit of IL-23) for the treatment of ulcerative colitis are unknown.
67. Povidone Iodine vs Chlorhexidine Gluconate in Alcohol for Preoperative Skin Antisepsis: A Randomized Clinical Trial.
作者: Andreas F Widmer.;Andrew Atkinson.;Stefan P Kuster.;Aline Wolfensberger.;Steffi Klimke.;Rami Sommerstein.;Friedrich S Eckstein.;Florian Schoenhoff.;Guido Beldi.;Christian A Gutschow.;Jonas Marschall.;Alexander Schweiger.;Philipp Jent.
来源: JAMA. 2024年332卷7期541-549页
Preoperative skin antisepsis is an established procedure to prevent surgical site infections (SSIs). The choice of antiseptic agent, povidone iodine or chlorhexidine gluconate, remains debated.
68. Dapagliflozin for Critically Ill Patients With Acute Organ Dysfunction: The DEFENDER Randomized Clinical Trial.
作者: Caio A M Tavares.;Luciano C P Azevedo.;Álvaro Rea-Neto.;Niklas S Campos.;Cristina P Amendola.;Amanda C Kozesinski-Nakatani.;Paula G David-João.;Suzana M Lobo.;Thiago C Filiponi.;Guacyra M B Almeida.;Ricardo R Bergo.;Mário R R Guimarães-Júnior.;Rodrigo C Figueiredo.;Joan R Castro.;Clewer J Schuler.;Glauco A Westphal.;Ana C R Carioca.;Frederico Monfradini.;Josue Nieri.;Flavia M O Neves.;Jaqueline A Paulo.;Camila S N Albuquerque.;Mariana C R Silva.;Mikhail N Kosiborod.;Adriano J Pereira.;Lucas P Damiani.;Thiago D Corrêa.;Ary Serpa-Neto.;Otavio Berwanger.;Fernando G Zampieri.; .
来源: JAMA. 2024年332卷5期401-411页
Sodium-glucose cotransporter 2 (SGLT-2) inhibitors improve outcomes in patients with type 2 diabetes, heart failure, and chronic kidney disease, but their effect on outcomes of critically ill patients with organ failure is unknown.
69. Continuous vs Intermittent β-Lactam Antibiotic Infusions in Critically Ill Patients With Sepsis: The BLING III Randomized Clinical Trial.
作者: Joel M Dulhunty.;Stephen J Brett.;Jan J De Waele.;Dorrilyn Rajbhandari.;Laurent Billot.;Menino O Cotta.;Joshua S Davis.;Simon Finfer.;Naomi E Hammond.;Serena Knowles.;Xiaoqiu Liu.;Shay McGuinness.;Jayanthi Mysore.;David L Paterson.;Sandra Peake.;Andrew Rhodes.;Jason A Roberts.;Claire Roger.;Charudatt Shirwadkar.;Therese Starr.;Colman Taylor.;John A Myburgh.;Jeffrey Lipman.; .
来源: JAMA. 2024年332卷8期629-637页
Whether β-lactam antibiotics administered by continuous compared with intermittent infusion reduces the risk of death in patients with sepsis is uncertain.
70. Electroencephalography-Guided Anesthesia and Delirium in Older Adults After Cardiac Surgery: The ENGAGES-Canada Randomized Clinical Trial.
作者: Alain Deschamps.;Arbi Ben Abdallah.;Eric Jacobsohn.;Tarit Saha.;George Djaiani.;Renée El-Gabalawy.;Charles Overbeek.;Jennifer Palermo.;Athanase Courbe.;Isabelle Cloutier.;Rob Tanzola.;Alex Kronzer.;Bradley A Fritz.;Eva M Schmitt.;Sharon K Inouye.;Michael S Avidan.; .
来源: JAMA. 2024年332卷2期112-123页
Intraoperative electroencephalogram (EEG) waveform suppression, suggesting excessive general anesthesia, has been associated with postoperative delirium.
71. Home Blood Pressure Telemonitoring and Nurse Case Management in Black and Hispanic Patients With Stroke: A Randomized Clinical Trial.
作者: Gbenga Ogedegbe.;Jeanne A Teresi.;Stephen K Williams.;Adebayo Ogunlade.;Chigozirim Izeogu.;Joseph P Eimicke.;Jian Kong.;Stephanie A Silver.;Olajide Williams.;Helen Valsamis.;Susan Law.;Steven R Levine.;Salina P Waddy.;Tanya M Spruill.
来源: JAMA. 2024年332卷1期41-50页
Black and Hispanic patients have high rates of recurrent stroke and uncontrolled hypertension in the US. The effectiveness of home blood pressure telemonitoring (HBPTM) and telephonic nurse case management (NCM) among low-income Black and Hispanic patients with stroke is unknown.
72. Stepped Palliative Care for Patients With Advanced Lung Cancer: A Randomized Clinical Trial.
作者: Jennifer S Temel.;Vicki A Jackson.;Areej El-Jawahri.;Simone P Rinaldi.;Laura A Petrillo.;Pallavi Kumar.;Kathryn A McGrath.;Thomas W LeBlanc.;Arif H Kamal.;Christopher A Jones.;Dustin J Rabideau.;Nora Horick.;Kedie Pintro.;Emily R Gallagher Medeiros.;Kathryn E Post.;Joseph A Greer.
来源: JAMA. 2024年332卷6期471-481页
Despite the evidence for early palliative care improving outcomes, it has not been widely implemented in part due to palliative care workforce limitations.
73. Ivonescimab Plus Chemotherapy in Non-Small Cell Lung Cancer With EGFR Variant: A Randomized Clinical Trial.
作者: .;Wenfeng Fang.;Yuanyuan Zhao.;Yongzhong Luo.;Runxiang Yang.;Yan Huang.;Zhiyong He.;Hui Zhao.;Mingjun Li.;Kai Li.;Qibing Song.;Xiaobo Du.;Yulan Sun.;Wei Li.;Fei Xu.;Zhiyu Wang.;Kunning Yang.;Yun Fan.;Baogang Liu.;Hongyun Zhao.;Ying Hu.;Li Jia.;Shen Xu.;Tienan Yi.;Dongqing Lv.;Haitao Lan.;Mengxia Li.;Wenhua Liang.;Yongsheng Wang.;Hui Yang.;Yuming Jia.;Yuan Chen.;Junguo Lu.;Jifeng Feng.;Chunling Liu.;Ming Zhou.;Jianya Zhou.;Xianling Liu.;Ningning Zhou.;Ming He.;Xiaorong Dong.;Hualin Chen.;Yongxing Chen.;Haichuan Su.;Xiaoling Li.;Zhihong Zhang.;Lei Yang.;Ying Cheng.;Likun Chen.;Xue Hou.;Yu Zhang.;Jun Guo.;Zhen Wang.;Hong Lu.;Di Wu.;Weineng Feng.;Wen Li.;Jianan Huang.;Yan Wang.;Xia Song.;Jiewen Peng.;Laiyu Liu.;Yubiao Guo.;Wenting Li.;Dongmei Lu.;Mingxiu Hu.;Zhongmin Maxwell Wang.;Baiyong Li.;Michelle Xia.;Li Zhang.
来源: JAMA. 2024年332卷7期561-570页
For patients with non-small cell lung cancer whose disease progressed while receiving EGFR tyrosine kinase inhibitor (EGFR-TKI) therapy, particularly third-generation TKIs, optimal treatment options remain limited.
74. Tirzepatide for Weight Reduction in Chinese Adults With Obesity: The SURMOUNT-CN Randomized Clinical Trial.
作者: Lin Zhao.;Zhifeng Cheng.;Yibing Lu.;Ming Liu.;Hong Chen.;Min Zhang.;Rui Wang.;Yuan Yuan.;Xiaoying Li.
来源: JAMA. 2024年332卷7期551-560页
Obesity has become a global public health concern and China has the largest number of affected people worldwide.
75. Krill Oil for Knee Osteoarthritis: A Randomized Clinical Trial.
作者: Laura L Laslett.;Lieke E J M Scheepers.;Benny Antony.;Anita E Wluka.;Guoqi Cai.;Catherine L Hill.;Lyn March.;Helen I Keen.;Petr Otahal.;Flavia M Cicuttini.;Graeme Jones.
来源: JAMA. 2024年331卷23期1997-2006页
Knee osteoarthritis is disabling, with few effective treatments. Preliminary evidence suggested that krill oil supplementation improved knee pain, but effects on knee osteoarthritis remain unclear.
76. Bisoprolol in Patients With Chronic Obstructive Pulmonary Disease at High Risk of Exacerbation: The BICS Randomized Clinical Trial.
作者: Graham Devereux.;Seonaidh Cotton.;Mintu Nath.;Nicola McMeekin.;Karen Campbell.;Rekha Chaudhuri.;Gourab Choudhury.;Anthony De Soyza.;Shona Fielding.;Simon Gompertz.;John Haughney.;Amanda J Lee.;Graeme MacLennan.;Alyn Morice.;John Norrie.;David Price.;Philip Short.;Jorgen Vestbo.;Paul Walker.;Jadwiga Wedzicha.;Andrew Wilson.;Olivia Wu.;Brian J Lipworth.
来源: JAMA. 2024年332卷6期462-470页
Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. Observational studies report that β-blocker use may be associated with reduced risk of COPD exacerbations. However, a recent trial reported that metoprolol did not reduce COPD exacerbations and increased COPD exacerbations requiring hospital admission.
77. Acetaminophen for Prevention and Treatment of Organ Dysfunction in Critically Ill Patients With Sepsis: The ASTER Randomized Clinical Trial.
作者: Lorraine B Ware.;D Clark Files.;Alpha Fowler.;Michael S Aboodi.;Neil R Aggarwal.;Roy G Brower.;Steven Y Chang.;Ivor S Douglas.;Scott Fields.;Andrea S Foulkes.;Adit A Ginde.;Estelle S Harris.;Gregory W Hendey.;R Duncan Hite.;Weixing Huang.;Poying Lai.;Kathleen D Liu.;B Taylor Thompson.;Michael A Matthay.; .
来源: JAMA. 2024年332卷5期390-400页
Acetaminophen (paracetamol) has many pharmacological effects that might be beneficial in sepsis, including inhibition of cell-free hemoglobin-induced oxidation of lipids and other substrates.
78. Pamrevlumab for Idiopathic Pulmonary Fibrosis: The ZEPHYRUS-1 Randomized Clinical Trial.
作者: Ganesh Raghu.;Luca Richeldi.;Evans R Fernández Pérez.;Maria Cristina De Salvo.;Rafael S Silva.;Jin Woo Song.;Takashi Ogura.;Zuo Jun Xu.;Elizabeth A Belloli.;Xueping Zhang.;Lorilyn L Seid.;Lona Poole.; .
来源: JAMA. 2024年332卷5期380-389页
Current treatments for idiopathic pulmonary fibrosis slow the rate of lung function decline, but may be associated with adverse events that affect medication adherence. In phase 2 trials, pamrevlumab (a fully human monoclonal antibody that binds to and inhibits connective tissue growth factor activity) attenuated the progression of idiopathic pulmonary fibrosis without substantial adverse events.
79. Text Messages With Financial Incentives for Men With Obesity: A Randomized Clinical Trial.
作者: Pat Hoddinott.;Catriona O'Dolan.;Lisa Macaulay.;Stephan U Dombrowski.;James Swingler.;Seonaidh Cotton.;Alison Avenell.;Abraham M Getaneh.;Cindy Gray.;Kate Hunt.;Frank Kee.;Alice MacLean.;Michelle McKinley.;Claire Torrens.;Katrina Turner.;Marjon van der Pol.;Graeme MacLennan.
来源: JAMA. 2024年332卷1期31-40页
Effective weight loss interventions are needed for men with obesity.
80. An Adaptive Behavioral Intervention for Weight Loss Management: A Randomized Clinical Trial.
作者: Bonnie Spring.;Angela F Pfammatter.;Laura Scanlan.;Elyse Daly.;Jean Reading.;Sam Battalio.;H Gene McFadden.;Don Hedeker.;Juned Siddique.;Inbal Nahum-Shani.
来源: JAMA. 2024年332卷1期21-30页
Lifestyle interventions for weight loss are difficult to implement in clinical practice. Self-managed mobile health implementations without or with added support after unsuccessful weight loss attempts could offer effective population-level obesity management.
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