770. TREM2 variants in Alzheimer's disease.
作者: Rita Guerreiro.;Aleksandra Wojtas.;Jose Bras.;Minerva Carrasquillo.;Ekaterina Rogaeva.;Elisa Majounie.;Carlos Cruchaga.;Celeste Sassi.;John S K Kauwe.;Steven Younkin.;Lilinaz Hazrati.;John Collinge.;Jennifer Pocock.;Tammaryn Lashley.;Julie Williams.;Jean-Charles Lambert.;Philippe Amouyel.;Alison Goate.;Rosa Rademakers.;Kevin Morgan.;John Powell.;Peter St George-Hyslop.;Andrew Singleton.;John Hardy.; .
来源: N Engl J Med. 2013年368卷2期117-27页
Homozygous loss-of-function mutations in TREM2, encoding the triggering receptor expressed on myeloid cells 2 protein, have previously been associated with an autosomal recessive form of early-onset dementia.
771. Monitoring ventilation with capnography.
作者: Rafael Ortega.;Christopher Connor.;Sora Kim.;Robin Djang.;Kunal Patel.
来源: N Engl J Med. 2012年367卷19期e27页
Capnography, the graphic display of the exhaled and inhaled carbon dioxide concentration plotted against time, is used to monitor ventilation. This video reviews the principles of capnography and explains how to interpret the information it provides.
772. Hand eczema.
Hand eczema is an inflammation of the skin; the cause is often multifactorial. Initial management includes avoiding causative irritants or allergens (e.g., by wearing impermeable gloves) and applying emollients and potent topical glucocorticoids.
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