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742. Increased risk of lymphoma among inflammatory bowel disease patients treated with azathioprine and 6-mercaptopurine.
Inflammatory bowel disease (IBD) is commonly treated with immunomodulators such as azathioprine and 6-mercaptopurine (6-MP). Studies examining lymphoma risk in IBD patients treated with these medications have been underpowered and have yielded conflicting conclusions.
743. 5-Aminosalicylate use and colorectal cancer risk in inflammatory bowel disease: a large epidemiological study.
The objective of this study was to evaluate the risk of colorectal cancer (CRC) in patients taking aminosalicylates (5-ASA) for inflammatory bowel disease (IBD).
748. Insulin resistance and steatosis in hepatitis C virus infection.
The relationship between hepatitis C virus (HCV), steatosis, and insulin resistance is genotype specific, and steatosis and insulin resistance are closely linked to the progression of liver disease in HCV infected patients.
749. Reinforcing the mucus: a new therapeutic approach for ulcerative colitis?
Luminal delivery of phosphatidyl rich phospholipids appears to reduce mucosal inflammatory activity in a high proportion of patients with chronically active ulcerative colitis. The simplicity and apparent safety of this therapeutic approach offers new insights into the importance of the mucus barrier in the pathogenesis and treatment of ulcerative colitis.
750. Probiotics and barrier function in colitis.
Probiotic administration may exert a protective effect in colitis by preventing mucosal barrier disruption and influencing the extent of mucosal injury.
752. Intestinal gas dynamics: mechanisms and clinical relevance.
Patients with functional gut disorders, irritable bowel disease, and related syndromes frequently attribute their symptoms to intestinal gas. While patients are usually convinced of their interpretation, the doctor has few arguments to confirm or refute it, and in this context intestinal gas has become a myth. Studies of intestinal gas dynamics have demonstrated subtle dysfunctions in intestinal motility. Hopefully, extension of these studies may help both in the classification of patients complaining of gas symptoms based on pathophysiological mechanisms, and in identification of objective markers to test mechanistically oriented treatment options.
754. Guidelines for the management of gastroenteropancreatic neuroendocrine (including carcinoid) tumours.
作者: J K Ramage.;A H G Davies.;J Ardill.;N Bax.;M Caplin.;A Grossman.;R Hawkins.;A M McNicol.;N Reed.;R Sutton.;R Thakker.;S Aylwin.;D Breen.;K Britton.;K Buchanan.;P Corrie.;A Gillams.;V Lewington.;D McCance.;K Meeran.;A Watkinson.; .
来源: Gut. 2005年54 Suppl 4卷Suppl 4期iv1-16页 757. Quality in the technical performance of screening flexible sigmoidoscopy: recommendations of an international multi-society task group.
作者: T R Levin.;F A Farraye.;R E Schoen.;G Hoff.;W Atkin.;J H Bond.;S Winawer.;R W Burt.;D A Johnson.;L M Kirk.;S C Litin.;D K Rex.
来源: Gut. 2005年54卷6期807-13页
Flexible sigmoidoscopy (FS) is a complex technical procedure performed in a variety of settings, by examiners with diverse professional backgrounds, training, and experience. Potential variation in technical quality may have a profound impact on the effectiveness of FS on the early detection and prevention of colorectal cancer.
759. Bacterial interactions with cells of the intestinal mucosa: Toll-like receptors and NOD2.
Toll-like receptors (TLR) and NOD2 are emerging as key mediators of innate host defence in the intestinal mucosa, crucially involved in maintaining mucosal as well as commensal homeostasis. Recent observations suggest new (patho-) physiological mechanisms of how functional versus dysfunctional TLRx/NOD2 pathways may oppose or favour inflammatory bowel disease (IBD). In health, TLRx signalling protects the intestinal epithelial barrier and confers commensal tolerance whereas NOD2 signalling exerts antimicrobial activity and prevents pathogenic invasion. In disease, aberrant TLRx and/or NOD2 signalling may stimulate diverse inflammatory responses leading to acute and chronic intestinal inflammation with many different clinical phenotypes.
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