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701. Relationship of radiographic progression status to low disease activity in patients with PsA receiving secukinumab treatment for 2 years.
作者: Philip J Mease.;Laura C Coates.;Corine Gaillez.;Alexis Shew.;Weibin Bao.;Christopher T Ritchlin.
来源: Rheumatology (Oxford). 2026年65卷1期
To examine relationships between radiographic progression and achievement of low disease activity (LDA) or remission at week 104 in patients with PsA receiving secukinumab.
702. Association of SSc with risk of premature ovarian insufficiency: a retrospective cohort study.
作者: Liyi Dai.;Yu-Hsun Wang.;Lin Zeng.;James Cheng-Chung Wei.;Rong Mu.
来源: Rheumatology (Oxford). 2026年65卷1期
Premature ovarian insufficiency (POI) is linked to an elevated risk of premature mortality. Nonetheless, evidence regarding the risk associated with POI in SSc is deficient. This study aimed to evaluate the risk of POI in SSc, offering insights to advance clinical management strategies.
703. Differences in spinal structural lesions between patients with early axSpA and non-axSpA chronic back pain: 2-year SPACE cohort results.
作者: Gizem Ayan.;Liese de Bruin.;Miranda van Lunteren.;Manouk de Hooge.;Ana Bento da Silva.;Mary Lucy Marques.;Monique Reijnierse.;Victoria Navarro-Compán.;Marleen van de Sande.;Inger Jorid Berg.;Roberta Ramonda.;Sofia Exarchou.;Désirée van der Heijde.;Floris van Gaalen.;Sofia Ramiro.
来源: Rheumatology (Oxford). 2026年65卷1期
To compare spinal structural lesions on radiography and magnetic resonance imaging (MRI) over 2 years, between patients with early axial spondyloarthritis (axSpA) and non-axSpA chronic back pain.
704. SIRT3 inhibits fibroblast-like synoviocytes activation in rheumatoid arthritis through delactylation of H3K18.
作者: Jianxiong Zheng.;Chunhua Liu.;Jiayao Hao.;Min Tan.;Jun Li.;Yakun Yu.;Jinyue Lu.;Jing Mao.;Hongxia Wang.;Haili Shen.
来源: Rheumatology (Oxford). 2025年64卷12期6387-6397页
Metabolic reprogramming and epigenetic modifications are key contributors to the development of RA. Recent studies have identified lactate-dependent histone modifications as a novel epigenetic mechanism linking glycolysis to gene regulation. However, the precise role of histone lactylation in RA pathogenesis remains unclear. We aimed to elucidate the specific mechanism of histone lactylation, particularly H3K18la, in the pathogenesis of RA and to explore the therapeutic potential of the SIRT3-mediated delactylation process.
706. The global, regional, and national burden attributable to low bone mineral density, 1990-2020: an analysis of a modifiable risk factor from the Global Burden of Disease Study 2021.
Fractures related to osteoporosis and low bone mineral density lead to substantial morbidity, mortality, and cost to individuals and health systems. Here we present the most up-to-date global, regional, and national estimates of the contribution of low bone mineral density to the burden of fractures from falls and additional categories of injuries from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021.
707. Methylprednisolone plus MTX-based regime vs prednisone-based standard of care for GCA: a propensity score study.
作者: Adriana Soto-Peleteiro.;José Hernández-Rodríguez.;Fátima Raad.;Borja de Miguel.;Leonor Acha.;Marina Torio.;Halbert Hernandez-Negrin.;Verónica Gómez-Caverzaschi.;Ioana Ruiz-Arruza.;Olga Araujo.;Sergio Prieto-González.;Georgina Espígol-Frigolé.;Maria C Cid.;Guillermo Ruiz-Irastorza.
来源: Rheumatology (Oxford). 2026年65卷1期
Treatment of GCA still requires substantial exposure to glucocorticoids (GCs), which are associated with significant toxicity. This study compares the efficacy and safety of the GC-only standard of care (SOC) with a regimen combining intravenous methylprednisolone (IVMP) pulses, MTX and lower doses of prednisone, in newly diagnosed patients with GCA.
708. N-formyl methionine peptide-driven neutrophil activation in idiopathic inflammatory myopathies.
作者: Jorge A Gonzalez-Chapa.;Begum Horuluoglu.;Antonella Notarnicola.;Arpit Rathee.;Noor Kaur.;Ryan D Stultz.;Lisa Christopher-Stine.;Jemima Albayda.;Inger Nennesmo.;Ingrid E Lundberg.;Christian Lood.
来源: Rheumatology (Oxford). 2026年65卷1期
Neutrophil activation is heightened in inflammatory myopathies and associated with disease activity, yet its mechanisms remain unclear. This study explores the role of N-formyl methionine (fMET) in formyl peptide receptor 1 (FPR1)-mediated neutrophil activation in idiopathic inflammatory myopathies (IIMs), focusing on dermatomyositis (DM) and inclusion body myositis (IBM).
709. A possible mechanism of facial contour and extremity deformity in paediatric patients with linear scleroderma.
作者: Guang-Ming Han.;Yi-Fei Xu.;Xi-Wen Zheng.;Xiao-Yi Zhang.;Zhao-Xia Li.;Yuan-Zhen Lu.;Fang Wang.;Min-Shan Chen.;Yu-Jian Zou.
来源: Rheumatology (Oxford). 2026年65卷1期 710. Hydroxychloroquine discontinuation in SLE: a retrospective cohort study with 3-year follow-up.
作者: Milena Delai.;Rachel B Simon.;Eduardo M Cardoso.;Vasileios C Kyttaris.
来源: Rheumatology (Oxford). 2026年65卷1期
To evaluate the incidence and factors associated with SLE flares following HCQ discontinuation.
711. Should all polymyalgia rheumatica be referred to rheumatology? A call for unified stratified specialist care of the GCA-PMR spectrum.
作者: Bhaskar Dasgupta.;Christian Dejaco.;Kornelis van der Geest.;Humphrey Hodgson.;Kenneth J Warrington.
来源: Rheumatology (Oxford). 2026年65卷1期 712. Ten-year cardiovascular risk changes and major adverse events in gout patients.
The long-term interaction between cardiovascular (CV) risk profiles and gout may influence the risk of cardiovascular events. However, the impact of gout and long-term changes in CV risk profile on CV events is unclear.
713. Elevated pre-eclampsia risk in lupus nephritis and antiphospholipid syndrome: a nationwide Spanish registry analysis.
作者: Mario Martín-Portugués.;Jorge Esteban-Sampedro.;Susana Mellor-Pita.;Pablo Tutor de Ureta.;Román Fernández-Guitián.;Ana Huerta.;Guillermo Ruiz-Irastorza.;Luis Dueña-Bartolome.;Ana Royuela.;Alfonso Ortega-de la Puente.;Marina de la Cruz-Echeandía.;Víctor Moreno-Torres.
来源: Rheumatology (Oxford). 2026年65卷1期
Evaluate the association of APS and SLE, focusing on LN, with risk of pre-eclampsia (PE) and PE with severity criteria (PESC).
715. Impact of dactylitis and enthesitis resolution on disease control in guselkumab-treated psoriatic arthritis patients with TNFi-IR: COSMOS post hoc analysis.
作者: Helena Marzo-Ortega.;Iain B McInnes.;Mohamed Sharaf.;Alen Zabotti.;Emmanouil Rampakakis.;Dennis McGonagle.;Ahmed Abogamal.;Pascal Richette.;Georg Schett.
来源: Rheumatology (Oxford). 2026年65卷1期
To evaluate guselkumab efficacy on dactylitis resolution (DR) and enthesitis resolution (ER), and their impact on subsequent disease control, in patients with active psoriatic arthritis (PsA) and prior inadequate response to tumour necrosis factor inhibitors (TNFi-IR).
717. Efficacy and safety of a millimetre wave medical device for pain neuromodulation in peripheral OA: a crossover randomized trial.
作者: Caroline Maindet.;Joris Giai.;Corentin Leroy.;Marion Proust.;Gilliane Lalami.;Isabelle Boudry.;Marlène Thiers.;Jean-Luc Bosson.;Laurent Grange.
来源: Rheumatology (Oxford). 2026年65卷1期
To manage OA-related pain, current guidelines recommend a combination of non-pharmacological and pharmacological treatments. The objective of this study was to assess a millimetre-wave-emitting medical device (MD) for neuromodulation of pain in patients with peripheral OA.
718. Comment on: Risk of venous thromboembolism in people with rheumatoid arthritis: a population-based study in the UK: reply.
作者: Mark D Russell.;Katie Bechman.;Mark Gibson.;Victoria Basey.;Michael Mclean.;Saqib Rana.;Anna Barkaway.;Simon de Lusignan.;Maya H Buch.;James B Galloway.
来源: Rheumatology (Oxford). 2026年65卷1期 719. Lipid-rich pericoronary adipose tissue in systemic lupus erythematosus.
作者: Lévi-Dan Azoulay.;Nadjia Kachenoura.;Khaoula Bouazizi.;Samia Boussouar.;Thomas Broussaud.;Nassim Ait-Abdallah.;Julien Haroche.;Alexis Mathian.;Zahir Amoura.;Alban Redheuil.
来源: Rheumatology (Oxford). 2026年65卷1期 |